BAU V 1 KES IMPULAN
1. Hubungan
amoksisilin
antara dengan
kombinas i
asani
aktivitas
k l a v u 1 anat
antibakteri
dan
terhadap
Staphylococcus aureus penghasil beta-laktamase adalah sebagai berikut
;
- H u b u n g a n a n t a r a arnoksisilin d e n g a n a k t i v i t a s bakteri
adalah
dalam bentuk
kuadratik
klavulanat akan meningkatkan aktivitas
dan
antiasam
antihakteri
d a r i arnoksisilin. 3 . Kombinasi
tidak
optinla1
asam klnvulanat
dan
amoksisilin
dapat ditentukan dari p e r s a r n a a n / h u h u n g a n
diperoleh.
yang
BAB VII SARAN-SARAN
Perlu dilakukan penelitian lebih lanjut mengenai
1. Kadar
:
hambat minimal ko~nbinasi amoksisi 1 in clan t erhadap S t a p h y l o c o c c u s a u r e u s
klavulanat
asaln
penghas i 1
beta-laktamase.
2. Hubungan antara kombinasi amoksisilin dan asam klavulanat
dengan aktivitas antibakteri terhadap
bakteri
Gram positif lain penghasil beta-laktarnasc. 3. Hubungan
pengikat
antara
komhinasi amoksisilin
beta-laktamase
antibakteri
lainnya
dan
dengan
terhadap bakteri Gram positif
beta-laktamase.
senyawa aktivitas penghasil
S u d t u p e n e 1 i t i a r l ~ n e n g e ni ~h~u b u n g d n a n t a r a horn11 i n a \ i asarn k l a v u l a n a t d a n a m o h s i s i 1 i n d e n g i i n a k t i v i ~ : t s a n t 1 bakt er i t e r h a d d p S t a p h j - l o c o c c u s cluz-eus p e n g h a s i 1 b e t a l a k t a m a s e t e 1 a h d i 1 a k u h a n d e n g a n incnguhur c1ia1ne.terd a e r a h hambatan pertumhuhan yang t e r h e n l u k . Diameter d a e r d h h a m b a t a n p e l t u r n l ~ u h ~ i ~d ~i p e r o l c h den gar^ m e n g g u n a k a n rne t o d e " r l g a r Ovr r 1 a y " d e r l g a n reserv o i r c a k r a m k e r t a s . P e r s a r n a a n / h u b u n g n n ,\ c ~ n g t e r l l a i k j - a n g d i p e r o l e h a d a l a h Y = 0 , 8 0 6 5 X i t 0 , 3 3 1 ' Z,- - 0 , 0 1 5 s X I 2 + 20,3110 (n = 30, r = 0.9-52, F = lh-.Cl42). n n r i h u b u n g a n g a n g i l i p e i o l c h t c r ~ c h u ril i i o h c t u n t ul. men~ntukan koml~i~~a< s i i n ~ L c , ~ ~s iI I I ( l c ~ i i h l a ~ ~ ~ l ~ ~ r ~ , ~ y a n g o p t i n i a l y a i ti1 clellgan had,^^ terkeci 1 l \ ~ e ~ n l )i c ia k t 11 i tas ant ibakt rr i yang i ~ ~ ~ ~ h s i ~ n n l D a r i h a s i 1 p e r h i t u n g a n t e r s c b i ~ t d i d a p . i t h a n 13;ihua k o m b i n a s i o p t i m a l d a r i a n l n h s i . z i l i l l ~ l a r ia s a n i h l a ~ u l a n a t t i d a h d a p a t d i tentuhan d a r i r ) e ~ - s a i n a ~ ~ r i / h u b u n gyaann g ( l i p e r o l e h . L I ~ C I I I I
.
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