ACTA MEDICINAE 11/2016 | Kazuistiky | Kompletní literatura 2
Jak snížit kardiovaskulární riziko nově diagnostikovaného hypertonika
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Praktické využití fixní kombinace perindopril/indapamid u staršího pacienta ve vysokém kardiovaskulárním riziku
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Alirocumab u pacientů s familiární hypercholesterolemií
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Afinitor (everolimus) ve vyšší linii léčby metastatického renálního karcinomu
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Avastin s paklitaxelem u pacientky s triple negativním karcinomem prsu
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Léčba Avastinem u pacienta s NSCLC
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Metastatický a inoperabilní bazocelulární karcinom léčený vismodegibem
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Léčba ALK inhibitorem – Xalkori
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Léčba starší nemocné s chronickou lymfocytární leukemií kombinací obinutuzumab a chlorambucil
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GOLD 2017: novinky v léčbě CHOPN
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Hyperandrogenní stavy v gynekologii
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Manažersky dokonalá erekce
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Jednostranné postižení tonzily nejasné etiologie
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Atypický průběh Gaucherovy choroby
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Gravidita po čtyřech měsících od prvního podání alemtuzumabu
MUDr. Eva Kociánová I. interní klinika – kardiologická, FN, Olomouc
MUDr. Petr Razák Kardiologie na Bulovce, s. r. o., Praha
prof. MUDr. Vladimír Bláha, CSc. III. interní gerontometabolická klinika LF UK a FN, Hradec Králové MUDr. Hana Korunková Onkologická a radioterapeutická klinika FN, Plzeň
MUDr. Ivana Bustová Onkologické oddělení, Nemocnice České Budějovice, a. s.
MUDr. Lenka Jakubíková, Ph.D. | MUDr. Jana Špeldová | MUDr. Ondřej Venclíček | prof. MUDr. Jana Skřičková, CSc. Klinika nemocí plicních a tuberkulózy FN, Brno MUDr. David Šulc | MUDr. Denisa Šmejkalová Onkologické oddělení, Krajská zdravotní, Masarykova nemocnice, Ústí nad Labem MUDr. Leona Koubková Pneumologická klinika 2. LF UK a FN Motol, Praha MUDr. Jana Zuchnická | MUDr. Jana Fečková Mihályová Klinika hematoonkologie FN, Ostrava prof. MUDr. Roman Hájek, CSc. Klinika hematoonkologie FN, Ostrava, LF Ostravské univerzity, Ostrava MUDr. Eva Voláková Klinika plicních nemocí a tuberkulózy, FN, Olomouc MUDr. Petr Křepelka, Ph.D. Ústav pro péči o matku a dítě, Praha MUDr. Lukáš Bittner, FEBU, FECSM Urologická klinika 3. LF UK a FNKV, Praha MUDr. David Jilich Klinika infekčních, parazitárních a tropických nemocí Nemocnice na Bulovce, Praha MUDr. Věra Malinová Klinika dětského a dorostového lékařství VFN a 1. LF UK, Praha MUDr. Petra Lišková | MUDr. Eva Meluzínová Neurologická klinika 2. LF UK a FN Motol, Praha
Jak snížit kardiovaskulární riziko nově diagnostikovaného hypertonika MUDr. Eva Kociánová I. interní klinika – kardiologická, FN, Olomouc 1 Neaton, J. D. – Wentworth, D.: Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med, 1992, 152, s. 56–64. 2 World Health Organization. Global atlas on cardiovascular disease prevention and control. Dostupné z: www.world-heart-federation. org/fileadmin/user_upload/images/CVD_Health/Global_CVD_Atlas. pdf, vyhledáno 23. 2. 2015. 3 Authors/Task Force Members: Lancia, G. – Fagard, R. – Narkiewicz, R., et al.: 2013 ESH/ESC Guidelines for the management of arterial hypertension. European Heart Journal, 2013, 34, s. 2159–2219. 4 Bakris, G. – Briasoulis, A. – Dahlof, B., et al.: ACCOMPLISH Investigators. Comparison of benazepril plus amlodipine or hydrochlorothiazide in high-risk patients with hypertension and coronary artery disease. Am J Cardiol, 2013, 112, s. 255–259.
5 Filipovský, J. – Widimský jr., J. – Ceral, J., et al.: Diagnostické a léčebné postupy u arteriální hypertenze – verze 2012. Doporučení České společnosti pro hypertenzi. Hypertenze & kardiovaskulární prevence, 2012, 3, s. 1–16. 6 Authors/Task Force Members: Piepoli, M. F. – Hoes, A. W. – Agewall, S., et al.: 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis, 2016, 252, s. 207–274. 7 Conroy, R. M. – Pyörälä, K. – Fitzgerald, A. P., et al.: Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE Project. Eur Heart J, 2003, 11, s. 987–1003. 8 Cífková, R. – Býma, S. – Češka, R., et al.: Prevence kardiovaskulárních
onemocnění v dospělém věku. Cor Vasa, 2005, 47, s. 3–14. 9 2016 ESC/EAS Guidelines for the Management of Dyslipidemia. Šéfredaktor Thomas F. Lüscher, European Heart Journal. DOI: http://dx. doi.org/10.1093/eurheartj/ehw272 ehw272, publikováno online 27. 8. 2016. 10 Chapman, R. H. – Banner, J. S. – Petrilla, A. A., et al.: Predictors of adherence with antihypertensive and lipid-lowering therapy. Arch Intern Med, 2005, 165, s. 1147–1152. 11 Poulter, N. R. – Prabhakaran, D. – Caulfield, M.: Hypertension. Lancet, 2015, 386, s. 801–812, doi: 10.1016/S0140-6736(14)61468–1469. Review. 12 Jackson, R. – Lawes, C. M. – Bennett, D. A., et al.: Treatment with drugs to lower blood pressure and blood cholesterol based on an individual’s absolute cardiovascular risk. Lancet, 2005, 365, s. 434–441.
Praktické využití fixní kombinace perindopril/indapamid u staršího pacienta ve vysokém kardiovaskulárním riziku MUDr. Petr Razák Kardiologie na Bulovce, s. r. o., Praha 1 Dostupné z: http://www.uzis.cz/cr-kraje, vyhledáno 29. 11. 2016. 2 Lancia, G. – De Backer, G. – Dominiczak, A., et al.: The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). 2007 Guidelines for the management of arterial hypertension. J Hypertens, 2007, 25, s. 1105–1187. 3 Filipovský, J. – Widimský, J. Jr. – Ceral, J., et al.: Diagnostické a léčebné postupy u arteriální hypertenze – verze 2012. Doporučení České společnosti pro hypertenzi. Vnitř Lék, 2012, 58, s. 785–801. 4 Pella, D.: Efficacy and safety of treatment of hypertensive patients with fixed combination perindopril/indapamide up to 10/2.5mg. Results of the FALCO FORTE programme. High Blood Press Cardiovasc Prev, 2011, 18, s. 107–113. 5 Progress Collaborative Group: Randomised trial of a perindopril-based blood pressure lowering regimen among 6105 individuals
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with previous stroke or transient ischaemic attack. Lancet, 2001, 358, s. 1033–1041. Arima, H. – Chalmers, J. – Woodward, M., et al.: PROGRESS Collaborative Group. Lower target blood pressures are safe and effective for the prevention of recurrent stroke: the PROGRESS trial. J Hypertens, 2006, 24, s. 1201–1208. Yusuf, S. – Diener, H. C. – Sacco, R. L., et al.: Telmisartan to prevent recurrent stroke and cardiovascular events. NEJM, 2008, 359, s. 1225–1237. Van Vark, L. C. – Bertrand, M. – Akkerhuis, K. M., et al.: Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomised clinical trials of RAAS inhibitors involving 158 998 patients. Eur Heart J, 2012, 33, s. 2088–2097. Brugts, J. J. – van Vark, L. – Akkerhuis, M., et al.: Impact of renin-angiotensin system inhibitors on mortality and major cardiovascular
endpoints in hypertension: A number-needed-to-treat analysis. Int J Cardiol, 2015, 181, s. 425–429. 10 Bangalore, S. – Fakheri, R. – Toklu, B., et al.: Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in patients with out heart failure? Insights from 254 301 patients from randomized trials. Mayo Clin Proc, 2016, 91, s. 51–60. 11 Ferrari, R. – Boersma, E.: The impact of ACE inhibition on all-cause and cardiovascular mortality in contemporary hypertension trials. Expert Rev Cardiovasc Ther, 2013, 11, s. 705–717. 12 Savarese, G. – Costanzo, P. – Cleland, J. G., et al.: A meta-analysis reporting effects of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in patients without heart failure. J Am Coll Cardiol, 2013, 61, s. 131–142.
Alirocumab u pacientů s familiární hypercholesterolemií prof. MUDr. Vladimír Bláha, CSc. III. interní gerontometabolická klinika LF UK a FN, Hradec Králové 1 Navarese, E. P. – Kolodziejczak, M., et al.: Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: a systematic review and meta-analysis. Ann Intern Med, 2015, 163, s. 40. 2 Zhang, X. L. – Zhu, Q. Q. – Zhu, L., et al.: Safety and efficacy of anti-PCSK9 antibodies: a meta-analysis of 25 randomized, controlled t rials. BMC Med, 2015, 13, s. 123. 3 Sattar, N. – Preiss, D. – Robinson, J. G., et al.: Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes: a meta-analysis of individual patient data. Publikováno online před tiskem 8. 2. 2016, Lancet Diabetes Endocrinol, doi:10.1016/ S2213-8587(16)00003–6. 4 Ricotta, D. N. – Frishman, W. H.: Mipomersen: a safe and effective antisense therapy adjunct to statins in patients with hypercholesterolemia. Cardiol in Rev, 2012, 20, s. 90–95. 5 Reiner, Ž.: Management of patients with familial hypercholestero laemia. Nat Rev Cardiol, 2015, 12, s. 565–575. 6 Kastelein, J. J. P. – Ginsberg, H. N. – Langslet, G., et al.: ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholester-olaemia. Eur Heart J, 2015, doi: http://dx.doi.org/10.1093/eurheartj/ehv370. 7 Roth, E. M. – McKenney, J. M.: ODYSSEY MONO: effect of alirocumab
75 mg subcutaneously every 2 weeks as monotherapy versus ezetimibe over 24 weeks. Future Cardiol, 2015, 11, s. 27–37. 8 Kereiakes, D. J. – Robinson, J. G., et al.: Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: The ODYSSEY COMBO I study. Am Heart J, 2015, 169, s. 906–915, e13. 9 Canon, C. P. – Cariou, B. – Blom, D., et al.: Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately control led hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial. Eur Heart J, 2015, 36, s. 1186–1194. 10 Bays, H. – Gaudet, D. – Weiss, R., et al.: Alirocumab as add-on to atorvastatin versus other lipid treatment strategies: ODYSSEY OPTIONS I randomized trial. J Clin Endocrinol Metab, 2015, 100, s. 3140–3148. 11 Bays, H. – Farnier, M. – Gaudet, D., et al.: Efficacy and safety of combining alirocumab with atorvastatin or rosuvastatin versus statin intensification or adding ezetimibe in high cardiovascular risk patients: ODYSSEY OPTIONS I and II. Dostupné z: https://professional.heart.org/ idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_469615.pdf, vyhledáno 28. 11. 2016. 12 Lipinami, M. J. – Benedetto, U. – Escarcega, R. O., et al.: The impact
of proprotein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia: a network meta-analysis. Eur Heart J, 2015, doi: http://dx.doi.org/10.1093/eurheartj/ehv563. 13 Sanofi/Regeneron. ODYSSEY Outcomes: evaluation of cardiovascular outcomes after an acute coronary syndrome during treatment with alirocumab SAR236553 (REGN727). ClinicalTrials.gov [database online]. Bethesda (MD): National Library of Medicine (US). Dostupné z: https://clinicaltrials.gov/ct2/show/NCT01663402, vyhledáno 28. 11. 2016. 14 Tice, J. A. – Ollendorf, D. A. – Cunningham, C., et al.: PCSK9 inhibitors for treatment of high cholesterol: effectiveness, value, and value-based price benchmarks draft report. Institute for Clinical and Economic Review (ICER), 8. 9. 2015. Dostupné z: https://icer-review.org/wp-content/uploads/2016/01/Final-Report-for-Posting-11-24-15-1.pdf, vyhledáno 28. 11. 2016. 15 Robinson, J. G. – Farnier, M. – Krempf, M., et al.: Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med, 2015, 372, s. 1489–1499, http://dx.doi.org/10.1056/NEJMoa1501031. 16 Pfizer discontinues global de velopment of bococizumab, its investigational PCSK9 inhibitor. Dostupné z: http:// www.pfizer.com/news/press-release/press-release-detail/
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pfizer_discontinues_global_development_of_bococizumab_its_ investigational_pcsk9_inhibitor, vyhledáno 28. 11. 2016. 17 Stein, E. A. – Sampietro, T. – Santos, R., et al.: Long-term treatment with evolocumab homozygous familial hypercholesterolemia
patients: Results from the trial assessing long-term use of PCSK9 inhibition in subjects with genetic LDL disorders (TAUSSIG). Kongres European Atherosclerosis Society, 31. 5. 2016, Innsbruck, Rakousko, abstrakt 146.
18 Moriarty, P. M. – Parhofer, K. G. – Baborák, S. P., et al.: Alirocumab in patients with heterozygous familial hypercholesterolemia undergoing lipoprotein apheresis: the ODYSSEY ESCAPE trial. Eur Heart J, 2016, 0, s. 1–8, doi:10.1093/eurheartj/ehw388.
Afinitor (everolimus) ve vyšší linii léčby metastatického renálního karcinomu MUDr. Hana Korunková Onkologická a radioterapeutická klinika FN, Plzeň 1 Procopio, G. – Verzoni, E. – Iacovelli, R., et al.: Overall survival (OS) in metastatic renal cell carcinoma (mRCC) sequentially treated with different targeted therapies (TTs): Results from a large cohort of patients. 2012 ASCO Annual Meeting. Citace: J Clin Oncol, 2012, 30, abstrakt 4629.
Avastin s paklitaxelem u pacientky s triple negativním karcinomem prsu MUDr. Ivana Bustová Onkologické oddělení, Nemocnice České Budějovice, a. s. 1 Kümler, I. – Christiansen, O. G. – Nielsen, D. L.: A systematic review of bevacizumab efficacy in breast cancer. Cancer Treat Rev, 2014, 40, s. 960–973. 2 Gligorov, J. – Doval, D. – Bines, J. et al.: Maintenance capecitabine
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3 Adaptováno z: Delaloge, S., et al.: Results of a multicenter national observational study. J Clin Oncol, 2016, 34, abstrakt 1013, ASCO 2016.
Léčba Avastinem u pacienta s NSCLC MUDr. Lenka Jakubíková, Ph.D. | MUDr. Jana Špeldová | MUDr. Ondřej Venclíček | prof. MUDr. Jana Skřičková, CSc. Klinika nemocí plicních a tuberkulózy FN, Brno 1 Sandler, A. – Gray, R. – Perry, M. C., et al.: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer M D N Engl J Med, 2006, 355, s. 2542–2550. 2 Reck, M. – von Pawel, J. – Zatloukal, P., et al.: Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line
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Metastatický a inoperabilní bazocelulární karcinom léčený vismodegibem MUDr. David Šulc | MUDr. Denisa Šmejkalová Onkologické oddělení, Krajská zdravotní, Masarykova nemocnice, Ústí nad Labem 1 Lear, J. T. – Harvey, I. – de Berker, D. – Strange, R. C. – Fryer, A. A.: Basal cell carcinoma. J R Soc Med, 1998, 91, s. 585–588. 2 Roewert-Huber, J. – Lange-Asschenfeldt, B. – Stockfleth, E. – Kerl, H.: Epidemiology and aetiology of basal cell carcinoma.
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4 Sekulic, A., et al.: Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med, 2012, 366, s. 2171–2179.
Léčba ALK inhibitorem – Xalkori MUDr. Leona Koubková Pneumologická klinika 2. LF UK a FN Motol, Praha 1 Klak, E. L. – Bang, Y. – Camidge, D. R., et al.: Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med, 2010, 363, s. 1693–1703. 2 Camidge, D. R. – Bang,Y. – J. Kwak, E. L, et al.: Activity and safety
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1007 investigators: Phase III study of crizotinib vs pemetrexed or docetaxel chemotherapy in patients with advanced ALK-positive NSCLC. Prezentováno na 37. kongresu ESMO Congress, Vídeň, Rakousko, 2012, abstrakt LBA1 PR.
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Léčba starší nemocné s chronickou lymfocytární leukemií kombinací obinutuzumab a chlorambucil MUDr. Jana Zuchnická | MUDr. Jana Fečková Mihályová Klinika hematoonkologie FN, Ostrava prof. MUDr. Roman Hájek, CSc. Klinika hematoonkologie FN, Ostrava, LF Ostravské univerzity, Ostrava 1 Herting, F. – Friess, T. – Bader, S., et al.: Enhanced anti-tumor activity of the glycoengineered type II CD20 antibody obinutuzumab (GA101) in combination with chemotherapy in xenograft models of human lymphoma. Leuk Lymphoma, 2014, 55, s. 2151–2160. 2 Cartron, G. – de Guibert, S. – Dilhuydy, M. S., et al.: Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study. Blood, 2014, 124, s. 2196–2202. 3 Salvi, F. – Miller, M. D. – Grilli, A., et al.: A manual of guidelines to score the modified cumulative illness rating scale and its valida tion in acute hospitalized elderly patients. J Am Geriatr Soc, 2008, 56, s. 1926–1931.
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GOLD 2017: novinky v léčbě CHOPN MUDr. Eva Voláková Klinika plicních nemocí a tuberkulózy, FN, Olomouc 1 GOLD 2017 Global Strategy for the Diagnosis, Management and Prevention of COPD. Dostupné z: goldcopd.org. 2 Cazzola, M. – Page, C. P. – Calzetta, L., et al.: Pharmacology and therapeutics of bronchodilators. Pharm Reviews, 2012, 64, s. 450–504.
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Hyperandrogenní stavy v gynekologii MUDr. Petr Křepelka, Ph.D. Ústav pro péči o matku a dítě, Praha 1 Cordain, L. – Lindeberg, S. – Hurtado, M., et al.: Acne vulgaris: a disease of western civilization. Arch Dermatol, 2002, 138, s. 1584–1590. 2 Thiboutot, D. – Martin, P. – Volikos, L., et al.: Oxidative activity of the type 2 isozyme of 17B-Hydroxysteroid dehydrogenase (17B-HSD) predominates in human sebaceous glands. J Invest Dermatol, 1998, 111, s. 390–395. 3 O’Connell, K. – Westhoff, C.: Pharmocology of hormonal contraceptives and acne. Cutis, 2008, 81, s. 8–12. 4 Ferriman, D. – Gallwey, J. D.: Clinical assessment of body hair growth in women. J Clin Endocrinol Metab, 1961, 21, s. 1440. 5 Azziz, R. – Carmina, E. – Dewailly, D., et al.: The Androgen Excess and
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ACTA MEDICINAE 11/2016 | kazuistiky | Kompletní literatura
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7 Ruck, T. – Bittner, S. – Wiendl, H., et al.: Alemtuzumab in multiple sclerosis: mechanism of action and beyond. Int J Mol Sci, 2015, 16, s. 16414–16439. 8 Achiron, A. – Chambers, Ch. – Fox, E. J., et al.: Pregnancy outcomes in patients with active RRMS who received alemtuzumab in the clinical development program. 31st Congress of the European Commitee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 7.–10. 10. 2015, Barcelona, Španělsko, P1120.
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