Acharya SD, Ullal SD, Padiyar S, Rao YD, Upadhyaya K, Pillai D, Raj V. Analgesic effect of extracts of Alpinia Galanga rhizome in mice

46

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56

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57

Wuryaningsih L E et al. Uji Analgesik Ekstrak Etanol Kering Rimpang Kencur Asal Purwodadi pada Mencit Dengan Metode Geliat (Writhing Reflex Test), Warta Tumbuhan Obat Indonesia; 1996; hal. 24-25

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Gupta M et al. Studies on Anti- inflammatory, Analgesic and Antipyretic Properties of Methanol Extract of Caesalpinia bonducella leaves in Experimental Animal Models, Iranian J. Pharmacology & Therapeutics. Calcutta, India: Razi Institute for Drug Research; 2003

51

LAMPIRAN

Lampiran 1

52

Lampiran 2

53

Lampiran 3 Tabel Konversi Perhitungan Dosis (Laurance & Bacharach, 1964)

Mencit 20 g

Tikus 200 g

Marmot 400 g

Kelinci 1,5 kg

Kucing 2 kg

Kera 4 kg

Anjing 12 kg

Manusia 70 kg

Mencit 20 g

1,0

7,0

12,25

27,8

29,7

64,1

124,2

387,9

Tikus 200 g

0,14

1,0

1,74

3,9

4,2

9,2

17,8

56,0

Marmot 400 g

0,08

0,57

1,0

2,25

2,4

5,2

10,2

31,5

Kelinci 1,5 kg

0,04

0,25

0,44

1,0

1,08

2,4

4,5

14,2

Kucing 2 kg

0,03

0,23

0,41

0,92

1,0

2,2

4,1

13,0

Kera 4 kg

0,016

0,11

0,19

0,42

0,45

1,0

1,9

6,1

Anjing 12 kg

0,008

0,06

0,1

0,22

0,24

0,52

1,0

3,1

Manusia 70 kg

0,0026

0,018

0,031

0,07

0,076

0,16

0,32

1,0

54

Lampiran 4 Perhitungan Dosis Aspirin Dosis lazim aspirin sekali adalah 325-650 mg pada manusia dewasa. Dikonversi ke mencit yang beratnya 20 gram menjadi: 0,0026 x 500 = 1,3 mg/20 gramBB Produk X Dosis lazim Produk X 15-30 ml pada manusia dewasa. Dikonversi ke mencit yang beratnya 20 gram menjadi: 1. 0,0026 x 30 = 0,078 ml/20 gramBB ≈ 0,1 ml/20 gramBB 2. 0,0026 x 4(30) = 0,312 ml/20 gramBB ≈ 0,35 ml/20 gramBB

55

Lampiran 5 Hasil Penelititan Jumlah Geliat Mencit Ke

15 Menit I

15 Menit II

K1

K2

P1

P2

K (-)

K (+)

P1

P2

1

5

8

3

1

8

6

0

0

2

6

3

5

0

3

0

2

0

3

11

1

4

0

7

1

3

0

4

4

2

7

0

6

1

9

0

5

8

1

3

0

7

0

0

0

6

4

3

3

0

2

2

1

0

56

Lampiran 6 Analisis Data Explore Kelompok

57

Jumlah geliat 15 menit I

58

Jumlah geliat 15 menit II

59

T-Test (K1) Paired Samples Statistics

Pair 1

Mean 6.33 5.50

Jumlah geliat 15 menit I Jumlah geliat 15 menit II

N 6 6

Std. Deviation 2.733 2.429

Std. Error Mean 1.116 .992

Paired Samples Correlations N Pair 1

Jumlah geliat 15 menit I & Jumlah geliat 15 menit II

Correlation 6

.422

Sig. .405

Paired Samples Test

Paired Differences

Mean Std. Deviation Std. Error Mean 95% Confidence Interval of the Difference

t df Sig. (2-tailed)

Pair 1 Jumlah geliat 15 menit I Jumlah geliat 15 menit II .833 2.787 1.138 Lower Upper

-2.091 3.758 .732 5 .497

60

NPar Tests (K2) Wilcoxon Signed Ranks Test Ranks N Jumlah geliat 15 menit II Jumlah geliat 15 menit I

Negative Ranks Positive Ranks Ties Total

a. Jumlah geliat 15 menit II < Jumlah geliat 15 menit I b. Jumlah geliat 15 menit II > Jumlah geliat 15 menit I c. Jumlah geliat 15 menit II = Jumlah geliat 15 menit I

Test Statisticsb

Z Asymp. Sig. (2-tailed)

Jumlah geliat 15 menit II Jumlah geliat 15 menit I -2.060a .039

a. Based on positive ranks. b. Wilcoxon Signed Ranks Test

5a 0b 1c 6

Mean Rank 3.00 .00

Sum of Ranks 15.00 .00

61

NPar Tests (P1) Wilcoxon Signed Ranks Test Ranks N Jumlah geliat 15 menit II Jumlah geliat 15 menit I



Test Statisticsb




5a 1b 0c 6

Mean Rank 3.70 2.50

Sum of Ranks 18.50 2.50

62

NPar Tests (P2) Wilcoxon Signed Ranks Test Ranks N Jumlah geliat 15 menit II Jumlah geliat 15 menit I



Test Statisticsb




1a 0b 5c 6

Mean Rank 1.00 .00

Sum of Ranks 1.00 .00

63

NPar Tests Kruskal-Wallis Test

64

NPar Tests Mann-Whitney Test Ranks Kelompok K1 K2 Total K1 K2 Total



N 6 6 12 6 6 12

Mean Rank 8.75 4.25


9.00 4.00

54.00 24.00

Test Statisticsb

Mann-Whitney U Wilcoxon W Z Asymp. Sig. (2-tailed) Exact Sig. [2*(1-tailed Sig.)]

Jumlah geliat 15 menit I 4.500 25.500 -2.177 .029

a. Not corrected for ties. b. Grouping Variable: Kelompok

a

.026

Jumlah geliat 15 menit II 3.000 24.000 -2.423 .015 a

.015

65

NPar Tests Mann-Whitney Test Ranks Kelompok K1 P1 Total K1 P1 Total



N 6 6 12 6 6 12

Mean Rank 8.25 4.75


8.17 4.83

49.00 29.00

Test Statisticsb




a

.093


.132

66




N 6 6 12 6 6 12

Mean Rank 9.50 3.50


9.50 3.50

57.00 21.00

Test Statisticsb


Jumlah geliat 15 menit I .000 21.000 -2.994 .003


a

.002

Jumlah geliat 15 menit II .000 21.000 -3.083 .002 a

.002

67




N 6 6 12 6 6 12

Mean Rank 5.00 8.00


6.08 6.92

36.50 41.50

Test Statisticsb




a

.180

Jumlah geliat 15 menit II 15.500 36.500 -.411 .681 a

.699

68




N 6 6 12 6 6 12

Mean Rank 9.33 3.67


8.50 4.50

51.00 27.00

Test Statisticsb




a

.004


.065

69

NPar Tests Mann-Whitney Test Ranks Kelompok P1 P2 Total P1 P2 Total



N 6 6 12 6 6 12

Mean Rank 9.50 3.50


8.50 4.50

51.00 27.00

Test Statisticsb


Jumlah geliat 15 menit I .000 21.000 -3.011 .003


a

.002


.065

70

Lampiran 7 Dokumentasi Penelitian

71

Lampiran 8 BIODATA MAHASISWA

Identitas Nama

: Hizkia Christian Wilianto

NIM

: 22010112130079

Tempat/ tanggal lahir : Bekasi, 27 Oktober 1993 Jenis kelamin

: Laki-laki

Alamat

: Jl. Gondang Timur 4 No. 66B, Bulusan, Tembalang

Nomor telepon

:-

Nomor HP

: 08561921992

E-mail

: [email protected]

Riwayat Pendidikan Formal 1)

2)

3)

4)

SD

: SD Kasih Bunda

Lulus tahun

: 2006

SMP

: SMP Negeri 1 Bekasi

Lulus tahun

: 2009

SMA

: SMA Negeri 1 Bekasi

Lulus tahun

: 2012

Universitas

: Univ. Diponegoro Fakultas Kedokteran Prodi Pendidikan Dokter

Masuk tahun : 2012

Acharya SD, Ullal SD, Padiyar S, Rao YD, Upadhyaya K, Pillai D, Raj V. Analgesic effect of extracts of Alpinia Galanga rhizome in mice

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