RINGKASAN SindToma meiabotifc merupakan Kumpuian beberapa faktor resiKo yang terdiri dari hipertensi, dislipidemia, gangguan toleransi glukosa dan obesitas memiliki hubungan dengan patomek.anisrne penyakit kardiovaskuter. taporan WHO tahun 2<3<33 menyebutkan, di dunia lebih dari 300 juta orang dewasa menderita obesitas. Sampai saat ini peranan jaringan adiposa pada penyakit infeksi dan perubahan kuafitas adiposit setelah paparan kuman patogen belum banyak diungkap. Di sisi lain, prevalensi penyakit infeksi os negara berkembang masih tinggi, beberapa studi menyebutkan bahwa terdapat hubungan antara infeksi T. gondii dengan fungsi jaringan adiposa. PTOfifin adaian tomponet! rnerribTari f. gontfnyang rnarfipu rnernacu eteptesi iL-12 dan sitokin proinflamasi lain sel dendritik melalui ikatan pada TLR-1 '\. Hal ini munpkin terjadi juga di sei iemaK setringga roerocu disfangsi adiposil y&r\q rnengarah fc.e sindToma rnetabolik. Penelitian sebelumnya menyebutkan bahwa sindroma metabolik yang terkait dengan jaringan ferna^ serfato rivitieniMan dengan temaX visera<, padahai temafc subkutanjuga berpotensi menjadi patogenik, Oleh karena itu pertu penelitian lebih lanjut bagaimanateh efek paparan prof&n terh&dap adiposit subkvrfan secara in viYro sebagai upaya untuk menjelaskan keteriibatan disfungsi adiposit pada patomekanisme sindroma metaboi* aWbat snfekss parasrt protozoa. Peneffian mi bertujuan untuk membuktikan pengaruh paparan profilin terhadap ekspresi TLR-11, !L-6, dan TNF-a. pada kuitur kadar TLR-11, !L-6, dan TN?-a dilakukan dengan teknik ELISA. Hasi! peneiitian TOenuTijufeten bahwa efek paparan profit cJos'Js 5:. 15 cfan 2-5 n^/m{ menin^katkan kadar IL6 dan TNF-a tetapi menurunkan kadar TLR-11. Penelitian ini membuktikan bahwa paparan prof&n menyebabkan disfungsi adiposit meteiui peningkatan kadar adipositokin proinfiamasi sebagai patomekanisme sindroma metabolik terkait dengan jaringan adiposa.
SUMMARY Metabofic syndrome is a group of severaJ risk factors consists of hypertension, dyslipidemia, glucose tolerance disorders and obesity. It has a relationship with cardsovascuter disease patomekanisme. WHO reported in 2CC3 that more than 3<3O million adults in the world suffered from obesity. The role of adipose tissue in. infectious diseases and adipocyte quality changes after exposure to pathogens has not been revealed. On the other hand, the prevalence of infectious diseases in developing countries are stifl fcigft, some stucfes reported that there is a reJationship between the infection of T gondii and adipose tissue function. Profi;in is a membrave component of T Qondti, ltialJ^ atfe io slYrfratete expression of 1L-12 and other cytoKines proinfiamafion of dendritic cells through binding with TLR-11. This may occur in the fat cell, trigering the acKpocyte cfysfang'tion Inat teatis to roetabofc syndrorrie. Previews studies have mentioned that the metabolic syndrome associated with fat tissue is always reffered to viscera? fst, ^ereas sutculaneovis fat is afeo potentia^y to become pathogenic. Therefore it is necessary to study how the effects of further profilin exposure to subcutaneous adipocyte OT vSro in order to explain the invo&ement adiposit ciysfunction in nrtetabolic syndrome athomechanism due to protozoan parasite infections. This study aims to prove the influence of profitin exposure to the expression of TLR-11,
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