Publications: György M. Keserű
1.
György M. Keserű, Gabriella Mezey-Vándor, Mihály Nógrádi, Borbála Vermes and Mária Kajtár-Peredy: Total Synthesis of Plagiochins C and D, Macrocyclic Bis(bibenzyl) Constituents of Plagiochila acantophylla Tetrahedron, 48(5), 913-922, (1992).
2.
László Kametler, György M. Keserű, Mihály Nógrádi, Gabriella Mezey-Vándor, Borbála Vermes und Mária Kajtár-Peredy: Synthese von Plagiochin A und B, zwei macrocyclishe Bis(bibenzylether) aus Plagiochila acantophylla Liebigs Ann. Chem. 1239, (1992).
3.
György M. Keserű and Mihály Nógrádi: Biosynthesis and Molecular Strain. A computational Sutdy on the Conformation of Cyclic Bis(bibenzyl) Constituents of Liverwort Species Phytochemistry 31(5), 1573-1576 (1992).
4.
Mária Kajtár-Peredy, György M. Keserű and Mihály Nógrádi: Determination of the Preferred Conformation of a Macrocyclic Bis(bibenzyl) by Nuclear Magnetic Resonance Spectroscopy and Molecular Mechanics Calculations J. Chem. Soc. Perkin Trans. 2. 563, (1993).
5.
Borbála Vermes, György M. Keserű, Gabriella Mezey-Vándor, Mihály Nógrádi and Gábor Tóth: The Synthesis of Garugamblin-1 Tetrahedron, 49(22), 4893-4900, (1993)
6.
Ferenc Bertha, József Fetter, Mária Kajtár-Peredy, György M. Keserű, Károly Lempert, László Párkányi and József Tamás: On the Anomalous Behavior of (3RS,4RS)-[(2RS)-3-Acetylthiazolidin-2-yl]-1-(4-methoxyphenyl)azetidin-2ones towards Cerium(IV) Ammonium Nitrate (CAN). An Unprecedeted Oxidative Ring Transformation Tetrahedron, 49(35), 7803-7822, (1993)
7.
György M. Keserű and Mihály Nógrádi: Prediction of Antibacterial Activity of Some Diarylheptanoids Isolated from Garuga Species by Molecular Mechanics and Molecular Orbital Calculations J. Mol. Structure THEOCHEM 286, 259-265 (1993)
8.
György M. Keserű, Zoltán Dienes, Mihály Nógrádi and Mária Kajtár-Peredy: Synthesis and Revised Structure of Garuganin III J. Org. Chem. 58(24), 6725-6728, (1993)
9.
Gergely Makara and György M. Keserű and Attila Kovács: Chemoselectivity in the Alkylation of Quinoline Carboxylic Acids J. Chem. Soc. Perkin Trans 2. 591, (1994).
10.
Zsolt Böcskei and György M. Keserű: Structure and Conformation of Pakyonol J. Chem. Soc. Perkin Trans. 2. 594, (1994).
11.
György M. Keserű, R. Klinga, G. Mezey-Vándor, M. Nógrádi, G. Tóth: Ketal Mediated Diels-Alder Type Dimerization of an Arylideneacetone Monatsh. Chem. 125, 425-432 (1994).
12.
György M. Keserű, Zoltán Hajnal, Gábor Kenessey and György Liptay: Back Donation in Dichloro-bispyridine-cobalt(II) complexes J. Mol. Struct. THEOCHEM 306(2-3), 289-292 (1994).
13.
G. Kenessey, L. Párkányi, P.-E. Werner, G. M. Keserű, T. Wadsten, L. Bihátsi, G. Liptay: Pyridine Type Complexes of Transition-Metal Halides III. Structural and Thermal Relationships Among the Cobalt(II) Complexes with Halide Ions and 2-, 3- and 4-Methylpyridine, the Crystal Structure of Dibromo-tetrakis(3methylpyridine)-cobalt(II) Structural Chemistry 5(2), 123-128, (1994).
14.
L. Hitunen, G. Kenessey, G. M: Keserű, G. Liptay and L. Niinistö: Pyridine Type Complexes of Transition-Metal Halides V. Preparation, Thermal Studies and Single Crystal Structure of Dibromo-tetrakis-(2-bromopyridine)-cobalt(II) Acta Chem. Scand. 48, 456, (1994)
15.
György M. Keserű, M. Nógrádi and Mária Kajtár-Peredy: Synthesis of Garugamblin-2 Liebigs Ann. Chem. 361, (1994).
16.
György M. Keserű, Helga Vásárhelyi and Gergely Makara: Conformational Analysis of a Condensed Macrocyclic -Lactam J. Mol. Structure 326, 151-155 (1994)
17.
György M. Keserű and Gábor Náray-Szabó: Designed -Face Selectivity by Molecular Electrostatic Potential Tetrahedron Letters, 35(49), 9255-9258, (1994).
18.
György M. Keserű and M. Nógrádi: The Synthesis, Chemistry and Biochemistry of Bis(bibenzyls) Natural Products Report 12, 69 (1995).
19.
György M. Keserű, Mihály Nógrádi, Attila Kovács and Uwe Himmelreich: Conformation
of
6H,12H,18H-tribenzo[b,f,j][1,5,9]trithiacyclododecin
Revisited J. Chem. Soc. Perkin Trans. 2. 1995, 935-938. 20.
A. Kovács, R. J. M. Konings, A.S. Booij and Gy.M. Keserű: The infrared spectrum of BI3(g) Vibrational Spectroscopy 9, 209-214, (1995).
21.
Enikő Kámory, György M. Keserű and Beáta Papp: Isolation and Antibacterial Activity of Marchantin A, Macrocyclic Bis(bibenzyl) Constituent of Hungarian Marchantia polymorpha Planta Medica 61(4), 387-388, (1995).
22.
György M. Keserű and Mihály Nógrádi: Structure and Activity of Macrocyclic Diarylheptanoids Isolated from Garuga Species in American Institute of Physics Conf. Proc. 330 (Ed.: F. Bernardi and J.-L. Rivail) pp. 379 (1995) AIP Press, Woodbury, NY. USA.
23.
György M. Keserű, István Kolossváry and Mihály Nógrádi: Molecular Asymmetry of Macrocyclic Bis(bibenzyls), Natural Products from Liverwort species J. Mol. Structure 356(2), 143-148 (1995).
24.
György M. Keserű and Mihály Nógrádi: Biological Activity of Macrocyclic Bis(bibenzyls): A Rational Approach Bioorg. Med. Chem. 3(11), 1511-1517 (1995).
25.
Attila
Sápi,
Ferenc
Bertha,
József
Fetter,
Mária
Kajtár-Peredy,
György M. Keserű, Károly Lempert: On the Anomalous Behavior of Certain 1(4-methoxyphenyl)-azetidin-2-ones towards Cerium(IV) Ammonium Nitrate (CAN). Structure-Reactivity Studies Tetrahedron 52(3), 771-782 (1996).
26.
Zsolt Böcskei, György M. Keserű, Dóra Menyhárd, Péter Huszthy, Jerald S. Bradshaw, R. S. Izatt: Crystal Structure and Conformational Analysis of (S, S)Dimethyldiketopyridino-18-Crow-6 Acta Crystallographica C C52(2), 463-466 (1996).
27.
Gergely Makara, György M. Keserű, Mária Kajtár-Peredy and Wayne K. Anderson: NMR and Molecular Modeling Study on Mycophenolic Acid: Implications for Binding to Inosine Monophosphatase Dehydrogenase J. Med. Chem. 39(6), 1236-1242 (1996)
28.
György M. Keserű and Mihály Nógrádi: Molecular Similarity Analysis on Biologically Active Bis(bibenzyls) J. Mol. Recogn. 9(2), 133-138 (1996).
29.
Péter Várnai and György M. Keserű: Theoretical Study on the Retro-Ene Rearrangements of Propargylic Ethers J. Org. Chem. 61(17), 5831-5836 (1996).
30.
György M. Keserű, István Kolossváry and Mihály Nógrádi: Formation and E/Z Isomerization of Macrocyclic -methoxyenones J. Mol. Structure THEOCHEM 366(3), 195-201 (1996).
31.
György M. Keserű, Zoltán Kovári and Gábor Náray-Szabó: Theoretical Study on the Long-range Substituent Effects in the Reduction of Norbornan-7-ones J. Chem. Soc. Perkin Trans. 2. 2231 (1996).
32.
György M. Keserű, László Tôke, Zoltán Hell, Zsuzsanna M. Jászay, Imre Petneházy and László Korecz: Theoretical Study on the 5-Exo/6-endo Selectivity in the Cyclisation of Electrophilic Radicals J. Mol. Structure THEOCHEM 392(1-3), 95-99 (1997)
33.
Joachim Busch, György M. Keserű, Zoltán Kovári and Urs Sequin: Steris vs. Electrostatic Effects in the Nucleophilic Addition to a Hindered Cyclohexanone Structural Chemistry 8(4), 257-261 (1997)
34.
György M. Keserű, Mihály Nógrádi and János Rétey: Enantioselective Synthesis of Both Optically Active 1,3-Dideuteroallene Tetrahedron, 53(6), 2049-2054 (1997)
35.
György Keglevich, Luis D. Quin, Zsolt Böcskei, György M. Keserű, Rajdeep Kalgutkar, Paul, M. Lathi: Phospholes with Reduced Pyramidal Character from Steric Crowding III. NMR and X-ray Diffraction Studies on 1-(2,4,6-triisopropylphenyl)-3-methylphosphole. J. Orgmet. Chem. 532(1-2), 109-116 (1997)
36.
János Gerencsér, György M. Keserű, István Macsári, Mihály Nógrádi, Mária Kajtár-Peredy and Áron Szöllősy: Synthesis of Isoplagiochin A J. Org. Chem. 62(11), 3666-3670 (1997)
37.
György M. Keserű, István Kolossváry and Béla Bertók: Cytochrome P450 Catalysed Insecticide Metabolism. Prediction of Regio- and Stereoselectivity in the Primer Metabolism of Carbofuran J. Am. Chem. Soc. 119(22), 5126-5131 (1997)
38.
György Keglevich, Zsolt Böcskei, György M. Keserű, Kálmán Ujszászy and Luis D. Quin: 1-(2,4,6-Tri-tert-butylphenyl)-3-methylphosphole: A Phosphole with a Significantly Flattened Phosphorus Pyramid Having Pronounced Characteristic of Aromaticity J. Am. Chem. Soc. 119(22), 5095-5099 (1997)
39.
Gergely Makara and György M. Keserű: On the Conformation of Thiazofurin Analogues J. Med. Chem. 40(25), 4154-4159 (1997)
40.
László Tőke, Péter Bakó, György M. Keserű, Melinda Albert and László Fenichel: Asymmetric Michael Addition and Deracemisation of Enolate by Chiral Crown Ether Tetrahedron 54(1-2), 213-222 (1998).
41.
Attila Kovács, Gábor I. Csonka and György M. Keserű: Comparison of ab Initio and Density Functional Methods for the Vibrational Analysis of TeCl4 J. Comput. Chem. 19(3), 308-318 (1998)
42.
Mihály Nógrádi, György M. Keserű, Mária Kajtár-Peredy, Borbála Vermes, Ngyuen Thi Thu Ha: The Unwanted Synthesis of (E,E)-4,21-Dimethoxy-2,19dioxahexacyclo[30,2,2,2,1,1]tetratriacontan-3,5,7(35),13,15,17,20,22,24(38)30,32,34,36,39-tetradecaen-12,29-dione and Other Attempts at the Synthesis of Acerogenins ACH Models in Chemistry 135(1-2), 57-78 (1998)
43.
György M. Keserű: Cytochrome P450 Catalysed Insecticide Metabolism: Chemical and Theoretical Models Science Progress 81, 245 (1998)
44.
Keserű György Miklós: Elméleti és preparatív enzimmodellek alkalmazása citokrom P450 katalizált metabolitikus reakciók vizsgálatára Acta Pham. Hung. 68(2), 65-69 (1998)
45.
György M. Keserű, Mihály Nógrádi and Áron Szőlőssy: Synthesis of Acerogenin C and (+)-Acerogenin A, Two Macrocyclic Diarylheptanoid Constituents of Acer nikoense Eur. J. Org. Chem. (3) 521-524 (1998)
46.
Dóra K. Menyhárd and György M. Keserű: Stereoelectronic Control on the Coordination of Substrates to Globin Proteins. The Role of His93 on the NO Release and Binding to Myoglobin J. Am. Chem. Soc. 120(31), 7991-7992 (1998)
47.
Zoltán Hell, Zoltán Finta, Tamás Grünvald, Zsolt Böcskei, Daniella Balán, György M. Keserű, László Tőke: Diastereoselectivity in the Formation of Cyclopropane Carboxylic Acid Lactones. Tetrahedron, 55(5), 1367-1376 (1999).
48.
György M. Keserű, György T. Balogh, Irén Czudor, Tamás Karancsi, András Fehér and Béla Bertók: Chemical Models of Cytochrome P450 Catalyzed Insecticide Metabolism. Application to the Oxidative Metabolism of Carbamate Insecticides. J. Agric. Food Chem. 47(2), 762-769 (1999)
49.
György Keglevich, György M. Keserű, Henrietta Forintos, Áron Szöllősy, Krisztina Ludányi, László Tőke: The effect of a sterically demanding Psubstituent on the reactivity of P heterocycles: selective transformations during the ring enlargement of a 1-(2,4,6-triisopropylphenyl)-2,5-dihydro-1H-phosphole 1-oxide J. C. S. Perkin Trans 1. (13) 1801-1805 (1999)
50.
György Keglevich, Kinga Steinhauser, György M. Keserű, Zsolt Böcskei, Kálmán Ujszászy, György Marosi, Imre Ravadits, László Tőke: The ability of 2phosphabicyclo[2.2.2]oct-5-ene 2-oxides to undergo fragmentation of the bridging P-moiety J. Organomet. Chem. 579(1-2), 182-189 (1999).
51.
Zoltán Hajnal, György M. Keserű and Kálmán Simon: A Semiempirical Approach to Hydrogen Bonding Networks. Application of Cyclic Cluster Model to Organic Crystals. J. Mol. Structure THEOCHEM 463(1-2), 169-174 (1999).
52.
György M. Keserű, György T. Balogh, Sándor Bokotey, Géza Árvai and Béla Bertók: Metalloporphyrin Catalysed Biomimetic Oxidation of Aryl Benzyl ethers. Implications for Lignin Peroxidase Catalysis. Tetrahedron 55(14), 4457-4466 (1999)
53.
György M. Keserű, István Kolossváry and István Székely: Theoretical Investigations of the Inhibitory Action of Methylenedioxyphenyl Synergists Int. J. Quantum Chem. 73(2), 123-135 (1999)
54.
György M. Keserű and Dóra K. Menyhárd: The Role of Proximal His93 on the NO Binding to Metmyoglobin. Application of Continuum Solvation in Monte Carlo Protein Simulations. Biochemistry 38(20), 6614-6622 (1999)
55.
Ferenc Faigl, Katalin Fogassy, Erzsébet Szűcs, Krisztina Kovács, György M. Keserű, Veronika Harmat, Zsolt Böcskei, László Tőke: Special Effect of Triflouromethyl Group on the Molecular Structure: Competitive Mono- and Dilithiation of 1-[(Trifluoromethyl)phenyl]pyrroles. Tetrahedron 55(25), 7881-7892 (1999)
56.
György M. Keserű, István Kolossváry and István Székely: Piperonyl Butoxide Mediated Inhibition of Cytochrome P450: A Rational Approach Pesticide Sci. 55(10), 1004-1006 (1999)
57.
György M. Keserű, György Keglevich: Stereospecific Cyclodimerisation of 1Methylphosphole-1-oxide: A Theoretical Study. J. Organomet. Chem. 586(2), 166-170 (1999)
58.
Le Thang Giang, József Fetter, Mária Kajtár-Peredy, Károly Lempert, Ferenc Bertha, György M. Keserű and Gábor Czira: Oxidative Cyclisation by Lead(IV) Acetate of 1-(4-Methoxyphenyl)-4-(tetrazol-5-ylmethyl)azetidin-2-ones to 3Methoxy-9,9a-dihydroazeto[1,2-a]tetrazolo-[5,1/d][1,5]benzodiazepin11(10H)-ones and Related Ractions. Tetrahedron 55(28), 8457-8474 (1999)
59.
Keserű György Miklós: Makromolekuláris szimulációk alkalmazási lehetőségei a racionális hatóanyagtervezésben Acta Pham. Hung. 188 (1999)
60.
Tímea Gérczei, Zsolt Böcskei, György M. Keserű, Erika Samu, Péter Huszthy: Enantiomeric recognition of alpha-(1-naphthyl)ethylammonium perchlorate by enantiomerically pure dimethylphenazino-18-crown-6 ligand in solid and gas phases Tetrahedron Asymmetry 10(10), 1995-2005 (1999).
61.
György M. Keserű, Balázs Volk, György T. Balogh: Cytochrome P450 Catalyzed Nitric Oxide Synthesis: A Theoretical Study J. Biomol. Struct. Dyn. 17(4), 759-767 (2000)
62.
Éva Kozsda-Kovács, György M. Keserű, Zsolt Böcskei, Ildikó Szilágyi, Kálmán Simon, Béla Bertók and Elemér Fogassy: Role of the Solvent in Optical Resolution of trans Chrysanthemic Acid via Diastereomeric Salt Formation with (1R,3R)-1-(4-nitrophenyl)-2-dimethylamino-1,3-propanediol J. C. S. Perkin Trans. 2 (1) 149-153 (2000)
63.
Timea Gérczei, Ágoston Fazekas and György M. Keserű: Theoretical Study on the Nitric Oxide Binding to Nitrophorin 1, an NO-carrier Protein from a Bloodsucking Insect J. Mol. Struct. THEOCHEM 503(1-2), 51-58 (2000)
64.
Tímea Gérczei, György M. Keserű and Gábor Náray-Szabó: Construction of a 3D Model of Oligopeptidase B, a Potential Processing Enzyme in Prokariotes J. Mol. Graph. 18(1), 7-17 (2000)
65.
György Keglevich, Henrietta Forintos, György M. Keserű, László Hegedűs, László Tőke: Synthesis of the Spiro Derivatives of 1,2-Oxaphosphetanes by 2+2 Cycloaddition of Cyclic 1-(2,4,6-Triisopropylphenyl)phosphine Oxides with Dimethyl Acetylenedicarboxylate. Tetrahedron 56(27), 4823-4828 (2000)
66.
Dinya, Z, Keserű, G. M, Nógrádi, M, Szöllősy, A: Synthesis of new rotenoids for structure-insecticidal activity studiesACH-Models Chem. 137(5-6), 591-605. (2000)
67.
Keserű György Miklós, Kolossváry István: Konformációs számítások Magyar Kémikusok Lapja 55, 478 (2000)
68.
Le Thang Giang, József Fetter, Mária Kajtár-Peredy, Károly Lempert, Ferenc Bertha, György M. Keserű and Gábor Czira: Oxidative Cyclisation of 1-Phenyland 1-(Substituted phenyl)-5-tetrazol-5-ylmethyl)pyrrolididn-2-ones and -6(Tetrazol-5-ylmethyl)piperidin-2-ones with Phenyl Substituents Other than 4Methoxy and 4-Hydroxy. J. Chem. Res. (5) 204-205 (2000)
69.
György M. Keserű, László Molnár, István Greiner: A Neural Network Based Virtual High Throughput Screening Test for CNS Active Compounds. Comb. Chem. & HTS, 3(6), 535-540 (2000)
70.
György M. Keserű, György T. Balogh, and Tamás Karancsi: Metalloporphyrin Catalyzed Oxidation of N-hydroxyguanidines: A Biomimetic Model for the H2O2Dependent Activity of Nitric Oxide Sythase. Bioorg. Med. Chem. Lett. 10(15), 1775-1777 (2000)
71.
Z. M. Jászay, G. M. Keserű, G. Clementis, I. Petneházy, K. Kováts, L. Tőke: Unusually large reactivity differences in the transformation of cyclopropane lactones to 1-aminocyclopropane-1-phosphonic acids and their carboxylic acid analogues Heteroatom Chem. 12(2), 90-96 (2001)
72.
György M. Keserű, László Molnár: High throughput in silico prediction of bloodbrain partitioning: a thermodynamic approach. J. Chem. Inf. Comput. Sci. 41(1), 120-128 (2001)
73.
István Kolossváry, György M. Keserű: Hessian-Free Low Mode Conformational Search for Large Scale Protein Loop Optimization: Application to c-jun Nterminal kinase JNK3 J. Comp. Chem. 22(1), 21-30 (2001)
74.
Fogassy, K., Kovács, K, Keserű, G.M., Tőke, L., Faigl, F: Solvent and ligand effects on selective mono- and dilithiation of 1-(chlorophenyl)pyrroles and 1(methoxyphenyl)pyrrolesJ. Chem. Soc.-Perkin Trans. 1 (9) 1039-1043 (2001)
75.
Keserű, G. M.: A virtual high throughput screen for high affinity cytochrome P450cam substrates. Implications for in silico prediction of drug metabolism J. Comput.-Aided Mol. Des. 15(7), 649-657 (2001).
76.
Bitter, I., Török, Z., Csókai, V., Grün, A, Balázs, B., Tóth, G, Keserű, G. M., Kovári, Z, Czugler, M.: Synthesis and conformational analysis of dicationic N,N '-bridged bis(benzimidazolium) and bis(imidazolium) macrocycles Eur. J. Org. Chem. (15) 2861-2868 (2001).
77.
Ferenc Orosz, Judit Oláh, György M. Keserű, Beáta Szabó, Gábor Wágner, Zoltán Kovári, Margit Horányi, Klára Baróti, Joseph A. Martial, Susan Hollán, Judit Ovádi: Distinct Behavior of Mutant Triosephosphate Isomerase in Hemolysate and Isolated Form. Molecular Basis of Enzyme Deficiency. Blood 98(10), 3106-3112 (2001).
78.
György M. Keserű, István Kolossváry: Fully Flexible Low-Mode Docking: Application to Induced Fit in HIV Integrase J. Am. Chem. Soc. 123(50), 12708-12709 (2001)
79.
Kozsda-Kovács É., Keserű György M., Böcskei Zsolt, Szilágyi I., Simon K., Bertók B., Fogassy E.: Role of the solvent in optical resolution of transchrysanthemic acid via diastereomeric salt formation with (1R, 2R)-1-(4-nitrophenyl)-2-dimethylaminopropane-1,3-diol. J. Chem. Soc. Perkin Trans. 2, (1), 149-153 (2001)
80.
Karancsi-Menyhárd D., Keserű Gy. M., Náray-Szabó G.: Myoglobin Theoretical and Computational Chemistry, 9, 57-94. (2001)
81.
László Molnár, György M. Keserű: A Neural Network Based Virtual High Throughput Screening of Cytochrome P450 3A4 Inhibitors Bioorg. Med. Chem. Lett. 12(3), 419-421 (2002)
82.
György M. Keserű, László Molnár: METAPRINT: a Metabolic Fingerprint. Application to Casette Design in ADME HTS J. Chem. Inf. Comput. Sci. 42(2), 437-444 (2002)
83.
Oláh Judit, Orosz Ferenc, Keserű György Miklós, Kovári Zoltán, Kovács János, Susan
Hollán,
Ovádi
Judit:
Triosephosphate
isomerase
deficiency:
a
neurodegenerative misfolding disease Biochem Soc Trans 30(2), 30-38 (2002) 84.
Keserű G. M., Molnár L.: METAPRINT: a metabolikus ujjlenyomat Acta Pharm. Hung. 72(2), 92-100 (2002)
85.
Fernando Bernardi, Andrea Bottoni, Marco De Vivo, Marco Garavelli, György Keserű and Gábor Náray-Szabó: A hypothetical mechanism for HIV-1 integrase catalytic action: DFT modelling of a bio-mimetic environment Chem. Phys. Lett. 362(1-2), 1-7 (2002)
86.
Darvas F, Keserű G, Papp A, Dormán G, Ürge L, Krajcsi P.: In Silico and Ex silico ADME approaches for drug discovery. Curr. Top. Med. Chem. 2(12), 1287-1304 (2002)
87.
Éles J, Kalaus G, Greiner I, Kajtár-Peredy M, Szabó P, Keserű G. M., Szabó L, Szántay Cs. Synthesis of vinca alkaloids and related compounds. 100. Stereoselective oxidation reactions of compounds with the aspidospermane and quebrachamine ring system. First synthesis of some alkaloids containing the epoxy ring. J. Org. Chem. 67(21), 7255-7260 (2002)
88.
Faigl, F., Fogassy, K., Szűcs, E., Kovács, K., Tőke, L., Keserű, Gy. M., Harmat, V.,
Böcskei,
Z.:
Regioselective
[(trifluoromethyl)phenyl]pyrroles
[Az
metalation
reactions
of
1-
1-[trifluor-metil)fenil]pirrolok
regioszelektív metallálási reakciói] Magyar Kémiai Folyóirat, Kémiai Közlemények, 108(7), 317-324. (2002) 89.
Keserű Gy. M.: Structure/function/SAR and molecular design. Molecular Diversity, 7(1), 1. (2003)
90.
Lobell M, Molnar L, Keserű G. M.: Recent advances in the prediction of bloodbrain partitioning from molecular structure. J. Pharm. Sci. 92(2), 360-370 (2003)
91.
György M. Keserű: Prediction of hERG Potassium Channel Affinity by Traditional and Hologram QSAR Methods Bioorg. Med. Chem. Lett. 13(16), 2773-2775, (2003)
92.
Balogh György Tibor, Keserű György Miklós: Lehetőségek metalloporfirinek jelenlétében végzett biomimetikus oxidációk alkalmazására Acta Pharm. Hung. 73(3), 153-162 (2003)
93.
László Molnár, György M. Keserű, Ákos Papp, Zsolt Gulyás and Ferenc Darvas: A neural network based prediction of octanol–water partition coefficients using atomic5 fragmental descriptors Bioorg. Med. Chem. Lett. 14(4), 851-853 (2004)
94.
Wéber C, Bielik A, Szendrei G. I., Keserű G. M., Greiner I.: Solid-phase synthesis of an N-(phenylalkyl)cinnamide library via Horner-WadsworthEmmons reaction. Bioorg. Med. Chem. Lett. 14(5), 1279-1281 (2004)
95.
György T. Balogh, György M. Keserű: Metalloporphyrin mediated biomimetic oxidations. A useful tool for the investigation of cytochrome P450 catalyzed oxidative metabolism ARKIVOK (7), 124-139 (2004)
96.
András Bauer, Zoltán Kovári and György M. Keserű: Optimization of virtual screening protocols: FlexX based virtual screening for COX-2 inhibitors reveals the importance of tailoring screen parameters J. Mol. Struct. THEOCHEM 676(1-3), 1-5 (2004)
97.
Keserű György Miklós: A nagy áteresztőképességű tesztelés szerepe a gyógyszerkutatás korai stádiumában Acta Pharm. Hung. 74(1), 5-10 (2004)
98.
Greiner
István,
Keserű
György
Miklós,
Szombathelyi
Zsolt:
Nagy
áteresztőképességű módszerek a gyógyszerkutatásban Magy. Kém. Lapja 59, 208-213 (2004) 99.
Gizella Barta-Szalai, István Borza, Éva Bozó, Csilla Kiss, Béla Ágai, Ágnes Proszenyák, György M. Keserű, Anikó Gere, Sándor Kolok, Kornél Galgóczy, Csilla Horváth, Sándor Farkas and György Domány: Oxamides as novel NR2B selective NMDA receptor antagonists Bioorg. Med. Chem. Lett. 14(15), 3953-3956 (2004)
100.
Róbert Kiss, Zoltán Kovári, György M. Keserű: Homology modeling and binding site mapping of the human histamine H1 receptor Eur. J. Med. Chem. 39(11), 959-967 (2004)
101.
Baki Andrea, Bielik Attila, Molnár László, Keserű György Miklós: Tesztfejlesztés automatizált környezetben Biokémia 28, 89 (2004)
102.
György T. Balogh, Balázs Dalmadi, Attila Bielik, György M. Keserű: Identification of Nitric Oxide Donors by Biomimetic HTS Application Comb. Chem. & HTS 8(4), 347-352 (2005)
103.
Zsolt Bánki, Miklós Báthor, László Molnár, Attila Bielik and György M. Keserű: Scheduling
a
Flexible,
Open-Architecture
Robotic
Workstation
Under
LabWindows Journal of the Association for Laboratory Automation 10(3), 149-154 (2005) 104.
Polgár, T.; Keserű, G. M: Virtual Screening for -Secretase (BACE1) Inhibitors Reveals the Importance of Protonation States at Asp32 and Asp228 J. Med. Chem. 48(11), 3749-3755 (2005)
105.
István Virág, Tímea Polgár and György M. Keserű: Functional virtual screening of estrogen receptor α modulators by FlexX-Pharm Journal of Molecular Structure: THEOCHEM, 725(1-3), 239-242 (2005)
106.
Csaba Wéber, , Attila Bielik, Ádám Demeter, István Borza, Györgyi I. Szendrei, György M. Keserű and István Greiner: Solid-phase synthesis of 6-hydroxy-2,4diaminoquinazolines Tetrahedron 61(39), 9375-9380 (2005)
107.
D. Menyhárd, G. Keserű: Protonation state of Asp30 exerts crucial influence over surface loop rearrangements responsible for NO release in nitrophorin 4. FEBS Letters 579(24), 5392-5398 (2005)
108.
Keserű György Miklós: Szerkezet alapú szűrővizsgálatok a felfedező kutatásban Magyar Kémiai Folyóirat, 111, 159 (2005)
109.
Tímea Polgár, Andrea Baki, Györgyi I. Szendrei, and György M. Keserű: Comparative Virtual and Experimental High-Throughput Screening for Glycogen Synthase Kinase-3 Inhibitors J. Med. Chem. 48(25), 7946-7959 (2005)
110.
Molnár, L., Keseru, G.M., Papp, Á., Lorincz, Z., Ambrus, G., Darvas, F.: A neural network based classification scheme for cytotoxicity predictions: Validation on 30,000 compounds Bioorg. Med. Chem. Lett. 16(4), 1037-1039 (2006)
111.
Keserű, G.M., Makara, G.M. : Hit discovery and hit-to-lead approaches Drug Discovery Today 11(15-16), 741-748 (2006)
1th most downloaded paper between July-Sept 2006 from all articles appeared in 82 pharmaceutical science journals via ScienceDirect (http://top25.sciencedirect.com/subject/pharmacology-toxicology-andpharmaceutical-science/20/journal/drug-discoverytoday/13596446/archive/9/), 14th in Q4 2006, 20th in Q1 2007
Top Review by Editor’s Choice June 2007 and January 2008 (http://www.drugdiscoverytoday.com/echoice/jun2007/ and (http://www.drugdiscoverytoday.com/echoice/jan2008/)
112.
More than 5000 downloads via Sciencedirect during 2007
11th most cited paper of DDT in 2005-2006
Polgár, T., Keserű, G.M.: Ensemble docking into flexible active sites. Critical evaluation of FlexE against JNK-3 and β-secretase Journal of Chemical Information and Modeling 46(4), 1795-1805 (2006)
6th most accessed paper in Q3 2006 (http://pubs.acs.org/journals/jcisd8/promo/most/most_accessed/2006q 3.html)
113.
Dóra K. Menyhárd, György M. Keserű: Binding mode analysis of the NADH cofactor in nitric oxide reductase: A theoretical study Journal of Molecular Graphics and Modelling 25(3), 363-372 (2006)
114.
István Borza, Éva Bozó, Gizella Barta-Szalai, Csilla Kiss, Gábor Tárkányi, Ádám Demeter, Tamás Gáti, Viktor Háda, Sándor Kolok, Anikó Gere, László Fodor, József Nagy, Kornél Galgóczy, Ildikó Magdó, Béla Ágai, József Fetter, Ferenc Bertha, György M. Keserű, Csilla Horváth, Sándor Farkas, István Greiner, and György Domány: Selective NR1/2B N-Methyl-D-aspartate Receptor Antagonists among Indole-2-carboxamides and Benzimidazole-2-carboxamides Journal of Medicinal Chemistry 50(5), 901-914 (2007)
115.
Andrea Baki, Attila Bielik, László Molnár, Györgyi Szendrei, György M. Keserű: A High Throughput Luminescent Assay for Glycogen Synthase Kinase-3β Inhibitors ASSAY and Drug Development Technologies 5(1), 75-83 (2007)
116.
Tímea Polgár, György M. Keserű: Structure-Based Virtual Screening Frontiers in Drug Design & Discovery 3, 477 (2007)
117.
Balázs Balogh, Csaba Hetényi, György M. Keserű, Péter Mátyus: Structure-based calculation of binding affinities of alpha2A-adrenoreceptor agonists ChemMedChem, 2, 801 (2007)
118.
Polgár, T., Menyhárd, D.K., Keserű, G.M. Effective virtual screening protocol for CYP2C9 ligands using a screening site constructed from flurbiprofen and Swarfarin pockets Journal of Computer-Aided Molecular Design 21, 539 (2007)
119.
Éva Ágai-Csongor , Katalin Nógrádi, János Galambos, István Vágó, Attila Bielik, Ildikó Magdó, Györgyi Ignácz-Szendrei, György Miklós Keserű, István Greiner, István Laszlovszky, Éva Schmidt, Béla Kiss, Katalin Sághy, Judit Laszy, István Gyertyán, Mária Zájer-Balázs, Larisza Gémesi, György Domány: Novel Sulfonamides Having Dual Dopamine D2 and D3 Receptor Affinity Show In Vivo Antipsychotic Efficacy with Beneficial Cognitive and EPS Profile Bioorg. Med. Chem. Lett. 17, 5340 (2007).
120.
András Visegrády, András Boros, Zsolt Némethy, Béla Kiss, György M. Keserű: Application of the BD ACTOneTM technology for the high-throughput screening of Gs-coupled receptor antagonists J. Biomol. Screening 12, 1068 (2007)
121.
Polgár, T.; Magyar, C.; Simon, I.; Keserű, G. M. Impact of Ligand Protonation on Virtual Screening against -Secretase (BACE1) J. Chem. Inf. Model. 47, 2366 (2007)
122.
Róbert Kiss, Béla Noszál, Ákos Rácz, András Falus, Dániel Erős, György M. Keserű: Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor Eur. J. Med. Chem. 43, 1059 (2008)
123.
József Huszár, Zoltán Timár, Krisztina Katalin Szalai, György Keserű, Ferenc Fülöp and Botond Penke: Novel bradykinin-1 antagonists containing a (1,2,3,4tetrahydro-isoquinolin-1-yl)acetic acid scaffold Eur. J. Med. Chem. 43, 1552 (2008)
124.
Balázs Jójárt, Róbert Kiss,| Béla Viskolcz, and György M. Keserű: Activation Mechanism of the Human Histamine H4 Receptor - An Explicit Membrane Molecular Dynamics Simulation Study J. Chem. Inf. Model. 48, 1199 (2008)
125.
Róbert Kiss, Béla Kiss, Árpád Könczöl, Ferenc Szalai, Ivett Jelinek, Valéria László, Béla Noszál, András Falus, and György M. Keserű: Discovery of Novel Human Histamine H4 Receptor Ligands by Large-Scale Structure-Based Virtual Screening J. Med. Chem. 51, 3145 (2008)
126.
Mónika Vastag, György M, Keserű: Current in vitro and in silico models of blood-brain barrier penetration: A practical view Curr. Opin. Drug Disc. Dev. 12, 115 (2009)
127.
Róbert Kiss, György M. Keserű: Histamine H4 receptor ligands and their potential therapeutic applications Expert Opin. Ther. Patents 19, 119 (2009)
128.
György M. Keserű, Gergely M. Makara: The influence of lead discovery strategies on the properties of drug candidates Nature Rev. Drug Discov. 8, 203 (2009)
http://www.medicalonline.hu/cikk.php?id=3224 http://www.mta.hu/index.php?id=634&no_cache=1&backPid=390&tt_news=10521&c Hash=08e4c7c73f (MTA Hírlevél 10/2009 (03.12.)) http://www.mta.hu/index.php?id=858&no_cache=1&backPid=406&tt_news=10537&c Hash=0c6e764469 http://www.mgyt.hu/index.php?option=com_content&task=view&id=511&Itemid=6 http://practicalfragments.blogspot.com/2009/04/lelp-fragments-reach-theirpotential.html
129.
Keserű György Miklós, Kiss János Balázs: A felfedezői attitűd szerepe a gyógyszerkutatásban. Magyar Tudomány, 170, 415 (2009).
130.
József Huszár, Zoltán Timár, Ferenc Bogár, Botond Penke, Róbert Kiss, Krisztina Katalin Szalai, Éva Schmidt, Andrea Papp, György M. Keserű: Aspartic acid scaffold in bradykinin B1 antagonists J. Peptide Sci. 15, 423 (2009).
131.
Róbert Kiss, Tímea Polgár, Annet Kirabo, Jacqueline Sayyah, Nicholas C. Figueroa, Alan F. List, Lubomir Sokol, Kenneth S. Zuckerman, Meghanath Gali, Kirpal S. Bisht, Peter P. Sayeski, and György M. Keserű: Identification of a Novel Inhibitor of JAK2 Tyrosine Kinase by Structure-Based Virtual Screening Biorg. Med. Chem. Lett. 19, 3598-3601 (2009).
132.
György Szabó, Róbert Kiss, Dóra Páyer-Lengyel, Krisztina Vukics, Judit Szikra, Andrea Baki, László Molnár, János Fischer, György M. Keserű: Hit-to-lead Optimization of Pyrrolo[1,2-a]quinoxalines as Novel Cannabinoid Type 1 Receptor Antagonists Biorg. Med. Chem. Lett. 19, 3471-3475 (2009).
133.
György T. Balogh, Benjámin Gyarmati, Balázs Nagy, László Molnár and György M. Keserű: Comparative evaluation of in silico pKa prediction tools on the Gold Standard dataset QSAR & Comb. Sci. 28, 1148-1155 (2009)
134.
Dóra K. Menyhárd, György M. Keserű and Gábor Náray-Szabó: Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design Curr. Comp.-Aided Drug Des. 5, 264-279 (2009)
135.
Balázs Jójárt, Róbert Kiss, Béla Viskolcz, István Kolossváry, György M. Keserű: Molecular Dynamics Simulation at High Sodium Chloride Concentration: Toward the Inactive Conformation of the Human Adenosine A2A Receptor. J. Phys. Chem. Lett. 1, 1008-1013 (2010)
136.
Kiss, R., Sayeski, P.P., Keserű, G.M.: Recent developments on JAK2 inhibitors: A patent review. Exp. Opin. Ther. Pat. 20, 471-495 (2010)
137.
György M. Keserű: Lead finding strategies and optimization case studies 2009 Drugs of the Future 35, 143-153 (2010)
138.
Tarcsay, Á., Kiss, R., Keserű, G.M Site of metabolism prediction on cytochrome P450 2C9: A knowledge-based docking approach J. Comp.-Aided Mol. Des. 24, 399-408 (2010)
139.
Könczöl, A., Kéry, A., Keserű, G.M., Balogh, G.T.
LC Determination of
Peroxynitrite Scavenging Activity of Phenols from Salvia spp. Chromatographia 71, 51-59 (2010) 140.
Márk Sándor, Róbert Kiss and György M. Keserű: Virtual Fragment Docking by Glide: a Validation Study on 190 Protein−Fragment Complexes J. Chem. Inf. Model. 50, 1165–1172 (2010)
141.
3rd most read paper in Q2 2010
12th most read paper in Q3 2010
20th most read paper in the last 12 months (Q4 2010)
Wágner, G., Wéber, C., Nyéki, O., Nógrádi, K., Bielik, A., Molnár, L., Bobok, A., Horváth, A., Kiss, B., Kolok, S., Nagy, J., Kurkó, D., Gál, K., Greiner, I., Szombathelyi, Z., Keserű, G.M., Domány, G.
Hit-to-lead optimization of
disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs Bioorg. Med. Chem. Lett. 20, 3737–3741 (2010) 142.
János Galambos, Gábor Wágner, Katalin Nógrádi, Attila Bielik, László Molnár, Amrita Bobok, Attila Horváth, Béla Kiss, Sándor Kolok, József Nagy, Dalma Kurkó, Mónika L. Bakk, Mónika Vastag, Katalin Sághy, István Gyertyán, Krisztina Gál, István Greiner, Zsolt Szombathelyi, György M. Keserű, György Domány:
Carbamoyloximes
as
novel
non-competitive
mGlu5
receptor
antagonists Bioorg. Med. Chem. Lett. 20, 4371-4375 (2010) 143.
György G. Ferenczy, György M. Keserű: Enthalpic Efficiency of Ligand Binding J. Chem. Inf. Model. 50, 1536-1541 (2010)
10th most read paper in Q3 2010
4th most read paper in Q4 2010
20th most read paper in the last 12 months (Q4 2010)
15th most read paper in the last 12 months (Q1 2011)
8th most read paper in the last 12 months (Q2 2011)
144.
Majumder A, Govindasamy L, Magis A, Kiss R, Polgár T, Baskin R, Allan RW, Agbandje-McKenna M, Reuther GW, Keserű GM, Bisht KS, Sayeski PP.: Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core. J. Biol. Chem. 285, 31399-407 (2010)
145.
Ferenczy GG, Keserű GM: Thermodynamics guided lead discovery and optimization. Drug Discov Today 15, 919-932 (2010)
146.
Keynote review November 2010
Top Review by Editor’s Choice December 2010
10th most read paper in Q4 2010
Annet Kirabo, Jennifer Embury, Róbert Kiss, Tímea Polgár, Meghanath Gali, Anurima Majumder, Kirpal S. Bisht, Christopher R. Cogle, György M. Keserű and Peter P. Sayeski: The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F mediated human pathological cell growth in vitro and in vivo J. Biol. Chem. 286, 4280-91 (2011)
147.
Tarcsay, A., Keserű, G.M.: Homology modeling and binding site assessment of the human P-glycoprotein Future Medicinal Chemistry 3, 297-307 (2011)
148.
Tarcsay, A., Keserű, G.M.: In silico site of metabolism prediction of cytochrome P450-mediated biotransformations Exp. Opin. Drug Metab. Tox. 7, 299-312 (2011)
149.
Majumder, Anurima; Kirabo, Annet; Karrupiah, Kanchana; Tsuda, Shigeharu; Caldwell-Busby, Jennifer; Cardounel, Arturo; Keserű, M. György; Sayeski, Peter: Cell Death Induced by the Jak2 Inhibitor, G6, Correlates with Cleavage of Vimentin Filaments. Biochemistry 50, 7774-7786 (2011)
150.
Tímea Polgár, György M. Keserű: Integration of Virtual and High Throughput Screening in Lead Discovery Settings Comb. Chem. & HTS 14, 889-897 (2011)
151.
Árpád Könczöl, Zoltán Béni, Márta Meszlényi Sipos, Attila Rill, Viktor Háda, Judit Hohmann, Imre Máthé, Csaba Szántay Jr., György Miklós Keserű and György Tibor Balogh: Antioxidant activity-guided phytochemical investigation of Artemisia gmelinii Webb. ex Stechm.: Isolation and spectroscopic challenges of 3,5-O-dicaffeoyl (epi?) quinic acid and its ethyl este J. Pharm. Biomed. Anal. 59, 83– 89 (2012)
152.
Anurima Majumder, Andrew T. Magis, Sung O. Park, Nicholas C. Figueroa, Rebekah Baskin, Annet Kirabo, Robert W. Allan, Zhizhuang Joe Zhao, Kirpal S. Bisht, György M. Keserű, Peter P. Sayeski: A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth Experimental Hematology 40, 22-34(2012)
153.
Róbert Kiss, Márk Sándor, Anikó Gere, Éva Schmidt, György T. Balogh, Béla Kiss, László Molnár, Christian Lemmen, and György M. Keserű: Discovery of Novel Histamine H4 and Serotonin Transporter Ligands Using the Topological Feature Tree Descriptor J. Chem. Inf. Model. 52, 233-242 (2012)
154.
Rebekah Baskin, Meghanath Gali, Sung O. Park, Zhizhuang Joe Zhao, György M. Keserű, Kirpal S. Bisht, and Peter P. Sayeski: Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the parahydroxyl orientation Bioorg. Med. Chem. Lett. 22, 1402-1407 (2012)
155.
Ákos Tarcsay, Kinga Nyíri and György M. Keserű: The Impact of Lipophilic Efficiency on Compound Quality J. Med. Chem. 55, 1252–1260 (2012) Recommended by the Faculty of 1000 (F1000) Biology and Medicine 2nd most read paper in Q1 2012
156.
Róbert Kiss, György M. Keserű: Histamine H4 receptor ligands and their potential therapeutic applications: an update Expert Opin. Ther. Patents 22, 205-21 (2012)
157.
János Éles, Gyula Beke, István Vágó, Éva Bozó, József Huszár, Ákos Tarcsay, Sándor Kolok, Éva Schmidt, Mónika Vastag, Katalin Hornok, Sándor Farkas, György Domány, György M. Keserű:Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists Bioorg. Med. Chem. Lett. 22, 3095–3099 (2012)
158.
Éva Ágai-Csongor, György Domány, Katalin Nógrádi, János Galambos, István Vágó, György M. Keserű, István Greiner, István Laszlovszky, Anikó Gere, Éva Schmidt, Béla Kiss, Mónika Vastag, Károly Tihanyi, Katalin Sághy, Judit Laszy, István Gyertyán, Mária Zájer-Balázs, Larisza Gémesi, Margit Kapás, Zsolt Szombathelyi: Discovery of Cariprazine (RGH-188): a Novel Antipsychotic Acting on Dopamine D3/D2 Receptors Bioorg. Med. Chem. Lett. 22, 3437-3440 (2012)
159.
György G. Ferenczy, György M. Keserű: Thermodynamics of Fragment Binding J. Chem Inf. Mod. 52, 1039–1045 (2012)
160.
Michael M. Hann, György M. Keserű: Finding the sweet spot:the role of nature and nurture in medicinal chemistry Nature Rev. Drug Discov. 11, 355-365 (2012) Recommended by the Faculty of 1000 (F1000) Biology and Medicine
161.
Vass, M., Tarcsay, A., Keserű, G.M.: Multiple ligand docking by Glide: implications for virtual second-site screening J. Comp-Aided Mol. Design 26, 821-834 (2012)
162.
Annet Kirabo, Sung O. Park, Heather L. Wamsley, Meghanath Gali, Rebekah Baskin, Mary K. Reinhard, Zhizhuang J. Zhao, Kirpal S. Bisht, György M. Keserű, Christopher R. Cogle, Peter P. Sayeski: The Small Molecule Inhibitor G6 Significantly Reduces Bone Marrow Fibrosis and the Mutant Burden in a Mouse Model of Jak2-Mediated Myelofibrosis The Am. J. Pathol. 181, 858–865 (2012)
Books and book chapters
1.
Csonka Gábor, Keserű György Miklós: Molekulamodellezés Shell Chemicals, Budapest, (1993)
2.
György M. Keserű and Mihály Nógrádi: The Chemistry of Diarylheptanoids in Studies on Natural Products Chemistry (Ed.: Atta-Ur-Rahman) Vol. 17, pp. 357 (1995) Elsevier, The Netherlands.
3.
Keserű György Miklós, Náray-Szabó Gábor: Molekulamechanika A kémia újabb eredményei 80., Akadémiai Kiadó, Budapest, (1995)
4.
György M. Keserű and Mihály Nógrádi: Natural Products by Oxidative Phenolic Coupling, Phytochemsitry, Biochemistry, Synthesis in Studies on Natural Products Chemistry (Ed.: Atta-Ur-Rahman) Vol. 20, pp. 263-322 (1998) Elsevier, The Netherlands.
5.
György M. Keserű and István Kolossváry: Molecular Mechanics and Conformational Analysis in Drug Design Blackwell Science, Oxford, UK (1999)
Amazon #26 Best Seller in Molecular Pharmacology 6.
Dóra K. Menyhárd, György M. Keserű, Gábor Náray-Szabó: Myoglobin in Theoretical Biohemistry (Ed.: L. A. Eriksson) (2001) Elsevier, The Netherlands.
7.
György M. Keserű, Ildikó Magdó, Gábor Náray-Szabó: Introduction to Structure and Ligand Based Drug Design In: Molecular Pathomechanism and New Trends in Drug Research. (Eds.: Gy Kéri and I Tóth) (2003) Taylor and Francis Group, London and New York.
8.
György M. Keserű, Zoltán Kovári: In silico chemical genomics in Chemical Genomics (Edited by: Ferenc Darvas; Andras Guttman; Gyorgy Dorman) (2004) Marcel Dekker, New York, USA
9.
Tímea Polgár, György M. Keserű: Virtual Screening in Encyclopedia of Pharmaceutical Technology (Edited by: James Swarbrick and James C. Boylan) (2005) Taylor and Francis Group, London and New York.
10.
Keserű
György Miklós,
Kolossváry István:
Bevezetés a számítógépes
gyógyszertervezésbe (MTA Nívódíj, Academy Award) A kémia újabb eredményei 96., Akadémiai Kiadó, Budapest, (2006)
Tímea Polgár, György M. Keserű: Virtual and Experimental High Throughput
11.
Screening on Kinase Targets. in Drug Design and Discovery for Developing Countries, Ed(s): E. Megnassan, L. Owono, S. Miertus, ICS-UNIDO, Trieste, Italy, 2009. Róbert Kiss and György M. Keserű: Virtual Screening on Homology Models
12.
in Virtual Screening. Principles, Challenges, and Practical Guidelines. Sotriffer, Christoph (Ed.) Wiley-VCH, Weinheim, 2011 László Molnár and György M. Keserű: Recent advances in ADME predictions. in
13.
Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates (K. Tihanyi, M. Vastag Eds.) Bentham Science, 2011. e-book: eISBN: 978-1-60805120-5. Keserű György Miklós (szerk.) A gyógyszerkutatás kémiája, Akadémiai Kiadó,
14.
Budapest, 2011
Invited lectures (2007-)
1.
György M. Keserű: ADME Properties Prediction in Drug Discovery. ICS UNIDO Training Course on Molecular Design and Computer-assisted Combinatorial Chemistry, 9-12 July 2007, Trieste, Italy
2.
György M. Keserű: Virtual and experimental high throughput screening are complementary. EuroCombi 4, 15 - 18 July 2007, Florence, Italy
3.
György M. Keserű: Predictive models of CNS penetration. ADMET (2008) A Focus on Drug Discovery, 2-3 July 2008, London, UK
4.
György M. Keserű: Virtual and experimental high throughput screening on kinase targets. International Conference on "Drug Design and Discovery for Developing Countries" ICS-UNIDO, 3-5 July 2008, Trieste, Italy
5.
György M. Keserű: ADME Properties Prediction in Drug Discovery. ICS UNIDO Training Course on Molecular Design and Computer-assisted Combinatorial Chemistry, 8-12 June 2009, Trieste, Italy
6.
György M. Keserű: The impact of lead discovery strategies on the quality of leads. Highlighted lecture. IQPC Optimised Lead Discovery Conference, July 6 - 8, 2009, Berlin, Germany.
7.
György M. Keserű: Oxadiazoles and Tetrazoles as Negative Modulators of Metabotropic Glutamate 5 Receptor Subtype13th Blue Danube Symposium on Heterocyclic Chemistry, 20-23 Spetember, 2009, Bled, Slovenia.
8.
György M. Keserű: The Impact of Lead Discovery Strategies on Lead Quality. 5th Annual Modern Drug Discovery & Development Summit, Oct 14-16, 2009, San Diego, USA
9.
György M. Keserű: Virtual Fragment Screening by Glide. Screening Europe, February 11-12, 2010, Barcelona, Spain
10.
György M. Keserű: The Impact of Fragment Optimization on Lead Quality. MedChem Europe, April 8-9, Munich, Germany
11.
György M. Keserű: Virtual Screening and HTS Are Complementary. SMI HTS Conference, April 26-27, 2010, London, UK
12.
Advances amd progress in Drug Design, SMI, February 22-23, 2011, London, UK
13.
Drug Metabolism Discussion Group ADME workshop, March 19, 2011, Budapest, Hungary
14.
MedChem Europe, April 8-9, 2011, Munich, Germany
15.
7th Joint Meeting on Medicinal Chemistry, June 29- July 2, 2011, Catania, Italy
16.
MIPTEC Conference, September 21-23, 2011, Basel, Switzerland
17.
CECAM workshop on Structure Based Drug Design, October 3-6, Lausanne, Switzerland, 2011
18.
Discovery Chemistry Congress, March 13-14, Munich 2012
19.
12th PhysChem Forum, April 19, Budapest, 2012
20.
30th Camerino-Cyprus-Noordwijkerhout Symposium, Amsterdam, May 1418, 2012
21.
Medicinal Chemistry Symposium, American Chemical Society, 2012 Philadelphia
22.
Society of Chemistry and Industry, SCI, 2012 London
23.
SMI Conference: Advances and Progress in Drug Design, February 18-19, London, 2013
24.
EFMC short course on Molecular Recognition, April 21-24, Leiden, 2013
25.
Structure Based Drug Design workshop, May 24-26, Barcelona, Spain, 2013
26.
CECAM workshop on Structure Based Drug Design, October 5-8, Lausanne, Switzerland, 2013
Patents and patent applications 1.
New sulfonamide derivatives as D3 receptor agonsits EP 02765129
2.
Piperidine derivatives as NMDA receptor antagonists EP 02753161
3.
Process and making isomers of Norelgestromin and method using the same HU 0301981
4.
New compounds (mGluR5) tetrazoles HU P05 00921
5.
New compounds (mGluR5) oxadiazols HU P05 00921
6.
New phenylsulfamoyl benzamide derivatives as bradykinin antagonists HU P0500431
7.
Idegrendszeri megbetegedések gyógyítására alkalmas új béta-szekretáz gátlóvegyületek és azokat tartalmazó gyógyászati készítmények HU P0501153
8.
New compounds (mGluR5) carbomoyloximes HU P05 01163
9.
New compounds (mGluR5) arylsulfonyl HU P05 01165
10.
New compounds (mGluR5) tienopyridine HU P05 01166
11.
New compounds (mGluR5) tienopyridine HU P05 01168
12.
New compounds (mGluR5) tienopyridine HU P05 01170
13.
New compounds (mGluR5) tienopyridine HU P05 01171
14.
NEW SULFONAMIDE DERIVATES AS BRADYKININ ANTAGONISTS HU
15.
NEW PHENYLSULFAMOYL BENZAMIDE DERIVATES AS BRADYKININ ANTAGONIST
P06 00810
HU P06 00809 16.
NEW BENZAMIDE DERIVATES AS BRADYKININ ANTAGONISTS
17.
SULFONYL-QUINOLINE DERIVATIVES HU P07 00417
18.
KINASE INHIBITOR COMPOUNDS US 60/933,449
19.
KINASE INHIBITOR COMPOUNDS US 12/663,521
20.
BENZOTRIAZOLE
DERIVATIVES
AS
HU P06 00808
POSITIVE
ALLOSTERIC
MODULATORS OF MGLUR2 RECEPTORS T 2011-10 (13.892) U.S. Serial Number 61/512,650
21.
BENZO-IMIDAZO-PYRAZINE/PYRAZINONE
DERIVATIVES
AS
POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS T 2011-09 (13.891) U.S. Serial Number 61/512,645
