LAMPIRAN A HASIL UJI KERAGAMAN BOBOT TABLET LIKUISOLID IBUPROFEN Hasil Uji Keragaman Bobot Tablet Formula A No
1 2 3 4 5 6 7 8 9 10 Ratarata PK (%) SD KV
Replikasi I Bobot Y Tablet (%) (mg) 764,6 99,25 763,1 99,06 763,0 99,05 763,8 99,15 756,8 98,24 770,2 99,98 768,3 99,73 773,5 100,41 767,8 99,67 764,7 99,27
Replikasi II Bobot Y Tablet (%) (mg) 756,8 99,96 775,3 102,4 754,9 99,71 757,9 100,10 760,0 100,38 764,2 100,94 759,9 100,37 755,8 99,83 763,2 100,8 762,5 100,7
Replikasi III Bobot Y Tablet (%) (mg) 758,9 101,12 774,2 103,20 756,2 100,76 756,7 100,82 755,8 100,70 756,3 100,77 770,3 102,64 754,8 100,57 749,9 99,92 745,6 99,35
765,58 99,38 99,38 0,60 0,60
761,05 100,52 100,52 0,78 0,78
757,87 100,98 100,98 1,14 1,13
76
Hasil Uji Keragaman Bobot Tablet Formula B No
1 2 3 4 5 6 7 8 9 10 Rata-rata PK (%) SD KV
Replikasi I Bobot Y Tablet (%) (mg) 751,7 100,86 751,1 100,78 748,0 100,36 758,3 101,74 747,5 100,29 749,8 100,60 750,1 100,64 748,3 100,40 750,9 100,75 751,1 100,78 750,68 100,72 100,72 0,40 0,41
Replikasi II Bobot Y Tablet (%) (mg) 764,3 100,25 773,5 101,45 757,4 99,34 761,6 99,89 773,2 101,41 757,6 99,37 760,1 99,70 761,5 99,88 763,3 100,12 771,5 101,19 764,4 100,26 100,26 0,80 0,81
77
Replikasi III Bobot Y Tablet (%) (mg) 747,0 98,71 751,6 99,32 753,3 99,55 754,2 99,67 755,3 99,81 759,1 100,31 750,8 99,22 749,1 98,99 759,3 100,34 761,1 100,58 754,08 99,65 99,65 0,62 0,62
Hasil Uji Keragaman Bobot Tablet Formula C No
1 2 3 4 5 6 7 8 9 10 Ratarata PK(%) SD KV
Replikasi I Bobot Y Tablet (%) (mg) 748,0 100,35 744,8 99,92 751,0 100,75 751,9 100,87 746,2 100,11 744,7 99,91 739,4 99,20 739,6 99,22 750,6 100,70 747,4 100,27
Replikasi II Bobot Y Tablet (%) (mg) 757,7 99,46 762,0 100,03 766,0 100,55 758,3 99,54 755,4 99,16 760,0 99,76 751,3 98,62 757,6 99,45 756,0 99,24 757,1 99,38
Replikasi III Bobot Y Tablet (%) (mg) 748,2 100,16 748,3 100,17 760,5 101,81 760,3 101,78 750,1 100,41 748,3 100,17 741,1 99,21 758,3 101,51 750,1 100,41 758,7 101,56
746,36 100,13 100,13 0,59 0,59
758,14 99,52 99,52 0,52 0,52
752,39 100,72 100,72 0,88 0,88
78
Hasil Uji Keragaman Bobot Tablet Formula D No
1 2 3 4 5 6 7 8 9 10 Ratarata PK(%) SD KV
Replikasi I Bobot Y Tablet (%) (mg) 728,4 100,04 739,6 101,58 739,2 101,53 744,4 102,24 739,0 101,50 731,1 100,41 729,4 100,18 732,7 100,63 734,8 100,92 735,9 101,07
Replikasi II Bobot Y Tablet (%) (mg) 758,0 99,49 757,9 99,48 751,0 98,57 750,1 98,45 761,2 99,91 753,4 98,89 760,8 99,86 761,8 99,99 754,5 99,03 756,0 99,23
Replikasi III Bobot Y Tablet (%) (mg) 757,8 99,79 775,4 102,10 768,1 101,14 766,3 100,90 742,7 97,80 750,9 98,88 761,4 100,26 770,3 101,43 769,5 101,33 754,7 99,38
735,45 101,01 101,01 0,71 0,70
756,47 99,29 99,29 0,55 0,55
761,71 100,30 100,30 1,34 1,33
79
LAMPIRAN B HASIL UJI KESERAGAMAN KANDUNGAN TABLET LIKUISOLID IBUPROFEN Hasil Uji Keseragaman Kandungan Tablet Formula A Replikasi I Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,534 0,524 0,528 0,531 0,520 0,533 0,541 0,528 0,527 0,526
764,6 763,1 763,0 763,8 756,8 770,2 768,3 773,5 767,8 764,7
287,90 282,45 284,63 286,26 280,27 287,36 291,72 284,63 284,08 283,54
286,73 286,16 286,13 286,43 283,80 288,83 288,11 290,06 287,93 286,76 Rata-rata SD KV
100,41 98,70 99,48 99,94 98,75 99,49 101,25 98,13 98,67 98,88 99,37 0,95 0,95
Hasil Uji Keseragaman Kandungan Tablet Formula A ReplikasiII Abs 0,522 0,541 0,519 0,532 0,530 0,526 0,527 0,521 0,531 0,533
W sampel (mg) 756,8 775,3 754,9 757,9 760,0 764,2 759,9 755,8 763,2 762,5
C sampel (µg/ml) 281,36 291,72 279,72 286,81 285,72 283,54 284,08 280,81 286,26 287,36
80
C teoritis (µg/ml) 283,80 290,74 283,09 284,21 285,00 286,58 284,96 283,43 286,20 285,94 Rata-rata SD KV
Kadar (%) 99,14 100,34 98,81 100,91 100,25 98,94 99,69 99,08 100,02 100,50 99,77 0,74 0,74
Hasil Uji Keseragaman Kandungan Tablet Formula A Replikasi III Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,522 0,536 0,523 0,534 0,522 0,531 0,526 0,525 0,520 0,523
758,9 774,2 756,2 756,7 755,8 756,3 770,3 754,8 749,9 745,6
281,36 288,99 281,90 287,90 281,36 286,26 283,54 282,99 280,27 281,90
284,59 290,33 283,58 283,76 283,43 283,61 288,86 283,05 281,21 279,60 Rata-rata SD KV
98,86 99,54 99,41 101,46 99,27 100,94 98,16 99,98 99,66 100,82 99,81 1,01 1,01
Hasil Uji Keseragaman Kandungan Tablet Formula B Replikasi I Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,524 0,513 0,518 0,531 0,515 0,519 0,523 0,530 0,515 0,520
751,7 751,1 748,0 758,3 747,5 749,8 750,1 748,3 750,9 751,1
282,45 276,45 279,17 286,26 277,54 279,72 281,90 285,72 277,54 280,27
281,89 281,66 280,50 284,36 280,31 281,18 281,29 280,61 281,59 281,66 Rata-rata SD KV
100,2 98,10 99,53 100,67 99,01 99,48 100,22 101,82 98,56 99,50 99,71 1,07 1,07
81
Hasil Uji Keseragaman Kandungan Tablet Formula B Replikasi II Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,529 0,526 0,527 0,535 0,535 0,517 0,529 0,538 0,531 0,525
764,3 773,5 757,4 761,6 773,2 757,6 760,1 761,5 763,3 771,5
285,17 283,54 284,08 288,45 288,45 278,63 285,17 290,08 286,26 282,99
286,61 290,06 284,03 285,60 289,95 284,10 285,04 285,56 286,24 289,31 Rata-rata SD KV
99,50 97,75 100,02 101,00 99,48 98,07 100,05 101,58 100,01 97,82 99,53 1,31 1,31
Hasil Uji Keragaman Kandungan Tablet Formula B ReplikasiIII Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,518 0,518 0,520 0,527 0,530 0,527 0,531 0,522 0,525 0,530
747,0 751,6 753,3 754,2 755,3 759,1 750,8 749,1 759,3 761,1
279,17 279,17 280,27 284,08 285,72 284,08 286,26 281,00 282,99 285,72
280,13 281,85 282,49 282,83 283,24 284,66 281,55 280,91 284,74 285,41 Rata-rata SD KV
99,66 99,05 99,21 100,44 100,88 99,80 101,67 100,16 99,39 100,11 100,04 0,81 0,81
82
Hasil Uji Keseragaman Kandungan Tablet Formula C Replikasi I Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,518 0,516 0,531 0,524 0,522 0,516 0,516 0,514 0,518 0,528
748,0 744,8 751,0 751,9 746,2 744,7 739,4 739,6 750,6 747,4
279,17 278,08 286,30 282,45 281,36 278,08 278,08 276,99 279,17 284,63
280,50 279,30 281,63 281,96 279,83 279,26 277,28 277,35 281,48 280,28 Rata-rata SD KV
99,53 99,56 101,60 100,17 100,55 99,58 100,29 99,87 99,18 101,55 100,19 0,85 0,84
Hasil Uji Keseragaman Kandungan Tablet Formula C ReplikasiII Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,521 0,529 0,533 0,524 0,527 0,523 0,520 0,529 0,524 0,533
757,7 762,0 766,0 758,3 755,4 760,0 751,3 757,6 756,0 757,1
280,81 285,17 287,36 282,45 284,08 281,90 280,27 285,17 282,45 287,36
284,14 285,75 287,25 284,36 283,28 285,00 281,74 284,10 283,50 283,91 Rata-rata SD KV
98,83 99,80 100,04 99,33 100,29 98,91 99,48 100,38 99,63 101,21 99,79 0,72 0,72
83
Hasil Uji Keseragaman Kandungan Tablet Formula C Replikasi III Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,519 0,518 0,532 0,529 0,519 0,527 0,510 0,530 0,516 0,527
748,2 748,3 760,5 760,3 750,1 748,3 741,1 758,3 750,1 758,7
279,72 279,17 286,81 285,17 279,72 284,08 274,81 285,72 278,08 284,08
280,58 280,61 285,19 285,11 281,29 280,61 277,91 284,36 281,29 284,51 Rata-rata SD KV
99,70 99,49 100,57 100,02 99,44 101,24 98,88 100,48 98,86 99,85 99,85 0,75 0,75
Hasil Uji Keseragaman Kandungan Tablet Formula D Replikasi I Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,515 0,515 0,511 0,528 0,511 0,518 0,502 0,517 0,503 0,511
728,4 739,6 739,2 744,4 739,0 731,1 729,4 732,7 734,8 735,9
277,54 277,54 275,36 284,63 275,36 279,17 270,45 278,63 270,99 275,36
273,15 277,35 277,20 279,15 277,13 274,16 273,53 274,76 275,55 275,96 Rata-rata SD KV
101,61 100,07 99,34 101,96 99,36 101,83 98,88 101,41 98,35 99,78 100,26 1,33 1,33
84
Hasil Uji Keseragaman Kandungan Tablet Formula D Replikasi II Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,521 0,523 0,529 0,520 0,523 0,525 0,519 0,529 0,531 0,522
758,0 757,9 751,0 750,1 761,2 753,4 760,8 761,8 754,5 756,0
280,81 281,90 285,17 280,27 281,90 283,00 279,72 285,17 286,26 281,36
284,25 284,21 281,63 281,29 285,45 282,53 285,30 285,68 282,94 283,50 Rata-rata SD KV
98,79 99,19 101,26 99,64 98,76 100,17 98,04 99,82 101,18 99,24 99,61 1,04 1,04
Hasil Uji Keseragaman Kandungan Tablet Formula D Replikasi III Abs
W sampel (mg)
C sampel (µg/ml)
C teoritis (µg/ml)
Kadar (%)
0,535 0,534 0,531 0,537 0,512 0,521 0,535 0,527 0,524 0,520
757,8 775,4 768,1 766,3 742,7 750,9 761,4 770,3 769,5 754,7
288,45 287,90 286,26 289,50 275,90 280,81 288,45 284,08 282,45 280,27
284,18 290,78 288,04 287,36 278,51 281,59 285,53 288,86 288,56 283,01 Rata-rata SD KV
101,5 99,01 99,38 100,76 99,06 99,72 101,02 98,35 97,88 99,03 99,57 1,18 1,18
85
LAMPIRAN C HASIL PENETAPAN KADAR TABLET LIKUISOLID IBUPROFEN
Formula A
B
C
D
Replikasi
Absorbansi
I II III I II III I II III I II III
0,553 0,559 0,562 0,561 0,559 0,555 0,557 0,553 0,560 0,562 0,552 0,558
Csampel (μg/ml) 298,26 301,54 303,17 302,63 301,54 299,35 300,44 298,26 302,08 303,17 297,72 300,99
86
Cteoritis (μg/ml) 300,11 299,96 300,23 300,45 300,75 300,41 300,04 299,70 299,92 300,15 299,85 300,08
Kadar (%) 99,38 100,52 100,98 100,72 100,26 99,65 100,13 99,52 100,72 101,01 99,29 100,30
Rata-rata ±SD 100,30 ± 0,82 100,21 ± 0,54 100,13 ± 0,60 100,20 ± 0,86
KV 0,82
0,54
0,60
0,86
LAMPIRAN D HASIL UJI DISOLUSI TABLET LIKUISOLID IBUPROFEN FORMULA A Repli kasi
I
II
III
t (menit) 10 20 30 45 60
0,224 0,249 0,275 0,330 0,347
C (µg/ml) 118,83 132,47 146,65 176,64 185,91
Wt (mg) 106,9 119,2 132,0 159,0 167,3
%obat terlepas 53,31 59,43 65,79 79,25 83,41
10 20 30 45 60
0,225 0,251 0,278 0,329 0,349
119,38 133,56 148,28 176,10 187,00
107,4 120,2 133,5 158,5 168,3
53,56 59,92 66,53 79,01 83,90
10 20 30 45 60
0,223 0,247 0,279 0,325 0,343
118,29 131,38 148,83 173,92 183,73
106,5 118,2 133,9 156,5 165,4
53,07 58,94 66,77 78,03 82,43
A
87
AUC (µg menit / ml) 534,74 1130,84 1256,01 2182,20 2447,26 7551,06 537,20 1138,21 1268,28 2189,57 2450,94 7584,19 532,29 1123,48 1260,92 2178,52 2414,13 7509,34
HASIL UJI DISOLUSI TABLET LIKUISOLID IBUPROFEN FORMULA B Repli kasi
I
II
III
0,288 0,311 0,349 0,389 0,393
C (µg/ml) 153,74 166,28 187,01 208,82 211,00
Wt (mg) 138,4 149,7 168,3 187,9 189,9
%obat terlepas 69,04 74,67 83,98 93,77 94,75
AUC (µg menit / ml) 691,81 1440,08 1589,78 2671,82 2833,8
10 20 30 45 60
0,289 0,310 0,351 0,388 0,394
154,28 165,74 188,10 208,28 211,55
138,9 149,2 169,3 187,4 190,4
69,28 74,42 84,47 93,53 95,00
9227,3 694,27 1440,08 1592,24 2675,5 2833,8
10 20 30 45 60
0,289 0,312 0,352 0,387 0,391
154,28 166,83 188,64 207,73 209,91
138,9 150,1 169,8 187,0 188,9
69,28 74,91 84,71 93,30 94,30
9235,89 694,27 1444,99 1599,6 2675,5 2819,08
t (menit)
A
10 20 30 45 60
9233,43
88
HASIL UJI DISOLUSI TABLET LIKUISOLID IBUPROFEN FORMULA C Repli kasi
I
II
III
t (menit)
A
C (µg/ml)
Wt (mg)
%obat terlepas
AUC (µg menit / ml)
10 20 30 45 60
0,281 0,307 0,338 0,376 0,383
149,92 164,10 181,01 201,73 205,55
134,9 147,7 162,9 181,6 185,0
67,38 73,75 81,35 90,66 92,38
674,64 1413,08 1552,97 2583,47 2749,13
10 20 30 45 60
0,280 0,305 0,336 0,375 0,385
149,37 163,01 179,92 201,19 206,64
134,4 146,7 161,9 181,1 186,0
67,13 73,26 80,86 90,42 92,87
10 20 30 45 60
0,283 0,307 0,337 0,375 0,383
151,01 164,1 180,46 201,19 205,55
135,9 147,7 162,4 181,1 185,0
67,87 73,75 81,10 90,42 92,38
8973,3 672,18 1405,72 1543,15 2572,43 2752,81 8946,29 679,54 1417,99 1550,52 2576,11 2745,45 8969,6
89
HASIL UJI DISOLUSI TABLET LIKUISOLID IBUPROFEN FORMULA D Repli kasi
I
II
III
t (menit) 10 20 30 45 60
A 0,277 0,310 0,332 0,352 0,369
C (µg/ml) 147,74 165,74 177,73 188,64 197,91
Wt (mg) 132,96 149,16 159,96 169,78 178,12
%obat terlepas 66,30 74,43 79,82 84,72 88,88
AUC (µg menit / ml) 664,82 1410,63 1545,61 2473,03 2609,24
10 20 30 45 60
0,274 0,311 0,331 0,353 0,368
146,1 166,28 177,19 189,19 197,37
131,49 149,65 159,47 170,27 177,63
65,61 74,68 79,58 84,96 88,64
8703,32 657,46 1405,72 1545,61 2473,03 2609,2
10 20 30 45 60
0,275 0,299 0,334 0,351 0,368
146,65 159,74 178,82 188,1 197,37
131,98 143,76 160,94 169,29 177,63
65,86 71,74 80,31 84,47 88,64
8691,05 659,91 1378,72 1523,52 2476,71 2601,88 8640,74
90
LAMPIRAN E HASIL UJI JUMLAH IBUPROFEN TERLARUT DALAM TWEEN 80 DAN AQUADEST
IBUPROFEN TERLARUT DALAM TWEEN 80 W sampel (gram) 10,4973
Abs.
C sampel (μg/ml)
Cs x FP (mg/ml)
0,452
243,18
243,18
11,0759 11,5237
0,444 0,481
238,82 259,00
238,82 259,00
Rata-rata (mg/ml) ± SD
247,00 ± 10,62
IBUPROFEN TERLARUT DALAM AQUADEST W sampel (gram) 0,9881
Abs. 0,072
C sampel (μg/ml) 35,93
Cs x FP (μg/ml) 0,18
0,9285
0,063
31,03
0,16
0,9747
0,067
33,21
0,17
91
Rata-rata (mg/ml) ± SD
0,17± 0,01
LAMPIRAN F CONTOH PERHITUNGAN
Contoh perhitungan indeks kompresibilitas dan Hausner ratio: Formula A : Berat gelas = 111,29 g (W1) Berat gelas + granul = 148,3 g (W2) V1 = 100 ml V2 = 84 ml Bj nyata
=
(W2 W1 ) = V1
Bj mampat
=
(W2 W1 ) = V2
% kompresibilitas
= 1
= 0,3701
= 0,4460
Bj.nyata x100% = 16% Bj.mampat Bj mampat
Formula A: HR =
= 1,19
Contoh perhitungan akurasi & presisi: Dapar fosfat Matriks % 0,2M Pipet (mg) pH7,2 Ad 100 200 600 100 1,5 Absorbansi = 0,558 → y = 0,0018x + 0,0061 Bahan aktif (mg)
92
Dapar fosfat 0,2M pH7,2 Ad 10
Konsentrasi (ppm) 300
Konsentrasi sebenarnya = 300,99 ppm Konsentrasi teoritis = 300,45 ppm % perolehan kembali = (konsentrasi sebenarnya / konsentrasi teoritis) x 100% = (300,99/ 300,45) x 100% = 100,18% Untuk menghitung % KV = SD x 100% X = = 1,01 % Contoh perhitungan % obat terlepas:
Wt
% obat terlepas =
PK dosis 100
100%
Formula A replikasi 1 pada t = 10 menit % obat terlepas =
106,9 100% 53,31% 100,30 200 100
Contoh perhitungan AUC pada disolusi: Rumus: Formula A replikasi 1 Wtn-1 = 106,9 Wtn
= 119,2
tn = 20 menit tn-1 = 10 menit AUC =
1006,9 119,2 x(20 10) 2
= 534,74
93
Luas □ = 60 x penetapan kadar x dosis = 60 x 100,30% x 200 mg = 12035,6 % ED Formula A replikasi 1= (∑ AUC / luas □) x 100% = (7551,06/12035,6) x 100% = 62,74 %
94
LAMPIRAN G HASIL UJI STATISTIK KEKERASAN TABLET LIKUISOLID IBUPROFEN ANTAR FORMULA Descriptives
Kekerasan 95% Confidence N
Mean
Std.
Std.
Deviation Error
Interval for Mean Minimum Maximum Lower
Upper
Bound
Bound
A
3
7.2900
1.45523 .84018
3.6750
10.9050
5.61
8.16
B
3
5.1067
.25482
.14712
4.4737
5.7397
4.94
5.40
C
3
5.4767
.38527
.22244
4.5196
6.4337
5.10
5.87
D
3
5.2400
.36346
.20984
4.3371
6.1429
4.93
5.64
Total
12
5.7783
1.13928 .32888
5.0545
6.5022
4.93
8.16
Test of Homogeneity of Variances Kekerasan Levene Statistic 7.405
df1
df2 3
Sig. 8
95
.011
ANOVA Kekerasan Sum of Squares
Df
Mean Square
Between Groups
9.351
3
3.117
Within Groups
4.926
8
.616
Total
14.278
11
F
Sig.
5.062
.030
F hitung = 5,062> F tabel0,05(3,8) = 4,07, maka H0 ditolak dan ada perbedaan bermakna antar formula.
96
Kekerasan LSD Mean (I)
(J)
Formula
Formula
95% Confidence Interval
Difference Std. Error
Sig. Lower Bound
(I-J) A
B
C
D
Upper Bound
B
2.18333*
.64072
.009
.7058
3.6608
C
1.81333*
.64072
.022
.3358
3.2908
D
2.05000*
.64072
.013
.5725
3.5275
A
-2.18333*
.64072
.009
-3.6608
-.7058
C
-.37000
.64072
.580
-1.8475
1.1075
D
-.13333
.64072
.840
-1.6108
1.3442
A
-1.81333*
.64072
.022
-3.2908
-.3358
B
.37000
.64072
.580
-1.1075
1.8475
D
.23667
.64072
.721
-1.2408
1.7142
A
-2.05000*
.64072
.013
-3.5275
-.5725
B
.13333
.64072
.840
-1.3442
1.6108
C
-.23667
.64072
.721
-1.7142
1.2408
*. The mean difference is significant at the 0.05 level.
97
LAMPIRAN H HASIL UJI STATISTIK KERAPUHAN TABLET LIKUISOLID IBUPROFEN ANTAR FORMULA
Descriptives Kerapuhan 95% Confidence N
Mean
Std.
Std.
Interval for Mean
Deviation
Error
Lower
Upper
Bound
Bound
Minimum Maximum
A
3 .4400
.07000
.04041
.2661
.6139
.37
.51
B
3 .3367
.03786
.02186
.2426
.4307
.31
.38
C
3 .4600
.07810
.04509
.2660
.6540
.37
.51
D
3 .4333
.10693
.06173
.1677
.6990
.31
.50
Total
12 .4175
.08259
.02384
.3650
.4700
.31
.51
Test of Homogeneity of Variances Kerapuhan Levene Statistic 1.593
df1
df2 3
Sig. 8
98
.266
ANOVA Kerapuhan Sum of Squares
Mean df
Square
Between Groups
.027
3
.009
Within Groups
.048
8
.006
Total
.075
11
F 1.525
Sig. .281
F hitung = 1,525< F tabel0,05(3,8) = 4,07, maka H0 diterima dan tidak ada perbedaan bermakna antar formula.
99
LAMPIRAN I HASIL UJI STATISTIK WAKTU HANCUR TABLET LIKUISOLID IBUPROFEN ANTAR FORMULA
Descriptives WaktuHancur 95% Confidence N
Mean
Std.
Interval for Mean
Std.
Deviation Error
Minimum Maximum Lower
Upper
Bound
Bound
A
3
1.4800
.25515 .14731
.8462
2.1138
1.29
1.77
B
3
.9233
.09504 .05487
.6872
1.1594
.83
1.02
C
3
1.2967
.02517 .01453
1.2342
1.3592
1.27
1.32
D
3
1.4167
.33292 .19221
.5897
2.2437
1.20
1.80
Total
12
1.2792
.29072 .08392
1.0945
1.4639
.83
1.80
Test of Homogeneity of Variances WaktuHancur Levene Statistic 5.893
df1
df2 3
Sig. 8
100
.020
ANOVA WaktuHancur Sum of Squares
Mean df
Square
Between Groups
.558
3
.186
Within Groups
.371
8
.046
Total
.930
11
F 4.012
Sig. .052
F hitung = 4.012< F tabel0,05(3,8) = 4,07, maka H0 diterima dan tidak ada perbedaan bermakna antar formula.
101
LAMPIRAN J HASIL UJI STATISTIK KADAR TABLET LIKUISOLID IBUPROFEN ANTAR FORMULA
Descriptives PK 95% Confidence N
Std.
Mean
Std.
Deviation Error
Interval for Mean Minimum Maximum Lower
Upper
Bound
Bound
A
3
100.2933
.82373 .47558 98.2471 102.3396
99.38
100.98
B
3
100.2100
.53675 .30989 98.8766 101.5434
99.65
100.72
C
3
100.1233
.60003 .34643 98.6328 101.6139
99.52
100.72
D
3
100.2000
.86435 .49903 98.0528 102.3472
99.29
101.01
Total 12 100.2067
.61726 .17819 99.8145 100.5989
99.29
101.01
Test of Homogeneity of Variances PK Levene Statistic .380
df1
df2 3
Sig. 8
102
.770
ANOVA PK Sum of Squares
Mean df
Square
Between Groups
.044
3
.015
Within Groups
4.148
8
.518
Total
4.191
11
F .028
Sig. .993
F hitung = 0, 028< F tabel0,05(3,8) = 4,07, maka H0 diterima dan tidak ada perbedaan bermakna antar formula.
103
LAMPIRAN K HASIL UJI STATISTIK DISOLUSI BERDASARKAN %ED60 TABLET LIKUISOLID IBUPROFEN ANTAR FORMULA
Descriptives ED 95% Confidence N
Mean
Std.
Std.
Interval for Mean
Deviation
Error
Lower
Upper
Bound
Bound
Minimum Maximum
A
3 62.7135
.31164
.17993 61.9393 63.4877
62.39
63.01
B
3 76.7738
.03679
.02124 76.6824 76.8652
76.73
76.80
C
3 74.5952
.12184
.07034 74.2925 74.8979
74.46
74.68
D
3 72.1754
.27580
.15923 71.4903 72.8605
71.86
72.38
Total
12 71.5645
5.60427 1.61781 68.0037 75.1253
62.39
76.80
Test of Homogeneity of Variances ED Levene Statistic 2.493
df1
df2 3
Sig. 8
104
.134
ANOVA ED Sum of Squares
df
Mean Square
Between Groups
345.107
3
Within Groups
.379
8
Total 345.486
11
F
115.036 2429.665 .047
F hitung = 2429,66> F tabel0,05(3,8) = 4,07, maka H0 ditolak dan ada perbedaan bermakna antar formula.
105
Sig. .000
disolusi_ED LSD 95% Confidence (I)
Mean
(J)
Formula Formula
A
B
C
D
Interval
Difference (I- Std. Error Sig. J)
Lower
Upper
Bound
Bound
B
-14.06033*
.17766
.000 -14.4700 -13.6506
C
-11.88169*
.17766
.000 -12.2914 -11.4720
D
-9.46189*
.17766
.000
-9.8716
-9.0522
A
14.06033*
.17766
.000
13.6506
14.4700
C
2.17864*
.17766
.000
1.7689
2.5883
D
4.59844*
.17766
.000
4.1887
5.0081
A
11.88169*
.17766
.000
11.4720
12.2914
B
-2.17864*
.17766
.000
-2.5883
-1.7689
D
2.41980*
.17766
.000
2.0101
2.8295
A
9.46189*
.17766
.000
9.0522
9.8716
B
-4.59844*
.17766
.000
-5.0081
-4.1887
C
-2.41980*
.17766
.000
-2.8295
-2.0101
*. The mean difference is significant at the 0.05 level.
106
LAMPIRAN L HASIL UJI STATISTIK KONSTANTA LAJU DISOLUSI TABLET LIKUISOLID IBUPROFEN ANTAR FORMULA
Descriptives LajuDisolusi 95% Confidence N
Mean
Std.
Interval for Mean
Std.
Minimum Maximum
Deviation Error
Lower
Upper
Bound
Bound
A
3 .0544
.00215 .00124
.0490
.0597
.05
.06
B
3 .0904
.00625 .00361
.0749
.1059
.08
.09
C
3 .0724
.00465 .00268
.0609
.0840
.07
.08
D
3 .0503
.00187 .00108
.0456
.0549
.05
.05
Total
12 .0669
.01702 .00491
.0560
.0777
.05
.09
Test of Homogeneity of Variances LajuDisolusi Levene Statistic 2.449
df1
df2 3
Sig. 8
107
.138
ANOVA LajuDisolusi Sum of Squares
df
Mean Square
F
Between Groups
.003
3
.001 59.019
Within Groups
.000
8
.000
Total
.003
11
Sig. .000
F hitung = 59,019> F tabel0,05(3,8) = 4,07, maka H0 ditolak dan ada perbedaan bermakna antar formula.
108
disolusi_kdisolusi LSD 95% Confidence (I)
(J)
Mean
Formula Formula Difference (I-J)
A
B
C
D
Std. Error
Interval Sig. Lower
Upper
Bound
Bound
B
-.03603*
.00339
.000
-.0438
-.0282
C
-.01805*
.00339
.001
-.0259
-.0102
D
.00409
.00339
.262
-.0037
.0119
A
.03603*
.00339
.000
.0282
.0438
C
.01798*
.00339
.001
.0102
.0258
D
.04012*
.00339
.000
.0323
.0479
A
.01805*
.00339
.001
.0102
.0259
B
-.01798*
.00339
.001
-.0258
-.0102
D
.02214*
.00339
.000
.0143
.0299
A
-.00409
.00339
.262
-.0119
.0037
B
-.04012*
.00339
.000
-.0479
-.0323
C
-.02214*
.00339
.000
-.0299
-.0143
*. The mean difference is significant at the 0.05 level.
109
LAMPIRAN M HASIL UJI KURVA BAKU REPLIKASI I KONSENTRASI
ABSORBANSI
X2
Y2
XY
75,45
0,129
5692,703
0,0166
9,7330
100,6
0,178
10120,36
0,0317
17,9068
201,2
0,359
40481,44
0,1289
72,2308
301,8
0,563
91083,24
0,3170
169,9134
402,4
0,728
161925,8
0,5300
292,9472
503
0,928
253009
0,8612
466,784
KONSENTRASI
ABSORBANSI
X2
Y2
XY
75,38
0,144
5682,144
0,0207
10,8547
100,5
0,184
10100,25
0,0338
18,492
201
0,378
40401
0,1429
75,978
301,5
0,568
90902,25
0,3226
171,252
402
0,742
161604
0,5506
298,284
502,5
0,923
252506,3
0,8519
463,8075
REPLIKASI II
110
REPLIKASI III KONSENTRASI
ABSORBANSI
X2
Y2
XY
75,3
0,169
5670,09
0,0286
12,7257
100,4
0,211
10080,16
0,0445
21,1844
200,8
0,386
40320,64
0,1490
77,5088
301,2
0,571
90721,44
0,3260
171,9852
401,6
0,747
161282,6
0,5580
299,9952
502
0,91
252004
0,8281
456,82
Replikasi I Replikasi II Replikasi III Pooled regression Common regression
ƩX2
ƩXY
ƩY2
N
562312,5 561195,9 560078,9
1029,5153 1038,6682 1040,2193
1,8853 1,9226 1,9342
6 6 6
1683587
3108,4028
5,7422
Residual SS 4,45.10-4 2,13. 10-4 2,266. 10-3
RDF 3 3 3
2,91. 10-3
9
3,13.10-3
11
F hitung < F tabel 0,05 (3,9) = 0,3287 < 4,26 Karena F hitung lebih kecil dari F tabel maka tidak ada perbedaan bermakna antar persamaan regresi.
111
LAMPIRAN N SERTIFIKAT ANALISIS IBUPROFEN
112
113
LAMPIRAN O SERTIFIKAT ANALISIS AVICEL PH 102
LAMPIRAN P SERTIFIKAT ANALISIS MAGNESIUM STEARAT
114
LAMPIRAN P SERTIFIKAT ANALISIS MAGNESIUM STEARAT
115
LAMPIRAN Q SERTIFIKAT ANALISIS SODIUM STARCH GLYCOLATE
116
LAMPIRAN R SERTIFIKAT ANALISIS HYDROXY PROPYL METHYL CELLULOSE K4M
117
LAMPIRAN S TABEL UJI F
118
119
LAMPIRAN T TABEL UJI R
Dikutip dari: Soedigdo & Soedigdo (1977).
120
LAMPIRAN U TABEL UJI HSD (0,05)
121
