30/09/2013
Teknologi Nano (Nanotechnology) di bidang Pangan
Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected] Disampaikan pada acara: Food Day Festival (Foodival) Himpunan Ilmu dan Teknologi Pangan (Himitepa) Tgl 29 September 2013 AMN Fateta IPB Purwiyatno Hariyadi/seafast center, ipb.
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• SEJARAH ... Pemenang Nobel Fisika Richard Feynman, pada 29 Desember 1959, memberikan Presentasi di Pertemuan Tahunan Americal Physical Society, di Caltech.
Richard Feynman
• Judul presentasi “There's Plenty of Room at the Bottom” • Pertama kali mengemukakan bahwa karakteristik bahan (material) pada skala nanometer akan memberikan berbagai peluang baru ke masa depan. Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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• SEJARAH ... Ahli Fisika dan penulis :
K. Eric Drexler
• Engines of Creation: The Coming Era of Nanotechnology (1986 untuk umum, dan • Nanosystems: Molecular Machinery, Manufacturing, and Computation (a quantitative, physics-based analysis) untuk spesialist. • Pertama kali menggunakan dan mempopulerkan istilah Nanotechnology/Nanosystem: Purwiyatno Hariyadi/seafast center, ipb.
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• TEKNOLOGI NANO. Apa itu? • Teknologi Nano (Nanotechnology) : • Mencakup disain, karakterisasi, produksi dan aplikasi suatu stuktur (bahan), alat atau sistem pada skala nano. • Mencakup kegiatan yang sangat luas lebih tepat disebut sebagai teknologi-teknologi nano ('nanotechnologies‘).
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO ? Berasal dari Yunani; yang artinya “kerdil” kecil
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO ? Berasal dari Yunani; yang artinya “kerdil” kecil
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO ? Berasal dari Yunani; yang artinya “kerdil” kecil - 1 nm = 10-9 m
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO: Seberapa kecil ? 1 m = 1 mikron
1Å= 1 Angstrom
10-1
1
10
102
103
1 mm 1 cm
104
105
106
107
108
Nanometer
Skala nano Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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• NANO: Seberapa kecil ?
10-1
1
10
102
103
104
105
106
107
108
Nanometer
Skala nano Purwiyatno Hariyadi/seafast center, ipb.
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• NANO: Seberapa kecil ?
10-1
1
10
102
103
104
105
106
107
108
Nanometer Sukrosa :
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO: Seberapa kecil ?
10-1
1
10
102
103
104
105
106
107
108
Nanometer
~ 5000 nm
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO: Seberapa kecil ?
~8*103 nm
10-1
1
10
102
103
104
105
106
107
108
Nanometer
~ 5000 nm
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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30/09/2013
• NANO: Seberapa kecil ?
~8*103 nm
10-1
1
10
102
103
104
105
106
107
108
Nanometer
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO: Seberapa kecil ?
~8*103 nm
10-1
1
10
102
103
104
105
106
107
108
Nanometer
10 nm Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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• NANO: Seberapa kecil ?
10-1
1
10
102
103
104
105
106
107
108
Nanometer
2 nm diameter molekul DNA (helix) 5 nm diameter molekul insulin 6 nm diameter molekul hemoglobin 10nm ketebalan dinding sel bakteri gram negatif 200nm diameter bakteri terkecil
10 nm Purwiyatno Hariyadi/seafast center, ipb.
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• NANO: Seberapa kecil ?
10-1
1
10
102
103
104
105
106
107
108
Nanometer
• Teknologi Susu : – – – –
Misel kasein 50-300 nm Protein whey 4-6 nm Laktosa 0.5 nm Gobula lemak 300 nm
10 nm Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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30/09/2013
• NANO: Seberapa kecil ?
10-1
1
10
102
103
104
105
106
107
108
Nanometer
• Teknologi Nano tidak merupakan teknologi yang sama sekali BARU • Hanya.. • Perkembangan peralatan dan instrumentasi telah memungkinkan perkembangan yg BARU
10 nm
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO: Seberapa kecil ?
10-1
1
10
102
103
104
105
106
107
108
Nanometer
Microscopy: • scanning electron, • transmission electron, and • atomic force microscopy 10 nm Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different
Skala Nano
Skala Makro
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different
Potensi perubahan salah satu (atau lebih) sifat-sifat : • Optis (warna, transparansi)? atau • Elektrik (konduktivitas)? atau • Fisik (kekerasan,titik leleh, difusifitas) atau • Kimia (reaktivitas, (konstant) laju reaksi)
Sifat-sifat baru (“nano-ness”) ini menciptakan partikel atau bahan yang unik (‘baru’)
Skala Nano
Skala Makro
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Meningkatnya luas permukaan 1 kubus p=l=t=1cm
64 kubus @ p=l=t=0.25cm
8 kubus @ p=l=t=0.5cm A= 6*(0,5*0,5) cm2 A= 1,5 cm2
A=6*1cm2 A=6 cm2 A= 8 *1,5 cm2 A= 12 cm2
• NANO.
A= 6*(0,25*0,25) cm2 A= 0,375 cm2
A= 8*8 * 0,375 cm2 A= 24 cm2 Purwiyatno Hariyadi/seafast center, ipb.
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Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different
1 kubus p=l=t=1cm
A=6*1cm2 A=6 cm2
Luas Permukaan TOTAL (cm2)
Meningkatnya luas permukaan 250 200 150 100 50 0 0
0,5
1
1,5
Sisi kubus (cm) Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Meningkatnya luas permukaan
Meningkatkan reaktivitas?
Meningkatnya bioavailabilitas
Meningkatkan Toksisitas?
Dosis efektif lebih kecil
Menurunkan dosis toksik? (LD50 <<)?
Meningkatnya kemampuan penetrasi
Mempengaruhi ekosistem permukaan?
Mempercepat “onset of action”
Toksisitas baru? Karena rute/transport yg berbeda?
Risiko BARU
Potensi BARU
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness
There is an indication that nanoparticles interact with biological systems like molecules.
J. Nanosci. Nanotechnol. 2007, 7, 3048.
Risiko BARU Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Emas :
• Dalam skala makro (bulk gold) berwarna kuning (emas)
• Dalam skala nano berwarna merah Partikel emas (12 nm)
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Zink : • Dalam skala makro (bulk zink) berwarna putih dan opaque; • Zinc nano : transparan
• Karbon : • Carbon nanotubes : penghantar listrik Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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13
30/09/2013
• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Partikel ZnO ukuran makro: • Menahan cahaya UV • Menyebarkan cahaya tampa • Berwarna putih • Partikel ZnO ukuran nano • Menahan cahaya UV • Tidak menyebarkan cahaya tampak • Transparan • Application to sunscreen • TiO2 : Application to sunscreen Purwiyatno Hariyadi/seafast center, ipb.
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• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Silver • Pada skala makro, perak inerrt • Pada kala nano : partikel perak , 1 nm - 100 nm. • Campuran antara perak dan perak oksida. • Anti bakterial, anti kapang • Aplikasi : • Refrigerator , AC ( pelapisan nano perak pada permukaan yang dilalui aliran udara). • Bandage (plester) • Kaos kaki & pakaian dalam
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Silver
http://www.theecologist.org/green_green_living/behind_the_label/340403/behind_the_label_nanosilver.html Purwiyatno Hariyadi/seafast center, ipb.
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• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Silver
http://www.sharperimagebest.com/zn021.html Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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15
30/09/2013
• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Silver
Purwiyatno Hariyadi/seafast center, ipb.
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• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Silver
http://www.bluemoongoods.com/silver_nanoparticle_food_containers.htm Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
• NANO.
Size matters !
POTENSI karena ukuran kecilnya ‘Nano’ is best understood to mean fundamentally different Contoh Nano-ness • Silver
http://babydream.en.ec21.com
Purwiyatno Hariyadi/seafast center, ipb.
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http://babydream.en.ec21.com
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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• TEKNOLOGI NANO di Bidang PANGAN? Pada 2008: 104 Jenis pangan, bahan tambahan pangan, food contact materials (kemasan, dll), peralatan masak, dan kimia pertanian mengandung partikel nano (FOE, 2008)
Purwiyatno Hariyadi/seafast center, ipb.
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• TEKNOLOGI NANO di Bidang PANGAN? Nanofood ? Food which has been cultivated, produced, processed or packaged using nanotechnology techniques or tools, or to which manufactured nanomaterials have been added (Joseph and Morrison 2006).
Contoh : • Nano-ingredients, nanomaterial additives • Nano iron or zinc, dll Joseph T, Morrison M. 2006. Nanotechnology in Agriculture and Food. Nanoforum Report. Available at: http://www.nanoforum.org/dateien/temp/nanotechnology%20in%20a griculture%20and%20food.pdf?08122006200524 (accessed 17 January 2008).
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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• TEKNOLOGI NANO di Bidang PANGAN?
Strawberries in a conventional food container (upper row) and nano-silver container (lower row). (Test series and pictures: The Innovation Society Ltd.) http://www.nanowerk.com/news/newsid=9292.php#ixzz2CchTJQhr Purwiyatno Hariyadi/seafast center, ipb.
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• TEKNOLOGI NANO di Bidang PANGAN? Contoh aplikasi teknologi nano dan partikel nano pada bidang pangan, pertanian, dan kemasan pangan
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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30/09/2013
• TEKNOLOGI NANO di Bidang PANGAN? Contoh aplikasi teknologi nano dan partikel nano pada bidang pangan, pertanian, dan kemasan pangan
Purwiyatno Hariyadi/seafast center, ipb.
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• TEKNOLOGI NANO di Bidang PANGAN? Contoh aplikasi teknologi nano dan partikel nano pada bidang pangan, pertanian, dan kemasan pangan
• Nano Synergy Energy Booster (Vitamin, Calcium, B-Complex)
• Lycopene (supplement carotenoid, phytosterols by BASF) Source: www.sprayforlife.com, BASF, The Chemical Company
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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• TEKNOLOGI NANO di Bidang PANGAN? Contoh aplikasi teknologi nano dan partikel nano pada bidang pangan, pertanian, dan kemasan pangan Health Ingredient
Main Reason for Formulation
Nanopartikel
Carotenoids
Bioavailability Color Strength
Solid
Co-Enzyme Q10
Bioavailability
Solid
Vitamin A
Stability through encapsulation
Droplet
Vitamin E
Compressibility, use in tablets Droplet
Vitamin D, K
Stability through encapsulation
Droplet
PUFAs
Stability through encapsulation
Droplet Purwiyatno Hariyadi/seafast center, ipb.
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• TEKNOLOGI NANO di Bidang PANGAN? Contoh aplikasi teknologi nano dan partikel nano pada bidang pangan, pertanian, dan kemasan pangan Nanoparticles: Vitamins and Carotenoids Principles (BASF)
Powder Particle, 0.3 mm
• Partikel nano bebas tidak bertahan dalam udara teroksidasi spontan • Partikel nano perlu dilindungi dlm struktur matriks; berada dalam partikel bubuk makro Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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• TEKNOLOGI NANO di Bidang PANGAN? Contoh aplikasi teknologi nano dan partikel nano pada bidang pangan, pertanian, dan kemasan pangan • lebih ringan •Lebih kuat • Lebih mampu menahan gas (minimisasi kehilangan CO2 pada produk bir, (carbonated products) Nanoclay particle based Beer Bottle (Nanocor Inc) Purwiyatno Hariyadi/seafast center, ipb.
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• TEKNOLOGI NANO di Bidang PANGAN? Contoh aplikasi teknologi nano dan partikel nano pada bidang pangan, pertanian, dan kemasan pangan
Purwiyatno Hariyadi/seafast center, ipb.
[email protected]
Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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30/09/2013
• TEKNOLOGI NANO di Bidang PANGAN?
A selection of major food and agriculture companies engaged in nanotechnology research and development (ETC Group 2004; Innovest 2006; Renton 2006; Wolfe 2005). Purwiyatno Hariyadi/seafast center, ipb.
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• TEKNOLOGI NANO di Bidang PANGAN?
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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30/09/2013
Nano-foods now on sale include (FOE, 2008): • Cooking oil, teas • ‘Health’ supplements and diet products • Colour and nutritional additives for soft drinks, dairy and bakery products • Food processing aids • Long-life packaging • Antibacterial kitchenware • Fertilisers, pesticides and agrochemicals
Purwiyatno Hariyadi/seafast center, ipb.
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Contoh produk di US : Perusahaan Nanoceuticals™ (RBC Life Sciences) • Produk : “Slim Shake Chocolate” • Milkshake untuk diet; menggunakan partikel nano silika dilapiskan pada “cocoa clusters” • Meningkatkan citarasa dengan jumlah cocoa dan gula yg lebih sedikit • Health risks? Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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Precautionary principles : The UK Royal Society recommended in 2004: • Full safety assessment of all products that contain nano prior to market release • All nano ingredients to be labelled • Environmental release of nanomaterials to be avoided as far as possible • Factories and research laboratories to treat nanomaterials as if they were hazardous
Purwiyatno Hariyadi/seafast center, ipb.
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Masa depan?
Pertimbangan umum dalam evaluasi produk teknologi Nano : • Karakterisasi • Keamanan • Dampak lingkungan
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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Masa depan?
Jeffery, B. 2011. Food worries: Food Risk Eurobarometer Purwiyatno Hariyadi/seafast center, ipb.
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Terimakasih ... Purwiyatno Hariyadi:
[email protected]
"The Next Big Thing Is Really Small”
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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http://tulangsendisehat.com/anlene.php (Akses: May 17 2012)
Purwiyatno Hariyadi/seafast center, ipb.
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http://tulangsendisehat.com/anlene.php (Akses: May 17 2012)
Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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30/09/2013
http://www.kalbe.co.id/product-300-fatigon-spirit.html (Akses: May 17 2012) Purwiyatno Hariyadi/seafast center, ipb.
[email protected]
BPOM SD 021504861
http://www.kalbe.co.id/product-300-fatigon-spirit.html (Akses: May 17 2012) Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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http://www.propolisnano.org/p/propolis-nano-c9.html (Akses: May 17 2012) Purwiyatno Hariyadi/seafast center, ipb.
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http://www.propolisnano.org/p/propolis-nano-c9.html (Akses: May 17 2012) Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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BPOM TI.084 627 821
http://www.propolisnano.org/p/propolis-nano-c9.html (Akses: May 17 2012) Purwiyatno Hariyadi/seafast center, ipb.
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http://www.bundaherbal.com/products-page/kopi-nano-goji/coffee-nano-goji (Akses: May 17 2012) Purwiyatno Hariyadi/seafast center, ipb.
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Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
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BPOM MD 6499090006423
http://www.bundaherbal.com/products-page/kopi-nano-goji/coffee-nano-goji (Akses: May 17 2012) Purwiyatno Hariyadi/seafast center, ipb.
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Terimakasih ... Purwiyatno Hariyadi:
[email protected]
"The Next Big Thing Is Really Small”
Purwiyatno Hariyadi/seafast center, ipb.
[email protected]
Purwiyatno Hariyadi http://phariyadi.staff.ipb.ac.id/
[email protected]
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