2014 Onkologie

ACTA MEDICINAE 8/2014 Onkologie Kompletní literatura 2

Predikce incidence a prevalence nádorových onemocnění a počtu léčených onkologických pacientů v ČR v letech 2015 a 2020

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Predikce počtu pacientů indikovaných k vyšetření PET/CT v ČR: první výsledky projektu PET/CT-CZ(Q)

3

Doporučení pro léčbu sarkomů měkkých tkání Evropské společnosti klinické onkologie, ESMO

3

Novinky v hormonální léčbě karcinomu prsu před a po ASCO 2014

3

Antracykliny v první linii léčby karcinomu prsu mohou být účinnější, než si myslíme – kazuistika

4

Nemalobuněčný karcinom plic – novinky v léčbě

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Nemalobuněčný karcinom plic s přestavbou genu EML4-ALK – nové možnosti léčby

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Možnosti systémové léčby gastroenteropankreatických neuroendokrinních tumorů

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Gastrointestinální stromální tumor – základní algoritmus diagnostiky a léčby

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Výběr optimální sekvence v léčbě metastatického renálního karcinomu

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Karcinom ovaria – současnost a novinky v léčbě

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Stanovení strategie léčby u metastatického melanomu

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Role parenterální výživy v podpůrné onkologické léčbě – nový pohled

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Novinky v léčbě průlomové bolesti

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Qutenza v léčbě chemoterapií indukované polyneuropatie

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HPV infekce u mužů

doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha RNDr. Tomáš Pavlík, Ph.D. | RNDr. Ondřej Májek, Ph.D. | Mgr. Jakub Gregor, Ph.D. IBA, LF MU, Brno RNDr. Jan Mužík, Ph.D. IBA, LF MU, Brno, ÚZIS ČR, Praha RNDr. Denisa Malúšková | Mgr. Jana Koptíková, Ph.D. | Mgr. Zbyněk Bortlíček IBA, LF MU, Brno prof. MUDr. Jitka Abrahámová, DrSc. Thomayerova nemocnice, Praha doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha prof. MUDr. Jiří Petera, Ph.D. | doc. MUDr. Jiří Doležal, Ph.D. Fakultní nemocnice Hradec Králové prof. MUDr. Vlastimil Válek, CSc. Fakultní nemocnice Brno RNDr. Tomáš Pavlík, Ph.D. | RNDr. Ondřej Májek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno Mgr. Michal Burger Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha Mgr. Jakub Gregor, Ph.D. | Mgr. Jana Koptíková, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno RNDr. Jan Mužík, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha MUDr. Kateřina Kubáčková Onkologická klinika 2. LF UK a FN Motol, Praha

prof. MUDr. Luboš Petruželka, CSc. | MUDr. Zuzana Ušiaková | MUDr. Michal Vočka | MUDr. Lucie Hussarová Onkologická klinika 1. LF UK a VFN v Praze a Ústřední vojenská nemocnice – Vojenská fakultní nemocnice Praha, Ústav radiační onkologie Nemocnice Na Bulovce v Praze doc. MUDr. Petra Tesařová, CSc. Onkologická klinika 1. LF UK a VFN v Praze

prof. MUDr. Jana Skřičková, CSc. | MUDr. Ondřej Venclíček | MUDr. Bohdan Kadlec, Ph.D. | MUDr. Marcela Tomíšková | MUDr. Lenka Jakubíková, Ph.D. | Jana Špaldová Klinika nemocí plicních a tuberkulózy LF MU a FN Brno prof. MUDr. Miloš Pešek, CSc. Klinika tuberkulózy a respiračních nemocí FN Plzeň prof. Dr. med. Michael Hilker, FETCS Universitätsklinikum Regensburg, Německo RNDr. Petr Grossmann FN Plzeň, Šiklův patologicko-anatomický ústav Plzeň

MUDr. Jiří Tomášek, Ph.D. Klinika komplexní onkologické péče MOÚ Brno, LF MU, Brno MUDr. Zdeněk Linke Onkologická klinika FN Motol a 2. LF UK, Praha MUDr. Hana Študentová Onkologická klinika FN Olomouc

MUDr. Josef Chovanec, Ph.D. Oddělení gynekologické onkologie, MOÚ Brno MUDr. Eugen Kubala Klinika onkologie a radioterapie LF UK a FN Hradec Králové MUDr. Petr Beneš Interní oddělení, Nemocnice Na Homolce, Praha

MUDr. Marek Hakl, Ph.D. Centrum pro léčbu bolesti ARK LF MU a FN u sv. Anny v Brně MUDr. Marek Hakl, Ph.D. Centrum pro léčbu bolesti ARK LF MU a FN u sv. Anny v Brně doc. MUDr. Tomáš Fait, Ph.D. Gynekologicko-porodnická klinika 1. LF UK a VFN Praha

Predikce incidence a prevalence nádorových onemocnění a počtu léčených onkologických pacientů v ČR v letech 2015 a 2020 doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha RNDr. Tomáš Pavlík, Ph.D. | RNDr. Ondřej Májek, Ph.D. | Mgr. Jakub Gregor, Ph.D. IBA, LF MU, Brno RNDr. Jan Mužík, Ph.D. IBA, LF MU, Brno, ÚZIS ČR, Praha RNDr. Denisa Malúšková | Mgr. Jana Koptíková, Ph.D. | Mgr. Zbyněk Bortlíček IBA, LF MU, Brno prof. MUDr. Jitka Abrahámová, DrSc. Thomayerova nemocnice, Praha 1 Curado, M. P. – Edwards, B. – Shin, H. R., et al. (eds.): Cancer incidence in five continents, roč. IX. IARC Scientific Publications č. 160. International Agency for Research on Cancer, Lyon, 2007, vyhledáno 8. 5. 2014, dostupné z: http://ci5.iarc.fr. 2 Ferlay, J. – Soerjomataram, I. – Ervik, M., et al.: GLOBOCAN 2012 v1.0, cancer incidence and mortality eorldwide: IARC CancerBase č. 11 [internet]. International agency for research on cancer, Lyon, 2013. Vyhledáno 5. 6. 2014, dostupné z: http://globocan.iarc.fr. 3 Dušek, L. – Mužík, J. – Kubásek, M., et al.: Epidemiology of malignant

tumors in the Czech Republic [internet]. Masaryk University, Brno, 2005, vyhledáno 8. 5. 2014, dostupné z: http://www.svod.cz. 4 Clerc, L. – Jooste, V. – Lejeune, C., et al.: Cost of care of colorectal cancers according to health care patterns and stage at diagnosis in France. Eur J Health Econ, 2008, 9, s. 361–367. 5 Pavlík, T. – Májek, O. – Mužík, J., et al.: Estimating the number of colorectal cancer patients treated with anti-tumour therapy in 2015: the analysis of the Czech National Cancer Registry. BMC Public Health, 2012, 12, s. 117.

6 Maddams, J. – Utley, M. – Miller, H.: Projections of cancer prevalence in the United Kingdom, 2010–2040. Br J Cancer, 2012, 107, s. 1195–1202. 7 Mariotto, A. B. – Yabroff, K. R. – Sbal, Y., et al.: Projections of the cost of cancer care in the United States: 2010–2020. J Natl Cancer Inst, 2011, 103, s. 117–128. 8 Travis, L. B.: The epidemiology of second primary cancers. Cancer Epidemiol Biomarkers Prev, 2006, 15, s. 2020–2026.

Predikce počtu pacientů indikovaných k vyšetření PET/CT v ČR: první výsledky projektu PET/CT-CZ(Q) doc. RNDr. Ladislav Dušek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha prof. MUDr. Jiří Petera, Ph.D. | doc. MUDr. Jiří Doležal, Ph.D. Fakultní nemocnice Hradec Králové prof. MUDr. Vlastimil Válek, CSc. Fakultní nemocnice Brno RNDr. Tomáš Pavlík, Ph.D. | RNDr. Ondřej Májek, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno Mgr. Michal Burger Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha Mgr. Jakub Gregor, Ph.D. | Mgr. Jana Koptíková, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno RNDr. Jan Mužík, Ph.D. Institut biostatistiky a analýz, Lékařská fakulta Masarykovy univerzity, Brno, Ústav zdravotnických informací a statistiky ČR, Praha 1 Dušek, L. – Mužík, J. – Kubásek, M. – Koptíková, J. – Žaloudík, J. – Vyzula R.: SVOD.cz – Epidemiologie zhoubných nádorů v České republice (internetová stránka). Masarykova univerzita, 2007, vyhledáno 3. 7. 2014, dostupné na www.svod.cz. 2 Ferlay, J. – Autier, P. – Boniol, M. – Heanue, M. – Colombet, M. – Boyle, P.: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol, 2007, 18, s. 581–592. 3 Ferlay, J. – Steliarova-Foucher, E. – Lortet-Tieulent, J. – Rosso, S. – Coebergh, J. W. – Comber, H., et al.: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer, 2013, 49, s. 1374–1403. 4 Dyba, T. – Hakulinen, T.: Comparison of different approaches to incidence prediction based on simple interpolation techniques. Stat Med, 2000, 19, s. 1741–1752. 5 Verdecchia, A. – De Angelis, G. – Capocaccia, R.: Estimation and projections of cancer prevalence from cancer registry data. Stat Med, 2002, 21, s. 3511–3526.

6 De Angelis, R. – Sant, M. – Coleman, M. P. – Francisci, S. – Baili, P. – Pierannunzio, D., et al.: Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5-a population-based study. Lancet Oncol, 2014, 15, s. 23–34. 7 Warren, J. L. – Klabunde, C. N. – Schrag, D. – Bach, P. B. – Riley, G. F.: Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population. Med Care, 2002, 40 (dopl.), s. IV-3-18. 8 Czernin, J. – Allen-Auerbach, M. – Schelbert, H. R.: Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006. J Nucl Med, 2007, 48, dopl. 1, s. 78S-88S. 9 Czernin, J. – Allen-Auerbach, M. – Nathanson, D. – Herrmann, K.: PET/CT in Oncology: Current Status and Perspectives. Curr Radiol Rep, 2013, 1, s. 177–190. 10 Farwell, M. D. – Pryma, D. A. – Mankoff, D. A.: PET/CT imaging in cancer: Current applications and future directions. Cancer, 19. 6. 2014. 11 Umbehr, M. H. – Muntener, M. – Hany, T. – Sulser, T. – Bachmann, L.

M.: The role of 11C-choline and 18F-fluorocholine positron emission tomography (PET) and PET/CT in prostate cancer: a systematic review and meta-analysis. Eur Urol, 2013, 64, s. 106–117. 12 Ferda, J. – Kastner, J. – Ferdová, E. – Mírka, H. – Hora, M. – Hes, O., et al.: Zobrazení karcinomu prostaty na molekulární úrovni – naše zkušenosti. Ces Radiol, 2012, 66, s. 289–295. 13 Dusek, L., et al.: Czech cancer care in numbers 2008–2009. Praha, Grada Publishing, 2009. 14 Blaha, M. – Janča, D. – Klika, P. – Mužík, J. – Dušek, L.: Project I-COP – architecture of software tool for decision support in oncology. In: Blobel, B. – Hasman, A. – Zvárová, J. (eds.): Data and knowledge for medical decision support: Proceedings of the EFMI special topic conference, 17-19 April 2013, Prague, Czech Republic: IOS Press; 2013. 15 Pavlík, T. – Májek, O. – Mužík, J., et al.: Estimating the number of colorectal cancer patients treated with anti-tumour therapy in 2015: the analysis of the Czech National Cancer Registry. BMC Public Health, 2012, 12, s. 117.

ACTA MEDICINAE 8/2014 ONKOLOGIE Kompletní literatura

Doporučení pro léčbu sarkomů měkkých tkání Evropské společnosti klinické onkologie, ESMO MUDr. Kateřina Kubáčková Onkologická klinika 2. LF UK a FN Motol, Praha 1 ESMO/European Sarcomas Network Working Group. Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 2012, 23 (7), s. vii92–vii99.

Novinky v hormonální léčbě karcinomu prsu před a po ASCO 2014 prof. MUDr. Luboš Petruželka, CSc. | MUDr. Zuzana Ušiaková | MUDr. Michal Vočka | MUDr. Lucie Hussarová Onkologická klinika 1. LF UK a VFN v Praze a Ústřední vojenská nemocnice – Vojenská fakultní nemocnice Praha, Ústav radiační onkologie Nemocnice Na Bulovce v Praze 1 ASCO Annual Meeting Abstracts, 30. května – 3. června 2014. 2 Bachelot, T., et al.: Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. J Clin Oncol, 2012, 30, s. 2718–2724. 3 Baselga, J., et al.: Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med, 2012. 4 Di Leo, A. – Jerusalem, G. – Petruzelka, L., et al.: Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. J Clin Oncol, 2010. 5 Jones, S. E., et al.: Randomized phase III study of docetaxel compared with paclitaxel in metastatic breast cancer. J Clin Oncol, 2005. 6 Kaufman, B., et al.: Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study. J Clin Oncol, 2009. 7 Ellis, M. J., et al.: Whole-genome analysis informs breast cancer res ponse to aromatase inhibition. Nature, 2012. 8 Finek, J. – Petruželka, L., et al.: První česko-moravský konsensus hormonální léčby karcinomu prsu. 2014 (v přípravě k tisku). 9 Finn, R. S., et al.: PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res, 2009. 10 Finn, R. S., et al.: Final results of a randomized Phase II study of PD 0332991, a cyclin-dependent kinase (CDK)-4/6 inhibitor, in combination with letrozole vs. letrozole alone for first-line treatment of ER+/ HER2- advanced breast cancer (PALOMA-1; TRIO-18). AACR, abstrakt CT101, 2014. 11 Giordano, S. H., et al.: Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology Clinical Practice Guideline.

J Clin Oncol, 2014. 12 Hober, J., et al.: Higher efficacy of letrozole in combination with tras tuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer—results of the eLEcTRA trial. Breast, 2012. 13 Jerusalem, G., et al.: Safety analysis of BOLERO-3: a phase 3 trial of daily everolimus (EVE) vs. placebo (PBO), both with weekly trastuzumab (TRAS) and vinorelbine in trastuzumab-resistant, advanced breast cancer. San Antonio Breast Cancer Symposium; abstrakt S2-02, 2013. 14 Lee, A. V. – Davidson, N. E.: Genomics, drug approval, and optimal treatment duration. Nat Rev Clin Oncol, 2014. 15 Martin, M., et al.: S1-7. Phase III trial evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for advanced breast cancer—First efficacy results from the LEA study. Cancer Res, 2012. 16 Montemurro, M., et al.: Humen epidermal growth factor receptor 2 (HER2) positive and hormone receptor-positive breast cancer: new insights into molecular interactions and clinical implications. Ann Oncol, 2013. 17 Palmieri, C., et al.: Breast cancer: Current and future endocrine therapies. Molecular and Cellular Endocrinology, 2014. 18 Petruželka, L. – Vočka, M. – Matějů, M.: Metastazující hormonálně dependentní karcinomy prsu – doporučené postupy nebo jen obecné léčebné principy ve světle nových poznatků? 2014. 19 Piccart, M., et al.: Everolimus for postmenopausal women with advanced breast cancer: updated results of the BOLERO-2 phase III trial [abstrakt 559]. J Clin Oncol, 2012. 20 Piccart, M., et al.: Everolimus plus exemestane for hormone receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2-) advanced breast cancer (BC): overall survival results from BOLERO-2. Přednáška, abstrakt LBA1. European Breast Cancer Conference (EBCC-9), 2014. 21 Swain, S. M., et al.: Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival

results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol, 2013. 22 Seidman, A. D., et al.: Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: Final results of Cancer and Leukemia Group B protocol 9840. J Clin Oncol, 2008. 23 Schwartzberg, L. S., et al.: Lapatinib plus letrozole as first-line therapy for HER-2+ hormone receptor-positive metastatic breast cancer. Oncologist, 2010. 24 Yardley, D. A., et al.: Results of ENCORE 301, a randomized, phase II, double-blind, placebo-controlled study of exemestane with or with out entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive (ER+) breast cancer progres sing on a nonsteroidal aromatase inhibitor (AI). J Clin Oncol, 2013. 25 Yardley, D. A., et al.: Hormonal therapy plus bevacizumab in postmenopausal patients who have hormone receptor-positive metastatic breast cancer: a phase II Trial of the Sarah Cannon Oncology Research Consortium. Clin Breast Cancer, 2011. 26 Moore, H. C. F.: abstrakt LBA505, prezentováno na ASCO Annual Meeting, 30. 5. – 3. 6. 2014, Chicago. 27 Pagani, O. – Regan, M. M. – Walley, B. – Fleming, G. F. – Colleoni, M. – Lang, I. – Gomez, H. L. – Tondini, C. – Burstein, H. J., et al.: Randomized comparison of adjuvant aromatase inhibitor (AI) exemestane (E) plus ovarian function suppression (OFS) vs tamoxifen (T) plus OFS in premenopausal women with hormone receptor-positive (HR+) early breast cancer (BC): Joint analysis of IBCSG TEXT and SOFT trials. J Clin Oncol, 2014, 32, abstrakt LBA1. 28 Piccart, M.: abstrakt LBA9200, prezentováno na ASCO Annual Meeting, 30. 5. – 3. 6. 2014, Chicago. 29 Hortobagyi, G. N.: abstrakt LBA9500, prezentováno na ASCO Annual Meeting, 30. 5. – 3. 6. 2014, Chicago.

Antracykliny v první linii léčby karcinomu prsu mohou být účinnější, než si myslíme – kazuistika doc. MUDr. Petra Tesařová, CSc. Onkologická klinika 1. LF UK a VFN v Praze 1 Gennari, A. – D’Amico, M.: Anthracyclines in the management of metastatic breastcancer: state of the art. EJC supplements 9, 2011, 2, s. 11–15. 2 Rivera, E.: Liposomal anthracyclines in metastatic breast cancer: clinical update. Oncologist, 2003, 8, dopl. 2, s. 3–9.

3 Gennari, A. – Piccininno, M. – Sarti, S.: The role of liposomal anthracyclines in metastatic breast cancer. Current Breast Cancer Reports, 2013, 5, s. 23–30. 4 Doval, D. C. – Dutta, K. – Batra, U. – Talwar, V.: Neoadjuvant chemotherapy in breast cancer: review of literature. J Indian Med Assoc, 2013,

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Nemalobuněčný karcinom plic – novinky v léčbě prof. MUDr. Jana Skřičková, CSc. | MUDr. Ondřej Venclíček | MUDr. Bohdan Kadlec, Ph.D. | MUDr. Marcela Tomíšková | MUDr. Lenka Jakubíková, Ph.D. | Jana Špaldová Klinika nemocí plicních a tuberkulózy LF MU a FN Brno 1 Dušek, L. – Májek, O. – Mužík, J. – Kostíková, J. – Pavlík, T. – Skřičková, J.: Epidemiologie zhoubných nádorů plic, průdušnice a průdušek v ČR. In: Skřičková, J. – Kolek, V., et al.: Základy moderní pneumoonkologie. Maxdorf, Praha, 2012. 2 Giroux, D. J. – Rami-Porta, R. – Chansky, K., et al.: The IASLC Lung Cancer Staging Project: data elements for the prospective project. J Thorac Oncol, 2009, 4, s. 679–83. 3 Pešek, M.: Nemalobuněčný karcinom plic. EUNI, dostupné z: http:// www.euni.cz/tema.php?, vyhledáno 22. 9. 2014. 4 Škarda, J. – Überall, I. – Tichý, T. – Matěj, R.: Novinky v klasifikaci adenokarcinomů plic a potenciální prognostické a prediktivní faktory u nemalobuněčných plicních karcinomů. Cesk Patol, 2011, 47, s. 168–172. 5 Travis, W. D. – Brambilla, E. – Noguchi, M., et al.: International associa tion for the study of lung cancer / american thoracic society / european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol, 2011, 6, s. 244–285. 6 Skřičková, J. – Kolek, V., et al.: Základy moderní pneumoonkologie. Maxdorf, Praha, 2012. 7 Paz-Ares, L. – de Marinis, F., et al.: Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial. Lancet Oncol, 2012, 13, s. 247–255. 8 Lunch, T. J. – Bell, D. W. – Sordella, R., et al.: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med, 2004, 350, s. 2129–2139. 9 Bonomi, P.: Clinical studies with non-iressa EGFR tyrosine kinase inhibitors. Lung Cancer, 2003, 41, s. S43–S48. 10 Duffield, E. L. – Watkins, C. L. – Armour, A. A. – Fukuoka, M.: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. New England Journal of Medicine, 2009, 361, s. 947–957. 11 Kim, E. S. – Hirsch, V. – Mok, T., et al.: Gefitinib versus docetaxel in previously treated non-small-cell lung cancer: a randomised Phase III trial (INTEREST). Lancet, 2008, 372, s. 1809–1818.

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Možnosti systémové léčby gastroenteropankreatických neuroendokrinních tumorů MUDr. Jiří Tomášek, Ph.D. Klinika komplexní onkologické péče MOÚ Brno, LF MU, Brno 1 Yao, J. C. – Hassan, M. – Phan, A., et al.: One hundred years after „carcinoid“: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol, 2008, 26, s. 3063–3072. 2 Rinke, A. – Miller, H. H. – Schade-Brittinger, C., et al.: Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patiens with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol, 2009, 27, s. 4656–4663. 3 Caplin, M. – Ruszniewski, P. – Pavel, M., et al.: A randomized, double-blind, placebo-controlled study of Lanreotide Antiproliferative

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Gastrointestinální stromální tumor – základní algoritmus diagnostiky a léčby MUDr. Zdeněk Linke Onkologická klinika FN Motol a 2. LF UK, Praha 1 Blanke, C. – Demetri, G., et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. NEJM, 2002, 347, s. 472–480. 2 Verweij, J. – Casali, P. G. – Zalcberg, J. – Le Cesne, A. – Reichardt, P. – Blay, J. Y.: Progression free survival in gastrointestinal stromal tumor with high a low dose imatinib: randomised trial. Lancet, 2004, 364, s. 1127–1134. 3 Rankin, C. – Von Mehren, M. – Blanke, C. – Benjamin, R. – Fletcher, C. D. M. – Bramwell, V.: Dose effect of imatinib in patients with metastatic GIST: Phase III Sarcoma Group Study S0033 (abstrakt 9005), Proc ASCO, 2004, 23, s. 815. 4 Van Glabbeke, M. – Verweij, J., et al.: Initial and late resistance to imatinib in advanced gastro-intestinal stromal tumor are predicted by different prognostic factors, an eortc-isg-agitg study. J Clin Oncol, 2005, 23, s. 5795–5804. 5 Blay, J. Y. – Le Cesne, A., et al.: Prospective multicenter randomized phase III study of imatinib in patients with advanced gastrointestinal stromal tumors comparing interruption versus continuation of treatment beyond 1 year: The French Sarmoma Group. J Clin Oncol, 25, s. 1107–1113. 6 Rios, M. – La Cesne, A., et al.: Interruption of imatinib in GIST patients with advanced diasease after one year of treatment: Updated results of the prospective French Sarcoma Group randomized phase III trial on long term survival. ASCO Ann Meet, 2007, abstrakt 10016. 7 Van Glabbeke, M. M. – Lazar, K. – Rankin, C., et al.: Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST): A meta-metaanalysis based on 1.640 patients. ASCO Ann Meet, 2007, abstrakt 10004. 8 Heindrich, M. C. – Maki, R. G. – Corless, C. L., et al.: Sunitinib response in imatinib-resistant GIST correlates with KIT and PDGFR mutation status. J Clin Oncol, 2006, 24, s. 9502. 9 Demetri, G. D. – van Oosterom, A. T., et al.: Efficacy and safety of sunitinib in patients with advanced gastointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet, 2006, s. 6736–6746. 10 Van Oosterom, A. T. – Dumez, H. – Desai, J., et al.: Combination signal transduction inhibition: A phase I/II trial of the oral m-TOR-inhibitor everolimus (E, RAD001) and imatinib mesylate in patients with gastrointestinal stromal tumors refractory to imatinib mesylate. J Clin Oncol, 2004, 22, s. 3002. 11 Demetri, G. D.: Inhibition of the Heat Shock Protein 90 (Hsp90) chaperone with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors (TKIs) in metastatic GIST: Updated results of a phase I trial. ASCO Annual Meeting, 2007, Sarcina. 12 Von Mehren, M. – Reichardt, P. – Casali, P. G. – Blay, J.: A phase I study of AMN107 alone and in combination with imatinib in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (GIST) – Study Update. ASCO Meeting, 2007. 13 Data on file, Novartis UK Ltd. Study No STI571B2222. Open, randomized, phase II study of Glivec in patients with unresectable or

metastatic malignant gastrointestinal stromal tumors expressing c-kit. Report 15. 12. 2003. 14 Chandrajit, P. R. – DeMatteo, R. P.: Prognostic factors for primary GIST: prime time for personalized therapy? Annals of Surgical Oncology, 15, 1, s. 4–6. 15 De Matyek, R. P. – Antonescu, C. R., et al.: Adjuvant imatinib mesylate in patients with primary high risk gastrointestinal stromal tumor (GIST) following complete resection: Safety results from the U.S. Intergroup Phase II trial ACOSOG Z9000. ASCO, 2008. 16 De Matyek, R. P. – Owzar, K., et al.: Adjuvant imatinib mesylate in creases recurrence free survival (RFS) in patients with completely resected localized primary gastrointestinal stromal tumor (GIST): North American Intergroup Phase III trial ACOSOG Z9001. ASCO, 2008. 17 Zhan, W. H.: Efficacy and safety of adjuvant post-surgical therapy with imatinib in patients with high risk of relapsing GIST. JCO, 25, 18S. 18 Nilsson, B. – Sjolund, K. – Kindblom, L. C., et al.: Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk gastrointestinal stromal tumours (GIST). Br J Cancer, 2007, 96, s. 1656–1658. 19 Scandinavian Sarcoma Group: Study comparing 12 months versus 36 months of imatinib in the treatment of gastrointestinal stromal tumor (GIST). SSGXVIII/AIO. Dostupné z: http:www.clinicaltrials.gov/ ct/show/NCT00116935?order=1, vyhledáno 25. 10. 2007. 20 European Organisation for Research and Treatment of Cancer: Imatinib mesylate or observation only in treating patients who have undergone surgery for localized gastrointestinal stromal tumor- EORTC-62024. Dostupné z: www.clinicaltrials.gov/ct/show/ NCT00103168?order=1, vyhledáno 25. 10. 2007. 21 RTOG S-0132 protocol. A phase II trial of neoadjuvant / adjuvant STI-571 (Gleevec NSC 716051) for primary and recurrent operable malignant GIST expressing the KIT receptor tyrosine kinase (CD117). Dostupné z: www.rtog.org/members/protocols/s0132/s0132.pdf, vyhledáno 3. 10. 2007. 22 Demetri, G. D. – Reichardt, P. – Kang, Y. K. – Blay, J. Y – Joensuu, H. – Maki, R. G. – Rutkowski, P. – Hohenberger, P. – Gelderblom, H. – Leahy, M. G. – von Mehren, M. – Schöffski, P. – Blackstein, M. E. – Le Cesne, A. – Badalamenti, G. – Xu, J. M. – Nishida, T. – Laurent, D. – Kuss, I. – Casali, P. G., on behalf of GRID Investigators: Randomized phase III trial of regorafenib in patients (pts) with metastatic and/or unresectable gastrointestinal stromal tumor (GIST) progressing despite prior treatment with at least imatinib (IM) and sunitinib (SU): The GRID Trial. 23 Rutkowski, P. – Bylina, E. – Klimczak, T. – Switaj, T. – Limon, J., et al.: The outcome and predictive factors of sunitinib in advanced gastrointestinal stromal tumor (GIST) after imatinib failure—one institution study. BMC Cancer, 2012, 12, s. 107. 24 ENESTg1: A randomized, open-label, multi-center phase III study to evaluate the efficacy and safety of nilotinib versus imatinib in adult patients with unresectable or metastatic gastrointestinal stromal tumor (GIST). http://clinicaltrials.gov/show/NCT00785785.

25 An open-label, multi-center, single arm study to evaluate the efficacy of nilotinib in adult patients with metastatic or unresectable gastrointestinal stromal tumors in first line treatment. http://clinicaltrials. gov/ct2/show/NCT00756509. 26 Randomized phase III trial comparing nilotinib 800 mg imatinib 800 mg for the treatment of patients with advanced and/or metastatic gastrointestinal stromal tumor refractory to imatinib 400 mg. http:// clinicaltrials.gov/ct2/show/NCT00751036. 27 A phase II, non-randomized, open-label multicenter study of 5 years adjuvant imatinib mesylate (Gleevec®) in patients at significant risk of recurrence following complete resection of primary gastrointestinal stromal tumor (GIST). http://clinicaltrials.gov/ct2/show/ NCT00867113. 28 A phase II, open-label study of PTK787/ZK222584 in the treatment of metastatic gastrointestinal stromal tumors (GIST) resistant to imatinib mesylate. http://clinicaltrials.gov/ct2/show/study/NCT00117299. 29 Phase 2 study of oral AB1010 in non pre-treated, inoperable patients with locally advanced / metastatic gastro-intestinal stromal tumor (GIST). http://clinicaltrials.gov/ct2/show/NCT00998751. 30 An open-label study of AMG 706 in subject with advanced gastrointestinal stromal tumors (GISTs) who developed progressive disease or relapsed while on imatinib mesylate. http://clinicaltrials.gov/ct2/ show/NCT00089960. 31 An open-label, phase II study to evaluate the biological activity of cediranib (AZD2171) as measured by (F 18) fluoro 2 deoxy d glucose – positron emission tomography (FDG-PET) response, in patients with metastatic gastro-intestinal stromal tumors (GISTs) resistant or intolerant to imatinib mesylate. http://clinicaltrials.gov/ct2/show/ study/NCT00385203. 32 An phase II study of sorafenib in patients with metastatic or advanced gastrointestinal stromal tumors (GISTs) who failed to imatinib and sunitinib. http://clinicaltrials.gov/ct2/show/NCT01091207. 33 A study evaluating STA-9090 in patients with metastatic and/or unresectable gastrointestinal stromal tumors (GIST). http://clinicaltrials. gov/ct2/show/NCT010339519. 34 Dasatinib first-line treatment in gastrointestinal stromal tumors. A multi center phase II trial. http://clinicaltrials.gov/ct2/show/ NCT00568750. 35 Phase II study of crenolanib (CP-868,596), a selective and potent inhibitor of PDGFR, for the treatment of patients with advanced gastrointestinal stromal tumors with the D842-related mutations and deletions, including the D842V mutation, in the PDGFRA gene. http:// clinicaltrials.gov/ct2/show/NCT01243346. 36 A study evaluating the safety, tolerability and pharmacokinetics of GDC-0973 in combination with GDC-0941 when administered daily in patients with locally advanced or metastatic solid tumor. http:// clinicaltrials.gov/ct2/show/NCT0133184. 37 A study evaluating GDC-0980 administered once daily in patients with refractory solid tumors or non-Hodgkin‘s lymphoma. http://clinicaltrials.gov/ct2/show/NCT000997765.


Výběr optimální sekvence v léčbě metastatického renálního karcinomu MUDr. Hana Študentová Onkologická klinika FN Olomouc 1 Négrier, S. – Gratis, G. – Pérol, D., et al.: Temsirolimus and bevacizumab or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial. Lancet Oncol, 2011, 12, s. 673–80. 2 Bracarda, S. – Bellmunt, J. – Melichar, B., et al.: Overall survival in patinets with metastatic renal cel carcinoma initially treated with bevacizumab plus interferon-α2a and subsequent therapy with tyrosine kinase inhibitors: a retrospective analysis of the phase III AVOREN trial. 3 Motzer, R. J. – Barrios, C. H. – Kim, T. M., et al.: 1. Phase II randomized trial comparing sequential first-line everolimus and second-line sunitinib versus first-line sunitinib and second-line everolimus in patients with metastatic renal cell carcinoma. J Clin Oncol, 2014, 32, s. 2765–2772. 4 Steiner, F. – Chastonay, R. – Liewen, H., et al.: A pooled analysis of sequential therapies with sorafenib and sunitinib in metastatic renal cell carcinoma. Oncology, 2012, 82, s. 333–340.

5 Büchler, T. – Klapka, R. – Melichar, B., et al.: Sunitinib followed by sorafenib or vice versa for metastatic renal cell carcinoma—data from the Czech registry. Ann Oncol, 2012, 23, s. 395–401. 6 Rini, B. I. – Escudier, B. – Tomczak, P., et al.: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet, 2011, 378, s. 1931–1939. 7 Hutson, T. – Escudier, B. – Esteban, E., et al.: Randomized phase III trial of temsirolimus versus sorafenib as second-line therapy after sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol, 2014, 32, s. 760–767. 8 Motzer, R. J. – Escudier, B. – Oudars, S., et al.: Phase 3 trial of everolimus for metastatis renal cell carcinoma: final results and analysis of prognostic factors. Cancer, 2012, 116, s. 4256–4265. 9 Motzer, R. J. – Porta, C. – Vogelzang, N. J., et al.: Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial. Lancet

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Novinky v léčbě průlomové bolesti MUDr. Marek Hakl, Ph.D. Centrum pro léčbu bolesti ARK LF MU a FN u sv. Anny v Brně 1 Hakl, M. – Hřib, R.: Farmakoterapie léčby onkologické bolesti. Interní medicína pro praxi, 2007, 9, s. 229–300. 2 Kabelka, L. – Kozák, J. – Lejčko, J. – Sláma, O.: Doporučený postup pro léčbu průlomové bolesti. Bolest, 2011, 14, dopl. 1. 3 Webster, L. R.: Breakthrough pain in the management of chronic persistent pain syndromes. Am J Manag Care, 2008, 14, s. 116–122. 4 Dickman, A.: Integrated strategies for the successful management of breakthrough cancer pain. Curr Opin Support Palliat Care, 2011, 5, s. 8–14.

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Qutenza v léčbě chemoterapií indukované polyneuropatie MUDr. Marek Hakl, Ph.D. Centrum pro léčbu bolesti ARK LF MU a FN u sv. Anny v Brně 1 Ehler, E.: Neuropatická bolest u diabetické polyneuropatie. Neurologie pro praxi, 2010, 11, s. 107–111. 2 Attal, N. – Cruccu, G. – Baron, R. – Haanpaa, M. – Hanson, P. – Jensen, T. – Numikko, T.: EFNS guidelines on the pharmacological treatment of neuropathic pain: 2009 revision. European Journal of

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