49
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22. Sukandar E. Nefrologi Klinik. Bandung: Pusat Informasi Ilmiah UNPAD 2006. 23. Parsudi I, Siregar P, Roesli RMA. Hemodialisis. In Sudoyo AW, Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta: InternaPublishing 2009:1050-1052. 24. Hamilton RW. Complications of Dialysis: Selected Topics. In Schrier RW, (Ed). Atlas of Disease of The Kidney. Colorado 1998. 25. Zepeda-Orozco D, Quigley R. Dialysis disequilibrium syndrome. Pediatric nephrology. 2012;27(12):2205-2211. 26. Bakta IM. Pendekatan Terhadap Pasien Anemia. In Sudoyo AW, Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta: InternaPublishing 2009:1109-1115. 27. Turgeon ML. Clinical hematology : theory and procedures. Philadelphia: Lippincott Williams & Wilkins 2004. 28. WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva: World Health Organization [Internet]. 2011 [cited 2014 Jan 2]. Available from: http://www.who.int/vmnis/indicators/haemoglobin/en/ 29. Schrier RW. Diseases of the kidney & urinary tract. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins 2007. 30. Mehdi U, Toto RD. Anemia, diabetes, and chronic kidney disease. Diabetes care [Internet]. 2009 [cited 2014 Jan 5];32(7):1320-1326. Available from : PubMed Central. 31. McClellan W, Aronoff SL, Bolton WK, et al. The prevalence of anemia in patients with chronic kidney disease. Current medical research and opinion [Internet]. 2004 [cited 2014 Jan 7];20(9):1501-1510. Available from : Informa Healthcare. 32. Suega K, Bakta M, Dharmayudha TG, et al. Profile of anemia in chronic renal failure patients: comparison between predialyzed and dialyzed patients at the Division of Nephrology, Department of Internal Medicine, Sanglah Hospital, Denpasar, Bali, Indonesia. Acta medica Indonesiana [Internet]. 2005 [cited 2014 Feb 7]; 37(4):190-194. Available from : ISoIM. 33. Astor BC, Muntner P, Levin A, et al. Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (19881994). Archives of internal medicine [Internet]. 2002 [cited 2014 Feb 7]; 162(12):1401-1408. Available from : JAMA International. 34. Rosenblatt SG, Drake S, Fadem S, et al. Gastrointestinal blood loss in patients with chronic renal failure. American journal of kidney diseases : the official journal of the National Kidney Foundation [Internet]. 1982 [cited 2014 Mar 2]; 1(4):232-236. Available from : Elsevier. 35. Kuo CC, Kuo HW, Lee IM, et al. The risk of upper gastrointestinal bleeding in patients treated with hemodialysis: a population-based cohort study. BMC nephrology [Internet]. 2013 [cited 2014 Mar 2];14:15. Available from : PubMed Central.
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36. Kaw D, Malhotra D. Platelet dysfunction and end-stage renal disease. Seminars in dialysis [Internet]. 2006 [cited 2014 Feb 2];19(4):317-322. Available from : WileyOnlineLibrary. 37. Boccardo P, Remuzzi G, Galbusera M. Platelet dysfunction in renal failure. Seminars in thrombosis and hemostasis [Internet]. 2004 [cited 2014 Feb 2]; 30(5):579-589. Available from : PubMed Central. 38. Fishbane S, Pollack S, Feldman HI, et al. Iron indices in chronic kidney disease in the National Health and Nutritional Examination Survey 19882004. Clinical journal of the American Society of Nephrology : CJASN [Internet]. 2009 [cited 2014 Jan 13];4(1):57-61. Available from : PubMed Central. 39. Bakta IM, Suega K, Dharmayuda TG. Anemia Defisiensi Besi. In Sudoyo AW, Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta: InternaPublishing 2009:1127-1137. 40. Spinowitz BS, Kausz AT, Baptista J, et al. Ferumoxytol for treating iron deficiency anemia in CKD. Journal of the American Society of Nephrology : JASN [Internet]. 2008 [cited 2014 Jan 13]; 19(8):1599-1605. Available from : PubMed Central. 41. Supandiman I, Fadjari H, Sukrisman L. Anemia Pada Penyakit Kronis. In Sudoyo AW, Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta: InternaPublishing 2009:1138-1140. 42. Poggiali E, Migone De Amicis M, Motta I. Anemia of chronic disease: A unique defect of iron recycling for many different chronic diseases. European journal of internal medicine [Internet]. 2014 [cited 2014 Jan 14]; 25(1):12-17. Available from: Elsevier. 43. Weiss G, Goodnough LT. Anemia of chronic disease. The New England journal of medicine [Internet]. 2005 [cited 2014 Mar 4];352(10):1011-1023. Available from: NEJM. 44. Rice L, Alfrey CP, Driscoll T, et al. Neocytolysis contributes to the anemia of renal disease. American journal of kidney diseases : the official journal of the National Kidney Foundation [Internet]. 1999 [cited 2013 Des 3];33(1):5962. Available from: Elsevier. 45. Means RT, Jr. Recent developments in the anemia of chronic disease. Current hematology reports [Internet]. 2003 [cited 2013 Des 17];2(2):116-121. Available from: PubMed. 46. Miller CB, Jones RJ, Piantadosi S, et al. Decreased erythropoietin response in patients with the anemia of cancer. The New England journal of medicine [Internet]. 1990 [cited 2014 Jan 22];322(24):1689-1692. Available from: NEJM 47. Maciejewski JP, Selleri C, Sato T, et al. Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. The Journal of clinical investigation [Internet]. 1995 [cited 2013 Des 25]; 96(2):1085-1092. Available from: PubMed Central.
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48. Armitage AE, Eddowes LA, Gileadi U, et al. Hepcidin regulation by innate immune and infectious stimuli. Blood [Internet]. 2011 [cited 2013 Des 25];118(15):4129-4139. Available from: BloodJournal. 49. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2002 [cited 2013 Des 29] ;99(7):4596-4601. Available from: PubMed Central. 50. Rinaldi I, Sudoyo AW. Anemia Hemolitik Non Imun. In Sudoyo AW, Setiyohadi B, Alwi I, et al., (Eds). Buku Ajar Ilmu Penyakit Dalam. Jakarta: InternaPublishing 2009:1157-1164. 51. Collins AJ, Foley RN, Chavers B, et al. 'United States Renal Data System 2011 Annual Data Report: Atlas of chronic kidney disease & end-stage renal disease in the United States. American journal of kidney diseases : the official journal of the National Kidney Foundation [Internet]. 2012 [cited 2014 Feb 25]; 59(1 Suppl 1):A7, e1-420. Available from: Elsevier. 52. Prakash S, O'Hare AM. Interaction of aging and chronic kidney disease. Seminars in nephrology [Internet]. 2009 [cited 2014 Jan 24];29(5):497-503. Available from: Elsevier. 53. Anderson S, Halter JB, Hazzard WR, et al. Prediction, progression, and outcomes of chronic kidney disease in older adults. Journal of the American Society of Nephrology : JASN [Internet]. 2009 [cited 2014 feb 2];20(6):1199-1209. Available from: Highwire. 54. Singh AK, Farag YM, Mittal BV, et al. Epidemiology and risk factors of chronic kidney disease in India - results from the SEEK (Screening and Early Evaluation of Kidney Disease) study. BMC nephrology [Internet]. 2013 [cited 2014 Mar 24];14:114. Available from: PubMed Central. 55. Akinsola A, Durosinmi MO, Akinola NO. The haematological profile of Nigerians with chronic renal failure. African journal of medicine and medical sciences [Internet]. 2000 [cited 2014 Jan 2];29(1):13-16. Available from: PubMed. 56. Neugarten J, Acharya A, Silbiger SR. Effect of gender on the progression of nondiabetic renal disease: a meta-analysis. Journal of the American Society of Nephrology : JASN [Internet]. 2000 [cited 2014 Jan 2];11(2):319-329. Available from: JASN. 57. Silbiger SR, Neugarten J. The impact of gender on the progression of chronic renal disease. American journal of kidney diseases : the official journal of the National Kidney Foundation [Internet]. 1995 [cited 2014 Apr 3];25(4):515533. Available from: Elsevier. 58. Prodjosudjadi W. Incidence, prevalence, treatment and cost of end-stage renal disease in Indonesia. Ethnicity & disease [Internet]. 2006 [cited 2014 Jan 16]; 16(2 Suppl 2):S2-14-16. Available from: PubMed. 59. Bennett PN, Hany A. Barriers to kidney transplants in Indonesia: a literature review. International nursing review [Internet]. 2009 [cited 2014 Mar 2]; 56(1):41-49. Available from: WileyOnlineLibrary. 60. Tangri N, Stevens LA, Griffith J, et al. A predictive model for progression of chronic kidney disease to kidney failure. JAMA : the journal of the American
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Lampiran 1. Lembar Inform Consent Persetujuan Setelah Penjelasan (INFORMED CONSENT) Berikut ini naskah yang akan dibacakan pada Responden / Ibu Responden Penelitian : Bapak/Ibu Yth : Saya Dhanny Candra Adiatma, mahasiswa Fakultas Kedokteran Universitas Diponegoro Semarang, Program Studi Kedokteran Umum. Saya bermaksud melakukan penelitian mengenai “Prevalensi dan Jenis Anemia Pada Pasien Penyakit Ginjal Kronik Yang Menjalani Hemodialisis Reguler”. Penelitian ini dilakukan sebagai tahap akhir dalam penyelesaian studi di Fakultas Kedokteran Universitas Diponogoro, Program Studi Kedokteran Umum. Pada penelitian ini akan dilakukan pengumpulan data berupa data karateristik demografi sampel berupa nama, umur, jenis kelamin, alamat, serta penyakit yang mendasari. Kemudian akan dilakukan pengambilan sampel darah vena sebanyak 5 cc untuk dilakukan pemeriksaan laboratorium yaitu kadar Hb, complete blood count, hitung retikulosit, serum besi, TIBC dan billirubin total. Terdapat ketidaknyamanan saat proses pengambilan darah vena. Analisis laboratorik akan dilakukan di laboratorium RSUP Dr. Kariadi Semarang. Seluruh biaya pada proses penelitian ditanggung oleh peneliti. Peneliti akan menjaga kerahasiaan identitas dan informasi yang diberikan dan hanya digunakan untuk kepentingan penelitian. Terima kasih atas kerjasama Bapak/Ibu/Sdr. Peneliti : Dhanny Candra Adiatma. Nomor kontak peneliti : 085641221493 Setelah mendengar dan memahami penjelasan Penelitian, dengan ini saya menyatakan SETUJU / TIDAK SETUJU Untuk ikut sebagai responden / sampel penelitian.
Semarang, Saksi :
Nama Terang :
Nama Terang :
Alamat :
Alamat :
56
Lampiran 2. Data Subjek No
Umur
1
55
W
Sex
Diabetes Mellitus
Penyakit
Hb 8.95
91.4 30.9
33.8
245
2.76
5.98
245
37
0.18
2
76
P
Hipertensi
9.85
90.5 30.7
33.9
160
1.41
5.37
287
44
0.39
3
64
P
Diabetes Mellitus
10.5
86.6 29.3
33.8
252
3.72
5.57
234
37
0.23
4
48
P
Diabetes Mellitus
8.5
75.9
27
33.2
248
3.72
7.62
249
38
0.23
5
54
P
Diabetes Mellitus
10.1
84.4 27.9
33
143
3.79
8.99
346
56
0.78
6
44
W
Hipertensi
10.3
90.4 29.6
32.8
251
1.56
4.85
222
114
0.31
7
50
P
Diabetes Mellitus
9.7
81.9 27.5
33.6
144
1.35
6.47
269
34
0.51
8
43
P
Obstruksi Ginjal
8.49
84.7 29.6
34.9
428
2.73
6.46
341
162
0.25
9
52
W
Hipertensi
10.2
77.6 26.7
33.1
271.2
2
6.6
273
134
0.39
10
62
W
Diabetes Mellitus
11.4
84.9
28
33
309.3
3.1
9.8
326
57
1.1
11
69
W
Obstruksi Ginjal
8.7
85.8 29.1
34
406
0.4
3.9
175
8
0.33
12
52
P
Obstruksi Ginjal
8.1
73.3 24.4
29
302
4.3
8.1
370
50
0.33
13
71
P
Diabetes Mellitus
9.1
29
33.7
161.8
1.1
4.4
285
97
0.24
14
57
P
Diabetes Mellitus
10.2
67.1 22.5
29.5
222.5
1.2
5.3
361
52
0.28
15
52
P
Diabetes Mellitus
8.2
74.4 24.6
30
225.7
0.5
5.9
346
16
1.39
16
61
P
Hipertensi
8.8
83 27.6
33.3
134
0.9
4.5
263
152
0.28
17
74
P
Hipertensi
9.9
83.7 28.6
34.1
170
1.4
5.7
244
51
0.43
18
49
W
Diabetes Mellitus
9.2
82.4 26.9
32
181.1
2.6
4.6
285
67
0.44
19
65
P
Diabetes Mellitus
8.7
82.5 28.3
34.2
76
0.4
2.2
338
89
1.18
20
66
P
Diabetes Mellitus
10.3
92.6 29.3
31.6
174.4 -
8.6
215
42
0.76
21
25
P
Hipertensi
8.9
84.2 29.1
34.6
198
2.71
7.4
236
182
0.37
22
53
P
Hipertensi
8.2
89
28
31.3
427
1.7
7.4
210
55
0.87
23
25
W
Hipertensi
9.6
78
26
33
218
0.4
5.9
223
53
0.35
24
54
W
Hipertensi
10.6
85
28
33.9
216.7
0.9
7
288
68
0.78
25
77
W
Hipertensi
8.7
89.2 30.1
33.7
254.4
1.3
9.7
172
44
0.51
26
36
P
Obstruksi Ginjal
8.2
83.2 28.8
34.5
209.5
1.33
6.1
235
50 -
27
52
W
Diabetes Mellitus
8.1
87 29.3
33.7
197.8
1.73
7.9
219
52
0.43
28
57
P
Diabetes Mellitus
8.1
82 26.5
32.3
155
3
5.3
209
49
0.23
29
76
P
Diabetes Mellitus
9.6
89.5 30.4
34
211.4
0.9
5.5
305
68
0.26
30
51
P
Hipertensi
8.8
82 27.7
33.7
139
1.24
5.5
245
49
0.33
31
55
P
Hipertensi
13.4
86.6 29.3
33.7
155.9
1.23
7.5
325
74
0.74
32
32
W
Hipertensi
12.1
82.6 27.6
33.4
230
1.5
7.8
355
33
52
P
Hipertensi
13.1
34
55
W
Diabetes Mellitus
12.5
35
54
P
Hipertensi
13
MCV
88
85
MCH MCHC Tromb
Rtc
Leu
TIBC
29
34
251 -
6.6 -
82.6 27.7
33.6
208 -
6.7
33.4
299.3 -
87
29
4.7 -
SI
Bill total
24 -
298
0.33 -
61 -
-
57
Lampiran 3. Ethical Clearance
