cxxxiii Lampiran 1
Hasil Uji Distribusi Ukuran Partikel Formula A Batch I
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 9,87 30,28 24,16 15,95 8,64 4,73 5,45 99,08 9,85 30,21 24,18 15,92 8,60 4,76 5,48 99,00 9,91 30,25 24,14 15,87 8,63 4,80 5,42 99,02
% Kumulatif bawah granulat 89,21 58,93 34,77 18,82 10,18 5,45
1,2378 0,2245 -0,3916 -0,8844 -1,2712 -1,6027
89,15 58,94 34,76 18,84 10,24 5,48
1,2344 0,2247 -0,3919 -0,8837 -1,2678 -1,6000
89,11 58,86 34,72 18,85 10,22 5,42
1,2322 0,2231 -0,3930 -0,8833 -1,2689 -1,6055
Nilai Z
cxxxiv Lampiran 2
Hasil Uji Distribusi Ukuran Partikel Formula A Batch II
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 10,01 29,92 23,77 15,93 8,88 4,57 5,86 98,94 10,03 30,12 23,82 16,09 8,64 4,63 5,81 99,14 10,56 29,88 23,75 15,87 8,63 4,59 5,79 99,07
% Kumulatif bawah granulat 88,93 59,01 35,24 19,31 10,43 5,86
1,2226 0,2261 -0,3789 -0,8667 -1,2572 -1,5667
89,11 58,99 35,17 19,08 10,44 5,81
1,2322 0,2257 -0,3808 -0,8750 -1,2567 -1,5708
88,51 58,63 34,88 19,01 10,38 5,79
1,2010 0,2179 -0,3886 -0,8775 -1,2600 -1,5725
Nilai Z
cxxxv Lampiran 3
Hasil Uji Distribusi Ukuran Partikel Formula A Batch III
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 9,95 31,02 24,23 16,08 8,83 4,34 4,50 98,95 9,91 31,08 24,12 16,20 8,78 4,37 4,64 99,1 9,96 31,05 24,18 15,97 8,75 4,35 4,56 98,82
% Kumulatif bawah granulat 89,00 57,98 33,75 17,67 8,84 4,50
1,2263 0,2013 -0,4192 -0,9281 -1,3506 -1,6956
89,19 58,11 33,99 17,79 9,01 4,64
1,2367 0,2046 -0,4127 -0,9235 -1,3400 -1,6810
88,86 57,81 33,63 17,66 8,91 4,56
1,2189 0,1970 -0,4225 -0,9285 -1,3462 -1,6890
Nilai Z
cxxxvi Lampiran 4
Hasil Uji Distribusi Ukuran Partikel Formula B Batch I
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 10,75 31,33 23,44 16,09 8,67 4,21 4,60 99,09 10,71 31,28 23,47 16,11 8,72 4,12 4,65 99,06 10,69 31,35 23,51 16,07 8,69 4,18 4,56 99,05
% Kumulatif bawah granulat 88,34 57,01 33,57 17,48 8,81 4,60
1,1921 0,1667 -0,4242 -0,9354 -1,3525 -1,6850
88,35 57,07 33,60 17,49 8,77 4,65
1,1926 0,1767 -0,3405 -0,9350 -1,3550 -1,6800
88,36 57,01 33,50 17,43 8,74 4,56
1,1932 0,1767 -0,4261 -0,9373 -1,3569 -1,6890
Nilai Z
cxxxvii Lampiran 5
Hasil Uji Distribusi Ukuran Partikel Formula B Batch II
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 10,71 32,44 22,85 16,29 9,24 3,31 4,12 98,96 10,68 32,52 22,88 16,31 9,2 3,27 4,19 99,05 10,75 32,4 22,79 16,32 9,18 3,39 4,28 99,11
% Kumulatif bawah granulat 88,25 55,81 32,96 16,67 7,43 4,12
1,1875 0,1462 -0,4411 -0,9672 -1,4443 -1,7367
88,37 55,85 32,97 16,66 7,46 4,19
1,1937 0,1472 -0,4408 -0,9676 -1,4421 -1,7289
88,36 55,96 33,17 16,85 7,67 4,28
1,1932 0,1500 -0,4353 -0,9600 -1,4279 -1,7189
Nilai Z
cxxxviii Lampiran 6
Hasil Uji Distribusi Ukuran Partikel Formula B Batch III
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 11,04 32,76 22,4 15,87 8,75 3,19 5,04 99,05 10,78 32,83 22,51 15,79 8,82 3,27 4,89 98,89 10,75 32,69 22,48 16,03 8,65 3,29 5,13 99,02
% Kumulatif bawah granulat 88,01 55,25 32,85 16,98 8,23 5,04
1,1755 0,1320 -0,4442 -0,9550 -1,3900 -1,6410
88,11 55,28 32,77 16,98 8,16 4,89
1,1805 0,1327 -0,4464 -0,9550 -1,3947 -1,6510
88,27 55,58 33,10 17,07 8,42 5,13
1,1885 0,1403 -0,4372 -0,9515 -1,3773 -1,6327
Nilai Z
cxxxix Lampiran 7
Hasil Uji Distribusi Ukuran Partikel Formula C Batch I
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 5,84 41,23 34,57 9,61 3,21 1,19 3,46 99,11 5,7 41,31 34,63 9,53 3,27 1,16 3,52 99,12 5,91 41,2 33,73 9,69 3,09 2,11 3,38 99,11
% Kumulatif bawah granulat 93,27 52,04 17,47 7,86 4,65 3,46 2.9.6. 2.9.8. 93,42 52,11 17,48 7,95 4,68 3,52
1,4962 0,0506 -0,9358 -1,4147 -1,6800 -1,8175 2.9.7. 2.9.9. 1,5077 0,0513 -0,9354 -1,4087 -1,6770 -1,8100
93,20 52,00 18,27 8,58 5,49 3,38
1,4908 0,0501 -0,9052 -1,3669 -1,5991 -1,8275
Nilai Z
cxl Lampiran 8
Hasil Uji Distribusi Ukuran Partikel Formula C Batch II
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 6,09 40,82 35,07 9,73 2,75 1,36 3,28 99,10 6,12 40,91 34,93 9,82 2,69 1,41 3,23 99,11 5,98 40,75 35,11 9,74 2,79 1,42 3,31 99,10
% Kumulatif bawah granulat 93,01 52,19 17,12 7,39 4,64 3,28
1,4764 0,0522 -0,9496 -1,4471 -1,6810 -1,8414
92,99 52,08 17,15 7,33 4,64 3,23
1,4750 0,0510 -0,9484 -1,4515 -1,6810 -1,8486
93,12 52,37 17,26 7,52 4,73 3,31
1,4846 0,0542 -0,9440 -1,4380 -1,6720 -1,8371
Nilai Z
cxli Lampiran 9
Hasil Uji Distribusi Ukuran Partikel Formula C Batch III
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 5,92 41,09 34,52 9,61 2,89 1,35 3,68 99,06 6,09 40,92 34,47 9,49 3,10 1,41 3,58 99,06 5,88 41,14 34,61 9,67 2,82 1,37 3,60 99,09
% Kumulatif bawah granulat 93,14 52,05 17,53 7,92 5,03 3,68
1,4862 0,0507 -0,9334 -1,4107 -1,6420 -1,7887
92,97 52,05 17,58 8,09 4,99 3,58
1,4736 0,0507 -0,9315 -1,3993 -1,6460 -1,8014
93,21 52,07 17,46 7,79 4,97 3,60
1,4915 0,0509 -0,9362 -1,4193 -1,6480 -1,7987
Nilai Z
cxlii Lampiran 10
Hasil Uji Distribusi Ukuran Partikel Formula D Batch I
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 4,28 30,79 23,17 18,86 12,93 3,96 5,12 99,11 4,24 30,73 23,1 18,81 12,88 4,15 5,19 99,10 4,32 30,69 23,27 18,84 12,86 3,99 5,14 99,11
% Kumulatif bawah granulat 94,83 64,04 40,87 22,01 9,08 5,12
1,6290 0,3595 -0,2308 -0,7717 -1,3359 -1,6336
94,86 64,13 41,03 22,22 9,34 5,19
1,6318 0,3619 -0,2267 -0,7647 -1,3200 -1,6270
94,79 64,10 40,83 21,99 9,13 5,14
1,6250 0,3611 -0,2318 -0,7724 -1,3329 -1,6318
Nilai Z
cxliii Lampiran 11
Hasil Uji Distribusi Ukuran Partikel Formula D Batch II
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 4,21 30,65 24,18 18,34 11,72 4,80 5,21 99,11 4,17 30,62 24,27 18,3 11,63 4,85 5,26 99,10 4,15 30,78 24,14 18,43 11,68 4,76 5,16 99,10
% Kumulatif bawah granulat 94,90 64,25 40,07 21,73 10,01 5,21
1,6355 0,3651 -0,2515 -0,7814 -1,2811 -1,6250
94,93 64,31 40,04 21,74 10,11 5,26
1,6398 0,3668 -0,2523 -0,7810 -1,2753 -1,6200
94,95 64,17 40,03 21,6 9,92 5,16
1,6400 0,3630 -0,2526 -0,7859 -1,2861 -1,6300
Nilai Z
cxliv Lampiran 12
Hasil Uji Distribusi Ukuran Partikel Formula D Batch III
Replikasi
I
II
III
No. Mesh
Diameter (d μm)
"n d (μm)
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
20 40 60 80 100 120 Pan
850 425 250 180 150 125 0
6,75 6,05 5,52 5,19 5,01 4,83
Berat granulat yang tertahan (W gram) 4,19 31,16 23,96 18,54 11,77 4,35 5,12 99,09 4,13 31,21 24,07 18,62 11,52 4,4 5,16 99,11 4,23 31,19 23,87 18,48 11,6 4,52 5,21 99,1
% Kumulatif bawah granulat 94,90 63,74 39,78 21,24 9,47 5,12
1,6355 0,3516 -0,2590 -0,7983 -1,3124 -1,6336
94,98 63,77 39,70 21,08 9,56 5,16
1,6422 0,3524 -0,2611 -0,6038 -1,3071 -1,6300
94,87 63,68 39,81 21,33 9,73 5,21
1,6327 0,3500 -0,2582 -0,7952 -1,2971 -1,6250
Nilai Z
145
Lampiran 13
4.8. Perhitungan ANAVA Kekerasan Tablet
4.9. Ulang an 4.16. 1 4.17. 2 4.18. 3 4.19. n 4.20. Rata -rata 4.21. Ji 4.22. Ji2
4.12. A 6,34 6,29 6,37 3
4.10. Perlakuan 4.13. B 4.14. C 6,85 8,02 6,84 8,22 7,02 8,15 3 3
6,333 19 361,00
6,903 20,71 428,90 4.23.
8,130 24,39 594,87
4.24. Perhitungan JK: 4.25. k =
4
4.26. n =
3
4.27. N =
12
4.28. 6 Yi 2
=
4.29. J = 6 Ji =
556,8878 81
4.30. JK Total =
6 Yij2
J2 N
=
10,1378
4.31. JK. Py
=
6J i2 J 2 n N
=
10,0454
4.32. JK.Ey
=
Total – Py
=
0,0924
4.11. Jumla h
4.15. D 5,57 5,52 5,81 3 5,633 16,9 285,61
12 81 1670,39
146
4.33. Tabel Anava SV db Py 4.34. 3 Ey 4.35. 8 TOTAL 4.36. 11
JK 10,0454 0,0924 10,1378
4.38. db (TOTAL)= 4.39. db (Py) = (k – 1)
RJK F hit. F (0.05) F (0.01 ) 3,3485 289,911 4,07 7,59 0,0115 4.37. kn – 1 RJK = JK / db F hitung = RJK (Py) / RJK (Ey)
4.40. db (Ey) = db (TOTAL – Py) 4.41. 4.42. Kriteria pengujian: 4.43. Bila F hitung > F (0,05) maka berbeda signifikan 4.44. 4.45. Pengujian Hipotesa: a. H : Pi = 0 4.46. Yang berarti tidak ada perbedaan kekerasan yang signifikan sebagai akibat perbedaan perlakuan. b. Kesimpulan: 4.47. Karena F hitung > F (0,05) maka H ditolak. 4.48. Jadi perlakuan-perlakuan mengakibatkan perbedaan kekerasan yang signifikan.
147
4.49. Uji HSD / TUCKEY 4.50. Perlakuan 4.51. Mean 4.56. A 4.57. B 4.58. C 4.59. D
6,333 6,903 8,130 5,633
4.60. 4.61. RJK
4.52. A 6,333 0
=
4.53. B 6,333 0,570 * 0
4.54. C 6,333 1,797 * 1,227 * 0
0,012
4.55. D 6,333 0,700 * 1,270 * 2,497 * 0
q(5%/2; p;db)
=
4,53 4.62. n
= 3
HSD (5%) = q
RJK n
= 0,281
4.63. db = 8 4.64. Keterangan: 4.65. * :
perbedaannya signifikan, karena selisihnya > HSD (5%)
4.66. TS
:
perbedaannya tidak signifikan, karena selisihnya < HSD (5%)
Kekerasan (kgf)
4.67.
10 8
6,333
6,903
A
B
8,130 5,633
6 4 2 0 C Formula
4.68.
4.69.
D
148
Lampiran 14
4.70. Perhitungan ANAVA Kerapuhan Tablet
4.71. Ulan gan 4.78. 1 4.79. 2 4.80. 3 4.81. n 4.82. Rata -rata 4.83. Ji 4.84. Ji2
4.72. Perlakuan 4.74. A 4.75. B 4.76. C 0,35666667 0,32 0,29333333 0,34666667 0,31333333 0,29 0,34333333 0,31666667 0,27666667 3 3 3
4.77. D 0,28333333 0,31 0,31333333 3
0,349 1,04666667 1,10
0,302 0,90666666 0,82
0,317 0,95 0,90 4.85.
0,287 0,86 0,74
4.86. Perhitungan JK: 4.87. k =
4
4.88. n =
3
4.89. N =
12
4.90. 6 Yi 2
=
1,187366666
4.91. J = 6 Ji =
3,763333333
4.92. JK Total =
6 Yij2
J2 N
=
0,0071
4.93. JK. Py
=
6J i2 J 2 n N
=
0,0063
4.94. JK.Ey
=
Total – Py
=
0,0008
4.73. Jumla h
12 3,76333333 3,56
149
4.95. Tabel Anava SV Py Ey TOTAL
db 3 8 11
JK 0,0063 0,0008 0,0071
4.97. db (TOTAL)= 4.98. db (Py) = (k – 1)
RJK F hit. F (0.05) F (0.01 ) 0,0021 20,712 4,07 7,59 0,0001 4.96. kn – 1 RJK = JK / db F hitung = RJK (Py) / RJK (Ey)
4.99. db (Ey) = db (TOTAL – Py) 4.100. 4.101. Kriteria pengujian: 4.102. Bila F hitung > F (0,05) maka berbeda signifikan 4.103. 4.104. Pengujian Hipotesa: a. H : Pi = 0 4.105. Yang berarti tidak ada perbedaan kerapuhan yang signifikan sebagai akibat perbedaan perlakuan. b. Kesimpulan: 4.106. Karena F hitung > F (0,05) maka H ditolak. 4.107. Jadi perlakuan-perlakuan mengakibatkan perbedaan kerapuhan yang signifikan.
150
4.108. Uji HSD / TUCKEY 4.109. Perlakuan 4.110. Mean 4.115. A 4.116. B 4.117. C 4.118. D 4.119. 4.120. RJK =
0,349 0,317 0,287 0,302
4.111. A 0,349 0
4.112. B 0,349 0,032 * 0
4.113. C 0,349 0,062 * 0,030 * 0
0,000
4.114. D 0,349 0,047 * 0,014 ts 0,016 ts 0
q(5%/2; p;db)
=
4,53 4.121. n = 3
HSD (5%) = q
RJK n
= 0,026
4.122. db = 8 4.123. Keterangan: 4.124. *
:
perbedaannya signifikan, karena selisihnya > HSD (5%)
4.125. TS
:
perbedaannya tidak signifikan, karena selisihnya < HSD (5%)
Kerapuhan (%)
4.126.
0,4
0,349
0,317
0,3
0,287
0,302
C
D
0,2 0,1 0 A
B
Formula
4.127. 4.128.
151
Lampiran 15
4.129. Perhitungan ANAVA Waktu Hancur Tablet
4.130. Ula ngan 4.137. 1 4.138. 2 4.139. 3 4.140. n 4.141. Rat a-rata 4.142. Ji 4.143. Ji2
4.131. Perlakuan 4.134. B 4.135. C 4,62667 3,703333 4,61667 3,706667 4,62333 3,653333 3 3
4.133. A 5,51 5,433333 5,586667 3 5,510 16,53 273,24
4.136. D 2,83333 2,81 2,81667
4,622 3,688 13,8667 11,06333 192,28 122,40 4.144.
4.145. Perhitungan JK: 4.146. k
=
4
4.147. n
=
3
4.148. N
4.149. 6 Yi 2
=
12
=
219,8453
4.150. J = 6 Ji =
49,92
4.151. JK Total
=
4.152. JK. Py = 4.153. JK.Ey =
6 Yij2
J2 N
4.132. Juml ah
=
12,1781
6J i2 J 2 n N
=
12,1642
Total – Py
=
0,0139
3 2,820 8,46 71,57
12 49,92 659,49
152
4.154. Tabel Anava SV Py Ey TOTAL
db 3 8 11
JK 12,1642 0,0139 12,1781
4.156. db (TOTAL)
RJK F hit. 4,0547 2336,778 0,0017 4.155. = kn – 1
F (0.05) F (0.01 ) 4,07 7,59 RJK
=
JK
/ db 4.157. db (Py) = (k – 1)
F hitung = RJK (Py) / RJK (Ey)
4.158. db (Ey) = db (TOTAL – Py) 4.159. 4.160. Kriteria pengujian: 4.161. Bila F hitung > F (0,05) maka berbeda signifikan 4.162. 4.163. Pengujian Hipotesa: a. H : Pi = 0 4.164. Yang berarti tidak ada perbedaan waktu hancur yang signifikan sebagai akibat perbedaan perlakuan. b. Kesimpulan: 4.165. Karena F hitung > F (0,05) maka H ditolak. 4.166. Jadi perlakuan-perlakuan mengakibatkan perbedaan waktu hancur yang signifikan. 4.167.
153
4.168. Uji HSD / TUCKEY 4.169. Perlakuan 4.170. Mean 4.175. A 4.176. B 4.177. C 4.178. D 4.179. 4.180. RJK =
5,510 4,622 3,688 2,820
4.171. A 5,510 0
4.172. B 5,510 0,888 * 0
4.173. C 5,510 1,822 * 0,934 * 0
0,002
4.174. D 5,510 2,690 * 1,802 * 0,868 * 0
q(5%/2; p;db)
=
4,53 4.181. n = 3
HSD (5%) = q
RJK n
= 0,109
4.182. db = 8 4.183. Keterangan: 4.184. *
:
perbedaannya signifikan, karena selisihnya > HSD (5%)
4.185. TS
:
perbedaannya tidak signifikan, karena selisihnya < HSD (5%)
Waktu Hancur (menit)
4.186.
6 5 4 3 2 1 0
5,510 4,622 3,688 2,820
A
B
C Formula
4.187. 4.188.
D
154
Lampiran 16
4.189. Perhitungan ANAVA Disolusi Tablet
4.190. Ula ngan 4.197. 1 4.198. 2 4.199. 3 4.200. n 4.201. Rat a-rata 4.202. Ji 4.203. Ji2
4.191. Perlakuan 4.194. B 4.195. C 96,36 97,74 96,42 97,8 96,42 97,67 3 3
4.193. A 95,09 95,21 94,96 3 95,087 285,26 81373,27
4.196. D 99,07 99,26 99,07
96,400 97,737 289,2 293,21 83636,64 85972,10 4.204.
4.205. Perhitungan JK: 4.206. k
=
4
4.207. n
=
3
4.208. N
4.209. 6 Yi 2
=
12
=
113142,9901
4.210. J = 6 Ji =
1165,07
4.211. JK Total
=
4.212. JK. Py = 4.213. JK.Ey =
6 Yij2
J2 N
4.192. Juml ah
=
27,3147
6J i2 J 2 n N
=
27,2485
Total – Py
=
0,0662
3 99,133 297,4 88446,76
12 1165,07 339428,77
155
4.214. Tabel Anava SV Py Ey TOTAL
db 3 8 11
JK 27,2485 0,0662 27,3147
4.216. db (TOTAL)
RJK F hit. 9,0828 1097,623 0,0083 4.215. = kn – 1
F (0.05) F (0.01 ) 4,07 7,59 RJK
=
JK
/ db 4.217. db (Py) = (k – 1)
F hitung = RJK (Py) / RJK (Ey)
4.218. db (Ey) = db (TOTAL – Py) 4.219. 4.220. Kriteria pengujian: 4.221. Bila F hitung > F (0,05) maka berbeda signifikan 4.222. 4.223. Pengujian Hipotesa: a. H : Pi = 0 4.224. Yang berarti tidak ada perbedaan disolusi obat yang signifikan sebagai akibat perbedaan perlakuan. b. Kesimpulan: 4.225. Karena F hitung > F (0,05) maka H ditolak. 4.226. Jadi perlakuan-perlakuan mengakibatkan perbedaan disolusi obat yang signifikan.
156
4.227. Uji HSD / TUCKEY 4.228. Perlakuan 4.229. Mean 4.234. A 4.235. B 4.236. C 4.237. D 4.238. 4.239. RJK =
95,087 96,400 97,737 99,133
4.230. A 95,087 0
4.231. B 95,087 1,313 * 0
4.232. C 95,087 2,650 * 1,337 * 0
0,008
4.233. D 95,087 4,047 * 2,733 * 1,397 * 0
q(5%/2; p;db)
=
4,53 4.240. n = 3
HSD (5%) = q
RJK n
= 0,238
4.241. db = 8 4.242. Keterangan: 4.243. *
:
perbedaannya signifikan, karena selisihnya > HSD (5%)
4.244. TS
:
perbedaannya tidak signifikan, karena selisihnya < HSD (5%) 4.245. 99,133
Harga Q (%)
100 97,737
98 96
96,400 95,087
94 92 A
B
C
Formula
4.246. 4.247.
D
clvii Lampiran 17
Surat Keterangan Identifikasi Delima
DINAS KESEHATAN PROPINSIJAWA TIMUR BALAI MATERIA MF;DICA lalan Lahor No.87 Telp. (0341) 593396 Batu (65313)
KOTABATU Nemer
: 074 / 77 / 111.1411V 12007
Sifat Perihal
: Biasa : Determina!d TaD.man Kulit Buab Delima
Fakultas
~emenuhi pennohonan saud.an;;-: Anastasia Parera : 2443003165 : Falcultas Fannasi Universitas Widya Mandala
Divisi Sub divisi
Penna! detenninasi tanaman Ku!it Buah Delima . : Angiospermae
Nama NIM
Kelas
Bangsa Suku Marga Jenis
: Spennatophyta
: Dicotyledenae : Myrtale,
: Punicaceae : Punica : Punica grana/urn Demikian detenninasi ini kami buat untuk dipergunakan sebagaimana
mcstinya.
clviii Lampiran 18
-
Sertifikat Analisa Aerosil
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clx Lampiran 20
Sertikat Analisa Amilum Pregelatinasi
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clxi Sertikat Analisa Amilum Pregelatinasi
COIO(con l Certificate of Analysis Product Name:
STARCH 1500 PARTIA.LLY PREOE:t.ATINIZEO KAI1.E STA.RCH
Product Number:
2001
Material Description:
Whlt.
Lot No:
5a157396
POwell!:
VBN:
IN511115
Quantity Supplied'
1000 KG .('
Ship To :
PT "_nj.flgan Saktl
10
SUI To:
PT Kenjan9"n S"kti
ttl
Customer Ord NO:
CCSOl28U9
Customer PO NO:
'ell)
CompllanceStlteme"lI:Thh Product m•• ta all .Wr••d upon .pacificatione SpecillcaUons Test
Method
Mlnlmllm
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This Product was _IIu/adllmltn 1I/g,cUil,1h1ll It n,utfud "Wt lit, UIIlI,d Stili" PDA. J.llld,r tht prowistOlll1 0/ til, 8'ot,"0""". l'rtpar,dru¥t lind R"p"'II" Act.
Manufacturad By:
o.t. Of M.nul.cture:
Manulacturing SII.· ~
R....v.lu.tlon Oat.:
2S-MAY-2010
Oat.:
lJ-AUC-1006
Approved By: Tille:
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26-KA,Y-2006
clxii Lampiran 21
Sertif"tkat Analisa Talkum
CERTlFICHE s rS . . ' . OF Al'iALy ' .
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clxiii Lampiran
Sc rtifikat Analisis Mllgaesium Stearat
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clxiv Lampiran 23
Tabel Z
k, I · 0
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2
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3
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•,.
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--_. 6 .~lJ3
)
0
. 5279 .531 9
.~
.
, ~39B
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.5 793 .!:G32 ,507' .5920 .S9M! .5987 .G(I2G .6064 .61 0 J .6 t" 1 . (,179 . [j ~ 17 .62::5 .6<:0 3 .G2 ~ 1 .63GO .6 406 . (44) .(;"00 .6 5 11
..
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i· " .5
'i
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1 .GG1B
.(,1 15 .69':;0
. G!)ll ~
"J~4
. (j(G~
. O:;G~6 .';(7 5 .5714
.S'SJ
6 700 .G7JG .l' 77 .. .6808 .G8 4'1 ,li8 7 Q
.70 1 'J .70:; "
1088 .1123 . '157.7190 .14:24
.1 J5J .1][>9 .7422 . '0154 .7486
. 7~17
. 1549
.6
• "12':. 7
.)
.7580 .7611 .1642 .1u7J .:170: .77 3<1 .11 64 .1794.7823 .185 2 . 7881 .7'Jl0 .19J ~ . 7961 . 7990;; .8 0 2 3 .805 , .B0 7 8 .0106 . 81Jl
•• •• . ) .....9 ", "2 , .3
", " , 6 II " , , , . 5
~
.)
... . 7
2.0 2. 2.2 2.3 2.' 2.' 2."
7291
.81 59 . 81 0 6 .82' 2 . 0238 .826 .. .8289 .allS .8340 . 0)65 .8389 .8413 . 8438 .8461 . 8485 .850 a .8531 .855 4 .8517 .8599 .8621 .8 643 .8GGS .86Du .8708 .8129 . 8749 .8770 .B}9 0 . !l610 . B031i! . M 49 ' .8869 .8BBB .8907
. 692~
.903= .9049 .9nOG .9062
.OO!J~
.9115.91:)1 .9141 .91v2 .9111
.9 192 . 920i .9222 .9236
.92~1
. 92G5 .9218 .9292 .9lOG .9319
.8944 .89_f)2 . 8980 .B991 .9015
.9332 .9 345 .9357 .9310 .93132 .!J39 • . 9.0G .9.'6 .9 43 0 .9 .'" .9.52
.~ .G3
.9474 .S4&.4
.~"'9~
.9554! .9564 . 9~73 .9582 .95"
.9505 .9615
~9S25
.9535 .9545
.9599 .9608 .961G .9625 .9633
.9$41 .964a .9650 .9664 .967\ .9678 .9686 .9693 .9700 .9706 .9713 .9719 .9726 .9732 . 9738 .9144 .9750 .9756 .976 2 .9167 .9112 .977a .9763 .97(HI .!t19::' .97Jia .raOl .9808 .9812 .9a17 .9!12 1 .9826 .9B30 .983'" .90lt .9
J4 .~
.584., .9050 .90:14 .9851
. 98G 1 .98G4 .9868 .9671 .9 074 .9'!7C1 .9601 .9684 .9661 .9890 .9893 .9B96 .U90 .9901 .9904 .,ao6 .9909 .99 I 1 .9913 .991G .9918 .9no .9922 .9925 .9927 .9929 .9931 . 9932 .993"
. !i!'l~6
.9938 .'940 .9941 .9943 .99.5 .9946 .99<8 .9Y49 .9951 .9952 .9953 .9955 .9956 .9957 .9959 .1960 .99Gl .9962 . 9963 .9964
, .\
2.7 2.•
.9905 .99(;6 .99 6 7 .9')(;8 .9909 .9970 .9971 .9<272 .9973
2..
.99Bl .9982 .9982 .9983 .Il,64 .990 • . 9965 .9985 .9986 .9986
3.
.9987 .9990 .9993 .9995 .9997 .999S .9998 .9999 . 9999 1 .0000
. ~y
.9974 .9915 .9976 .9977 .9977 .9ns .9979 .9979 .9980 .9981
clxv
Dikutip dari: Gennaro (1970).
clxvi Lampiran
24
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clxvii
clxviii
clxix
Dikutip dari: Sudjana (1985).
clxx Lampiran 25
Dikutip dari: Sudjana (1985).
