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Ghosh S, Hong C-S, Feingold E, et al. Epidemiology of Down syndrome: new insight into the multidimensional interactions among genetic and environmental risk factors in the oocyte. Am J Epidemiol. 2011.h:1009-16. doi:10.1093/aje/kwr240.
5.
Mohammed S, Harasi AL. Down Syndrome in Oman: Etiology, Prevalence and Potential Risk Factors. A Cytogenetic, Molecular Genetic and Epidemiological Study. 2010.h:1-12.
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Quintana EM, Gonzales FR, Jil Jose MM, Munoz JA, Lago VN. Clinical Outcome in Down Syndrome Patients with Congenital Heart Disease. 2010.h:245-50.
7.
Laksono Sony P, Qomariyah, Purwaningsih Endang. Persentase Distribusi Penyakit Genetik dan Penyakit yang Dapat Disebabkan oleh Faktor Genetik di RSUD Serang. 2011.h:267-71.
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Kumin L, Ph D. Speech intelligibility and Childhood Verbal Apraxia in Children with Down Syndrome. 2006.h:10-22.
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56
Lampiran 1. Ethical Clearance
57
Lampiran 2. Surat Ijin Penelitian dan Peminjaman Data Rekam Medis
58
Lampiran 3. Surat Pernyataan Penelitian di RSUP Dr. Kariadi Semarang
59
Lampiran 4. Data output SPSS Hasil Penelitian
Jenis kelamin * DDST
Crosstab
Jenis kelamin
Laki-laki
Perempuan
Total
Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total
DDST Normal Delay ed 3 19 4.1 17.9 50.0% 73.1% 9.4% 59.4% 3 7 1.9 8.1 50.0% 26.9% 9.4% 21.9% 6 26 6.0 26.0 100.0% 100.0% 18.8% 81.3%
Total 22 22.0 68.8% 68.8% 10 10.0 31.3% 31.3% 32 32.0 100.0% 100.0%
Chi-Square Tests
Pearson Chi-Square Continuity Correctiona Likelihood Ratio Fisher's Exact Test Linear-by -Linear Association N of Valid Cases
Value 1.208b .373 1.142
1.171
df 1 1 1
1
Asy mp. Sig. (2-sided) .272 .541 .285
Exact Sig. (2-sided)
Exact Sig. (1-sided)
.346
.264
.279
32
a. Computed only f or a 2x2 table b. 2 cells (50.0%) hav e expect ed count less than 5. The minimum expected count is 1. 88.
60
BERA AD * DDST
Crosstab DDST Delay ed 2 8 1.9 8.1 33.3% 30.8% 6.3% 25.0% 1 11 2.3 9.8 16.7% 42.3% 3.1% 34.4% 3 3 1.1 4.9 50.0% 11.5% 9.4% 9.4% 0 3 .6 2.4 .0% 11.5% .0% 9.4% 0 1 .2 .8 .0% 3.8% .0% 3.1% 6 26 6.0 26.0 100.0% 100.0% 18.8% 81.3%
Normal BERA AD
Normal
Ringan
Sedang
Berat
Sangat berat
Total
Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total
Chi-Square Tests
Pearson Chi-Square Likelihood Ratio Linear-by -Linear Association N of Valid Cases
Value 5.634a 5.675 .001
4 4
Asy mp. Sig. (2-sided) .228 .225
1
.979
df
32
a. 8 cells (80.0%) hav e expected count less t han 5. The minimum expected count is .19.
Total 10 10.0 31.3% 31.3% 12 12.0 37.5% 37.5% 6 6.0 18.8% 18.8% 3 3.0 9.4% 9.4% 1 1.0 3.1% 3.1% 32 32.0 100.0% 100.0%
61
BERA AS * DDST
Crosstab DDST Delay ed 1 7 1.5 6.5 16.7% 26.9% 3.1% 21.9% 1 10 2.1 8.9 16.7% 38.5% 3.1% 31.3% 2 4 1.1 4.9 33.3% 15.4% 6.3% 12.5% 1 4 .9 4.1 16.7% 15.4% 3.1% 12.5% 1 1 .4 1.6 16.7% 3.8% 3.1% 3.1% 6 26 6.0 26.0 100.0% 100.0% 18.8% 81.3%
Normal BERA AS
Normal
Ringan
Sedang
Berat
Sangat berat
Total
Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total
Total 8 8.0 25.0% 25.0% 11 11.0 34.4% 34.4% 6 6.0 18.8% 18.8% 5 5.0 15.6% 15.6% 2 2.0 6.3% 6.3% 32 32.0 100.0% 100.0%
62
Chi-Square Tests
Pearson Chi-Square Likelihood Ratio Linear-by -Linear Association N of Valid Cases
Value 3.004a 2.740
4 4
Asy mp. Sig. (2-sided) .557 .602
1
.209
df
1.579 32
a. 8 cells (80.0%) hav e expected count less t han 5. The minimum expected count is .38.
NPar Tests
Two-Sample Kolmogorov-Smirnov Test
Frequencies BERA AD
BERA AS
DDST Normal Delay ed Total Normal Delay ed Total
N 6 26 32 6 26 32
Test Statisticsa Most Extreme Dif f erences
Absolute Positiv e Negativ e
Kolmogorov -Smirnov Z Asy mp. Sig. (2-tailed) a. Grouping Variable: DDST
BERA AD .231 .231 -.154 .510 .958
BERA AS .321 .321 .000 .708 .698
63
BERA * DDST
Crosstab DDST Delay ed 1 7 1.5 6.5 16.7% 26.9% 3.1% 21.9% 1 10 2.1 8.9 16.7% 38.5% 3.1% 31.3% 2 4 1.1 4.9 33.3% 15.4% 6.3% 12.5% 1 4 .9 4.1 16.7% 15.4% 3.1% 12.5% 1 1 .4 1.6 16.7% 3.8% 3.1% 3.1% 6 26 6.0 26.0 100.0% 100.0% 18.8% 81.3%
Normal BERA
Normal
Ringan
Sedang
Berat
Sangat berat
Total
Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total Count Expected Count % wit hin DDST % of Total
Total 8 8.0 25.0% 25.0% 11 11.0 34.4% 34.4% 6 6.0 18.8% 18.8% 5 5.0 15.6% 15.6% 2 2.0 6.3% 6.3% 32 32.0 100.0% 100.0%
64
Chi-Square Tests
Pearson Chi-Square Likelihood Ratio Linear-by -Linear Association N of Valid Cases
Value 3.004a 2.740 1.579
4 4
Asy mp. Sig. (2-sided) .557 .602
1
.209
df
32
a. 8 cells (80.0%) hav e expected count less t han 5. The minimum expected count is .38.
NPar Tests
Two-Sample Kolmogorov-Smirnov Test
Frequencies BERA
DDST Normal Delay ed Total
N 6 26 32
Test Statisticsa Most Extreme Dif f erences
Absolute Positiv e Negativ e
Kolmogorov -Smirnov Z Asy mp. Sig. (2-tailed) a. Grouping Variable: DDST
BERA .321 .321 .000 .708 .698
65
Lampiran 5. Biodata Peneliti Identitas Nama
: Arge Raviadi Muhammad
NIM
: 22010111130067
Tempat, Tanggal Lahir
: Klaten, 21 Oktober 1993
Jenis Kelamin
: Laki – laki
Alamat
: Jalan Kanguru Tengah 23 Semarang
Nomor HP
: 081215894798
E-mail
:
[email protected]
Riwayat Pendidikan Formal SD
: SD Negeri Sompok
Lulus : 2005
SMP
: SMP Negeri 2 Semarang
Lulus : 2008
SMA
: SMA Negeri 3 Semarang
Lulus : 2011
Kuliah
: Fakultas Kedokteran Universitas Diponegoro
Masuk : 2011
Keanggotaan Organisasi Staff SENIOR HIMA KU 2011/2012 Ketua Bidang SENIOR HIMA KU 2012/2013
