Lampiran 1 : Surat Persetujuan Komite Etik

Lampiran 1 : Surat Persetujuan Komite Etik

Universitas Sumatera Utara

Lampiran 2 LEMBAR PENJELASAN KEPADA CALON SUBJEK PENELITIAN Selamat pagi/ siang Bapak/ Ibu, pada hari ini saya, dr. Rizqi Arini Siregar, peserta Pendidikan Pasca Sarjana Ilmu Penyakit Dalam/ Magister Klinik FK-USU Medan akan melakukan penelitian yang berjudul ”Hubungan Besar Varises Esofagus Secara Endoskopi dengan Forns Index pada Penderita Sirosis Hati”. Kepada Bapak/ Ibu yang bersedia mengikuti penelitian ini nantinya akan diminta mengisi surat persetujuan ikut dalam penelitian, mengikuti wawancara untuk mencari adanya hal-hal yang dapat mengganggu penelitian, dan dilakukan pemeriksaan laboratorium berupa pemeriksaan darah sebanyak 15 cc (1 sendok makan) yang akan diambil dari lengan oleh ahli untuk menilai sebuah skor yang disebut Forns index melalui parameter trombosit, γGT, dan kolesterol. Kemudian hasil skor tersebut akan saya bandingkan dengan hasi pemeriksaan endoskopi. Manfaat penelitian ini adalah dapat memberikan informasi tentang adanya varises esofagus pada penderita sirosis hati serta meringankan biaya pemeriksaan untuk pemantauan varises esofagus dan pemeriksaan menjadi lebih sederhana, murah dan tidak membutuhkan waktu yang lama. Pada penelitian ini tidak menimbulkan efek samping apapun, hanya risiko yang dapat terjadi dari penelitian ini adalah terjadinya lebam setelah pengambilan darah. Setelah hasil akhir diperoleh, nantinya akan terlihat apakah terdapat hubungan antara besar varises esofagus secara endoskopi dengan Forns index. Bila masih terdapat pertanyaan atau keluhan sewaktu penelitian ini berjalan, maka Bapak/Ibu dapat menghubungi saya pada: Nama

: dr. Rizqi Arini Siregar

Alamat

: Jl. Tridharma No. 148 Kampus USU Medan

Telepon

: 081370433555

Peneliti

(dr. Rizqi Arini Siregar)


Lampiran 3 SURAT PERSETUJUAN SETELAH PENJELASAN (INFORMED CONSENT ) Saya yang bertanda tangan dibawah ini : Nama

:...........................................................................................

Alamat

:...........................................................................................

Umur

:........................ Tahun

Jenis Kelamin : Laki-laki/ Perempuan* No Telp/ HP : Setelah mendapat penjelasan dari peneliti tentang kebaikan dan keburukan prosedur penelitian ini, menyatakan BERSEDIA ikut serta dalam penelitian tentang ”Hubungan Besar Varises Esofagus Secara Endoskopi dengan Forns Index pada Penderita Sirosis Hati”. Apabila sewaktu-waktu saya mengundurkan diri dari penelitian ini, kepada saya tidak dituntut apapun.

Demikianlah surat persetujuan bersedia ikut dalam penelitian ini saya buat, untuk dapat digunakan seperlunya.

Medan, ...........................2014

Yang memberi pernyataan,

(.............................................)

*Coret yang tidak perlu


Lampiran 4

DATA PESERTA

Tanggal:

MR

:

No. Peserta

:

I. IDENTITAS PRIBADI Nama

:

Tempat/ Tanggal lahir

:

Jenis kelamin

: Laki-laki / Perempuan

Pendidikan terakhir

:

Pekerjaan

:

Status

: Kawin / Belum Kawin.

Faktor risiko

:

No. Telp/Hp

:

No Telp................

II. PEMERIKSAAN FISIK

III. PEMERIKSAAN LABORATORIUM Parameter

Nilai

Trombosit (sel/mm3) Gamma GT (U/L) Total kolesterol (mg/dL)


Lampiran 5 DAFTAR RIWAYAT HIDUP I.

Identitas Pribadi Nama

: dr. Rizqi Arini Siregar

Tempat/Tgl Lahir : Medan/ 30 Agustus 1987

II.

III.

Suku/Bangsa

: Mandailing / Indonesia

Agama

: Islam

Alamat

: Jl. Tridharma No. 148 Kampus USU Medan

Pendidikan SD Harapan 1 Medan

Tamat Tahun 1999

SLTP Harapan 1 Medan

Tamat Tahun 2002

SMA Negeri 1 Medan

Tamat Tahun 2005

FK Universitas Sumatera Utara

Tamat Tahun 2010

Riwayat Pekerjaan Dokter jaga Klinik Polimas Tasbi Medan 2010 Pegawai Negeri Sipil di RS Pendidikan USU 2012-sekarang

IV.

Perkumpulan Profesi IDI Medan PAPDI Sumatera Utara

V.

Journal Reading 1. Yadav D, O’Connell M, Papachristou G. Natural history following the first attack of acute pancreatitis. Am J Gastroenterol 2012;107:1096-1103. 2. Sartori M, Andorno S, Rossini A, Boldorini R, Bozzola C, Carmagnola S, et al. A case-control histological study on the


effects of phlebotomy in patients with chronic hepatitis C. European Journal of Gastroenterology & Hepatology 2011, 23:1178-1184. 3. Ziegler PD, Glotzer TV, Daoud EG, Singer DE, Ezekowitz MD, Hoyt RH, et al. Detection of previously undiagnosed atrialfibrillation in patients with stroke risk factors and usefulness of continuous monitoring in primary stroke prevention. Am J Carrdiol 2012;110:1309-1314. 4. Ito H, Mifune M, Abe M, Oshikiri K, Antoku S, Takeuchi Y, et al. Hypertension resistant to antihypertensive agents commonly occurs with the progression of diabetic nephropathy in Japanese patients with type 2 diabetes mellitus: a prospective observational study. BMC Nephrology 2012, 13:48. 5. Yoo HH, Martin LC, Kochi AC, Telini LSR, Barretti P, caramori JT, et al. Could albumin level explain the higher mortality in hemodyalisis patients with pulmonary hypertension? BMC Nephrology 2012, 13:80. 6. Gonzalez JG, Mireles LG, Rodriguez RR, Almaguer DG, Lavalle FJ, Tamez HE, et al. Hyperglicemia related to high-dose glucocorticoid use in noncritically ill patients. Diabetology & Metabolic Syndrome 2013, 5:18. 7. Polverino E, Cilloniz C, Dambrava P, Gabarrus A, Ferrer M, Agusti C, et al. Systemic corticosteroids for community-acquired pneumonia: Reasons for use and lack of benefit on outcome. Respirology (2013) 18, 263-271. 8. Zubairi AS, Salahuddin N, Khawaja A, Awan S, Shah AA, Haque AS, et al. A randomized, double-blind, placebo-controlled trial of oral montelukast in acute asthma exacerbation. BMC Pulmonary Medicine 2013, 13:20.


9. Monteagudo M, Blanco TR, Liagostera M, Valero C, Bayona X, Ferrer M, et al. Factors associated with changes in quality of life of COPD patients: A prospective study in primary care. Respiratory Medicine (2013) 107, 1589-1597. 10. Lind M, Boman K, Johansson L, Nilsson TK, Jarvholm LS, Jansson JH. D-dimer predicts major bleeding, cardiovascular events and all-cause mortality during warfarin treatment. Clinical Biochemistry 47 (2014) 570-573. 11. Alam A, Huang M, Yi QL, Lin Y, Hannach B. Perioperative transfusion-related acute lung injury: The Canadian Blood Services Experience. Transfusion and Apheresis Science xxx (2014) xxx-xxx.

VI. Tulisan Ilmiah di Departemen Ilmu Penyakit Dalam 1. Diare Kronik pada Penderita HIV/AIDS 2. Penyakit Arteri Perifer 3. Penyakit Batu Ginjal 4. Sindroma Steven Johnson 5. Reaksi Transfusi

VII. Partisipasi Dalam Kegiatan Ilmiah 1. Peserta Kursus “Advanced Trauma Life Support”. IKABI. Medan, 17-19 Desember 2010. 2. Peserta Kursus “Tatalaksana Demam Berdarah Dengue”. FK USU. Medan, 15 Januari 2011. 3. Peserta Simposium “New Trends In Vaccination and Infection Control”. FK USU. Medan, 15 Januari 2011. 4. Peserta Simposium “Medical Update IDI SUMUT 2011”. IDI SUMUT. Medan, 18-19 Juni 2011.


5. Peserta Kursus “Medical Update IDI SUMUT 2011”. Minor Surgery dan Assessment of Fracture. IDI SUMUT. Medan, 19 Juni 2011. 6. Peserta Simposium “Clinical Rheumatology in Daily Practice”. Rheumatology Update 2011. Medan, 9-1 Juli 2011. 7. Peserta Simposium “Patophysiology and Recent Management of Chronic Constipation and Acute Diarrhea”. The Indonesian Society of Gastroenterology. Medan, 13 November 2011. 8. Peserta Kursus “Ultrasonografi”. Gastroentero-hepatologi Update 2012. Medan, 4 Oktober 2012. 9. Peserta Kursus “Hepatitis B dan C”. Gastroentero-hepatologi Update 2012. Medan, 4 Oktober 2012. 10. Peserta Workshop “Terapi Insulin”. Dies Natalis 60 FK-USU. Medan, 11 September 2012. 11. Peserta Simposium “Kongres Nasional XV Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (KOPAPDI XV)”, Medan, 12-15 Desember 2012. 12. Peserta Workshop “Managing Diabetes Mellitus: From A to Z”. Jeanne Latu Conference, 2 Maret 2013. 13. Peserta Simposium “Diagnosis & Tatalaksana Terpadu Hemofilia” Indonesian Hemophilia Society. Medan, 15 Maret 2014. 14. Peserta Kursus “Diagnosis & Tatalaksana Terpadu Hemofilia” Indonesian Hemophilia Society. Medan, 15 Maret 2014. 15. Peserta Pelatihan Program Pengembangan Pendidikan Keprofesian Berkelanjutan Ultrasonografi Tahap Satu bagi Spesialis dan PPDS Penyakit Dalam. Departemen Penyakit Dalam FK USU dan PUSKI. Medan, 7-10 Mei 2014.



Lampiran 6 DATA HASIL PENELITIAN

N o.

AST

Al bu min

ΔPT

INR

Asites

CP

Etio.S H

ø VE

Grup ø

ɣ GT

ALT

3.72

98

3.5

2.2

1.2

(-)

B

(-)

F2

besar

106

103

MR

Plt.(109 /L)

Bil. Total

L

523553

84

Umur

L/ P

62

Kol. Tot.

Forns index

157 160 167 60 95

9.69103 5.84699 6.58019 9.47657 7.66595 8.39724 8.9492

1

Nama Ma Yeddin Ben

2

Mazidah

62

P

524508

157

2.31

79

1.9

4

1.4

(-)

C

Hep.B

F2

besar

10

36

3

Mhd. Nur

37

L

518074

104

2.05

99

2.9

2.9

1.3

(-)

B

Hep.B

F2

besar

55

38

4

Rohmah

53

P

529692

57

3.03

41

1

8.9

1.8

berat

C

Hep.B

F3

besar

6

15

5

Suwarni W. Simanullang

60

P

516285

162

1.57

118

2

3.8

1.4

berat

B

(-)

F2

besar

42

40

48

L

530162

103

0.98

90

2.7

7

1.7

sedang

B

Hep.B

F2

besar

66

45

41

L

527796

83

2.14

56

1.7

5.2

1.5

berat

C

Hep.B

F2

besar

100

27

59

L

435662

39

0.79

38

2.1

6.1

1.7

berat

C

Hep.B

F3

besar

254

66

151

12.6879

35

P

553513

114

1.1

71

2.6

1.7

1.3

sedang

B

(-)

F1

kecil

10

18

194

4.39067

54

L

591287

107

4.2

77

2.7

1.6

1.6

min

B

Hep.B

F3

besar

118

57

92

9.44809

11

Zulkariadi Morlan Sinaga Rismawati A. Pangihutan Marpaung Al Ismet Perkasa

114 107

46

L

525959

116

3.45

134

2.5

1.1

1.1

min

C

Hep.B

F2

besar

37

110

12

Asijah

70

P

604776

208

0.56

31

3.2

1.7

2

sedang

C

(-)

F3

besar

164

21

13

Asli Manalu

53

L

604819

298

0.81

18

4.1

1.9

1.2

min

A

Hep.B

F3

besar

200

63

14

60

L

593013

445

0.37

23

2.1

7.2

1.9

berat

B

(-)

F1

kecil

251

16

6.73954 8.1597 4.96439 2.0764

15

Wilson Erisa br Siahaan

163 118 208 368

58

P

620072

33

0.62

18

2

2.9

1.2

sedang

B

Hep.C

F3

besar

18

15

16

Syafiah

53

P

590663

190

0.98

41

2

6.9

1.5

sedang

C

Hep.B

F2

besar

59

31

150 97

11.0984 6.97413

6 7 8 9 10


17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Wagini Bosmen Simanjuntak

88

P

618409

210

14.97

567

2.4

4

1.3

(-)

B

(-)

F1

kecil

530

130

296

7.34725

53

L

591558

73

5.79

93

1.2

1.5

1.6

(-)

B

Hep.B

F1

kecil

36

39

Hotmaida Darmen Syahputra Naunjur Siahaan Jimmy Panjaitan Redia Sianturi Hasoloan Siagian Irhas Hutagalung

42

P

619717

72

8.97

38

2.1

4.2

1.3

sedang

C

(-)

F3

besar

202

37

93 173

9.6393 9.10302

41

L

570666

114

1.04

41

3.2

1.2

1.3

sedang

C

(-)

F3

besar

124

22

104

8.16556

57

P

612356

32

0.71

34

3.2

2.1

1.1

(-)

B

Hep.B

F3

besar

105

33

108

13.0998

36

L

548819

66

2.66

47

1.9

1.7

1.7

sedang

C

(-)

F2

besar

62

27

192

7.65254

62

P

621249

162

4.78

175

1.6

5.8

1.3

sedang

C

Hep.B

F2

besar

343

76

120

9.06978

74

L

624605

136

3.17

91

2.7

2.7

15

(-)

A

C

F1

kecil

13

71

127

7.5769

44

L

606767

77

1.12

34

4.1

4.6

1.4

sedang

C

Hep.B

F3

besar

14

27

M.Syahni Iskandar N. Lubis Tetap

41 56

L L

602903 562188

44 336

1.25

22 25

2.2 4.2

4.5

1.4 1.4

min sedang

B

(-) (-)

F3 F1

besar

80 33

16 14

102 62

7.96343 11.392

52

L

606204

363

111

2.9

Hep.B

F1

203

38

204 395

3.42829 1.6742

Resta Ginting Mula Tua Sinaga Dra. Elida Nasution Rahayu Wijati Saharuddin

63

P

605787

31

20

2

(-)

F3

11

16

70

12.3162

107

9.37412

156

9.49998

221 199

3.44113 9.23066

196

7.29369

113

9.86507

Mulia Siregar Armen Sembiring

0.92 8.8 0.3

81

L

15785

115

49

P

136302

73

47

L

136431

447

60

L

156651

91

59

L

136481

183

2.75

25

1.6

44

3.2

26

2

176

2.8

97

3

L

548865

87

1.49

3.8

(-)

A

1

sedang

C

1.8 sedang

1 1.9

sedang

B B

berat

C

sedang 2.4 1.5

1.5

1.4

3.8

(-)

F1

(-)

F2

Hep.B

F1

Hep.B

F2

Hep.B

F3

B

kecil

31

20

132

52

311

53

199

161

280

72

139

29

besar kecil besar besar (-)

berat

kecil kecil besar

C

1.1

2.6 36

sedang

B C

2.4

1.2

1.79 53

1.1

2

1.2 1.3 2.02

5.3 1.9

F2

besar


Karno

62

L

137040

132

20

P

554549

58

52

L

597758

93

39

Atika P Nasution Arifin Nasution M. Syahyan

41

L

602903

54

40

Jumain

50

L

614860

103

41

Jolli Serman

34

L

606232

135

42

Daud S.

53

L

618951

139

Uparis Simamora Apul Sidabutar Januar Siahaan Nisma Siregar Nurmansyah

60

L

459933

78

36 37 38

43 44 45 46 47

50

Koko Saputra Mestianaa Sinurat Nuzul Indra

51

Poniah

48 49

1.63

94

2.4

23

2

343

2.9

29

2.2

44

2.1

91

4.4

40

1.7

62

2.7

0.99 7.63 0.68 0.26 1.26 3.58

L

619935

103

48

L

560001

82

131

2.5

86

2.7

P L

647935 693933

154 204

0.25 1.37

sedang

0.1 0.8 3.3 1.7 9

2.8 3.4

F2

Hep.B

F3

Hep.B

F3

C F3

Hep.B

F1

Hep.B

F2

sedang

(-)

F2

berat

C

(-)

(-) (-)

1

(-)

1.3

sedang

34

197

20

31

11

21

8

37

121

233

86

55

18

21

66

45

79

74

89

55

besar

Hep.B

F1

Hep.B

F2

C

1.7

1 1

besar besar kecil besar besar

F3

2.4

0.5 2.5

besar besar

(-)

0.9 1.6

Hep.B

C A A B C

sedang 1.1

11 31 284

C

1.5

21

2.99

sedang

1.6

1.3

2.72

55 38

1.2

7.4

3.7 48

2.3

kecil besar

102

8.15781

175

5.37362

107 62 137 178 110

7.69315 8.95249 8.69016 5.66532 6.84354

163

9.35536

162

7.86566

137

9.02264

min

C

sedang min

B A

(-) Hep.B

F1 F1

kecil kecil

26 190

13 105

102 115

7.0503 6.2594

(-)

B

Hep.B

F1

kecil

46

49

125

7.72708

min

C B B

Hep.B Hep.B Hep.B

F2 F2 F1

besar besar kecil

60 463 16

49 46 22

176 222 92

7.98621 4.45908 8.94325

0.9

48

L

632455

111

6.04

94

2.9

0.5

41 33 62

P L P

639024

73 240 89

0.9 3.46 3.54

76 241 44

2 3.1 2.9

4.2 2.5 10

642094 639024

1 1 2

sedang min

Lampiran 7


ANALISA STATISTIKA

Frequency Table Jenis Kelamin

Valid

Frequency

Percent

Valid Percent

Cumulative Percent

L

34

66,7

66,7

66,7

P

17

33,3

33,3

100,0

Total

51

100,0

100,0

EtioSH Valid Frequency Percent

Percent

Cumulative Percent

19

37,3

37,3

37,3

Hep.B 30

58,8

58,8

96,1

Hep.C 2

3,9

3,9

100,0

Total

100,0

100,0

Valid (-)

51

Child Pugh


Valid Frequency Percent

Percent

Cumulative Percent

6

11,8

11,8

11,8

B

21

41,2

41,2

52,9

C

24

47,1

47,1

100,0

Total

51

100,0

100,0

Valid A

Asites Valid Frequency Percent

Percent

Cumulative Percent

12

23,5

23,5

23,5

berat

8

15,7

15,7

39,2

min

8

15,7

15,7

54,9

sedang

23

45,1

45,1

100,0

Total

51

100,0

100,0

Valid (-)

Diameter Varises Esofagus


Valid Frequency Percent

Percent

Cumulative Percent

Valid F1

15

29,4

29,4

29,4

F2

19

37,3

37,3

66,7

F3

17

33,3

33,3

100,0

Total

51

100,0

100,0

Ukuran Varises Esofagus Valid Frequency Percent

Percent

Cumulative Percent

Valid besar

36

70,6

70,6

70,6

kecil

15

29,4

29,4

100,0

Total

51

100,0

100,0

Descriptives

umur

Mean

Statistic

Std. Error

52,04

1,726


95%

Confidence Lower

Interval for Mean

Bound Upper Bound

PLT (ribu/ul)

48,57

55,51

5% Trimmed Mean

51,69

Median

53,00

Variance

151,958

Std. Deviation

12,327

Minimum

20

Maximum

88

Range

68

Interquartile Range

18

Skewness

,297

,333

Kurtosis

1,130

,656

Mean

134,51

13,501

95%

Confidence Lower

Interval for Mean

Bound

107,39


Upper Bound

AST (unit/L)

161,63

5% Trimmed Mean

123,90

Median

104,00

Variance

9296,575

Std. Deviation

96,419

Minimum

31

Maximum

447

Range

416

Interquartile Range

89

Skewness

1,829

,333

Kurtosis

3,303

,656

Mean

87,20

13,412

95%

Confidence Lower

Interval for Mean

Bound Upper Bound

60,26

114,13

5% Trimmed Mean

72,63

Median

56,00


ALT (unit/L)

Variance

9173,441

Std. Deviation

95,778

Minimum

18

Maximum

567

Range

549

Interquartile Range

63

Skewness

3,213

,333

Kurtosis

12,818

,656

Mean

52,69

6,397

95%

Confidence Lower

Interval for Mean

Bound Upper Bound

39,84

65,53

5% Trimmed Mean

46,47

Median

38,00

Variance

2086,940

Std. Deviation

45,683

Minimum

13

Maximum

233


GGT (UI/L)

Range

220

Interquartile Range

41

Skewness

2,266

,333

Kurtosis

5,685

,656

Mean

111,31

16,383

95%

Confidence Lower

Interval for Mean

Bound Upper Bound

78,41

144,22

5% Trimmed Mean

97,51

Median

66,00

Variance

13688,860

Std. Deviation

116,999

Minimum

6

Maximum

530

Range

524

Interquartile Range

138

Skewness

1,760

,333

Kurtosis

3,293

,656


Bilirubin (mg/dl)

Total Mean 95%

2,6414 Confidence Lower

Interval for Mean

Bound Upper Bound

Albumin (g/L)

,38100

1,8761

3,4066

5% Trimmed Mean

2,2931

Median

1,6300

Variance

7,403

Std. Deviation

2,72087

Minimum

,25

Maximum

14,97

Range

14,72

Interquartile Range

2,48

Skewness

2,506

,333

Kurtosis

8,051

,656

Mean

2,540

,1053

95%

Confidence Lower

Interval for Mean

Bound

2,328


Upper Bound

PT (detik)

2,751

5% Trimmed Mean

2,520

Median

2,500

Variance

,566

Std. Deviation

,7522

Minimum

1,0

Maximum

4,4

Range

3,4

Interquartile Range

,9

Skewness

,479

,333

Kurtosis

,158

,656

Mean

3,8833

,49169

95%

Confidence Lower

Interval for Mean

Bound Upper Bound

2,8957

4,8709

5% Trimmed Mean

3,4962

Median

2,7000


INR

Variance

12,330

Std. Deviation

3,51136

Minimum

,10

Maximum

20,60

Range

20,50

Interquartile Range

3,50

Skewness

2,518

,333

Kurtosis

9,336

,656

Mean

1,7027

,26645

95%

Confidence Lower

Interval for Mean

Bound Upper Bound

1,1676

2,2379

5% Trimmed Mean

1,4373

Median

1,3600

Variance

3,621

Std. Deviation

1,90283

Minimum

,90


Maximum

14,80

Range

13,90

Interquartile Range

,46

Skewness

6,778

,333

Kurtosis

47,433

,656

Tests of Normality Kolmogorov-Smirnova

Shapiro-Wilk

Statistic

df

Sig.

Statistic

df

Sig.

umur

,111

51

,157

,972

51

,271

PLT (ribu/ul)

,204

51

,000

,802

51

,000

AST (unit/L)

,255

51

,000

,642

51

,000

ALT (unit/L)

,207

51

,000

,745

51

,000

GGT (UI/L)

,184

51

,000

,806

51

,000

,190

51

,000

,737

51

,000

Albumin (g/L)

,113

51

,121

,967

51

,161

PT (detik)

,170

51

,001

,772

51

,000

Bilirubin (mg/dl)

Total


INR

,370

51

,000

,257

51

,000

a. Lilliefors Significance Correction

Descriptives Statistic KolTot

Mean 95%

Std. Error

149,0980 9,45911 Confidence Lower

Interval for Mean

Bound Upper Bound

130,0989

168,0972

5% Trimmed Mean

142,0937

Median

137,0000

Variance

4563,210

Std. Deviation

67,55154

Minimum

60,00

Maximum

395,00

Range

335,00


Interquartile Range

72,00

Skewness

1,742

,333

Kurtosis

4,197

,656

Tests of Normality

KolTot

Kolmogorov-Smirnova

Shapiro-Wilk

Statistic

df

Sig.

Statistic

df

Sig.

,121

51

,062

,850

51

,000

a. Lilliefors Significance Correction

Child Pugh * Ukuran Varises Esofagus Crosstab Ukuran

Varises

Esofagus

Child Pugh A

besar

Kecil

Total

Count

3

3

6

Expected Count

4,2

1,8

6,0

% within Child Pugh

50,0%

50,0%

100,0%


%

within

Ukuran

8,3%

20,0%

11,8%

Count

12

9

21

Expected Count

14,8

6,2

21,0

% within Child Pugh

57,1%

42,9%

100,0%

33,3%

60,0%

41,2%

Count

21

3

24

Expected Count

16,9

7,1

24,0

% within Child Pugh

87,5%

12,5%

100,0%

58,3%

20,0%

47,1%

Count

36

15

51

Expected Count

36,0

15,0

51,0

% within Child Pugh

70,6%

29,4%

100,0%

100,0%

100,0%

100,0%

Varises Esofagus B

%

within

Ukuran

Varises Esofagus C

%

within

Ukuran

Varises Esofagus Total

%

within

Ukuran

Varises Esofagus


Chi-Square Tests Value

df

Asymp. Sig. (2-sided)

6,360a

2

,042

Likelihood Ratio

6,706

2

,035

N of Valid Cases

51

Pearson

Chi-

Square

a. 2 cells (33,3%) have expected count less than 5. The minimum expected count is 1,76.

Risk Estimate Value Odds Ratio for Child

a

Pugh (A / B) a. Risk Estimate statistics cannot be computed. They are only computed for a 2*2 table without empty cells.

Case Processing Summary Ukuran Esofagus

Varises Cases Valid

Missing

Total


N

Percent N

Percent N

Percent

Umur

Besar

36

100,0% 0

0,0%

36

100,0%

(tahun)

Kecil

15

100,0% 0

0,0%

15

100,0%

Descriptives Grup umur besar

Mean 95%

Confidence Lower

Interval for Mean

Bound Upper Bound

Statistic

Std. Error

50,19

1,809

46,52

53,87

5% Trimmed Mean

50,62

Median

53,00

Variance

117,818

Std. Deviation

10,854

Minimum

20

Maximum

70

Range

50


kecil

Interquartile Range

19

Skewness

-,596

,393

Kurtosis

,158

,768

Mean

56,47

3,816

95%

Confidence Lower

Interval for Mean

Bound Upper Bound

48,28

64,65

5% Trimmed Mean

55,91

Median

53,00

Variance

218,410

Std. Deviation

14,779

Minimum

35

Maximum

88

Range

53

Interquartile Range

14

Skewness

,844

,580

Kurtosis

,368

1,121


Tests of Normality Kolmogorov-Smirnova

Shapiro-Wilk

Statistic

Df

Sig.

Statistic

Df

Sig.

umur besar

,130

36

,132

,954

36

,138

kecil

,179

15

,200*

,924

15

,223

Grup

*. This is a lower bound of the true significance. a. Lilliefors Significance Correction

Case Processing Summary Cases Ukuran

Varises Valid

Missing

Total

Esofagus

N

Percent N

Percent N

Percent

Trombosit

Besar

36

100,0% 0

0,0%

36

100,0%

(ribu/ul)

Kecil

15

100,0% 0

0,0%

15

100,0%

Billirubin

Besar

36

100,0% 0

0,0%

36

100,0%

Total

Kecil

15

100,0% 0

0,0%

15

100,0%

(mg/dl)


AST

Besar

36

100,0% 0

0,0%

36

100,0%

(unit/L)

Kecil

15

100,0% 0

0,0%

15

100,0%

Albumin

Besar

36

100,0% 0

0,0%

36

100,0%

(UI/L)

Kecil

15

100,0% 0

0,0%

15

100,0%

PT (detik)

Besar

36

100,0% 0

0,0%

36

100,0%

Kecil

15

100,0% 0

0,0%

15

100,0%

Besar

36

100,0% 0

0,0%

36

100,0%

Kecil

15

100,0% 0

0,0%

15

100,0%

Gamma GT Besar

36

100,0% 0

0,0%

36

100,0%

(UI/L)

Kecil

15

100,0% 0

0,0%

15

100,0%

ALT

Besar

36

100,0% 0

0,0%

36

100,0%

(unit/L)

Kecil

15

100,0% 0

0,0%

15

100,0%

Kolesterol

Besar

36

100,0% 0

0,0%

36

100,0%

Total

Kecil

15

100,0% 0

0,0%

15

100,0%

Forns Index Besar

36

100,0% 0

0,0%

36

100,0%

Kecil

15

100,0% 0

0,0%

15

100,0%

INR

(mg/dl)

Descriptives


Std. Ukuran Varises Esofagus Trombosit (ribu/ul)

Besar

Mean

Statistic 107,1389

Error 10,192 37

95% Confidence Interval Lower Bound 86,4473 for Mean

Kecil

Upper Bound 127,8305

5% Trimmed Mean

102,1728

Median

89,0000

Variance

3739,837

Std. Deviation

61,15421

Minimum

31,00

Maximum

298,00

Range

267,00

Interquartile Range

70,50

Skewness

1,232

,393

Kurtosis

1,604

,768

Mean

200,2000

33,963 31



Billirubin (mg/dl)

Total Besar


5% Trimmed Mean

193,5556

Median

136,0000

Variance

17302,600

Std. Deviation

131,53935

Minimum

73,00

Maximum

447,00

Range

374,00

Interquartile Range

233,00

Skewness

1,047

,580

Kurtosis

-,418

1,121

Mean

2,2600

,31764


Upper Bound 2,9048

5% Trimmed Mean

2,0228

Median

1,6000

Variance

3,632


Kecil

Std. Deviation

1,90581

Minimum

,30

Maximum

8,97

Range

8,67

Interquartile Range

2,37

Skewness

1,948

,393

Kurtosis

4,440

,768

Mean

3,5567

1,0356 3


Upper Bound 5,7779

5% Trimmed Mean

3,1063

Median

2,7200

Variance

16,088

Std. Deviation

4,01097

Minimum

,25

Maximum

14,97

Range

14,72

Interquartile Range

4,87


AST (unit/L)

Besar

Skewness

1,912

,580

Kurtosis

3,985

1,121

Mean

77,4167

11,302 15


Kecil


5% Trimmed Mean

68,4815

Median

51,5000

Variance

4598,593

Std. Deviation

67,81293

Minimum

18,00

Maximum

343,00

Range

325,00

Interquartile Range

61,75

Skewness

2,279

,393

Kurtosis

6,314

,768

Mean

110,6667

36,904 98

95% Confidence Interval Lower Bound 31,5134


for Mean

Albumin (UI/L)

Besar


5% Trimmed Mean

90,1852

Median

71,0000

Variance

20429,667

Std. Deviation

142,93238

Minimum

23,00

Maximum

567,00

Range

544,00

Interquartile Range

85,00

Skewness

2,724

,580

Kurtosis

7,965

1,121

Mean

2,5342

,12888


Upper Bound 2,7958

5% Trimmed Mean

2,5108

Median

2,4500

Variance

,598

Std. Deviation

,77328

Minimum

1,00


Kecil

Maximum

4,40

Range

3,40

Interquartile Range

1,08

Skewness

,545

,393

Kurtosis

,076

,768

Mean

2,5533

,18718


PT (detik)

Besar

Upper Bound 2,9548

5% Trimmed Mean

2,5370

Median

2,6000

Variance

,526

Std. Deviation

,72493

Minimum

1,20

Maximum

4,20

Range

3,00

Interquartile Range

,80

Skewness

,327

,580

Kurtosis

1,114

1,121

Mean

3,6556

,43209



Kecil

Upper Bound 4,5327

5% Trimmed Mean

3,4895

Median

2,7500

Variance

6,721

Std. Deviation

2,59253

Minimum

,10

Maximum

10,60

Range

10,50

Interquartile Range

3,35

Skewness

1,038

,393

Kurtosis

,386

,768

Mean

4,4300

1,3361 1


Upper Bound 7,2957

5% Trimmed Mean

3,7500

Median

2,7000

Variance

26,778


INR

Besar

Std. Deviation

5,17473

Minimum

,50

Maximum

20,60

Range

20,10

Interquartile Range

3,85

Skewness

2,488

,580

Kurtosis

6,990

1,121

Mean

1,4703

,05381


Upper Bound 1,5795

5% Trimmed Mean

1,4425

Median

1,3800

Variance

,104

Std. Deviation

,32288

Minimum

1,00

Maximum

2,41

Range

1,41

Interquartile Range

,44

Skewness

1,302

,393


Kecil

Kurtosis

1,986

,768

Mean

2,2607

,90178

95% Confidence Interval Lower Bound ,3265 for Mean

Gamma GT (UI/L)

Besar

Upper Bound 4,1948

5% Trimmed Mean

1,6396

Median

1,2800

Variance

12,198

Std. Deviation

3,49258

Minimum

,90

Maximum

14,80

Range

13,90

Interquartile Range

,63

Skewness

3,785

,580

Kurtosis

14,503

1,121

Mean

105,0278

17,223 67

95% Confidence Interval Lower Bound 70,0619 for Mean 5% Trimmed Mean

Upper Bound 139,9937 93,5556


Kecil

Median

73,0000

Variance

10679,571

Std. Deviation

103,34201

Minimum

6,00

Maximum

463,00

Range

457,00

Interquartile Range

113,75

Skewness

1,708

,393

Kurtosis

3,286

,768

Mean

126,4000

38,161 41



5% Trimmed Mean

110,4444

Median

46,0000

Variance

21844,400

Std. Deviation

147,79851

Minimum

10,00

Maximum

530,00


ALT (unit/L)

Besar

Range

520,00

Interquartile Range

177,00

Skewness

1,691

,580

Kurtosis

2,877

1,121

Mean

49,7778

6,5452 2


Upper Bound 63,0653

5% Trimmed Mean

44,4198

Median

37,5000

Variance

1542,235

Std. Deviation

39,27130

Minimum

15,00

Maximum

197,00

Range

182,00

Interquartile Range

29,50

Skewness

2,321

,393

Kurtosis

6,057

,768


Kecil

Mean

59,6667

15,327 12


Kolesterol

Total Besar

Upper Bound 92,5401

5% Trimmed Mean

52,6296

Median

39,0000

Variance

3523,810

Std. Deviation

59,36168

Minimum

13,00

Maximum

233,00

Range

220,00

Interquartile Range

56,00

Skewness

2,035

,580

Kurtosis

4,656

1,121

Mean

(mg/dl)

135,1667

7,3498 2

95% Confidence Interval Lower Bound 120,2457 for Mean 5% Trimmed Mean

Upper Bound 150,0876 134,8148


Kecil

Median

128,5000

Variance

1944,714

Std. Deviation

44,09891

Minimum

60,00

Maximum

222,00

Range

162,00

Interquartile Range

69,00

Skewness

,068

,393

Kurtosis

-,933

,768

Mean

182,5333

25,480 13



5% Trimmed Mean

175,7593

Median

137,0000

Variance

9738,552

Std. Deviation

98,68410

Minimum

92,00

Maximum

395,00


Forns Index

Besar

Range

303,00

Interquartile Range

114,00

Skewness

1,228

,580

Kurtosis

,450

1,121

Mean

8,4678

,34164


Kecil

Upper Bound 9,1614

5% Trimmed Mean

8,4308

Median

8,2814

Variance

4,202

Std. Deviation

2,04986

Minimum

4,46

Maximum

13,10

Range

8,64

Interquartile Range

2,42

Skewness

,296

,393

Kurtosis

,134

,768

Mean

6,3656

,69116



Upper Bound 7,8480

5% Trimmed Mean

6,4444

Median

7,3472

Variance

7,166

Std. Deviation

2,67686

Minimum

1,67

Maximum

9,64

Range

7,97

Interquartile Range

5,25

Skewness

-,598

,580

Kurtosis

-1,056

1,121

Tests of Normality Ukuran Kolmogorov-Smirnova

Shapiro-Wilk

Varises Esofag

Statisti

us

c

Df

Sig.

Statistic

df

Sig.


Trombosit (ribu/ul)

Besar

,147

36

,048

,905

36

,005

Kecil

,237

15

,023

,806

15

,004

Total Besar

,164

36

,015

,797

36

,000

(mg/dl)

Kecil

,235

15

,025

,784

15

,002

AST (unit/L)

Besar

,208

36

,000

,756

36

,000

Kecil

,310

15

,000

,626

15

,000

Besar

,139

36

,074

,957

36

,177

Kecil

,183

15

,189

,967

15

,811

Besar

,170

36

,010

,899

36

,003

Kecil

,266

15

,005

,707

15

,000

Besar

,142

36

,065

,895

36

,003

Kecil

,419

15

,000

,383

15

,000

Besar

,169

36

,011

,829

36

,000

Kecil

,240

15

,020

,783

15

,002

Besar

,205

36

,001

,745

36

,000

Kecil

,216

15

,058

,767

15

,001

Total Besar

,135

36

,098

,959

36

,195

Kecil

,211

15

,071

,830

15

,009

Billirubin

Albumin (UI/L)

PT (detik)

INR

Gamma GT (UI/L)

ALT (unit/L)

Kolesterol (mg/dl)


Forns Index

Besar

,113

36

,200*

,972

36

,479

Kecil

,201

15

,105

,899

15

,093

*. This is a lower bound of the true significance. a. Lilliefors Significance Correction

T-Test Group Statistics Ukuran Varises

Std.

Esofagus

N Mean

Std. Deviation Mean

Albumin

besar

36 2,5342

,77328

,12888

(UI/L)

kecil

15 2,5533

,72493

,18718

Error

Independent Samples Test Levene's Test

for

Equality of Variances

t-test for Equality of Means


95%

F Albu

Equal variances

min

assumed

(UI/L)

,53 9

Equal variances not assumed

Sig.

,466

T

df

,082

-

49

,084 2

Error

Interval of the

Mean

(2-

Differ Differ Difference

tailed) ence

ence

,935

,0191 7

27,91

Confidence

Sig.

-

-

Std.

,933

,0191 7

,2334 9

,2272 6

Lower Upper ,4883 ,45006 9 ,4847 ,44641 4

KatFI * Ukuran Varises Esofagus Crosstabulation Ukuran

Varises

Esofagus

KatFI >=7,92 Count Expected Count

besar

Kecil

Total

23

4

27

19,1

7,9

27,0


%

within

Ukuran

63,9%

26,7%

52,9%

Count

13

11

24

Expected Count

16,9

7,1

24,0

36,1%

73,3%

47,1%

Count

36

15

51

Expected Count

36,0

15,0

51,0

100,0%

100,0%

100,0%

Varises Esofagus <7,92

%

within

Ukuran

Varises Esofagus Total

%

within

Ukuran

Varises Esofagus

ROC Curve Case Processing Summary Ukuran

Varises

Esofagus

Valid N (listwise)

Positivea

36

Negative

15


Larger values of the test result variable(s) indicate stronger evidence for a positive actual state. a. The positive actual state is Besar.

Area Under the Curve Test Result Variable(s): Forns Index Asymptotic 95% Confidence Asymptotic Area

Std. Errora Sig.b

Interval Lower Bound Upper Bound


,717

,079

,016

,561

,872

a. Under the nonparametric assumption b. Null hypothesis: true area = 0.5

Coordinates of the Curve Test Result Variable(s): Forns Index Positive if Greater Than or Equal Toa

Sensitivity

1 - Specificity

,6742

1,000

1,000

1,8753

1,000

,933

2,7523

1,000

,867

3,4347

1,000

,800

3,9159

1,000

,733

4,4249

1,000

,667

4,7117

,972

,667

5,1690

,944

,667

5,5195

,917

,667

5,7562

,889

,667

6,0532

,861

,667


6,4198

,861

,600

6,6599

,833

,600

6,7915

,806

,600

6,9088

,778

,600

7,0122

,750

,600

7,1720

,750

,533

7,3205

,722

,533

7,4621

,722

,467

7,6147

,722

,400

7,6592

,694

,400

7,6795

,667

,400

7,7101

,639

,400

7,7964

,639

,333

7,9145

,639

,267

7,9748

,611

,267

8,0720

,583

,267

8,1588

,556

,267

8,1626

,528

,267

8,2814

,500

,267


8,5437

,472

,267

8,8167

,472

,200

8,9462

,472

,133

8,9508

,444

,133

8,9876

,417

,133

9,0462

,389

,133

9,0864

,361

,133

9,1668

,333

,133

9,2930

,306

,133

9,3647

,278

,133

9,4111

,278

,067

9,4623

,250

,067

9,4883

,222

,067

9,5696

,194

,067

9,6652

,194

,000

9,7781

,167

,000

10,4817

,139

,000

11,2452

,111

,000

11,8541

,083

,000


12,5020

,056

,000

12,8938

,028

,000

14,0998

,000

,000

a. The smallest cutoff value is the minimum observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.


Lampiran 1 : Surat Persetujuan Komite Etik

Recommend Documents