BAB 5 KESIMPULAN & SARAN
5.1
Kesimpulan
1.
Konsentrasi SSG berpengaruh signifikan terhadap penurunan Hausner ratio dan penurunan waktu larut. Konsentrasi locust bean gum berpengaruh signifikan terhadap penurunan Hausner ratio dan peningkatan
waktu
larut.
Interaksi
konsentrasi
SSG
dan
konsentrasi locust bean gum berpengaruh signifikan terhadap peningkatan Hausner ratio. 2.
Formula optimum granul obat kumur povidone iodine yang diperoleh dengan program optimasi Design expert yaitu dengan menggunakan konsentrasi SSG sebesar 8,00% dan konsentrasi locust bean gum sebesar 0,116% dan menghasilkan mutu fisik granul yang memenuhi persyaratan yaitu Carr’s index 15,21%, Hausner ratio 1,18, dan waktu larut 63 detik.
3.
Formula optimum granul obat kumur povidone iodine mempunyai daya antibakteri terhadap Streptococcus mutans dengan rata-rata diameter DHP 12,73 ± 0,24 mm.
5.2
Saran Diperlukan penelitian lebih lanjut tentang daya antibakteri granul
obat kumur povidone iodine menggunakan bakteri mulut lainnya seperti Candida albicans dan Streptococcus pyogenes.
79
DAFTAR PUSTAKA
Addy, M., Griffiths, C. and Issac, R. 1977, The effect of povidone iodine on plaque and salivary bacteria, Journal of Periodontology, 48: 730732. Adriyati, P dan Santoso, O. 2011, ‘Pengaruh pemberian larutan ekstrak siwak (Salvadora persica) terhadap pembentukan plak gigi’, Karya Tulis Ilmiah. Fakultas Kedokteran Universitas Diponegoro. Semarang. Ambarwati, F.E., Utami,D.F. dan Pramono D. 2012, Pengaruh pemberian larutan ekstrak jeruk nipis (Citrus aurantifolia) terhadap pembentukan plak gigi, Jurnal Media Medika muda, hal 5. Anitasari, S. dan Rahayu, N.E. 2005, Hubungan frekuensi menyikat gigi dengan tingkat kebersihan gigi dan mulut siswa sekolah dasar negeri di kecamatan palaran kotamadya samarinda provinsi kalimantan timur, Majalah Kedokteran Gigi, 38: 8. Ansel, C. H. 1989, Pengantar Bentuk Sediaan Farmasi, 4th ed., Penerjemah Farida Ibrahim. Universitas Indonesia Press, Jakarta. Ansel, H. C., 2005, Pengantar Bentuk Sediaan Farmasi, 4th ed., Universitas Indonesia Press. Jakarta. Ansel, H. C., Allen L.V , dan Popovich N.G,. 2013, Bentuk Sediaan Farmasetis dan Sistem Penghantaran Obat, 9th ed., EGC. Jakarta. Bachtiar, E.W. 1997, Prospek vaksinasi dalam pencegahan karies dengan antigen hasil rekayasa protein dinding sel Streptococcus mutans, Jurnal Kedokteran Gigi Universitas Indonesia, 4: 641-647. Bailey, W. R. and Scott, E. G., 1974. Diagnostic Microbiology, 4th ed. The C. V Mosby Company, Saint Louis. Banker , G., and N.R. Anderson, 1986, ‘Tablet’, in: The Theory and Practice of Industrial Pharmacy: Tablet, L. Lachman, H.A. 80
Lieberman, and J. L. Kanig (Eds), 3rd ed., Lea and Febiger, Philiadelphia. Barel, A. O., Paye, M., Maibach, H. I., 2001, Handbook of Cosmetic Science and Technology. Marcel Dekker Inc, New York. Bassett, J., Denney, R. C., Jeffery, G. H., Mendham, J. 1994. Vogel’s of Quantitative Inorganic Analysis, 4th ed., ELBS, London. Bolton., S., 1990, Pharmaceutical Statistic: Pratical and Clinical Applications, 2nd ed., Marcel Dekker, Inc., New York. Brooks, G. F., Butel, J.S., Morse, S.A., 2001, Mikrobiologi Kedokteran, 22th ed., Salemba Medika, Jakarta. Carranza FA, Newman MG and Takei HH. 2002, Clinical periodontology. 9th ed., WB Saunders Company, Philadelphia, pp 97-98. Cawson RA, Odell EW and Porter S. 2002, Cawson’s Essential of oral Pathology and Oral Medicine. 7th ed, Churchill Livingstone, Spain, pp. 43-47. Chaplin M. 2005, Locust Bean http://www.Isbu.ac.uk/water/hyloc.html.
Gum.
(Online).
Departemen Kesehatan RI, 2014. Farmakope Indonesia Jilid V, Jakarta. George J, Shashikant Hegde, KS Rajesh and Arun Kumar. 2009, The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis: A clinico-biochemical study. Indian Journal of Dental Research, 20: 480-482. Gowda D.V. Rohan D.D. Keerthy H.S. and Siddaramaiaha. 2014, Study of locust bean gum as binder in formulatoin of immediate release atorvastartin calcium spheroids through extrusion and spheronization technique. International Journal of Pharmaceutical Science Review and Research, 27 (2): 396-397. Gronroos, L. 1998. General Bacteriological Aspect of Mutans Steptococci. (Online). http://ethesis.helsinki.fi/julkaisut/laa/hamma.html. 81
Hadisoewignyo, L., dan A. Fudholi, 2013, Sediaan Solida, Pustaka Pelajar, Yogyakarta. Hugo, W.B. and Russel, A.D., 1987. Pharmaceutical Microbiology, 4th ed. Blackwell Scientific Publication, London. Kusumawati R. 2010, ‘Hubungan tingkat keparahan karies gigi dengan status gizi siswa kelas dua SDN 01 Ciangsana Desa Ciangsana Kabupaten Bogor tahun 2010’, Skripsi, Sarjana Kesehatan Masyarakat, Universitas Islam Negeri Syarif Hidayatullah, Jakarta. Lestari, A.B.S., Trisusilawati, M.Y. 2010, Pengaruh asam fumarat natrium bikarbonat terhadap kualitas granul effervescent teh hijau secara granulasi kering, Majalah Farmasi Indonesia,21(4): 231-137. Lim, D., 1998. Microbiology, 2nd ed. The Mc. Graw-Hill Companies Inc, United State of America. Lorian, V., 1991, Antibiotic in Laboratory Medicine, 3rd ed., Williams and Wilkins, Baltimore. Madigan, M. T., J. M. Martikno, P. V. Dunlap, and D. P. Clark, 2008, Biology of Microorganisms, 12th ed., Pearson Benjamin Cummings, San Francisco. Mervrayano J, Rahmatini, Bahar E. 2015, Perbandingan efektivitas obat kumur yang mengandung chlorhexidine dengan povidone iodine terhadap Streptococcus mutans. Jurnal Kesehatan Andalas, 4(1): 170. Mitsui, T., 1993. New Cosmetic Science. Interscience Publishing, Tokyo. Neeraja,R. Anantharaj, A. Praveen,P. Karthik,V. Vinitha. and M. 2008, The effect of povidone iodine and chlorhexidine mouth rinses on plaque Streptococcus mutans count in 6 to 12 year old school children: An in vivo study. Journal of Indian Society of Pedodontics and Preventive Dentistry, 26: 14-15. Pader, M., 1989, Oral Hygiene Prdoduct and Practice, Marcell Dekker, Inc, New York. 82
Parrot, E.L., 1971, Phamaceitical Technology Fundamental Pharmaceutics, 3rd ed., Burgess Publishing Company, Minneapolis. Patel, P., D. Telange, N. Sharma, 2011, Comparison of different granulation techniques for lactose monohydrate, International Journal of Pharmacy and Pharmaceutical Sciences and Drug Research, 3(3): 222. Poucher, W. A., 1994. Perfumes, Cosmetics and Soap, Volume III. Chapman and Hall, London. Pratiwi R. 2005, Perbedaan daya hambat terhadap Streptococcus mutans dari beberapa pasta gigi yang mengandung herbal. Majalah Kedokteran Gigi, 38: 64. Quirynen M, Soers C, Desnyder M, Dekeyser C, Pauwels M and Steenberghe D. 2005, A 0.05% cetylpyridinium chloride 0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy. Journal of Clinical Periodontology, 32(4): 390392. Raharja, H. 2012, ‘Perbandingan efektivitas klorheksidin glukonat 0,2% dengan povidon iodin 1% sebagai obat kumur antiseptik terhadap penurunan jumlah koloni mikroorganisme di sekitar rongga mulut pada mahasiswa fakultas kedokteran universitas Sumatera Utara’, Karya Tulis Ilmiah, Fakultas Kedokteran Universitas Sumatera Utara, Medan. Rao D. 2011, Efficacy of an alcohol-free CPC containing mouthwash against oral multispecies biofilms, The Journal of Clinical Dentistry, 22(6): 187. Rawlinson A, Pollington S, Walsh TF, Lamb DJ, Marlow I, Haywood S and Wright P. 2008, Efficacy of two alcohol free cetylpyridinium chloride mouthwashes a randomized doubleblind crossover study, Journal of Clinical Periodontol, 35: 230-235. Riflianty, R., Azzahra, A.A., Rahmitasari, F., Tiarisna, H.N., Annisa, N.N. and Izzatul, B.E.H (eds). 2012. Antibodi monoklonal Streptococcus mutans 1 (c) 67 kDa sebagai imunisasi pasif dalam alternative 83
pencegahan karies gigi secara topical, Berkala Ilmiah Mahasiswa Kesehatan Gigi Indonesia (BIMKGI), 1(1):1-5. Rosenthal, M. W., 1972, Mouthwashes, in Cosmetics Science and Technology, M. S. Balsam and E. Sagarin (Eds), 2nd ed., Wiley Interscience, New York. Rowe, R., Sheskey, P. J and Quinn M. E., 2009, Handbook of Pharmaceutical Excipients, 6th ed, The Pharmaceutical Press, London. Santoso, O., Wardani, A. P., Kusumasari, N., 2012, Pengaruh larutan ekstrak siwak (Salvadora persica) terhadap Streptococcus mutans: Studi in vitro dan in vivo, Fakultas Kedokteran Gigi Universitas Diponegoro Semarang, Media Medika Indonesia, 46(3): 166. Sinaredi, B. R., Pradopo, S., Wibowo, T. B., 2014, Daya Antibakteri Obat Kumur Chlorhexidine, Povidone Iodine, Fluoride Suplementasi Zinc terhadap Streptococcus mutans dan Porphyromonas gingivalis, Dental Journal, 47(4). Siregar, Ch. J. P., 1992, Proses Validasi dan Manufaktur Sediaan Tablet, In: Asyarie., U. Mar’ u, S. Badruzzaman (Eds), Prosiding Seminar Validasi Industri Farmasi, Jurusan Farmasi, FMIPA ITB, Bandung. Siregar, Ch. J.P., 2010, Teknologi Farmasi Sediaan Tablet: Dasar-Dasar Praktis, EGC, Pharmaceutical Press, London. Suryana, 2010, Model Praktis Penelitian Kuantitatif dan Kualitatif, Buku Ajar Perkuliahan Metodelogi Penelitian, PT. Rineka Cipta, Jakarta, 2. Sweetman, S.C. 2009. Martindale: The Complete Drug Reference, 36th ed. 2009. Phamaceutical Press, London. Talaro, K.P. and Talaro, A., 1999. Foundation in Microbiology, 3th ed. The Mc. GrawHill Companies, USA. USP. Convention, 2005, United States Pharmacopoeia 30 – National Formulary 25, United States. 84
Walker, C.G. 1988, Microbiological effects of mouthrinses containing antimicrobials, Journal of clinical periodontology, 15(8); 499-505. Wells, J.T., 1988, Pharmaceutical Preformulation: The Physicochemical Properties of Drug Subtance, Ellis Howard, Ltd., Chester. Wilkins, E., 1991. Clinical Practice of Dental Hygienist, 3rd ed. Balliere Tyndall, London. Wilkinson, J. B. and Moore, R. J., 1982, Harry’s Cosmetology: The Principles and Practice of Modern Cosmetic. 7th ed, Chemical Publishing Inc. New York. Witt J, Ramji N, Gibb R, Dunavent J, Flood J and Barnes J. 2005, Antibacterial and antiplaque effects of a novel, alcohol- free oral rinse with cetylpyridinium chloride, Journal Contemporary Dental Practice, 6: 2,8.
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