DAFTAR ISI Hal HALAMAN JUDUL......................................................................................
i
HALAMAN PERSETUJUAN........................................................................
ii
HALAMAN PERNYATAAN........................................................................
iii
HALAMAN PRAKATA................................................................................
iv
DAFTAR ISI................................................................................................... vii DAFTAR TABEL...........................................................................................
xi
DAFTAR GAMBAR...................................................................................... xiii DAFTAR LAMPIRAN...................................................................................x xiv INTISARI.......................................................................................................
xv
ABSTRACT....................................................................................................
xvi
BAB I. PENDAHULUAN.........................................................................
1
A. Latar Belakang....................................................................................
1
B. Perumusan Masalah............................................................................
3
C. Tujuan Penelitian................................................................................
3
D. Manfaat Penelitian..............................................................................
4
E. Keaslian Penelitian..............................................................................
4
BAB II. TINJAUAN PUSTAKA...................................................................
6
A. Tuberkulosis Paru...............................................................................
6
1. Definisi dan Etiologi.....................................................................
6
2. Gejala Klinis.................................................................................
7
3. Diagnosis Tuberkulosis.................................................................
8
vii
4. Cara Penularan.............................................................................
9
5. Klasifikasi Penyakit dan Tipe Penderita....................................... 10 5.1.Klasifikasi berdasarkan organ yang terkena...........................
10
5.2.Klasifikasi berdasarkan tingkat keparahan penyakit..............
10
5.3.Klasifikasi berdasarkan Hasil BTA........................................
11
5.4.Klasifikasi berdasarkan tipe pasien........................................
12
B. PRINSIP PENGOBATAN.................................................................. 13 C. OBAT ANTI TUBERKULOSIS (OAT)............................................
14
1. Isoniazid (H).................................................................................
14
2. Rifampisin (R)..............................................................................
14
3. Pirazinamid (Z)............................................................................. 15 4. Etambutol (E)................................................................................ 16 5. Streptomisin (S)............................................................................
16
D. PANDUAN OAT DI INDONESIA.................................................... 18 1. OAT Kategori 1 (2HRZE/ 4H3R3)..............................................
18
2. OAT Kategori 2 (2HRZES / HRZE / 5H3R3E3).........................
18
E. HASIL PENGOBATAN..................................................................... 19 F. LANDASAN TEORI.......................................................................... 20 G. KERANGKA TEORI.........................................................................
23
H. KERANGKA KONSEP.....................................................................
24
I. HIPOTESIS........................................................................................
24
viii
BAB III. METODOLOGI PENELITIAN......................................................
25
A. RANCANGAN PENELITIAN........................................................... 26 B. INSTRUMEN DAN BAHAN PENELITIAN.................................... 27 C. VARIABEL PENELITIAN................................................................ 27 D. SUBJEK PENELITIAN...................................................................... 29 E. ESTIMASI BESAR SAMPEL...........................................................
31
F. LOKASI PENELITIAN.....................................................................
32
G. JALANNYA PENELITIAN............................................................... 33 H. ANALISIS DATA..............................................................................
34
BAB IV. HASIL DAN PEMBAHASAN ......................................................3 36 A. Karakteristik Dasar Subjek.................................................................
36
B. Analisis Univariat Faktor-Faktor Keberhasilan Terapi OAT.............
36
1. Jenis Kelamin................................................................................ 36 2. Pendidikan..................................................................................... 37 3. Usia Pasien...................................................................................
38
4. Pekerjaan Pasien...........................................................................
39
5. Status Merokok............................................................................. 40 6. Pengawas Minum Obat (PMO)..................................................... 42 7. Riwayat Penyakit Pasien..............................................................
43
8. Efek Samping OAT Pada Pasien..................................................
43
9. Riwayat Obat Lain Yang Digunakan Pasien...............................
44
C. Analisis Bivariat Faktor Prediktor Terhadap Keberhasilan Terapi OAT....................................................................................................
ix
45
D. Analisis Multivariat Faktor Prediktor Terhadap Keberhasilan Terapi OAT......................................................................................... 48 E. Keterbatasan Penelitian....................................................................... 53 BAB V. KESIMPULAN DAN SARAN........................................................
54
A. Kesimpulan.........................................................................................
54
B. Saran...................................................................................................
54
DAFTAR PUSTAKA..................................................................................... 55 LAMPIRAN...................................................................................................
59
RINGKASAN................................................................................................. 76 SUMMARY...................................................................................................... 96 NASKAH PUBLIKASI.................................................................................. 114
x
DAFTAR TABEL
Hal Tabel 1.
Keaslian
penelian
terkait
keberhasilan
terapi
obat
antituberkulosis ...................................................................
4
Tabel 2.
Dosis OAT KDT kategori 1.......................................................
18
Tabel 3.
Dosis OAT KDT kategori 2.......................................................
19
Tabel 4.
Variabel penelitian beserta definisi operasional dan skala pengukuran..........................................................................
Tabel 6.
Jenis kelamin pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta............................
Tabel 7.
41
PMO pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta....................................................
Tabel 12.
39
Status merokok pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta............................
Tabel 11.
37
Data pekerjaan pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta..............................
Tabel 10.
36
Data usia pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta...........................................
Tabel 9.
35
Tingkat pendidikan pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta.............................
Tabel 8.
28
43
Riwayat penyakit pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta.............................
xi
42
Tabel 13.
Efek samping OAT pada pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta....................
Tabel 14.
Riwayat obat lain pada pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta............................
Tabel 15.
45
Analisis bivariat faktor prediktor terhadap keberhasilan terapi OAT..................................................................................
Tabel 17.
44
Kelompok pasien tuberkulosis paru di Balai Besar Kesehatan Paru Masyarakat Kota Surakarta.............................................
Tabel 16.
43
46
Analisis multivariat faktor prediktor terhadap keberhasilan terapi OAT.................................................................................. 48
xii
DAFTAR GAMBAR
Hal Gambar 1.
Skema kerangka teori penelitian...............................
23
Gambar 2.
Skema kerangka konsep penelitian............................
24
Gambar 3.
Skema penelitian .....................................................
26
Gambar 4.
Skema alur penelitian................................................
35
xiii
DAFTAR LAMPIRAN
Hal Lampiran 1.
Kategori riwayat obat lain pada pasien tuberkulsosi paru yang menjalani terapi OAT di Balai Besar Kesehatan
Paru
Masyarakat
Kota
Surakarta...............................................................
59
Lampiran 2.
Tabel hasil statistik SPSS........................................
60
Lampiran 3.
Lembar Ethical Clearence...........................................
73
Lampiran 4.
Blanko data rekam medis pasien sembuh....................
74
Lampiran 5.
Blanko data rekam medis pasien tidak sembuh...........
75
xiv
