Lampiran 1 Perhitungan Statistik SPSS 15.0 Derajat Penurunan Berat Badan Akhir Siklus I (hari ke-26) Kruskal Wallis H Test Statistics(a,b)
Chi-Square
hasil 9.818
df
3
Asymp. Sig.
.020
Mann Whitney U KN-KBM
KN-KAOM+DSS
Test Statistics(b)
Test Statistics(b) hasil
hasil
Mann-Whitney U
17.500
Mann-Whitney U
Wilcoxon W
38.500
Wilcoxon W
21.000
Z
-3.052
Z
-.123
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.000
.902
Asymp. Sig. (2-tailed)
.002
.937(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
KBM-KAOM+DSS Test Statistics(b)
Mann-Whitney U
hasil 2.000
Wilcoxon W
23.000
Z
-2.768
Asymp. Sig. (2-tailed)
.006
Exact Sig. [2*(1-tailed Sig.)]
.009(a)
73
KN-KP Test Statistics(b) hasil Mann-Whitney U
12.000
Wilcoxon W
33.000
Z
-1.173
Asymp. Sig. (2-tailed)
.241
Exact Sig. [2*(1-tailed Sig.)]
.394(a)
KBM-KP Test Statistics(b) hasil Mann-Whitney U
13.500
Wilcoxon W
34.500
Z
-.866
Asymp. Sig. (2-tailed)
.386
Exact Sig. [2*(1-tailed Sig.)]
.485(a)
KAOM+DSS-KP Test Statistics(b)
Mann-Whitney U
hasil .000
Wilcoxon W
21.000
Z
-2.983
Asymp. Sig. (2-tailed)
.003
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
74
Akhir Siklus II (hari ke-47) Kruskal Wallis H Test Statistics(a,b)
hasil 9.818
Chi-Square df
3
Asymp. Sig.
.020
Mann Whitney U KN-KBM
KBM-KAOM+DSS Test Statistics(b)
Mann-Whitney U Wilcoxon W
Test Statistics(b)
hasil 18.000 39.000
Z
.000
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
Mann-Whitney U Wilcoxon W
21.000
Z
-2.966
1.000
Asymp. Sig. (2-tailed)
.003
1.000(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
KN-KAOM+DSS
KBM-KP
Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U
6.000
hasil Mann-Whitney U
15.000 36.000
Wilcoxon W
27.000
Wilcoxon W
Z
-2.309
Z
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
-.561
.021
Asymp. Sig. (2-tailed)
.575
.065(a)
Exact Sig. [2*(1-tailed Sig.)]
.699(a)
KN-KP
KAOM+DSS-KP Test Statistics(b)
Mann-Whitney U Wilcoxon W Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
hasil .000
Test Statistics(b)
hasil 18.000 39.000 .000
Mann-Whitney U
hasil .000
Wilcoxon W
21.000
Z
-2.983
1.000
Asymp. Sig. (2-tailed)
.003
1.000(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
75
Akhir Siklus III (hari ke-68) Kruskal Wallis H Test Statistics(a,b) hasil Chi-Square
9.857
df
3
Asymp. Sig.
.020
Mann Whitney U KN-KBM
KBM-KAOM+DSS Test Statistics(b)
Test Statistics(b)
hasil
hasil
Mann-Whitney U
15.000
Mann-Whitney U
Wilcoxon W
36.000
Wilcoxon W
27.000
Z
-1.000
Z
-2.309
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.317
Asymp. Sig. (2-tailed)
.021
.699(a)
Exact Sig. [2*(1-tailed Sig.)]
.065(a)
KN-KAOM+DSS
KBM-KP
Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U
.000
hasil Mann-Whitney U
18.000 39.000
Wilcoxon W
21.000
Wilcoxon W
Z
-3.052
Z
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.000
.002
Asymp. Sig. (2-tailed)
1.000
.002(a)
Exact Sig. [2*(1-tailed Sig.)]
1.000(a)
KN-KP
KAOM+DSS-KP Test Statistics(b)
Mann-Whitney U Wilcoxon W Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
6.000
Test Statistics(b)
hasil 12.000
Mann-Whitney U
hasil 6.000
33.000
Wilcoxon W
27.000
-1.173
Z
-2.309
.241
Asymp. Sig. (2-tailed)
.021
.394(a)
Exact Sig. [2*(1-tailed Sig.)]
.065(a)
76
Lampiran 2 Perhitungan Statistik SPSS 15.0 Derajat Beratnya Diare Akhir Siklus I (hari ke-26) Kruskal Wallis Test Statistics(a,b) hasil 15.134
Chi-Square df
3
Asymp. Sig.
.002
Mann Whitney U KN-KBM
KN-KP Test Statistics(b)
Mann-Whitney U Wilcoxon W Z
hasil 15.000
Mann-Whitney U Wilcoxon W
33.000
-1.000
Z
-1.173
.317
Asymp. Sig. (2-tailed)
.241
.699(a)
Exact Sig. [2*(1-tailed Sig.)]
.394(a)
KN-KAOM+DSS
KBM-KAOM+DSS
Test Statistics(b)
Mann-Whitney U
hasil 12.000
36.000
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
Test Statistics(b)
Test Statistics(b)
hasil .000
Mann-Whitney U
hasil 2.000
Wilcoxon W
21.000
Wilcoxon W
23.000
Z
-3.052
Z
-2.768
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.002
Asymp. Sig. (2-tailed)
.006
.002(a)
Exact Sig. [2*(1-tailed Sig.)]
.009(a)
77
KBM-KP
KAOM+DSS-KP Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U Wilcoxon W Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
hasil
13.500
Mann-Whitney U
34.500
Wilcoxon W
21.000
Z
-2.983
-.866
.000
.386
Asymp. Sig. (2-tailed)
.003
.485(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
78
Akhir Siklus II (hari ke-47) Kruskal Wallis H Test Statistics(a,b) hasil Chi-Square
14.991
df
3
Asymp. Sig.
.002
Mann Whitney U KN-KBM
KBM-KAOM+DSS Test Statistics(b)
Test Statistics(b)
hasil
hasil
Mann-Whitney U
15.000
Mann-Whitney U
Wilcoxon W
36.000
Wilcoxon W
21.000
Z
-2.966
Z
-.561
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.575
Asymp. Sig. (2-tailed)
.003
.699(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
KN-KAOM+DSS
KBM-KP
Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U
.000
hasil Mann-Whitney U
15.000 36.000
Wilcoxon W
21.000
Wilcoxon W
Z
-2.983
Z
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
-.561
.003
Asymp. Sig. (2-tailed)
.575
.002(a)
Exact Sig. [2*(1-tailed Sig.)]
.699(a)
KN-KP
KAOM+DSS-KP Test Statistics(b)
Mann-Whitney U Wilcoxon W Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.000
Test Statistics(b)
hasil 18.000 39.000 .000
Mann-Whitney U
hasil .000
Wilcoxon W
21.000
Z
-2.983
1.000
Asymp. Sig. (2-tailed)
.003
1.000(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
79
Akhir Siklus III (hari ke-68) Kruskal Wallis H Test Statistics(a,b) hasil Chi-Square
14.880
df
3
Asymp. Sig.
.002
a Kruskal Wallis Test b Grouping Variable: perlakuan
Mann Whitney U KBM-KAOM+DSS
KN-KBM
Test Statistics(b)
Test Statistics(b) hasil Mann-Whitney U
15.000
Wilcoxon W
36.000
Z
-.561
Asymp. Sig. (2-tailed)
.575
Exact Sig. [2*(1-tailed Sig.)]
.699(a)
Mann-Whitney U Wilcoxon W
21.000
Z
-3.035
Asymp. Sig. (2-tailed)
.002
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
KBM-KP
KN-KAOM+DSS
Test Statistics(b)
Test Statistics(b) hasil Mann-Whitney U
.000
Wilcoxon W
21.000
Z
-3.052
Asymp. Sig. (2-tailed)
.002
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
Mann-Whitney U Wilcoxon W
hasil 18.000 39.000
Z
.000
Asymp. Sig. (2-tailed)
1.000
Exact Sig. [2*(1-tailed Sig.)]
1.000(a)
KAOM+DSS-KP
KN-KP
Test Statistics(b)
Test Statistics(b)
Mann-Whitney U Wilcoxon W Z
hasil 15.000 36.000 -.561
Asymp. Sig. (2-tailed)
.575
Exact Sig. [2*(1-tailed Sig.)]
.699(a)
hasil .000
hasil Mann-Whitney U
.000
Wilcoxon W
21.000
Z
-3.035
Asymp. Sig. (2-tailed)
.002
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
80
Lampiran 3 Perhitungan Statistik SPSS 15.0 Derajat Perdarahan Rektum Akhir Siklus I (hari ke-68) Kruskal Wallis H Test Statistics(a,b) hasil 9.857
Chi-Square Df
3
Asymp. Sig.
.020
Mann Whitney U KN-KBM
KN-KP Test Statistics(b)
Test Statistics(b)
hasil
hasil
Mann-Whitney U
18.000
Mann-Whitney U
18.000
Wilcoxon W
39.000
Wilcoxon W
39.000
Z
.000
Z
.000
Asymp. Sig. (2-tailed)
1.000
Asymp. Sig. (2-tailed)
1.000
Exact Sig. [2*(1-tailed Sig.)]
1.000(a)
Exact Sig. [2*(1-tailed Sig.)]
1.000(a)
KN-KAOM+DSS
KBM-KAOM+DSS
Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U
9.000
Mann-Whitney U
Wilcoxon W
30.000
Wilcoxon W
Z
-1.915
Z
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
hasil 18.000 39.000 .000
.056
Asymp. Sig. (2-tailed)
1.000
.180(a)
Exact Sig. [2*(1-tailed Sig.)]
1.000(a)
81
KBM-KP
KAOM+DSS-KP
Test Statistics(b)
Test Statistics(b) hasil
hasil
Mann-Whitney U
18.000
Mann-Whitney U
Wilcoxon W
39.000
Wilcoxon W
30.000
Z
-1.915
Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.000
9.000
1.000
Asymp. Sig. (2-tailed)
.056
1.000(a)
Exact Sig. [2*(1-tailed Sig.)]
.180(a)
82
Lampiran 4 Perhitungan Statistik SPSS 15.0 Clinical Score Akhir Siklus I (hari ke-26) Kruskal Wallis H Test Statistics(a,b) hasil Chi-Square
15.938
df
3
Asymp. Sig.
.001
Mann Whitney U KN-KBM
KN-KP Test Statistics(b)
Mann-Whitney U Wilcoxon W
Test Statistics(b)
hasil 17.500 38.500
Z
-.123
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
Mann-Whitney U Wilcoxon W
33.000
Z
-1.173
.902
Asymp. Sig. (2-tailed)
.241
.937(a)
Exact Sig. [2*(1-tailed Sig.)]
.394(a)
KN-KAOM+DSS
KBM-KAOM+DSS
Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U
hasil 12.000
.000
hasil Mann-Whitney U
.500
Wilcoxon W
21.000
Wilcoxon W
21.500
Z
-3.047
Z
-2.968
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.002
Asymp. Sig. (2-tailed)
.003
.002(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
83
KBM-KP
KAOM+DSS-KP Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U Wilcoxon W Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
hasil
13.500
Mann-Whitney U
34.500
Wilcoxon W
21.000
Z
-2.983
-.866
.000
.386
Asymp. Sig. (2-tailed)
.003
.485(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
84
Akhir Siklus II (hari ke-47) Kruskal Wallis H Test Statistics(a,b) hasil Chi-Square
14.947
df
3
Asymp. Sig.
.002
Mann Whitney U KN-KBM
KN-KP Test Statistics(b)
Mann-Whitney U
Test Statistics(b)
hasil 12.000
Mann-Whitney U
Wilcoxon W
33.000
Wilcoxon W
Z
-1.173
Z
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
39.000 .000
.241
Asymp. Sig. (2-tailed)
1.000
.394(a)
Exact Sig. [2*(1-tailed Sig.)]
1.000(a)
KN-KAOM+DSS
KBM-KAOM+DSS
Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U
hasil 18.000
.000
hasil Mann-Whitney U
.000
Wilcoxon W
21.000
Wilcoxon W
21.000
Z
-2.994
Z
-2.934
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
.003
Asymp. Sig. (2-tailed)
.003
.002(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
85
KBM-KP
KAOM+DSS-KP Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U Wilcoxon W Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
hasil
15.000
Mann-Whitney U
36.000
Wilcoxon W
21.000
Z
-2.950
-.561
.000
.575
Asymp. Sig. (2-tailed)
.003
.699(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
86
Akhir Siklus III (hari ke-68) Kruskal Wallis H Test Statistics(a,b) hasil Chi-Square
13.933 3 .003
df Asymp. Sig.
Mann Whitney U KN-KBM
KBM-KAOM+DSS Test Statistics(b)
Mann-Whitney U Wilcoxon W Z
hasil .000
Mann-Whitney U Wilcoxon W
21.000
-2.950
Z
-2.929
.003
Asymp. Sig. (2-tailed)
.003
.002(a)
Exact Sig. [2*(1-tailed Sig.)]
.002(a)
KN-KAOM+DSS
KBM-KP
Test Statistics(b)
Mann-Whitney U
Test Statistics(b)
hasil .000
Mann-Whitney U
Wilcoxon W
21.000
Wilcoxon W
Z
-2.950
Z
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
hasil .000
21.000
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
Test Statistics(b)
hasil 15.000 36.000 -.561
.003
Asymp. Sig. (2-tailed)
.575
.002(a)
Exact Sig. [2*(1-tailed Sig.)]
.699(a)
KN-KP
KAOM+DSS-KP Test Statistics(b)
Test Statistics(b)
hasil Mann-Whitney U
hasil
12.000
Mann-Whitney U
Wilcoxon W
33.000
Wilcoxon W
27.000
Z
-1.173
Z
-1.992
Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]
6.000
.241
Asymp. Sig. (2-tailed)
.046
.394(a)
Exact Sig. [2*(1-tailed Sig.)]
.065(a)
87
Lampiran 5 Perhitungan Dosis Dosis buah merah Dosis manusia 70 kg
= 30 cc
Dosis untuk mencit 20 g
= 30 cc x 0,0026 = 0,078 cc
Dosis untuk mencit 24 g
=
x 0,078 cc = 0,0936 cc ~ 0,1 cc
Dosis azoxymethane (AOM) AOM = 12 mg/kgBB Rata-rata berat badan mencit 20-25 gram = dosis AOM 0,24 - 0,3 mg/mencit Untuk dosis intraperitoneal 0,4 ml yang mengandung 0,24- 0,3 mg AOM Stok konsentrasi AOM = 1 gram/ml Untuk pembuatan 0,24 mg AOM/400µL sebanyak 10 ml maka dibutuhkan AOM dari stok : (10ml x 0,24mg/400 ) : 1 gram/ml = 6 L Dosis dextran sulfate sodium (DSS) Garam DSS yang dipakai adalah 2,5 g dilarutkan dengan aquadest 100 mL sehingga didapatkan larutan DSS 2,5%. Larutan ini diberikan melalui air minum pada mencit.
88
Lampiran 6 Alat dan Bahan yang Digunakan
Sari Buah Merah
Sonde Lambung dan Spuit 1 mL
Neraca Analitik
89
RIWAYAT HIDUP
Nama
: Margareta Dewi
NRP
: 0710131
Tempat/Tanggal Lahir
: Bandar Lampung/13 Maret 1989
Alamat
: Jl. Raya Caringin 439 H, Bandung
Riwayat Pendidikan
:
SDK 6 BPK Penabur, Bandung (1996-2001) SMPK I BPK Penabur, Bandung (2001-2004) SMAK I BPK Penabur, Bandung (2004-2007) Fakultas Kedokteran Universitas Kristen Maranatha, Bandung (2007sekarang)
90
