Cover Page
The handle http://hdl.handle.net/1887/19858 holds various files of this Leiden University dissertation. Author: Dikken, Johannes Leen Title: Gastric cancer : staging, treatment, and surgical quality assurance Issue Date: 2012-09-26
phd thesis Leiden University Medical Center, Leiden, the Netherlands Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands Memorial Sloan-Kettering Cancer Center, New York, USA
Promotiecommissie promotores
prof. dr. C.J.H. van de Velde prof. dr. M. Verheij Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis Vrije Universiteit Amsterdam co-promotores
dr. A. Cats Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis dr. V.E.P.P. Lemmens Integraal Kankercentrum Zuid Erasmus Medisch Centrum overige leden
prof. dr. H. Putter prof. dr. R.A.E.M. Tollenaar dr. N.C.T. van Grieken VU Medisch Centrum dr. J.W. van Sandick Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis drs. M.W.J.M. Wouters Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis
dit proefschrift werd mede mogelijk gemaakt door
KWF Kankerbestrijding, AngioDynamics, Bard Medical, ChipSoft, Covidien, Eli Lilly, Erbe, GlaxoSmithKline, Integraal Kankercentrum Zuid, J.E. Jurriaanse Stichting, Johnson & Johnson Medical, Jo Keur Fonds, Lustra Beurs, Maag Lever Darm Stichting, Michael van Vloten Fonds, Nutricia Advanced Medical Nutrition, Olympus, Pfizer, Roche, Sanofi, Stichting Extracurriculaire Activiteiten Haagse Chirurgen en Uitgeverij Jaap ISBN 978 90 6464 574 7 Druk GVO drukkers & vormgevers B.V. | Ponsen & Looijen © 2012 Johan Dikken, Leiden, Nederland
gastric cancer staging, treatment, and surgical quality assurance
proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op woensdag 26 september 2012 klokke 16.15 uur
door Johannes Leen Dikken geboren te Apeldoorn in 1983
Contents introduction
1. General introduction and outline of this thesis
7
part i. staging and prognostication
2. The new American Joint Committee on Cancer/International Union Against Cancer staging system for adenocarcinoma of the stomach: increased complexity without clear improvement in predictive accuracy Annals of Surgical Oncology 2012
15
3. Prospective impact of tumor grade assessment in biopsies on tumor stage and prognostic grouping in gastroesophageal adenocarcinoma: relevance of the 7th edition AJCC staging manual revision Cancer 2012
31
4. Conditional probability of survival nomogram for one, two, and three year survivors after an R0 resection for gastric cancer Annals of Surgical Oncology 2012
45
5. Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiotherapy Submitted
59
part ii. multimodality treatment
6. Treatment of resectable gastric cancer Therapeutic Advances in Gastroenterology 2012
73
7. Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer Journal of Clinical Oncology 2010
99
8. Preoperative chemotherapy does not influence the number of evaluable lymph nodes in resected gastric cancer European Journal of Surgical Oncology 2012
115
9. Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS) BMC Cancer 2011
131
part iii. surgical quality assurance
10. Quality of care indicators for the surgical treatment of gastric cancer: a systematic review Annals of Surgical Oncology 2012
147
11. Increased incidence and survival for esophageal cancer but not for gastric cardia cancer in the Netherlands European Journal of Cancer 2012
173
12. Gastric cancer: decreasing incidence but stable survival in the Netherlands Submitted
187
13. Changes in treatment patterns and their influence on short-term mortality and long-term survival in patients with stage I-III gastric cancer in the Netherlands Submitted
199
14. Effect of hospital volume on postoperative mortality and survival after esophageal and gastric cancer surgery in the Netherlands between 1989 and 2009 European Journal of Cancer 2012
213
15. The influence of hospital type on outcomes after esophageal and gastric cancer surgery British Journal of Surgery 2012
229
16. Differences in outcomes of esophageal and gastric cancer surgery across Europe British Journal of Surgery 2012
243
discussion
17. General discussion and summary
261
appendices
Summary in Dutch (Nederlandse samenvatting) Acknowledgements (Dankwoord) List of publications Curriculum vitae
279 284 286 289
