F-06 Reference ranges of analytes OKB

LP F-06 Reference ranges of analytes OKB Laboratorní příručka/ LP vydaná - kapitoly - txt.+hlav.

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LP F-06 05 1 z 10 24.09.2015 0 05.10.2015

Název dokumentu

F-06 Reference ranges of analytes OKB

Abstrakt

Rozdělovník Funkce

Jméno

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Tento dokument je duchovním majetkem Pracoviště laboratorních metod IKEM. Podléhá všem náležitostem, které se týkají řízení dokumentace. Kopírování tohoto dokumentu je přípustné pouze se souhlasem správce dokumentace PLM.

Zpracoval MUDr. Sečník Peter, Lékař Oddělení klinické biochemie PLM

Kontroloval MUDr. Franeková Janka, Ph.D., vedoucí Oddělení klinické biochemie PLM

Dne 08.09.2015

Schválil MUDr. Franeková Janka, Ph.D., vedoucí Oddělení klinické biochemie PLM

Dne 24.09.2015 Revize ročně



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LP F-06 05 2 z 10 24.09.2015 0 05.10.2015

Reference ranges of analytes in serum/plasma (Li heparin) in adults Analyte Creatinine – males Creatinine – females Urea - males (over 50 years) Urea - males (under 50 years) Urea - females (over 50 years) Urea - females (under 50 years) Uric acid – males Uric acid – females Total protein Albumin Bilirubin total Bilirubin direct AST – males AST – females ALT - males ALT – females ALP females, males GGT – males GGT – females Cholinesterase – males Cholinesterase – females AMS AMS pancreatic isoenzyme Lipase LD CK – males CK – females Cholesterol total Triglycerides Cholesterol HDL – males Cholesterol HDL – females Cholesterol LDL - calculated Osmolality Sodium Potassium Chloride

Lower limit Upper limit 64 49 3,0 3,2 3,5 2,5 210 150 64 36 3,4 1,8 0,17 0,17 0,17 0,17 0,58 0,20 0,15 85 67 0,42 0,13 0,13 2,1 0,50 0,48 2,9 0,50 1,0 1,2 1,2 275 137 3,5 98

104 90 9,2 7,4 7,2 6,7 420 350 79 45 20 8,6 0,75 0,58 1,17 0,75 1,75 1,07 0,6 195 210 2,08 0,88 1,3 3,7 3,33 2,80 5,0 1,69 2,1 2,7 3,0 295 144 5,1 107

Unit µmol/l µmol/l mmol/l mmol/l mmol/l mmol/l μmol/l μmol/l g/l g/l μmol/l μmol/l μkat/l μkat/l μkat/l μkat/l μkat/l µkat/l µkat/l μkat/l μkat/l μkat/l μkat/l μkat/l μkat/l μkat/l μkat/l mmol/l mmol/l mmol/l mmol/l mmol/l mmol/kg mmol/l mmol/l mmol/l



Phosphorus inorganic, males (15 - 50 years) Phosphorus inorganic, males (over 50 years) Phosphorus inorganic – females Calcium Magnesium Iron - males Iron – females Copper – males Copper – females Zinc

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0,71 0,71 0,76 2,15 0,71 10,7 7,2 11,0 12,6 11,0

1,53 1,23 1,41 2,55 0,94 28,6 25,9 22,0 24,3 23,0

mmol/l mmol/l mmol/l mmol/l mmol/l μmol/l μmol/l µmol/l µmol/l µmol/l

3,6 20

0,37

5,59 42 < 5,60 < 7,8 1,47

mmol/l mmol/mol mmol/l mmol/l nml/l

3,3 5,7 0,26

qualitative qualitative qualitative 19,4 26,3 1,65

Diabetes mellitus Glucose HbA1c Glucose - OGTT 0.min. (fasting) Glucose - OGTT 120.min. (after p.o. glucose) C peptide

Monoclonal gammopathies Electrophoresis (serum proteins) Immunofixation (serum proteins) Immunofixation (urine proteins) Kappa free light chains Lambda free light chains Kappa free/lambda free

mg/l mg/l ratio

Plasma proteins Transferrin - males Transferrin – females Total iron binding capacity Transferrin saturation Ferritin – females Ferritin – males Cystatin C (1 - 50 years) males Cystatin C (1 - 50 let) females Cystatin C (nad 50 let) females Cystatin C (nad 50 let) males NGAL Apo A1 – males Apo A1 – females Apo B – males Apo B – females Lipoprotein (a)

1,74 1,80 45 16 4,6 21,8 0,31 0,40 0,40 0,41 37 1,05 1,05 0,60 0,55 7

3,64 3,82 72 45 204,0 274,7 0,79 0,99 0,99 0,99 106 1,75 2,05 1,40 1,30 75

g/l g/l µmol/l % µg/l µg/l mg/l mg/l mg/l mg/l µg/l g/l g/l g/l g/l nmol/l



Ceruloplasmin Prealbumin α-1-antitrypsin

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0,22 0,18 0,88

0,58 0,38 1,74

g/l g/l g/l

10 10 10 10 10 10 10 10 10 10

89 111 155 159 266 73 40 80 150 121 ≤ 14

ng/l ng/l ng/l ng/l ng/l ng/l ng/l ng/l ng/l ng/l ng/l

< 5,0 < 0,5 < 200 < 30 1,85 1,93 0,53 0,57 2,40 2,93 4,84 4,21 18,2 16,3 9,29 7,00 1,76 0,86

mg/l μg/l kIU/l kIU/l g/l g/l g/l g/l g/l g/l g/l g/l g/l g/l g/l g/l g/l g/l

4,94 5,7 19,0 < 4,11 < 5,61

mIU/l pmol/l pmol/l kIU/l kIU/l

Markers of myocardial damage BNP – females, under 45 years BNP – females, 45-54 years BNP – females, 55-64 years BNP – females, 65-74 years BNP – females, over 75 years BNP – males, under 45 years BNP – males, 45-54 years BNP – males, 55-64 years BNP – males, 65-74 years BNP – males, over 75 years hs – Troponin T

Inflammation markers, immunoglobulins CRP Procalcitonin ASLO Rheumatoid factor C3-complement – males C3-complement – females C4-complement – males C4-complement – females IgM – males IgM – females IgA – males IgA – females IgG – males IgG – females IgG subclass 1 IgG subclass 2 IgG subclass 3 IgG subclass 4

0,82 0,83 0,15 0,15 0,22 0,33 0,63 0,65 5,4 5,5 3,82 2,42 0,22 0,04

Thyroid gland TSH free T3 free T4 Anti-Tg Anti-TPO

0,35 2,63 9,0



Anti-TSH receptors

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< 1,75

IU/l

6,9 70 42 46 43 46 0,873 0,630 0,836 0,573 1,008

pmol/l µg/l µg/l µg/l µg/l µg/l µg/l µg/l µg/l µg/l µg/l

< 3,8 <7 < 35 < 70 < 140

µg/l µg/l kU/l pmol/l pmol/l

< 11,4

%

< 29,9

%

< 25 < 27 < 6,9 <3 100 2,6 5,3 2,64

kU/l kU/l kU/l µg/l % IU/l IU/l mg/l

Markers of bone metabolism Parathormone Osteocalcin – males (18 - 30 years) Osteocalcin – males (30 - 50 years) Osteocalcin – males (50 - 70 years) Osteocalcin – females (20 - 50 years) Osteocalcin – females (50 - 80 years) β-CrossLaps – males (18 - 30 years) β-CrossLaps – males (30 - 50 years) β-CrossLaps – males (50 - 80 years) β-CrossLaps – females (15 - 50 years) β-CrossLaps – females (50 - 80 years)

1,6 24 14 14 11 15 0,155 0,093 0,035 0,025 0,104

Tumour markers CEA AFP CA 125 HE 4 - premenopausal state HE 4 - postmenopausal state ROMA score - premenopausal state (low risk of epithelial ovarian cancer) ROMA score - postmenopausal state (low risk of epithelial ovarian cancer) CA 15-3 CA 19-9 CA 72-4 PSA fPSA/PSA β-HCG – males β-HCG – females β2-microglobulin

25 0 0 0,97

Serological diagnosis of infectious diseases anti-HAV-IgM anti-HAV-IgG HBsAg HBeAg anti-HBe anti-HBc-Total anti-HBc-IgM anti-HBs anti-HCV

0

qualitative qualitative qualitative qualitative qualitative qualitative qualitative 10 qualitative

IU/l



Syphilis HIV Ab/Ag Combo anti CMV-IgG anti CMV-IgM

0

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LP F-06 05 6 z 10 24.09.2015 0 05.10.2015

qualitative qualitative 6 qualitative

kAU/l



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Therapeutic drug monitoring Amikacin - before infusion

6,8

13,7

µmol/l

Amikacin - ½ - 1 hour after i.v. infusion

42,7

59,8

µmol/l

Gentamicin - before infusion Gentamicin - ½ - 1 hour after i.v. infusion Vancomycin - before infusion Vancomycin - ½ - 1 hour after i.v. infusion Digoxin Cyclosporine Tacrolimus Mycophenolic acid Sirolimus Everolimus

1,1 10,4 6,9 13,4 1,02 1,2 4,5 5

4,2 20,9 10 26,8 2,56 3,5 14 15

µmol/l µmol/l µmol/l µmol/l nmol/l µg/l µg/l mg/l µg/l µg/l

18 5,46 4,44 171 64 10,4 25,1 1,6 2,64 0,061

72 16,20 13,56 536 327 42,4 165 13,9 27,70 0,978

μmol/l µmol/l µmol/l nmol/l nmol/l nmol/l pmol/l pmol/l ng/l nmol/l

Other analytes Ammonia Homocysteine – males Homocysteine – females Cortisol, sample dawn in 7:00 - 10:00 Cortisol, sample drawn in 16:00 - 20:00 Folic acid Vitamin B12 – active (holotranscobalamin) ACTH Renin Aldosterone Serum

Plasma (Li heparin)

Plasma (K3EDTA)

Plasma (NaF,EDTA)

Urine



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Reference ranges of analytes in urine and stool in adults Urine chemistry (quantitative) Sodium – 24h excretion Potassium - 24h excretion Chloride - 24h excretion Calcium - 24h excretion Phosphorus inorganic - 24h excretion Creatinine – 24h excretion males Creatinine – 24h excretion females Urea - 24h excretion Uric acid - 24h excretion Proteins – 24h excretion Albuminuria – overnight excretion Albuminuria – 24h excretion Abumin/Creatinine (ACR) – morning sample Osmolality – 24h excretion Glucose Proteins morning sample Protein / creatinine (PCR) – morning sample Osmolality Amylase Transferrin Alpha-1-microglobulin β2-microglobulin β2-microglobulin / creatinine – morning sample NGAL

120 35 120 2,5 12,9 10,0 8,0 338 1,5 20 30 600 0,1 0,0 0 300

0,098 0 0,7

240 125 240 7,5 42,0 16,0 14,0 585 4,4 < 0,20 199 300 < 3,0 1200 0,8 0,149 14,9 1000 < 7,5 <2 < 12,5 0,32 27 9,8

mmol/day mmol/day mmol/day mmol/day mmol/day mmol/day mmol/day mmol/day mmol/day g/day µg/min mg/day g/mol mmol/day mmol/l g/l g/mol mmol/kg μkat/l mg/l mg/l mg/l mg/mol µg/l

Urine sediment + chemistry (disptick) Urine chemistry (disptick) Urine sediment – erythrocytes Urine sediment - leucocytes

semiquantitative <5 < 10

/µl /µl

Urine sediment - hyaline casts

<2

/µl

Urine sediment - patological casts Other epithelial cells Squamous epithelial cells Hamburger sediment - erythrocytes Hamburger sediment – leucocytes Hamburger sediment – casts Addis sediment – erythrocytes Addis sediment – leucocytes

<1 <4 < 20 < 35 < 70 <1 <1 <2

/µl /µl /µl /s /s /s x10e6 x10e6



Addis sediment – casts

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0

x10e5

Fecal occult bleeding Fecal occult bleeding (FOB) quantitative Serum Plasma (Li heparin) Plasma (K3EDTA)

< 50 Plasma (NaF,EDTA)

µg/l Urine



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Acid – base balance and blood gases Acid – base balance Arterial blood: O2 saturation pO2 pH BE pCO2 (males) pCO2 (females) HCO3 Lactate Venous blood: O2 saturation pO2 pH BE pCO2 HCO3 Lactate Mixed venous blood: O2 saturation pO2 pH BE pCO2 HCO3 Lactate

0,95 11,10 7,36 -2,5 4,70 4,30 22 0,3

0,99 14,40 7,44 +2,5 6,00 5,70 26 0,8

0,58 3,59 7,32 -2,5 5,45 22 0,5

0,85 5,32 7,41 +2,5 6,78 26 2,2

0,70 4,70 7,35 -2,0 4,90 21 0,3

0,80 6,00 7,43 3,0 6,70 26 1,5

mmol/L kPa mmol/L mmol/L

1,15 0,0

1,29 0,6

mmol/L mmol/L

0,20

0,34

mmol/L

kPa mmol/L kPa kPa mmol/L mmol/L

kPa mmol/L kPa mmol/L mmol/L

kPa

Other analytes Calcium ionised 3-OH-butyrate Central veno-venous hemodialysis: Calcium - ionised

F-06 Reference ranges of analytes OKB

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