DAFTAR PUSTAKA 1. Jayaraness S and Sthaneshwar P. Serum soluble transferrin receptor in hypochromic microcytic anaemia. Singapore Med J, 2006;49(2):38-42. 2. Worwood M, Hoffbrand A.V. Iron metabolisme, Iron deficiency and disorders of haem synthesis in Postgraduate haematology. 5th ed. Blackell Publishing, 2005: 26-43. 3. Brugnara C. Iron Deficiency and Erythropoiesis: New diagnostic approaches. Clin Chem, 2003;49(10):1573-78. 4. Provan D. Iron deficiency anemia in ABC of Clinical haematology. 2nd ed, BMJ Books, 2003:1-4. 5. Beutler E. Disorders of Iron metabolisme in Williams Hematology, 7th ed, McGraw-Hill, 2006:511-53. 6. Andrew NC. Iron deficiency and related disorder in Wintrobe Clinical Hematology, 11th ed, Lippincott Williams & Wilkins, 2004:979-1009. 7. Wu AC, Lesperance L, Bernstein H. Screening for iron deficiency. Pediatric in review 2002;23:171-78. 8. Hilman RS, Ault KA, Rinder HM: Iron Deficiency Anemia in Hematology in Clinical Practice, 4th edition, McGraw-Hill, 2005:1-20 45 Universitas Sumatera Utara
9. Killip S, Bennett JM and Chambers MD. Iron deficiency anemia. AAFP, 2007;75(5):671-8. 10. Word health organization. Worldwide prevalence of anemia 19932005 in WHO Global Database on Anemia, World Health Organization, 2008. 11. World Health Organization. Methode of assessing iron status in iron deficiency anemia assessment, prevention and control a guide for programme managers, WHO, 2001,33-43. 12. Pasricha SR, Casey GJ, Phuc TQ et all. Baseline iron indices as predictor of hemoglobin improvement in anemic Vietnamese womwn receiving weekly iron-folic acid supplementation and deworming. Am.J. Trop. Med. Hyg, 81(6),2009,1114-9. 13. Bakta IM, Suega K, Dharmayuda TG. Anemia defisiensi besi dalam buku ajar ilmu penyakit dalam, Edisi IV, Pusat Penerbitan Ilmu Penyakit Dalam FK-UI. Jakarta, 2006:634-40. 14. Mast AE, Blinder ma, Gronowski AM, Chumley C, Scott M. Clinical utility of the soluble transferring receptor and comparison with serum feritin in several population. Clinchem,44:1,1998,45-51. 15. Kern WF. Iron deficiency anemia, anemia of chronic disease, sideroblastic anemias , and megaloblastic anemia in PDQ Hematology. BC Deckeer, 2002:49-77. 46 Universitas Sumatera Utara
16. Crichton R: Pathophysiology of Iron Deficiency and Iron Overload in Man in Iron Metabolism from Molecular Mechanins to Clinical Consequences, 3rd edition , John Wiley & Son, 2009:299-325. 17. Punnonen K, Irjala K and Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood,1997;89(3):1052-57. 18. Simek M, Remkova A, Kratochvilova H. Serum transferrin receptor in diagnosis of iron deficiency. Bratis Lek Listy, 2002;103(12):44953. 19. Lawrence C, Ray S, Babyonyshev M, Galluser R, Borhani D W et all. Crystal structure of the ectodomain of human transferrin receptor. Science,1999;286:779-81. 20. Qian ZM, Li H, Sun H, Ho K. Target drug delivery via they transferrin
receptor
Mediated
endocytosis
pathway.
Pharmacological Review, 2002;54(4): 561-86 21. Cheng y, Zak O, Aisen P, Harrison SC. Structure of the human transferin receptor-transferrin complex. Cell,2004:116:565-76. 22. Crichton R. cellular iron uptake and export in mammals in iron metabolism from molecular mechanins to clinical consequences, 3rd edition , John Wiley & Son, 2009:141-75
47 Universitas Sumatera Utara
23. Testa U. Soluble transferrin receptor
in protein of iron
metabolisme, CRC Press, 2002:371-84. 24. Beard J. Indication of the iron status of population: free erythrocyte protoporphyrin and zinc protoporphyrin; serum and plasma iron, total iron binding capacity and transferrin saturation; and serum transferrin receptor in assessment the iron status of population, 2nd Edition. WHO, 2007:77-93. 25. Baynes RD. Assessment of iron status. Clin Biochem, . 1996;29:209-15 26. Bakta IM. System eritroid dalam hematologi klinik ringkas. Jakarta: Penerbit buku kedokteran, 2007;9-25. 27. World Health Organization. Iron Deficiency Anemia Assessment, Prevention and Control, A guide for Programme managers. World health organization, 2007, 3-18. 28. Christine A, Northrop-Clew: The Interpretation of Indicator of Iron Status during an acute Phase Response in Assessing the Iron Status of Population, 2nd edition World Health Organization, 2007:97-107. 29. Andrew N.C: The molecular basis of Iron metabolism in Molecular Hematology, 2nd edition, Blackell Publishing, 2005:150-8.
48 Universitas Sumatera Utara
30. Andrew NC: Disorders of iron metabolism in he New England Journal of Medicine, 1999;341(26):1986-96 31. Crichton R: Iron Absorbtion in Mammals, with Particular Reference to Man, and Regulation of Systemic Iron Balance in Iron Metabolism from Molecular Mechanins to Clinical Consequences, 3rd edition , John Wiley & Son, 2009:271-97. 32. Suominen P, Punnonen K, Rajamaki A, Irjala K. serum transferrin receptor and transferring-ferritin index identify healthy subjects with subclinical iron deficits. Blood, 1998(92):2934-39. 33. Handojo I. Imunoasai untuk penyakit yang terkait dengan infeksi jasad renik dalam
imunoasai terapan pada beberapa penyakit
infeksi, cetrakan pertama, 2004, 34. Means RT, Krantz SB. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood,80(7),1992:163947. 35. Zarychanski R, Houston DS. Anemia of chronic disease: a harmful disorder
or
an
adaptive,
beneficial
response?.
CMAJ,
2008179(4):333-37. 36. Rollins G. D272-6.ifferential anemia diagnosis in Clinical laboratory news 35,11, 2009.
49 Universitas Sumatera Utara
37. Suominen P, Punnonen K, Rajamaki A, Irjala K. Evaluation of new immunoenzymeometric assay for measuring serum transferrin receptor to detect iron deficiency in anemic patient. 38. Suominen P, Punnonen K, Rajamaki A. et all. Automated immunoturbidimetric method for measuring serum transferrin receptor in clinchem 45,8, 19991302-05. 39. Cobas integra manual sTfR. 40. Sunheimer RL, Threatte G, Lifdhitz MS, Pincus MR. Analysis: principles of instrumentation in Henry,s clinical diagnosis and management by laboratory methods. Elsevier,2007: 40-1. 41. Immunoturbidimetry versus nephelometry for the detection of protein, randox clinical diagnostic solution. 42. Rocks BF.
Absorption,
scatter
and
luminescence
techniques in routine clinical biochemistry in: Crocker J, Burneet D. The science of laboratory diagnosis, 2nd Ed, Wiley. 2005. 395-403 43. Madiyono B, Moeslichan S, Sastroasmoro S, Budiman I, Purwanto SH. Perkiraan besar sampel dalam dasar-dasar metodologi penelitian klinis, Jakarta, Binarupa Aksara, 1995,187-212. 44. Why is EDTA the anticoagulant of choice for hematology use. Tech talk 7(1);2009:1-2. 45. Elecsys
2010
user’s
electrochemiluminescence
manual-sandwhich
immunoassay.
Roche
principle diagnostics
gmbH, D-68298 mannheim. 50 Universitas Sumatera Utara
46. Rinaldi I, Sudoyo AW. Anemia hemolitik non imun dalam buku ajar ilmu penyakit dalam, Edisi IV, Pusat Penerbitan Ilmu Penyakit Dalam FK-UI. Jakarta. 2006:653-58 47. Lichtman MA, Beutler E, Kipps TJ, Williams WJ. Hereditary sherocytosis, elliptocytosis, and related disorder in Williams manual of hematology, 6th ed. Mc Graw Hill, 2003:77-86. 48. Soenarto. Anemia megaloblastik dalam buku ajar ilmu penyakit dalam, Edisi IV, Pusat Penerbitan Ilmu Penyakit Dalam FK-UI. Jakarta, 2006:643-649. 49. Taghizadeh M. Megaloblastic anemia in clinical hematology and fundamentals of hemostasis edit by Harmening DM, 4th ed. F.A. Davis company, Philadelphia: 112-28. 50. Carmel R. Megaloblastic anemia: disorder of impaired DNA synthesisn in Wintrobe clinical hematology, 11th ed. Lippincott Williams & Wilkins, 2004:1367-95. 51. Sukandar E. Pemeriksaan penunjang diagnosa bidang nefrologi dalam nefrologi klinik. PII bagian ilmu penyakit dalam FK UNPAD Bandung, 2006:11-6. 52. Effendi I, Markum HMS. Pemeriksaan penunjang pada penyakit ginjal dalam buku Ajar
Ilmu Penyakit Dalam, edisi ke-4. Pusat
Penerbitan Ilmu Penyakit Dalam FKUI Jakarta, 2006:22-3. 51 Universitas Sumatera Utara
53. Remacha FA.Sarda MP, Parellada M, Ubeda J, Manteiga R. The role serum transferrin receptor in the diagnosis of iron deficiency. Hematologica:1998;83:963-6. 54. Hanif Ejas, Ayyub M, Anwar M, Ali W, Bashir M. Evaluation of serum
transferrin
receptor
concentration
in
diagnosis
and
differentiating iron deficiency from anemia chronic disorder. JPMA:2005;55(1):541-6. 55. Wians FH, Urban JE, Keffer JH, Kroft SH. Discriminating between iron deficiency anemia and anemia of traditional
indices
of
iron
status
vs
shronic disease using transferring
receptor
concentration. AmJ Clin Patho:2005;115:112-8.
52 Universitas Sumatera Utara
Lampiran 1. FORMULIR PERSETUJUAN SETELAH PENJELASAN DEPARTEMEN PATOLOGI KLINIK FK-USU/RSUP H. ADAM MALIK MEDAN SURAT PERSETUJUAN PENELITIAN Saya yang bertanda tangan di bawah ini: Nama
;
Umur
:
Jenis Kelamin
:
Pekerjaan
:
Alamat
:
Setelah mendapat keterangan secukupnya serta manfaat dan resiko penelitian yang berjudul “ Pemeriksaan Kadar Serum Transferrin Receptor (sTfR) untuk diagnostik Anemia Defisiensi Besi” dan memahami bahwa subyek dalam penelitian ini sewaktu-waktu dapat mengundurkan diri dalam keikutsertaannya maka saya setuju ikut penelitian ini dan bersedia berperan serta dengan mematuhi semua ketentuan yang telah disepakati. Dengan ini biaya ditanggung peneliti. Medan, Mengetahui
Yang menyatakan
Penanggung jawab penelitian
Pesertas uji klinik
(Nama jelas)
(Nama jelas)
2010
Saksi
(nama jelas) i
Universitas Sumatera Utara
Lampiran 2 STATUS PASIEN Nama
:
Tanggal Lahir
:
Jenis kelamin
:
Suku / Bangsa
:
Pekerjaan
:
Alamat sekarang
:
MR
:
ANAMNESE Keluhan Umum
:
Anamnese
:
RPO
:
RPT
:
STATUS PRESENT TD
:
Anemi
:
HR
:
ikterus
:
RR
:
oedema
:
HT
:
ii
Universitas Sumatera Utara
HASIL LABORATORIUM DARAH LENGKAP NO
PEMERIKSAAN
1
Hb
2
MCV
3
MCH
4
MCHC
5
RDW
FUNGSI GINJAL NO PEMERIKSAAN 1
Ureum
2
Creatinin
FUNGSI HATI NO PEMERIKSAAN 1
Bilirubin Total
2
Bilirubin direct
STATUS BESI NO PEMERIKSAAN 1
HASIL
HASIL
HASIL
Feritin
NO 1
HASIL
PEMERIKSAAN
HASIL
CRP
DIAGNOSA
:
THERAPI
:
1. 2. iii
Universitas Sumatera Utara
iv Universitas Sumatera Utara
Lampiran 5. DAFTAR RIWAYAT HIDUP IDENTITAS Nama
: Dr. Pita Omas Lumban Gaol
Tempat, Tanggal lahir : Medan, 04 Januari 1971 Suku / bangsa
: Batak / Indonesia
Agama
: Kristen Protestan
Pekerjaan
: Dokter, PNS
Mulai Pendidikan
: 01 Juli 2006
Alamat
: Jln. H.M. Joni Gg. Beringin No. 17 Medan
Keluarga
Suami Dr. Sabam JMT Simatupang
Anak 1. Roni Hotasi R.P Simatupang 2. Aryani Yovanita B Simatupang 3. Grace Trinita L Simatupang 4. Peter Toyenbee R Simatupang
v
Universitas Sumatera Utara
Pendidikan 1. SD St. Antonius V Medan
: Tahun 1977
2. SMP RK Tri Sakti Medan
: Tahun 1983
3. SMA Negeri V Medan
: Tahun 1986
4. Fakultas Kedokteran USU Medan
: Tahun 1989
5. Mengikuti Program Pendidikan Dokter Spesialis Patologi Klinik Fakultas Kedokteran USU Medan mulai 1 Juli 2006 s/d juli 2010
Riwayat Pekerjaan 1. Dokter PTT Puskesmas Buhit, Kecamatan Pangururan,Kabupaten Tapanuli Utara, Sumatera Utara, tahun 1996-1999. 2. Dokter Puskesmas Uluan, Kecamatan Uluan, Kabupaten Toba Samosir, Sumatera Utara, tahun 2002-2006.
Perkumpulan profesi 1. Anggota IDI Kabupaten Toba Samosir. 2. Anggota Muda PDS PATKLIN Cabang Medan. 3. Anggota Konsil Kedokteran Indonesia.
PARTISIPASI DALAM KEGIATAN ILMIAH SEBAGAI PEMBICARA 6th National Congress &National Scientific Meeting of the Indonesian Assosiation of Clinical Pathologist, Makassar,1-4 November 2007. vi Universitas Sumatera Utara
SEBAGAI PESERTA 1. Wet and Dry workshop of Hematology, Makasar 1-4 November 2007. 2. Simposium Penanganan Thalasemia secara Menyeluruh, FK USU / RSUP H. Adam Malik Medan, 20 Mei 2008. 3. NS1 pada DHF, Tiara convention Hall, Medan, 2009
Laporan kasus 1. Nefritis lupus 2. Hepatitis C 3. Pneumoni yang disebabkan pneumococcus pneumoni
Sari pustaka 1. Cobas Integra 400 2. Ion Selective Electroda 3. Derajat Kemurnian 4. Pemantapan kualitas di bidang Kimia Klinik 5. Statistik Laboratorium 6. Manajemen Laboratorium 7. Analisa Gas Darah 8. Serum Protein Electrophoresis 9. Anemia defisiensi Besi 10. Pola kuman pada pus 11. Nefritis lupus vii
Universitas Sumatera Utara
