54
DAFTAR PUSTAKA
1.
Botham KM, Mayes PA. Pengangkutan dan Penyimpanan Lipid. In: Biokimia Harper. 27th ed. Jakarta: EGC; 2012.
2.
Prassl R, Laggner P. Lipoprotein Structure and Dynamics : Low Density Lipoprotein Viewed as a Highly Dynamic and Flexible Nanoparticle. Biochem Genet Mol Biol Lipoproteins - Role Heal Dis [Internet]. 2012;3– 20. Available from: http://www.intechopen.com/books/lipoproteins-role-inhealth-and-diseases/dyslipoproteinemia-in-chronic-hcv-infection
3.
Murtola T, Vuorela TA, Hyvönen MT, Marrink S-J, Karttunen M, Vattulainen I. Low density lipoprotein: structure, dynamics, and interactions of apoB-100 with lipids. Soft Matter [Internet]. 2011;7(18):8135. Available from: http://xlink.rsc.org/?DOI=c1sm05367a
4.
Centers for Disease Control and Prevention. Smoking and Tobacco Use; Fact Sheet; Bidis and Kreteks. [cited 2015 Dec 19]; Available from: http://www.cdc.gov/tobacco/data_statistics/fact_sheets/tobacco_industry/bi dis_kreteks/index.htm
5.
The Chemicals in Cigarette Smoke & Their Effects [Internet]. 2015 [cited 2015 Dec 12]. Available from: http://www.compoundchem.com/2014/05/01/the-chemicals-in-cigarettesmoke-their-effects/
6.
Seddon JM, Reynolds R, Rosner B. Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. Mol Vis [Internet]. 2010 Jan [cited 2015 Dec 6];16:2412–24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2994762&tool =pmcentrez&rendertype=abstract
7.
Preedy VR. Essential Oils in Food Preservation, Flavor and Safety [Internet]. Elsevier Science; 2015. Available from: https://books.google.co.id/books?id=uNDUBQAAQBAJ
8.
Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian
55
Pac J Trop Biomed. 2013;3(5):337–52. 9.
Ramzan I. Phytotherapies: Efficacy, Safety, and Regulation [Internet]. John Wiley & Sons; 2015 [cited 2015 Dec 1]. 672 p. Available from: https://books.google.com/books?id=SpIsCAAAQBAJ&pgis=1
10.
Ahmad S, Beg ZH. Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. Food Chem [Internet]. 2013;138(2-3):1116–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23411222
11.
Tasawar Z, Siraj Z, Ahmad N, Lashari MH. The Effects of Nigella sativa (Kalonji) on Lipid Profile in Patients with Stable Coronary Artery Disease in Multan , Pakistan. 2011;10(2):162–7.
12.
Bamosa A, Lebda F, Al Elq A, Al-Sultan A, Kaatabi H. Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients. J Fam Community Med. 2012;19(3):155.
13.
Al-Naqeep G, Al-Zubairi AS, Ismail M, Amom ZH, Esa NM. Antiatherogenic Potential of Nigella sativa Seeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits. Evid Based Complement Alternat Med [Internet]. 2011;2011:213628. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3136238&tool =pmcentrez&rendertype=abstract
14.
Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A. Clinical Evaluation of Nigella sativa Seeds for the Treatment of Hyperlipidemia: a Randomized, Placebo Controlled Clinical Trial. J Acad Med Sci Bosnia Herzegovina. 2012;66(3).
15.
Kaatabi H, Bamosa AO, Lebda FM, Al Elq AH, Al-Sultan AI. Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients. J Family Community Med [Internet]. 2012 Sep [cited 2015 Nov 19];19(3):155–61. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3515953&tool =pmcentrez&rendertype=abstract
16.
Ali SA, Asghar F, Nafees M, Tayyab M. Effect of Nigella Sativa (Kalonji) on Serum Lipid Profile. 2012;18(2):224–8.
17.
Soh J, Josekutty J, Hussain MM. Lipids and Dyslipoproteinemia. In: McPherson RA, Pincus MR, editors. Henry’s Clinical Diagnosis and
56
Management by Laboratory Methods. 22nd ed. Philadelphia: Elsevier Saunders; 2013. 18.
Gunawan SG, editor. Farmakologi dan Terapi. 5th ed. Jakarta: Balai Penerbit FKUI; 2012.
19.
Badan Penelitian dan Pengembangan Kementrian Kesehatan RI. Riset Kesehatan Dasar (Riskesdas). 2013;
20.
Marks DB. Biokimia Kedokteran Dasar; Sebuah Pendekatan Klinis. Jakarta: EGC; 2013.
21.
Vasudevan DM, S S, Vaidyanathan K. Textbook of Biochemistry for Medical Students [Internet]. JP Medical Ltd; 2013 [cited 2016 Jan 19]. 791 p. Available from: https://books.google.com/books?id=nQz8AAAAQBAJ&pgis=1
22.
Goldstein JL, Brown MS. The LDL Receptor. Arterioscler Thromb Vasc Biol [Internet]. 2009;29(4):431–8. Available from: http://atvb.ahajournals.org/cgi/doi/10.1161/ATVBAHA.108.179564
23.
Nigam PK. Serum Lipid Profile: Fasting or Non-fasting? Indian J Clin Biochem [Internet]. 2011;26(1):96–7. Available from: http://link.springer.com/10.1007/s12291-010-0095-x
24.
Adam JM. Dislipidemia. In: Setiati S, editor. Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta Pusat: Interna Publishing; 2014.
25.
Rosenson RS. High cholesterol and lipids (hyperlipidemia) [Internet]. 2015 [cited 2016 Jan 19]. Available from: http://www.uptodate.com/contents/high-cholesterol-and-lipidshyperlipidemia-beyond-the-basics
26.
Brehm B. Psychology of Health and Fitness [Internet]. F. A. Davis Company; 2014. Available from: https://books.google.co.id/books?id=1lYOAwAAQBAJ
27.
Palatini P, Longo D, Zaetta V, Perkovic D, Garbelotto R, Pessina AC. Evolution of blood pressure and cholesterol in stage 1 hypertension: role of autonomic nervous system activity. J Hypertens [Internet]. 2006;24(7). Available from: http://journals.lww.com/jhypertension/Fulltext/2006/07000/Evolution_of_b lood_pressure_and_cholesterol_in.23.aspx
57
28.
Harikumar K, Althaf SA, Kishore B, Ramunaik M, Suvarna CH. A Review on Hyperlipidemic. Int J Nov Trends Pharm Sci. 2013;3(4):59–70.
29.
Peraturan Pemerintah Republik Indonesia No. 19 Tahun 2003 Tentang Pengamanan Rokok Bagi Kesehatan [Internet]. [cited 2015 Dec 8]. Available from: http://portal.mahkamahkonstitusi.go.id/eLaw/mg58ufsc89hrsg/pp192003.p df
30.
CDC’s Office on Smoking and Health. Smoking and Tobacco Use; 2010 Surgeon General’s Report; Chemicals in Tobacco Smoke. 2010 [cited 2016 Feb 21]; Available from: http://www.cdc.gov/tobacco/data_statistics/sgr/2010/consumer_booklet/che micals_smoke/
31.
Centers for Disease Control and Prevention. Chemistry and Toxicology of Cigarette Smoke and Biomarkers of Exposure and Harm [Internet]. Centers for Disease Control and Prevention (US); 2010 [cited 2016 Feb 4]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK53014/
32.
What is Nicotine? [Internet]. [cited 2015 Dec 11]. Available from: http://www.news-medical.net/health/What-is-Nicotine.aspx
33.
Benowitz NL. Acute Biological Effects of Nicotine and Its Metabolites. In: Clarke P, Quik M, Adlkofer F, Thurau K, editors. Effects of Nicotine on Biological Systems II [Internet]. Birkhäuser; 2012 [cited 2015 Dec 12]. p. 407. Available from: https://books.google.com/books?id=piYGCAAAQBAJ&pgis=1
34.
Martin T. Cigarette Tar - Harmful Chemical Residue [Internet]. 2015 [cited 2015 Dec 12]. Available from: http://quitsmoking.about.com/od/chemicalsinsmoke/a/tar_in_cigs.htm
35.
Maisto S, Galizio M, Connors G. Drug Use and Abuse [Internet]. Cengage Learning; 2014 [cited 2015 Dec 12]. 512 p. Available from: https://books.google.com/books?id=2N8bCgAAQBAJ&pgis=1
36.
Martin T. Carbon Monoxide in Cigarette Smoke [Internet]. 2015 [cited 2015 Dec 12]. Available from: http://quitsmoking.about.com/od/chemicalsinsmoke/p/carbonmonoxide.htm
37.
Bano S, Saeed S. Gender Differences in Nicotine Induced Dyslipidemia and Hyperglycemia in mice. 2014;(1996):1–12.
58
38.
Tweed JO, Hsia SH, Lutfy K, Friedman TC. The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab [Internet]. 2012 Jul [cited 2016 Jan 20];23(7):334–42. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3389568&tool =pmcentrez&rendertype=abstract
39.
Peckett AJ, Wright DC, Riddell MC. The effects of glucocorticoids on adipose tissue lipid metabolism. Metabolism [Internet]. Elsevier Inc.; 2011;60(11):1500–10. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0026049511001922
40.
Bibi Z, Saeed S, Bano S. Metabolic and Behavioral Effects of Nicotine in Swim Stressed Mice. 2011;54–60.
41.
Pechura CJ. Key Players in Reverse Cholesterol Transport : The Plasma Enzyme LCAT. 2012;
42.
Miley E. Filtered vs. Unfiltered Cigarettes | eHow [Internet]. 2010 [cited 2016 Jan 11]. Available from: http://www.ehow.com/about_6501299_filtered-vs_-unfilteredcigarettes.html
43.
Boyle P. Tobacco: Science, Policy and Public Health [Internet]. OUP Oxford; 2010 [cited 2016 Jan 11]. 738 p. Available from: https://books.google.com/books?id=OC3merCRJmMC&pgis=1
44.
ASPA. Smoked Tobacco Products. Department of Health and Human Services; 2012 Aug 20 [cited 2015 Dec 19]; Available from: http://betobaccofree.hhs.gov/about-tobacco/Smoked-Tobacco-Products/
45.
Bernard D. Cigarette Smoke Toxicity: Linking Individual Chemicals to Human Diseases [Internet]. John Wiley & Sons; 2011 [cited 2015 Nov 22]. 388 p. Available from: https://books.google.com/books?id=8apWOtICB6MC&pgis=1
46.
Malloy MJ, Kane JP. Obat yang Digunakan pada Hiperlipidemia. In: Katzung BG, editor. Farmakologi Dasar & Klinik. 10th ed. Jakarta: EGC; 2012.
47.
Antman EM. Cardiovascular Therapeutics: A Companion to Braunwald’s Heart Disease [Internet]. Elsevier Health Sciences; 2012 [cited 2016 Jan 16]. 832 p. Available from: https://books.google.com/books?id=qSOhVrM7L0C&pgis=1
59
48.
McFarland AJ, Anoopkumar-Dukie S, Arora DS, Grant GD, McDermott CM, Perkins A V, et al. Molecular mechanisms underlying the effects of statins in the central nervous system. Int J Mol Sci [Internet]. 2014;15(11):20607–37. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4264186&tool =pmcentrez&rendertype=abstract
49.
Botham KM, Mayes PA. Sintesis, Transpor, & Ekskresi Kolesterol. In: Biokimia Harper. 27th ed. Jakarta: EGC; 2012.
50.
Moreau R, Kamal-Eldin A. Gourmet and Health-Promoting Specialty Oils [Internet]. Elsevier Science; 2015. Available from: https://books.google.co.id/books?id=1LF3CgAAQBAJ
51.
Al-attar AM, Al-taisan WA. Preventive Effects of Black Seed (Nigella Sativa) Extract on Sprague Dawley Rats Exposed to Diazinon. 2010;4(5):957–68.
52.
Al-Naqeep G, Ismail M, Yazan LS. Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression. J Funct Foods [Internet]. Elsevier Ltd; 2009;1(3):298– 303. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1756464609000371
53.
Shabana A, El-Menyar A, Asim M, Al-Azzeh H, Al Thani H. Cardiovascular benefits of black cumin (Nigella sativa). Cardiovasc Toxicol [Internet]. 2013;13(1):9–21. Available from: http://eds.a.ebscohost.com.ezproxy.endeavour.edu.au/eds/pdfviewer/pdfvie wer?sid=e901be1a-84da-479f-82f91b57342136e1@sessionmgr4005&vid=10&hid=4103
54.
Susianti. Pengaruh Ekstrak Jintan Hitam (Nigella Sativa L.) terhadap Gambaran Histopatologi Hepar, Paru, dan Testis Tikus Putih (Rattus Norvegicus) yang Diinduksi Gentamisin. 2013;II(2):107–18.
55.
Dalla RA. Efek Antiinflamasi Ekstrak Biji Jintan Hitam (Nigella sativa) pada Tikus Putih. UNIKA Widya Mandala; 2011.
56.
Adrianto NF. Uji Potensi Ekstrak Biji Jintan Hitam (Nigella sativa L.) Asal Indonesia Sebagai Obat Antiparkinson [Internet]. Universitas Pendidikan Indonesia; 2014. Available from: http://repository.upi.edu/11496/
60
57.
Merck Canada Inc. Product Monograph: Zocor. Distribution [Internet]. 2006;(April):1–40. Available from: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Product+ monograph#2
58.
Ihedioha JI, Noel-Uneke OA, Ihedioha TE. Reference values for the serum lipid profile of albino rats (Rattus norvegicus) of varied ages and sexes. Comp Clin Path. 2013;22(1):93–9.
59.
Damasceno DC, Sinzato YK, Bueno A, Dallaqua B, Lima PH, Calderon IMP, et al. Metabolic Profile and Genotoxicity in Obese Rats Exposed to Cigarette Smoke. Obesity. 2013;21(8):1596–601.
60.
Meenakshisundaram R, Rajendiran C, Thirumalaikolundusubramanian P, Loeper J, Goy J, Rozensztajn L, et al. Lipid and lipoprotein profiles among middle aged male smokers: a study from southern India. Tob Induc Dis [Internet]. BioMed Central; 2010 [cited 2016 Jun 27];8(1):11. Available from: http://tobaccoinduceddiseases.biomedcentral.com/articles/10.1186/16179625-8-11
61.
Lakshmi A, Lakshmanan A, Kumar G, Saravanan. Effect of intensity of cigarette smoking on haematological and lipid parameters. J Clin Diagn Res [Internet]. JCDR Research & Publications Private Limited; 2014 Jul [cited 2016 Jun 27];8(7):BC11–3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25177557
62.
Devaranavadgi B, Aski B, Kashinath R, Hundekari I. Effect of Cigarette Smoking on Blood Lipids – A Study in Belgaum, Northern Karnataka, India. 2012;12(6).
63.
Rao U, Hammen CL, London ED, Poland RE. Contribution of hypothalamic-pituitary-adrenal activity and environmental stress to vulnerability for smoking in adolescents. Neuropsychopharmacology [Internet]. NIH Public Access; 2009 Dec [cited 2016 Jun 27];34(13):2721– 32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19693006
64.
Tweed JO, Hsia SH, Lutfy K, Friedman TC. The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab [Internet]. Elsevier Ltd; 2012;23(7):334–42. Available from: http://dx.doi.org/10.1016/j.tem.2012.03.006\nhttp://www.sciencedirect.com /science/article/pii/S1043276012000501
65.
Food and Drug Administration. FDA Expands Advice on Statin Risks.
61
FDA Consum Heal Inf [Internet]. 2014;(January):1–2. Available from: http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm293330.htm 66.
Salea R, Widjojokusumo E, Hartanti AW, Veriansyah B, Tjandrawinata RR. Supercritical fluid carbon dioxide extraction of Nigella sativa (black cumi) seeds using taguchi method and full factorial design. Biochem Compd [Internet]. 2013;1(1):7. Available from: http://www.hoajonline.com/biochemcomp/2052-9341/1/1
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LAMPIRAN LAMPIRAN I – ETHICAL CLEARANCE
63
LAMPIRAN II – PERMOHONAN IZIN PENELITIAN
64
LL L
LAMPIRAN III – PERSETUJUAN IZIN PENELITIAN
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LAMPIRAN IV – PROSEDUR PEMBUATAN EKSTRAK JINTAN HITAM (METODE SOXHLETASI) Alat: 1. Soxhlet komplit
5. Gelas ukur
9. Neraca analitik
2. Cawan porselin
6. Statip
10. Water bath
3. Pipet tetes
7. Corong
11. Kompor listrik
4. Beaker glass
8. Kertas saring
12. Panci
Bahan: 1. Biji jintan 2. Pelarut etanol 70% 3. Akuades
Cara Kerja: 1. Biji jintan dikeringkan, kemudian ditumbuk sampai halus 2. Biji jintan yang telah ditumbuk ditimbang ± 200 gram (sesuai kapasitas tabung), dibungkus dengan kertas saring dan dibentuk menyerupai tabung sesuai besarnya diameter tabung tersebut
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3. Kertas saring berisi jintan hitam dimasukkan ke dalam extraction chamber, kemudian ditambah pelarut 200 ml 4. Labu alas bulat diisi pelarut 500 ml, kemudian dihubungkan dengan extraction chamber yang telah dipasang pada statip 5. Sisi bawah labu alas bulat dipasang alat pemanas (kompor) dan panci yang berisi air 6. Kran pada kondensor dipasang selang dan dihubungkan pada air mengalir, air dibiarkan mengalir selama proses ekstraksi 7. Pemanas (kompor) dinyalakan kurang lebih enam jam 8. Hasil ekstrak dalam labu alas bulat yang masih bercampur dengan pelarut dan air diambil, dituangkan dalam cawan porselin, lalu diuapkan diatas water bath dengan suhu maksimal 70° atau diangin-anginkan sampai pelarut dan airnya hilang dan didapatkan ekstraknya 9. Prosedur ini diulangi beberapa kali hingga didapatkan ekstrak yang diinginkan.
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LAMPIRAN V – HASIL UJI LABORATORIUM
No.
Kode sampel
Kadar kolesterol
LDL presipitan
Kadar LDL = kadar kolesterol – kadar LDL
1
N1
60,5
32,1
28,4 mg/dl
2
N2
65
39,2
25,8 mg/dl
3
N3
62,7
35,4
27,3 mg/dl
4
N4
44,4
22,6
21,8 mg/dl
5
N5
58,3
32,8
25,5 mg/dl
6
N6
50,5
28,1
22,4 mg/dl
7
R1
60,8
33,6
27,2 mg/dl
8
R2
53,3
29,2
24,1 mg/dl
9
R3
50
26,8
23,2 mg/dl
10
R4
60,7
34
26,7 mg/dl
11
R5
72,5
39,8
32,7 mg/dl
12
R6
52,1
26,4
25,7 mg/dl
13
J1
53
32,3
20,7 mg/dl
14
J2
54
31,9
22,1 mg/dl
15
J3
55,4
30,2
25,2 mg/dl
16
J4
51,4
25,8
25,6 mg/dl
17
J5
53,7
28,1
25,6 mg/dl
18
J6
55,1
31,6
23,5 mg/dl
19
S1
52,1
29,1
23 mg/dl
20
S2
75
46,7
28,3 mg/dl
21
S3
60,5
33,7
26,8 mg/dl
22
S4
58,7
29,5
29,2 mg/dl
23
S5
62
34,1
27,9 mg/dl
24
S6
56,5
31,2
25,3 mg/dl
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LAMPIRAN VI – HASIL ANALISIS (OUTPUT PROGRAM SPSS)
1. Jumlah sampel tiap kelompok Case Processing Summary
Kelompok Kadar LDL Kontrol Rokok Rokok + Jintan Rokok + Simvastatin
N
Valid Percent 6 100.0% 6 100.0% 6 100.0% 6 100.0%
Cases Missing N Percent 0 0.0% 0 0.0% 0 0.0% 0 0.0%
N
Total Percent 6 100.0% 6 100.0% 6 100.0% 6 100.0%
2. Analisis deskriptif pengaruh pemberian ekstrak jintan hitam terhadap kadar kolesterol LDL tikus yang terpapar asap rokok Descriptives
Kadar LDL
Kelompok Kontrol
Mean 95% Confidence Interval for Mean
Statistic 25.200 Lower Bound
22.443
Upper Bound
27.957
5% Trimmed Mean
25.211
Median
25.650
Variance
6.900
Std. Deviation
Rokok
2.6268
Minimum
21.8
Maximum
28.4
Range
6.6
Interquartile Range
5.3
Skewness Kurtosis Mean 95% Confidence Interval for Mean
-.314 -1.552 26.600 Lower Bound
23.082
Upper Bound
30.118
5% Trimmed Mean
26.450
Median
26.200
Variance
11.240
Std. Deviation
3.3526
Minimum
Std. Error 1.0724
23.2
.845 1.741 1.3687
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Maximum
32.7
Range
9.5
Interquartile Range
Rokok + Jintan
Skewness Kurtosis Mean 95% Confidence Interval for Mean
4.7 1.366 2.383 23.783 Lower Bound
21.631
Upper Bound
25.935
5% Trimmed Mean
23.854
Median
24.350
Variance
4.206
Std. Deviation
Rokok + Simvastatin
2.0508
Minimum
20.7
Maximum
25.6
Range
4.9
Interquartile Range
3.9
Skewness Kurtosis Mean 95% Confidence Interval for Mean
-.670 -1.334 26.750 Lower Bound
24.362
Upper Bound
29.138
5% Trimmed Mean
26.822
Median
27.350
Variance Std. Deviation
.845 1.741 .9291
5.179 2.2757
Minimum
23.0
Maximum
29.2
Range
6.2
Interquartile Range
3.8
Skewness Kurtosis
.845 1.741 .8372
-.912 .163
.845 1.741
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3. Hasil uji normalitas data pengaruh pemberian ekstrak jintan hitam terhadap kadar kolesterol LDL tikus yang terpapar asap rokok Tests of Normality Kolmogorov-Smirnova Kelompok Statistic df Sig. Kadar LDL Kontrol .212 6 .200* Rokok .262 6 .200* Rokok + Jintan .255 6 .200* Rokok + Simvastatin .193 6 .200* *. This is a lower bound of the true significance. a. Lilliefors Significance Correction
Statistic .924 .889 .872 .937
Shapiro-Wilk df 6 6 6 6
4. Hasil uji homogenitas varians dan uji parametrik One Way Anova
Oneway
Test of Homogeneity of Variances Kadar LDL Levene Statistic df1 df2 Sig. .201 3 20 .895
ANOVA Kadar LDL Between Groups Within Groups Total
Sum of Squares 34.690 137.623 172.313
df 3 20 23
Mean Square 11.563 6.881
F 1.680
Sig. .203
Sig. .533 .311 .236 .635
71
LAMPIRAN VII – DOKUMENTASI PENELITIAN
Proses pemaparan asap rokok pada tikus Sprague Dawley
Proses anestesi dan pengambilan darah tikus Sprague Dawley melalui pleksus retroorbita
72
Ekstraksi biji jintan hitam dengan metode Soxhletasi
Proses pemeriksaan kadar kolesterol LDL serum tikus Sprague Dawley
73
LAMPIRAN VIII – BIODATA MAHASISWA
Identitas Nama
: Lalita Khairunnisa
NIM
: 22010112130104
Tempat/tanggal lahir
: Jakarta, 15 Oktober 1994
Jenis kelamin
: Perempuan
Alamat
: Citra Gran blok I8/3, Jatisampurna, Bekasi
Nomor telepon
: 02184311296
Nomor HP
: 081319300559
E-mail
:
[email protected]
Riwayat Pendidikan Formal 1. SD
: SD Cindera Mata Bekasi
Lulus tahun: 2006
2. SMP
: SMP Negeri 1 Cibinong
Lulus tahun: 2009
3. SMA
: SMA Negeri 3 Bogor
Lulus tahun: 2012
4. FK Undip
: Masuk tahun: 2012
74
Keanggotaan Organisasi 1. Anggota Paduan Suara Mahasiswa (PSM) Universitas Diponegoro tahun 2012 2. Anggota Divisi Eksterna Badan Kelengkapan Reproductive Health Education Unit (RHEU) FK Undip tahun 2013 3. Anggota Sie. Acara Try Out FK Undip tahun 2013 4. Anggota Sie. Konsumsi Gebyar Ramadhan tahun 2013 5. Reporter Buletin Communication Medical FK Undip tahun 2013-2014 6. Ketua Badan Kelengkapan Reproductive Health Education Unit (RHEU) FK Undip masa jabatan tahun 2014-2015 7. Asisten Dosen Biokimia FK Undip masa jabatan 2014-2015 8. Anggota Sie. Acara Scientific Fair FK Undip tahun 2014 9. Anggota Paduan Suara Mahasiswa (PSM) Kedokteran Umum Undip tahun 2014-2015 10. Tim Penyusun Badan Semi Otonom (BSO) Jurnalistik FK Undip tahun 2014 11. Anggota Sie. Acara Porseni FK Undip tahun 2014 12. Sekretaris Umum BSO Lembaga Pers Mahasiswa (LPM) Impuls FK Undip masa jabatan 2015-2016 13. Steering Committee Badan Kelengkapan Reproductive Health Education Unit (RHEU) FK Undip masa jabatan tahun 2015-2016 14. Asisten Dosen Biokimia FK Undip masa jabatan 2015-2016 15. Anggota Sie. Pengabdian Masyarakat Kemah Bakti FK Undip tahun 2015
75
16. Konselor BSO Lembaga Pers Mahasiswa (LPM) Impuls FK Undip masa jabatan 2016-2017
