meneer, Wij wensen U veel leesplezier met deze INstruendum

www.instruchemie.nl ZOMER – juli 2009 Inhoudsopgave

Geachte mevrouw / meneer,

Pagina 1 Voorwoord en zomer 2009.

Hierbij ontvangt U INstruendum nummer 3, jaargang 2. Een editie met als thema QC preparaten, speciale diagnostica en nog veel meer.

Pagina 2 CRP Controls. Proteins & Controls. HbA1c Controls. Pagina 3 Metanephrines – HPLC. Calibration Standards & Controls. Pagina 4 25-OH Vitamin D3 – HPLC. Pagina 5 D-Dimer. Cystatin C. Apo C-II & Apo C-III. Pagina 6 TDM Control. Electrophoresis. Instruments, strips, reagents. Pagina 7 INstruchemie Catalogus. Pagina 8 Niche producten. Pagina 9 Enkele leveranciers. Pagina 10 Retour: Fax - Formulier.

Eens per 3 jaar produceren wij o.a. voor de regio’s Noord, Oost en Gelre grote batches Proteins controles en CRP controles met (extra) hoge CRP concentraties. Productie zal medio augustus/september 2009 plaatsvinden. Levering aan klanten: November 2009. De houdbaarheid is 3,5 jaar af productie voor deze preparaten. Wij verlenen altijd 15% korting op de prijslijstprijs bij afname ineens voor 3 jaar. Vrijwel alle gebruikers maken daar gebruik van. Mogelijk wilt U ook participeren. De redenen zouden kunnen zijn: (Te) hoge prijs per milliliter van Uw huidige controles. Instabiliteit van (enkele) parameters na productie of na oplossen / ontdooien. Kortere periode van gebruik af productie, bijv. 2 jaar of minder. o De noodzaak om bij -20 C op te slaan. Wij hebben nog proefflacons van de huidige batches voor U beschikbaar. In 2009 bestaat INstruchemie 30 jaar als een onafhankelijk (familie)bedrijf. Dat betekent nog altijd vrije keuzes in producten en strategieën voor binnen- en buitenland. Mede door Uw vertrouwen hebben wij deze mijlpaal kunnen bereiken. Wij zijn U daar zeer erkentelijk voor. Met name de volgende producten blijken erg succesvol: Humane Hb sneltest in feaces, QC preparaten, automatiseringsmogelijkheden van onze ammonia-, chymotrypsine-, hydroxyboterzuur-, galactose-, sorbitol dehydrogenase-, vrije vetzuren- en phospholipidenreagensset. Veel belovend is ook onze nieuwe Vitamine D3 bepaling op HPLC apparatuur. De monstervoorbereiding is nu sterk vereenvoudigd en uiterst snel. Dat bespaart vele arbeidsuren en reagenskosten. Zelfs de SPE kolommetjes zijn niet meer nodig. Wij wensen U veel leesplezier met deze INstruendum.

Delfzijl

Met vriendelijke groet, Irenus Nieland, directeur Fons Nieland, adjunct directeur

Delfsail 22 – 26 augustus 2009

Science without f(r)iction since 1979 Telephone Telefax E-mail Internet

(+31)(0)596 – 634 831 (+31)(0)596 – 634 755 [email protected] www.instruchemie.com

Visiting address Zwet 26 9932 AB Delfzijl The Netherlands

Postal address P.O. Box 120 9930 AC Delfzijl The Netherlands

ISO 9001 / 13485 / CE ABN-AMRO bank acc. no. V.A.T. no. Chamber of Commerce Groningen

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INstruendum-ZOMER editie-290702-1.FEN

www.instruchemie.nl Assay Controls CRP Controls * * * *

Accuracy and precision controls for the determination of C-Reactive Protein (CRP) by turbidimetry or nephelometry. Independent Controls. Stability 3.5 years from date of production. Liquid and ready for use.

Article nr.: 5009, CRP Control, Normal Level Value ± 10 mg/l

Contents: 10 x 1 ml

Article nr.: 2790, CRP Control, High Level Value ± 40 mg/l

Contents: 10 x 1 ml

Article nr.: 2789, CRP Control, Extra High Level Value ± 120 mg/l

Contents: 10 x 1 ml

*

Fabrikant: INstruchemie

GRATIS PROEFFLACONS BESCHIKBAAR.

Proteins Controls * * * *

*

Human serum preparations with analytical results for several proteins. Independent Controls. Stability 3.5 years from date of production. The following parameters can be measured: Albumin, IgG, IgM, IgA, Haptoglobin, Ceruloplasmin, α1-Acid Glycoprotein, α1-Antitrypsin, Transferrin, C-Reactive Protein, α2-Macroglobulin, C3, C4, pre-Albumin. Lyophilised.

Article nr.: 2466, Proteins Controls, Low Level Article nr.: 2467, Proteins Control, High Level

*

Contents: 10 x 2 ml Contents: 10 x 2 ml



HbA1c Controls * * * *

As controls for accuracy and precision for the determination of glycosylated haemoglobins for all methods in whole blood patients samples. Independent Controls. Stability 5 years from date of production. Lyophilised.

Article nr.: 2884, HbA1c Control, Normal Contents: 10 x 200 µl Component Method DCCT Range IFCC Range HbA1c All Methods 4.9% 4.2-5.6 3.0% 2.5-3.5 Article nr.: 2887, HbA1c Control, High Component Method DCCT HbA1c All Methods 9.9%

*

Contents: 10 x 200 µl Range IFCC Range 8.3-11.5 8.5% 7.1-9.9



Vraag meer informatie en/of testverpakking aan. Telephone Telefax E-mail Internet




ABN-AMRO bank acc. no. V.A.T. no. Chamber of Commerce Groningen

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www.instruchemie.nl Metanephrines HPLC Calibration Standards & Controls Metanephrines Urine Controls * *

* *

Lyophilized human urine preparations with analytical results for Free and Total (free+conjugated) normethanephrines and metanephrines in urine. The Metanephrines Urine Controls are intended for use as an assayed quality control urine to monitor the accuracy and precision for the determination of free and total metanephrines and normetanephrines by HPLC methods. Independent Controls. Stability 5 years from date of production.

Article nr.:2969, Metanephrines Urine Control, Normal Level Contents: 1 x 2 ml Component Method Mean Value Free Normetanephrines HPLC 0.18 µmol/l Free Metanephrines HPLC 0.14 µmol/l Total Normetanephrines HPLC 1.20 µmol/l Total Metanephrines HPLC 0.70 µmol/l Creatinine Colorimetric 12.95 mmol/l Article nr.:2970, Metanephrines Urine Control, High Level Contents: 1 x 2 ml Component Method Mean Value Free Normetanephrines HPLC 1.20 µmol/l Free Metanephrines HPLC 1.15 µmol/l Total Normetanephrines HPLC 2.05 µmol/l Total Metanephrines HPLC 1.60 µmol/l Creatinine Colorimetric 12.95 mmol/l

Range 0.13 – 0.23 0.10 -0.18 1.00 – 1.40 0.50 – 0.90

Mean Value 14 µmol/mol creatinine 11 µmol/mol creatinine 93 µmol/mol creatinine 54 µmol/mol creatinine

Range 10 -18 8 – 14 78 - 108 39 – 69

Range 1.00 – 1.40 1.00 – 1.30 1.75 – 2.35 1.40 – 1.80

Mean Value 93 µmol/mol creatinine 89 µmol/mol creatinine 158 µmol/mol creatinine 124 µmol/mol creatinine

Range 77 – 109 73 - 105 135 – 181 108 - 140

Metanephrines Plasma Controls

Metanephrines Calibration Standard

*

* * *

*

* *

Lyophilized human plasma preparations with analytical results for free normethanephrines and free metanephrines in plasma. The Metanephrines Plasma Controls are intended for use as an assayed quality control plasma to monitor the accuracy and precision for the determination of free normetanephrines and free metanephrines by HPLC methods. Independent Controls. Stability 5 years from date of production.

Article nr.: 2966, Metanephrines Plasma Control, Normal Level Contents: 10 x 3 ml Component Method Mean Value Range Free Normetanephrines HPLC 1.1 nanomol / liter 0.9 – 1.3 Free Metanephrines HPLC 1.0 nanomol / liter 0.8 – 1.2 Article nr.: 2967, Metanephrines Plasma Control, High Level Contents: 10 x 3 ml Component Method Mean Value Range Free Normetanephrines HPLC 3.0 nanomol / liter 2.5 – 3.5 Free Metanephrines HPLC 2.6 nanomol / liter 2.1 – 3.1

*

As calibrator for Normetanephrines and Metanephrines determinations by HPLC methods. Independent Calibration Standard. Stability 5 years from date of production. Lyophilized.

Article nr.: 2949, Metanephrines Calibration Standard Contents: 1 x 1 ml Component Method Concentration Normetanephrines HPLC 501 µmol/l Metanephrines HPLC 501 µmol/l

Also available: Metanephrines Internal Standard *

* * *

As internal standard preparation for Normetanephrines and Metanephrines determinations by HPLC. Independent Internal Standard. Stability 5 years from date of production. Lyophilized.

Article nr.: 2974, Metanephrines Internal Standard Contents: 1 x 1 ml






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www.instruchemie.nl 25-OH Vitamin D3 in Plasma / Serum

www.recipe.de Het aantal bepalingen van de 25-OH Vitamin D3 neemt in Nederland sterk toe. De HPLC techniek is nog altijd het meest betrouwbaar en blijft referentiemethodiek. Tot op heden is de monstervoorbereiding het meest problematisch en tijdrovend vanwege de vele te volgen stappen. Dat geldt vooral natuurlijk voor de grotere series. Dat is nu voorbij met onze methodiek. Ook de kosten per test zijn drastisch gedaald omdat veel minder reagens wordt gebruikt. SPE elutie kolommetjes zijn eveneens niet meer nodig. Onteiwitte sera of plasma’s, controles en standaarden worden na centrifugeren direct geïnjecteerd in het HPLC systeem. Wij willen U gaarne van aanvullende informatie voorzien of een demonstratie verzorgen.

Test Data:

Linearity: Recovery: Lower detection limit: Lower determination limit: Intra-assay precision: Inter-assay precision:

HPLC Parameters: Pump:

Injection volume: Injection interval: UV-Detector: HPLC-Thermostat:

1.8 – 500 µg/l 95 – 100 % 0.7 µg/l 1.8 µg/l 2.4 % 3.9 %

isocratic pump flow rate: 1.0 ml/min 50 µl 10 min 264 nm o 40 C

Sample Preparation: Extraction:

400 µl Precipitant P contains: Internal Standard IS

400 µl plasma/serum/control

HPLC Analysis:

↓

Centrifuge

Inject 50 µl of the supernatant

Vraag meer informatie en/of een demonstratie aan. Telephone Telefax E-mail Internet





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www.instruchemie.nl D-Dimer

www.spinreact.com Quantitative measurement of D-Dimer

D-Dimer Control & Calibrator

* * * * * * * *

*

Immuno Assay . Turbidimetric Method. Instrument Application Sheets Available. Use Citrated Plasma or Serum. Reagents are ready for use. Wavelength 570 nm (560 – 580). Normal Values: Up to 1.0 µg/ml. Measurement range: From 0.5 to 60 µg/ml. Regression equation Y = 0.97 x + 0.80 Y = 0.97 x + 0.85

Serum Plasma

Article nr.: 1709231, D-Dimer

The control OR calibrator is a human serum used to elevate the precision and accuracy of D-Dimer determinations in human plasma or serum. Stability > 3 years, from date of production. Lyophilized.

* *

Correlation coefficient r = 0.99 r = 0.99

Contents : 2 x 10 ml Diluent : 1 x 10 ml Latex

Article nr.: 17091117, D-Dimer Control Contents: 6 x 1 ml Component Value Average D-Dimer Low 1.5 – 4.5 µg/ml 3.0 ± 1.5 D-Dimer High 8 – 12 µg/ml 10 ± 2 Article nr.: 17091111, D-Dimer Calibrator D-Dimer 1 2 3 in µg/ml 0.0 1.0 3.0

Contents: 6 x 0.5 ml 4 5 6 16 32 62

Cystatin C Quantitative measurement of Cystatin C (C-CYS)

Cystatin C Control & Calibrator

* * * * * * * * *

*

Immuno Assay. Turbidimetric Method. Instrument Application Sheets Available. Use EDTA-plasma, heparinized-plasma or serum. Reagents are ready for use. Wavelength 546 nm. Reference Values: 0.59 – 1.03 mg/l. Measurement range: From 0.1 - 10 mg/l. No prozone effect up to 30 mg/l.

Article nr.: 43070, Cystanin C

Contents : 1 x 20 ml Diluent : 1 x 4 ml Latex

The control OR calibrator is prepared by spiking human sera with recombinant human Cystatin C. Stability > 3 years, from date of production. Control and/or Calibrator ready for use.

* *

Article nr.: 43076, Cystatin C Control Contents: 2 x 2 ml Component Value Average Cystatin C Low 0.64 – 1.04 mg/l 0.84 ± 0.2 Cystatin C High 3.53 – 4.53 mg/l 4.03 ± 0.5 Article nr.: 43075, Cystatin C Calibrator Cystatin C 1 2 in mg /l 0.5 1.5

3 3.0

Contents: 5 x 0.5 ml 4 5 6.0 10.0

Apo CII & CIII Quantitative measurement of Apolipoprotein C-II

Quantitative measurement of Apolipoprotein C-III

* * * * * * * * *

* * * * * * * * *

Immuno Assay. Turbidimetric method. Instrument Application Sheets Available. Use EDTA-plasma, heparinized-plasma or serum. Reagents are ready for use. Wavelength 340 nm. Reference Values: 1.6 – 4.2 mg/dL. Linearity: Up to 10 mg/dL. No prozone effect up to 28 mg/dL.

Article nr.: 93012, Apo-C-II

Contents : 1 x 45 ml Diluent : 1 x 15 ml Antibody

Immuno Assay. Turbidimetric method. Instrument Application Sheets Available. Use EDTA-plasma, heparinized-plasma or serum. Reagents are ready for use. Wavelength 340 nm. Reference Values: 5.5 – 9.5 mg/dL. Linearity: Up to 22 mg/dL. No prozone effect up to 55 mg/dL.

Article nr.: 93013, Apo-CIII

Contents : 1 x 45 ml Diluent : 1 x 15 ml Antibody






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www.instruchemie.nl Therapeutic Drugs Monitoring TDM Controls TDM Control *

* * *

Quantitative control for monitoring test procedures used to assay human specimens for the therapeutic drug levels. Independent Controls. Stability 3 years from date of production. Liquid and ready for use.

Article nr.: TDM/CON-001 Component Target in µg/ml Acetaminophen 40.20 Amikacin 15.30 Carabamazepine 7.58 Digoxin (ng/ml) 1.67 Gentamicin 3.78 Lidocaine 4.67 NAPA 8.60 Phenobarbital 28.13 Phenytoin 12.96 Primidone 8.64 Procainamide 7.32 Quinidine 3.25 Salicylate 144.00 Theophyline 13.21 Tobramycin 5.12 Valproic Acid 58.49 Vancomycin 20.90

Contents: 1 x 1 ml Range 34.17 – 46.23 13.01 – 17.60 6.44 – 8.72 1.42 – 1.92 3.21 – 4.35 3.97 – 5.37 7.31 – 9.89 23.91 – 32.35 11.02 – 14.90 7.34 – 9.94 6.22 – 8.42 2.76 – 3.74 122.4 – 165.6 11.23 – 15.19 4.35 – 5.89 49.93 – 67.55 17.77 – 24.04

These controls are successful used on the following clinical analysers: * * * * * * * * * * * * * * * * * * * * * * *

Advia®-series (1200, 1650, 2400) Aeroset® Alcyon® Architect® AU®-series (400, 560, 600, 2700, 5400) Axon® Cobas® Mira Dimension® Express® Hitachi®-series (911, 912, 917) Ilab®-series (500, 600, 900) Konelab® 20i Mega® Modular ® Monarch® Opera® Pentra® RA®-series (1000, 100-XT) Selectra®-series (1, 2) Space® Synchron®-series (CX, LX) Wako®-series (20R, 30R) XL® 600

Electrophoresis instruments, strips, reagents

www.biotec-fischer.de FILIPO – Biotec Fischer Electrophoresis tank with integrated power supply. * * * * * * * * *

Usable for all electrophoresis methods, (Serum proteins, Lipoproteins, Haemoglobins, Urine concentrated, a.s.o.). Compact and place saving dimensions. Very easy to operate and clean. High reproducible electrical migration conditions. Integrated diffusion protection at end of migration time. Usable for cellulose acetate membranes or agarose gels. Variety possibilities of electrical settings. Integrated digital timer. Extremely economical with low purchase price and low buffer volume.

Electrophoresis tank Filipo






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www.instruchemie.nl INstruchemie Catalogus

Clinical Chemistry Diagnostics * * * * * *

Enzymes Substrates Electrolytes (including blood-gas) Controls / standards Rapid tests HPLC

Laboratory Information Management system *

Computer program

Haematology Diagnostics * * * * *

Haemotology reagents Coagulation reagents Tissue typing Histology / cytology Controls / standards

* * * * * * * * * * *

Immunoglobulins Complement components Transport proteins Lipoproteins Tumor markers Other plasma proteins Hormones Drugs Auto immune Antisera Controls / standards

Biochemicals Antibodies Enzymes & Substrates

Disposables

Instrumentation

Microbiology Diagnostics * * * * *

Immuno Chemistry Diagnostics

* * * * * *

Bacteriology Virology Parasitology Mycology Controls / standards

Photometers Nephelometers Electrophoresis equipment Automated analyzers Elisa readers & washers Strip readers

Vraag meer informatie en/of catalogus aan. Telephone Telefax E-mail Internet





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www.instruchemie.nl Enkele niche producten van buitenlandse fabrikanten. Drugs of Abuse – Sneltesten * * * *

*

Single en/of panels. Urine panels (2 -12 parameters). Speeksel (max. 6 parameters). Amphetamine, Barbiturate, Benzodiazepines, Cocaine, Ecstasy, Marijuana, Metamphetamine, Metadone, Morphine, Opiate, Phencylidine, Propoxyphene, Tricyclic Antidepres. FDA-approved & CE-gemarkeerd.

*

GRATIS PROEFMATERIALEN BESCHIKBAAR.

Fabrikant: Innovacon

NAG Test kit * * * * * *

Colorimetric assay of N-Acetyl-ß-D-glucosaminidase. Use Urine. Wavelength 505 nm. Also for automated procedures. NAG/Creatinine Controls, low, medium, high. Creatinine Standards, low, medium, high.

Article nr.: 1290100, Nag test kit

Contents; 100 test/kit

Fabrikant: PPR Diagnostics

HEXAGON OBTI TEST * * * * * * * * * * *

Immunologische sneltest voor specifieke detectie van humaan occult bloed in faeces Klinische specificiteit: > 99%. Klinische gevoeligheid: > 99%. Detectielimiet: 0,05 mg Hb /gram faeces. Ingebouwde negatieve controle. Geen storende stoffen bekend. Patiënt hoeft geen dieet te volgen. Werkt zeer hygiënisch en geurloos. Resultaat binnen 5 minuten. Eventuele follow-up methode na een positieve à specifieke Guaiac methode uitslag.

Fabrikant: Human

GRATIS PROEFMATERIALEN BESCHIKBAAR.

Article nr.: 28009, Hexagon Obti

Contents; 24 tests

Urine Controls – KOVA Hycor * * * *

KOVA Urinanalysis Controls. Lyophilized and liquid urine preparations. Controls for qualitative procedures used in physiochemical and chemical determinations and for microscopic sediment analyses. Kova-controls, normal, abnormal, high abnormal

Article nr.: Kova-controls

Contents; 4x15 ml / 2x120ml

Fabrikant: Hycor






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www.instruchemie.nl Enkele leveranciers

www.instruchemie.nl * * * * *

In-Vitro diagnostic reagents, standards, controls Enzymatic, turbidimetric, colorimetric, HPLC Manufacturing ISO-9001 / 13485 / CE Exportprogram

www.instruchemie.nl

* * * *

QED Saliva Alcohol Test Elisa Drugs of Abuse: Saliva & Plasma Saliva Collection Device

*

Whole Blood Hematology Controls, Calibrators, Linearity materials For automated cell-counters

www.orasure.com

*

www.eurocelldiag.com

* * * *

Standardized Urine Sediments KOVA-system Urine Controls; liquid and lyophilized

* * * * *

In-Vitro Diagnostics: Kits & Determinations Free Fatty Acids – NEFA (HR) ACS-ACOD-MEHA Colorimetric method Control Serum Normal (I) & Abnormal (II)

*

In-Vitro Diagnostics: Quantitative Determinations of Drugs of Abuse Microbiology, immunology More than 250 different assays

* * *

www.hycorbiomedical.com

www.wako-chemicals.com

www.nal-vonminden.com

Meer dan 30 fabrikanten vertegenwoordigd INstruchemie in Nederland en tevens een aantal in diverse Europese landen, zie www.instruchemie.nl Telephone Telefax E-mail Internet





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www.instruchemie.nl RETOUR: FAX – FORMULIER : 0596 – 634 755 EMAIL: [email protected] Aan Attentie

INstruchemie B.V. Sales & Marketing Fons Nieland, Arie Jan de Graaf

Tel nr. Fax nr. E-mail

0596 – 634 831 0596 – 634 755 [email protected]

Datum Juli 2009 Referentie 290702-1.FEN

Ik wens: Persoonlijk contact. Over: Meer informatie.

Over:

Actuele prijzen.

Van: Producten / fabrikanten programma’s in een luxe ringband.

Catalogus 2009/2010 (Meer dan 1500 bepalingen, reagentia, standaarden, controles). Verzenden naar: Naam: Voorletters

Titel:

M/V

Functie: Instituut: Afdeling: Adres: PC/Plaats: Telefoon : Fax : Email: Telephone Telefax E-mail Internet





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meneer, Wij wensen U veel leesplezier met deze INstruendum

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