DAFTAR ISI Halaman
SAMPUL DALAM ....................................................................................................i PRASYARAT GELAR ..............................................................................................ii LEMBAR PERSETUJUAN.......................................................................................iii PENETAPAN PANITIA PENGUJI ..........................................................................iv PERNYATAAN BEBAS PLAGIAT .........................................................................v UCAPAN TERIMAKASIH .......................................................................................vi ABSTRAK .................................................................................................................ix ABSTRACT ...............................................................................................................x DAFTAR ISI ..............................................................................................................xi DAFTAR GAMBAR .................................................................................................xv DAFTAR TABEL ......................................................................................................xvi DAFTAR BAGAN ....................................................................................................xvi DAFTAR SINGKATAN ...........................................................................................xviii DAFTAR LAMPIRAN ..............................................................................................xx BAB I
PENDAHULUAN .....................................................................................1 1.1
Latar Belakang ...............................................................................1
1.2
Rumusan Masalah ..........................................................................6
1.3
Tujuan Penelitian ...........................................................................6
1.4
1.3.1
Tujuan Umum ..................................................................6
1.3.2
Tujuan Khusus .................................................................6
Manfaat Penelitian .........................................................................7
xi
BAB II
1.4.1
Manfaat Ilmiah ................................................................7
1.4.2
Manfaat Praktis ................................................................7
KAJIAN PUSTAKA .................................................................................8 2.1
Teori Penuaan ................................................................................8
2.2
Rambut ...........................................................................................11
2.3
2.4
2.2.1
Definisi ............................................................................11
2.2.2
Anatomi Rambut..............................................................12
2.2.3
Kecepatan Dan Siklus Pertumbuhan Rambut Normal ....17
2.2.4
Kerontokan Rambut (Effluvium).....................................21
2.2.5
Aging hair ........................................................................24
Minoxidil .......................................................................................26 2.3.1
Struktur Molekul..............................................................26
2.3.2
Mekanisme Kerja .............................................................27
2.3.3
Efek Samping Minoxidil .................................................28
Kayu Manis (Cinnamomum Burmanii) .........................................28 2.4.1
Kayu Manis Bagi Kesehatan ...........................................28
2.4.2
Klasifikasi Tanaman Kayu Manis ...................................29
2.4.3
Ikhtisar Tanaman Kayu Manis ........................................31
2.5
Minyak Atsiri Kayu Manis ............................................................32
2.6
Cinnamaldehyde Ekstrak Kayu Manis ..........................................33 2.6.1
Nama Lain dan Struktur Kimia Cinnamaldehyde ...........33
2.6.2
Farmakologi Cinnamaldehyde .........................................34
2.6.3
Dosis Toxic Topikal Cinnamaldehyde ............................36
xii
BAB IIIKERANGKA BERFIKIR, KONSEP DAN HIPOTESIS PENELITIAN ....38
BAB IV
3.1
Kerangka Berfikir ..........................................................................38
3.2
Konsep Penelitian ..........................................................................40
3.3
Hipotesis Penelitian .......................................................................41
METODE PENELITIAN .........................................................................42 4.1
Rancangan Penelitian.....................................................................42
4.2
Tempat dan Waktu Penelitian ........................................................44
4.3
4.4
4.5
4.6
4.2.1
Tempat Penelitian ............................................................44
4.2.2
Waktu Penelitian..............................................................44
Penentuan Sumber Data .................................................................44 4.3.1
Populasi Penelitian ..........................................................44
4.3.2
Tehnik Pengambilan Sampel ...........................................45 4.3.2.1
Kriteria Inklusi ..............................................45
4.3.2.3
Kriteria Drop Out ..........................................45
Variabel Penelitian.........................................................................46 4.4.1
Klasifikasi Variabel .........................................................46
4.4.2
Hubungan Antar Variabel Penelitian ...............................47
4.4.3
Definisi Operasional Variabel .........................................48
Pelaksanaan Penelitian...................................................................49 4.5.1
Pemilihan dan Pemeliharaan Hewan Uji .........................49
4.5.2
Prosedur Penelitian ..........................................................50
4.5.3
Perlakuan Terhadap Sampel ............................................53
Bahan Penelitian ............................................................................53
xiii
BAB V
4.6.1
Cara Penghalusan Kayu Manis ........................................54
4.6.2
Cara Pembuatan Minyak Atsiri kayu manis ....................54
4.7
Alur Penelitian ...............................................................................56
4.8
Analisis Data ..................................................................................57
HASIL PENELITIAN ...............................................................................58 5.1
Analisis Deskriptif .........................................................................58
5.2
Uji Normalitas Data .......................................................................59
5.3
Uji Homogenitas Data Antar Kelompok .......................................60
5.4
Uji Komparabilitas Data Ukuran Panjang dan Folikel Rambut ....61
5.5
Uji Lanjutan Ukuran Panjang dan Diameter Folikel Rambut........63
BAB VI PEMBAHASAN PENELITIAN ............................................................68 6.1
Subyek Penelitian ..........................................................................68
6.2
Proses Penuaan Terhadap Rambut.................................................69
6.3
Minyak Atsiri Kayu Manis meningkatkan panjang Rambut .........70
BAB VII SIMPULAN DAN SARAN ...................................................................73 7.1
Simpulan ........................................................................................73
7.2
Saran
DAFTAR PUSTAKA
......................................................................................... 73 .........................................................................................75
xiv
DAFTAR GAMBAR
Halaman Gambar
2.1
Jenis Rambut Kulit Kepala Manusia ....................................12
Gambar
2.2
Bagian Batang Rambut .........................................................14
Gambar
2.3
Siklus Pertumbuhan Rambut Normal ...................................19
Gambar
2.4
Kelainan Batang Rambut .....................................................23
Gambar
2.5
Struktur Kimia Minoxidil .....................................................27
Gambar
2.6
Kayu Manis ..........................................................................31
Gambar
2.7
Struktur Kimia Cinnamaldehyde ..........................................34
Gambar
2.8
Mekanisme IGF-1 Dalam Pertumbuhan Rambut .................36
Gambar
5.1
Grafik Rerata Panjang Rambut Antar Kelompok ................62
Gambar
5.2
Grafik Rerata Ukuran Diameter Folikel Rambut .................63
Gambar
5.3
Panjang Rambut Tikus Wistar..............................................65
Gambar
5.4
Histopatologi Folikel Rambut Tikus Wistar ........................67
xv
DAFTAR TABEL Halaman
Tabel
2.1
Jumlah Folikel Rambut Manusia Dewasa ............................16
Tabel
2.2
Kecepatan Pertumbuhan Rambut Dan Panjang Rambut ......17
Tabel
2.3
Komposisi Kimia Kayu Manis .............................................29
Tabel
2.4
Dosis Toksik Pemakaian Cinnamaldehyde Pada Kulit ........37
Tabel
5.1
Hasil Analisis Deskriptif ......................................................59
Tabel
5.2
Hasil Uji Normalitas Data ....................................................60
Tabel
5.3
Hasil Uji Homogenitas Data Antar kelompok .....................60
Tabel
5.4
Rerata Panjang Rambut Antar Kelompok ............................61
Tabel
5.5
Rerata Diameter Folikel Rambut Antar Kelompok ..............62
Tabel
5.6
Hasil Uji Lanjutan Panjang Rambut Antar Kelompok.........64
Tabel
5.7
Hasil Uji Lanjutan Diameter Folikel rambut ........................66
xvi
DAFTAR BAGAN
Halaman
Bagan
3.1
Bagan Konsep Penelitian .....................................................40
Bagan
4.1
Bagan Rancangan Penelitian ................................................42
Bagan
4.2
Bagan Hubungan Antar Variabel Penelitian ........................47
Bagan
4.3
Bagan Alur Penelitian ..........................................................56
xvii
DAFTAR SINGKATAN
Cm
:
Centimeter
COX-2
:
Cyclooxigenase-2
FGF-5
:
Fibroblast Growth Factor-5
HGF
:
Hepatocyte Growth Factor
ICAM
:
Intracelular Adhesion Molecule
IFN-γ
:
Interferon γ
IGF-1
:
Insulin Like Growth Factor-1
IL-1β
:
Interleukin-1 β
IL-1a
:
Interleukin-1 a
IL-1b
:
Interleukin-1 b
IL-2
:
Interleukin- 2
IL-4
:
Interleukin- 4
IL-5
:
Interleukin- 5
IUPAC
:
International Union and Applied Chemistry
L D 50
:
lethal dose pada 50% hewan coba
NO
:
Nitric Oxide
mm
:
Millimeter
PGE-2
:
Prostaglandin-2
TGF β1
:
Tumor Growth Factorβ1
TGF β2
:
Tumor Growth Factorβ2
Th
:
T Helper
xviii
Th 1
:
T Helper 1
Th 2
:
T Helper2
TNF-α
:
Tumor Necrosis Factor α
UV
:
Ultraviolet
VCAM
:
Vascular Cell Adhesion Molecule
VEGF
:
Vascular Endotel Growth Factor
xix
DAFTAR LAMPIRAN
Lampiran 1 Ethical Clearance.............................................................................. 84 Lampiran 2 Tabel Konversi Dosis Manusia dan Hewan ..................................... 86 Lampiran 3 Analisa Kuantitatif Minyak Atsiri Kayu Manis….............................87 Lampiran 4 Analisa Kuantitatif KadarCinnamaldehyde Minyak Atsiri Kayu Manis.....................................................................................................................90 Lampiran 5 Surat Pemeriksaan Histopatologi.......................................................91 Lampiran 6 Data Pemeriksaan Panjang Bulu Tikus..............................................92 Lampiran 7 Data Pemeriksaan Diameter Folikel Rambut.....................................93 Lampiran 8 Analisis Deskriptif ............................................................................94 Lampiran 9 Uji Normalitas........................................................................ ...........95 Lampiran 7 Uji Homogenitas .............................................................................. 95 Lampiran 8 Uji one way anova…........................................................................ 96 Lampiran 9 Uji LSD........................................................................................... .96
xx
