DAFTAR PUSTAKA. Agoes, G. (2012). Sediaan Farmasi Padat : Seri Farmasi Industri 6. Bandung: ITB

DAFTAR PUSTAKA Agoes, G. (2012). Sediaan Farmasi Padat : Seri Farmasi Industri – 6. Bandung: ITB. Anonim. (2008). MIMS Petunjuk Konsultasi. Jakarta: PT Medilata Anonim. (2010). Metformin Hydrocloride Extended-Release Tablets. The United Pharmachopeal Convention. September 2010. Ansel, H. C. (2008). Pengantar Bentuk Sediaan Farmasi Edisi Keempat. Jakarta: Universitas Indonesia Press. BPOM, (2004), Pedoman Uji Bioekivalensi, available at www. Pom.go.id/ publik/ hukum_perundangan/pdf/HK.0005.3.1 818.pdf, BPOM RI, Jakarta (hal 8) Choiri, S. 2012. Optimasi Sediaan Tablet Lepas Lambat Teofilin Menggunakan Bahan Matriks Montmorillonit dan HPMC dengan Simplex Lattice Design. Tugas Akhir. Surakarta: Fakultas Matematika dan Ilmu Pengetahuan Alam. Universitas Sebelas Maret. [DepKes RI] Departemen Kesehatan Republik Indonesia., (1979). Farmakope Indonesia Edisi III. Jakarta: Departemen Kesehatan Republik Indonesia. [DepKes RI] Departemen Kesehatan Republik Indonesia., (1995). Farmakope Indonesia Edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia. Edyaningrum, A. 2013. Perbandingan Mutu Fisik dan Profil Disolusi Tablet Glibenklamida Merk Dagang dan Generik. Skripsi. Surakarta: Fakultas Farmasi Universitas Muhammadiyah Surakarta . Fudholi, A. (2013). Disolusi dan Pelepasan Obat In Vitro. Yogyakarta: Pustaka Pelajar. Gennaro, A. R. Remington: The Science and Practice of Pharmacy. 20th ed. Vol. II. Pennsylvania: Mack Publishing Company. 2000. Haitami, L. M. 2010. Optimasi Tablet Sustained Release Teofilin Dengan Kombinasi Matrik Etilselulosa 20 cP dan Metilselulosa. Skripsi. Surakarta: Fakultas Farmasi. Universitas Muhammadiyah Surakarta. Ichikawa M., Watanabe S., and Miyake Y., (1991). A New Multiple-unit Oral Floating dosage system, I : Preparation and in vitro evaluation of floating and sustained release characteristics., J Pharm Sci 1991;80;1062-6

33 UJI DISOLUSI TERBANDING ..., INTAN RIYANTY MAHARANI,FARMASI, UMP 2017.

Werdana, R. K. 2016. Formulasi Tablet Floating Metformin HCl dengan Eksipien Methochel K4M CR (HPMC K4M CR) dan Natrium Bikarbonat (NaCHO3) Skripsi. Purwokerto: Fakultas Farmasi, Universitas Muhammadiyah Purwokerto. Lachman, L., Lieberman, H.A., dan Kaning, J.L., (1994). Teori dan Praktek Farmasi Industri II Edisi Ketiga. Jakarta: Universitas Indonesia Press. Milani, Parvin Zakeri et al. (2012). In-vitro bioequivalence study of 8 brands of metformin tablets in Iran market. Vol 02 (08): 194-197 Sari, D. P., Sulaiman. T. N. S., dan Mafruhah, O. R (2013). Uji Disolusi Terbanding Tablet Metformin Hidroklorida Generik Berlogo dan Bermerk. 9: 254-258 Shargel, L. Andrew, B.C.Yu. (1988). Biofarmasetika dan Farmakokinetika Terapan. edisi 2. Surabaya: Airlangga University Press.. Shargel, L., Wu-Pong, S. and Yu, B.C A. (2004). Biofarmasetika dan Farmakokinetika Terapan Edisi Kelima. Alih Bahasa: Fasich, B.S. Surabaya: Pusat Penerbitan dan Percetakan Universitas Airlangga. Siregar, C., Wikarsa., S. (2010). Teknologi Farmasi Sediaan Tablet Dasar – Dasar Praktis. Jakarta : EGC Siswanto, A. (2015). Formulasi dan Uji Bioavaibilitas Tablet Floating Aspirin Menggunakan Methocel K4M CR, Natrium Bikarbonat, dan Ethocel disertasi. Yogyakarta: Fakultas Faramasi. Universitas Gajah Mada. Stuart , A. V. (2015). Comparing the Dissolution Profiles of Seven Metformin Formulations in Simulated Intestinal Fluid. 10.14227/DT220115P17. (2001). Pengaruh Pollvlnllplrolldon K-30 Terhadap Suharmiati, et al. Peningkatan Laju Dlsolusl Andrografolida dengan Sistem Dispersi Solida. Vol 4 : 53-65 Syofyan. (2010). Perbandingan Mutu dan Harga Tablet Asam Mefenamat Generik dengan Bermerek Dagang yang Beredar di Pasaran. Universitas Andalas. Qureshi, S. A. (2013). F2 - Similarity Factor (A Deficiency). www.drugdissolution-testing.com


Lampiran 1. Evaluasi Sifat Fisik Tablet 1. Keseragaman ukuran tablet Replikasi

Ketebalan (cm)

Tablet floating metformin HCl 500 mg

Tablet A dari pabrik X

Tablet B dari pabrik Y

Tablet C dari pabrik Z

0,411 0,411 0,411 0,411 0 1,51 1,51 1,51 1,51 0 Tablet Tablet Tablet Tablet

0,69 0,69 0,69 0,69 0 2,1 2,1 2,1 2,1 0 Kaplet Kaplet Kaplet Kaplet



1 2 3

Rata – rata SD Diameter (cm)

1 2 3

Rata – rata SD Bentuk

1 2 3 Rata – rata

2. Keseragaman bobot tablet Bobot (mg)

Rep

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

Tablet floating metformin HCl 500 mg Bobot tablet (mg) 852,9 856,7 846,0 863,3 889,4 865,6 846,0 860,8 863,7 876,1 867,3 853,7 842,8 883,0 848,5 855,2 874,5 849,0 849,5

Kolom A (5%) 809,84 813,64 802,94 820,24 846,34 822,54 802,94 817,74 820,64 833,04 824,24 810,64 799,74 839,94 805,44 812,14 831,44 805,94 806,44

Tablet A dari pabrik X

Kolom B (10%) 765,13 768,93 758,23 775,53 801,63 777,83 758,23 773,03 775,93 788,33 779,53 765,93 755,03 795,23 760,73 767,43 786,73 761,23 761,73

Bobot tablet (mg) 1007,70 1004,60 1002,10 1011,80 1014,80 1003,80 1021,30 1004,60 1011,20 1011,00 1005,10 1010,90 1009,20 1009,90 1016,90 1010,30 1013,80 1013,20 1001,00

Kolom A (5%) 957,20 954,10 951,60 961,30 964,30 953,30 970,80 954,10 960,70 960,50 954,60 960,40 958,70 959,40 966,40 959,80 963,30 962,70 950,50

Kolom B (10%) 906,70 903,60 901,10 910,80 913,80 902,80 920,30 903,60 910,20 910,00 904,10 909,90 908,20 908,90 915,90 909,30 912,80 912,20 900,00

Tablet B dari pabrik Y Bobot tablet (mg) 857,4 882,1 860,3 864,5 873,4 880,8 858,1 873,5 863,9 869,8 871,7 865,7 860,6 870,8 869,8 853,2 861,9 875,7 871,7

Kolom A (5%) 814,01 838,71 816,91 821,11 830,01 837,41 814,71 830,11 820,51 826,41 828,31 822,31 817,21 827,41 826,41 809,81 818,51 832,31 828,31

Kolom B (10%) 770,63 795,33 773,53 777,73 786,63 794,03 771,33 786,73 777,13 783,03 784,93 778,93 773,83 784,03 783,03 766,43 775,13 788,93 784,93

Tablet C dari pabrik Z Bobot tablet (mg) 1031,1 1019,7 1012,0 1034,2 1018,1 1038,8 1015,3 1016,9 1027,3 1038,0 1015,6 1020,3 1035,8 1040,5 1040,8 1039,9 1037,6 1042,0 1025,7

Kolom A (5%) 979,70 968,30 960,60 982,80 966,70 987,40 963,90 965,50 975,90 986,60 964,20 968,90 984,40 989,10 989,40 988,50 986,20 990,60 974,30


Kolom B (10%) 928,30 916,90 909,20 931,40 915,30 936,00 912,50 914,10 924,50 935,20 912,80 917,50 933,00 937,70 938,00 937,10 934,80 939,20 922,90

20

877,7

Rata - rata SD CV (%)

861,1 11,17 1,09

834,64

789,93

1016,00 1009,6 5,31 0,53

965,50

915,00

869,1 867,7 7,74 0,89

825,71

782,33

1008,8

957,40

1027,92 11,17 1,087


906,00

Lampiran 2. Penetapan Kadar Metformin HCl 500 mg. a. Pembuatan kurva baku Konsentrasi (mg/ml) 0,01 0,02 0,03 0,04 0,05 0,06 0,07 0,08

Absorbansi 0,143 0,248 0,354 0,444 0,536 0,616 0,717 0,814

b. Perhitungan LOD dan LOQ Persamaan kurva baku y = 9.216x+0.059 Penimbangan sebenarnya 102,3 mg x (mg/ml)

Y

y - y’

(y-y’)2

0,0090 0,0204 0,0319 0,0416 0,0516 0,0603 0,0713 0,0818

0,143 0,248 0,354 0,444 0,536 0,616 0,717 0,814

-0,341 -0,236 -0,130 -0,040 0,052 0,132 0,233 0,330

0,116 0,055 0,016 0,002 0,002 0,017 0,054 0,108

y’

0,048

∑

0,373

=

Sb = LOD =

=

LOQ =

=

= 0,249 = 0,081 mg/ml = 0,271 mg/ml


c. Penetapan kadar metformin HCl dalam tablet i) Tablet floating metformin HCl 500 mg Berat penimbangan (mg) 859,4 859,1 859,2

Replikasi

Absorbansi

1a 1c 2a 2c 3a 3b

0,238 0,222 0,239 0,234 0,227 0,226

Konsentrasi (μg/ml) 0,97 0,88 0,97 0,95 0,91 0,90

Kadar (mg) 485,00 440,20 486,32 472,75 453,76 451,05

Rata – Rata SD CV (%)

% kadar 96,92 88,05 97,27 94,56 90,76 90,22 92,93 3,79 4,08

ii) Tablet A dari pabrik X Berat penimbangan (mg) 1011,4 1011,9 1010,2

Replikasi

Absorbansi

1a 1b 2a 2b 3a 3b

0,409 0,403 0,407 0,409 0,405 0,406

Konsentrasi (mg/ml) 0,95 0,93 0,94 0,95 0,94 0,94

Kadar (mg) 473,71 465,58 471,00 473,71 468,29 469,65

Rata - rata SD CV (%)

% kadar 94,61 92,98 94,07 94,61 93,53 93,80 93,93 0,64 0,68

iii) Tablet B dari pabrik Y Berat penimbangan (mg) 869,5 870,4 870,4 Rata - rata SD CV

Replikasi 1b 1c 2b 2c 3a 3b

Absorbansi 0,423 0,422 0,453 0,426 0,425 0,435

Konsentrasi (mg/ml) 0,99 0,98 1,07 0,99 0,99 1,02

Kadar (mg) 492,70 491,35 533,39 496,77 495,42 508,98

% kadar 98,34 98,07 106,46 99,15 98,88 101,59 100,41 3,21 3,20


iv) Tablet C dari pabrik Z Berat penimbangan (mg)

Replikasi

Absorbansi

1a 1b 2b 2c 3b 3c

1028 1028,3 1028

Konsentrasi (mg/ml)

0,418 0,405 0,420 0,424 0,425 0,422

0,97 0,94 0,98 0,99 0,99 0,98

Kadar (mg)

% kadar

485,92 468,29 488,63 494,06 495,41 491,35

Rata - rata SD CV

97,18 93,65 97,72 98,80 99,08 98,26 97,45 1,99 2,04

Contoh perhitungan penetapan kadar pada tablet floating metformin HCl replikasi 1. Penimbangan serbuk sebenarnya = 859,4 mg Perhitungan kadar metformin dalam campuran serbuk (secara penelitian) Absorbansi yang diperoleh = 0,238, pengenceran 50x Persamaan kurva baku metformin dalam cairan lambung buatan pH 1,2 : y = 9,216x + 0,059 0,238 = 9,216x + 0,059 x= x = 0,97 mg/ml Kadar metformin HCl dalam 500 ml mengandung : x= 0,97 mg/ml x 500 ml = 485 mg Kadar metformin HCl dalam tiap tablet = =

x 500 x 500 = 500,04 mg

% kadar metformin per tablet =

= 96,92 %


Lampiran 3. Hasil Uji Disolusi Tablet Floating Metformin HCl 1. Tabulasi hasil serapan metformin HCl pada uji disolusi Serapan Waktu

5 15 30 45 60 90 120 180 240 300 360 420 480 540 600

Pengence ran 5 5 5 5 5 5 5 5 5 10 10 10 10 10 10

Tablet floating metformin HCl 500 mg Replikasi 1 2 3 0,176 0,167 0,219 0,183 0,219 0,265 0,255 0,297 0,354 0,323 0,341 0,424 0,394 0,417 0,479 0,497 0,501 0,576 0,584 0,572 0,674 0,714 0,693 0,749 0,470 0,477 0,539 0,540 0,542 0,619 0,580 0,638 0,685 0,667 0,662 0,751 0,688 0,734 0,793 0,681 0,692 0,732 0,681 0,701 0,739

Tablet A

1 0,178 0,229 0,307 0,364 0,440 0,510 0,594 0,702 0,790 0,519 0,520 0,575 0,588 0,605 0,618

Replikasi 2 0,183 0,227 0,314 0,373 0,441 0,524 0,606 0,728 0,814 0,509 0,568 0,576 0,592 0,609 0,669

Tabet B

3 0,134 0,242 0,354 0,401 0,426 0,576 0,617 0,742 0,820 0,512 0,566 0,573 0,605 0,612 0,642

1 0,181 0,246 0,306 0,360 0,415 0,499 0,553 0,660 0,766 0,466 0,521 0,540 0,573 0,599 0,624

Replikasi 2 0,183 0,239 0,308 0,364 0,422 0,496 0,569 0,665 0,761 0,469 0,513 0,564 0,578 0,592 0,645

Tablet C

3 0,154 0,238 0,350 0,401 0,413 0,491 0,563 0,661 0,771 0,496 0,549 0,588 0,601 0,612 0,632

1 0,172 0,218 0,290 0,360 0,414 0,500 0,575 0,673 0,771 0,466 0,528 0,614 0,618 0,685 0,722

Replikasi 2 0,145 0,218 0,278 0,325 0,376 0,488 0,573 0,660 0,740 0,500 0,530 0,569 0,609 0,682 0,724

3 0,147 0,207 0,268 0,335 0,436 0,461 0,552 0,658 0,747 0,461 0,512 0,554 0,588 0,658 0,719

2. Tabulasi hasil persen disolusi Metformin HCl % disolusi Waktu 5 Rata–rata SD 15 Rata–rata SD 30 Rata–rata SD 45 Rata–rata SD 60 Rata–rata SD 90 Rata–rata SD 120 Rata–rata SD 180

Tablet floating metformin HCl 500 mg 1 2 3 7,515 6,966 10,452 8,311 1,87 7,979 10,627 13,646 10,751 2,84 13,028 16,102 19,752 16,294 3,37 17,703 19,168 24,581 20,484 3,62 22,607 24,482 28,403 25,164 2,96 29,789 30,369 35,074 31,744 2,90 35,780 35,333 41,821 37,644 3,62 44,797 43,824 46,995

Tablet A 1 7,695

11,207

16,567

20,564

25,800

30,676

36,480

43.987

2 8,128 6,811 1,92 11,159 11,473 0,50 17,285 17,882 1,69 21,415 21,665 1,24 26,155 25,562 0,74 31,979 32,585 2,27 37,741 37,374 0,78 46,254

Tablet B 3 4,609

1 7,848

12,053

12,405

19,793

16,560

23,015

20,259

24,732

24,054

35,101

29,865

37,902

33,626

46,546

41,030

2 8,107 7,319 1,15 12,035 12,067 0,32 16,823 17,638 1,64 20,757 21,348 1,48 24,804 24,243 0.49 30,019 29,700 0,43 35,109 34,311 0,75 41,822

Tablet C 3 6,002

1 7,280

11,763

10,445

19,531

15,411

23,029

20,259

23,870

23,999

29,217

29,955

34,198

35,191

40,958

41,951

2 5,454 6,084 0,85 10,564 10,204 0,43 14,752 14,660 0,65 18,034 18,925 0,96 21,604 23,677 1,58 29,452 28,849 1,23 35,417 34,678 0,89 41,514


3 5,519

9,604

13,819

18,482

25,429

27,140

33,425

40,738

Rata–rata SD 240 Rata–rata SD 300 Rata–rata SD 360 Rata–rata SD 420 Rata–rata SD 480 Rata–rata SD 540 Rata–rata SD 600 Rata–rata SD

55,825

65,535

70,951

83,057

86,008

106,211

106,332

45,206 1,62 57,337 59,424 4,98 66,395 69,346 5,87 79,921 78,718 7,24 83,267 86,900 6,48 93,376 93,167 7,06 109,369 110,063 4,24 110,979 111,076 4.,9

65,112

50,041

76,108

62,626

85,284

62,695

94,376

70,328

100,116

72,073

114,607

74,469

115,918

76,339

45,596 1,40 52,260 51,409 1,20 61,901 61,952 0,65 70,036 67,176 3,93 71,198 70,420 0,73 73,410 73,202 1,04 75,902 75,194 0,72 84,023 79,881 3,88

51,927

48,357

61,331

55,160

68,796

62,778

69,734

65,535

74,122

70.009

75,212

73.624

79,282

77.073

41,270 0,48 48,550 48,4875 0,11 56,174 56,810 2,04 62,391 63,892 2,27 69,560 68,971 3,18 71.436 71.676 1.80 73.410 74.073 0.97 80.900 78.625 2.01

48,554

48,718

59,096

55,174

66,505

63,831

71,817

75,702

73.584

76,339

75.184

85,523

77.902

90,620

41,401 0,50 47,101 47,579 0,81 60,529 56,679 2,74 64,729 63,283 1,46 70,190 70,992 3,56 75,790 74,658 2,00 86,053 84,374 2,01 91,891 90,824 0,80

Contoh perhitungan persen disolusi metformin HCl 500 mg Tablet floating replikasi 1 Menit ke-5 Absorbansi 0,176 pengenceran 5x Bobot rata – rata tablet 860,567 mg Bobot tablet yang didisolusi 862,50 mg Persamaan regresi y = 14, 406x + 0,067 x= x = 0,03648 mg/ml Kadar dalam 1000 ml x = 0,0364mg/ml x1000 ml = 36,48 mg Jumlah metformin HCl dalam satu tablet = =


46,919

54,336

61,290

67,085

71,845

81,545

89,961

% disolusi metformin HCl = =

3. Tabulasi hasil nilai F1 dan F2 Rep

Tablet floating

Tablet floating

Tablet floating

metformin HCl 500

metformin HCl 500

metformin HCl 500

mg dengan Tablet A

mg dengan Tablet B

mg dengan Tablet C

F1

F2

F1

F2

F1

F2

1

18,25

44,75

21,89

43,97

13,32

54,31

2

18,17

44,83

22,39

41,87

17,03

48,75

3

21,15

37,79

23,69

36,95

24,37

37,62

Rata – rata

19,19

42,45

22,65

40,93

18,24

46,89

Contoh perhitungan nilai f1, f2 Tablet floating metformin HCl dengan Tablet A replikasi 1. Menit 5 15 30 45 60 90 120 180 240 300 360 420 480 540 600

(T(t)) 7,515 7,979 13,028 17,703 22,607 29,789 35,780 44,797 55,825 65,535 70,951 83,057 86,008 106,211 106,332

(R(t)) 7,695 11,207 16,567 20,564 25,800 30,675 36,479 43,987 50,040 62,626 62,695 70,328 72,073 74,469 76,339

R(t) - T(t) 0,180 3,227 3,539 2,860 3,192 0,886 0,699 -0,810 -5,784 -2,908 -8,255 -12,729 -13,935 -31,742 -29,993

(R(t) - T(t))^2 0,032 10,416 12,525 8,182 10,194 0,785 0,489 0,656 33,455 8,461 68,156 162,050 194,184 1007,557 899,591

│R(t) - T(t)│ 0,180 3,227 3,539 2,860 3,192 0,886 0,699 0,810 5,784 2,908 8,255 12,729 13,935 31,742 29,993

Perhitungan f1 :

∑(R(t) = 661.551 42 UJI DISOLUSI TERBANDING ..., INTAN RIYANTY MAHARANI,FARMASI, UMP 2017.

∑│R(t) - T(t)│= 120.745

= 18,25

Perhitungan f2

∑(R(t) - T(t))^2 = 2416.741 = 12,330

Contoh perhitungan nilai C Tablet Floating 500 mg Nilai C C60 C120 C360 C600

1 22,607 35,780 70,951 106,332

Replikasi 2 24,482 35,333 79,921 110,979

3 25,164 37,644 78,718 111,076

SD 1,32 1,22 4,86 2,71

Perhitungan C60 tablet floating 500 mg C60 = C60 =

= 24,084


Contoh perhitungan nilai DE Tablet floating metformin HCl replikasi 1. Menit 0–5 5 – 15 15 – 30 30 – 45 45 – 60 60 – 90 90 – 120 120 – 180 180 – 240 240 – 300 300 – 360 360 – 420 420 – 480 480 – 540 540 – 600

% Disolusi 7,52 7,98 13,03 17,70 22,61 29,79 35,78 44,80 55,83 65,54 70,95 83,06 86,01 106,21 106,33

Luas AUC 18,79 77,48 157,56 230,49 302,33 785,95 983,55 2417,35 3018,69 3640,81 4094,60 4620,28 5071,99 5766,61 6376,33

Luas AUC menit 0 – 5 = Luas AUC menit 5 – 15 = Luas AUC menit 15 – 30 = Luas AUC menit 30 – 45 = Luas AUC menit 45 – 60 = Luas AUC menit 60 – 90 = Luas AUC menit 90 – 120 = Luas AUC menit 120 – 180 = Luas AUC menit 180 – 240 = Luas AUC menit 240 – 300 = Luas AUC menit 300 – 360 = 44 UJI DISOLUSI TERBANDING ..., INTAN RIYANTY MAHARANI,FARMASI, UMP 2017.

Luas AUC menit 360 – 420 = Luas AUC menit 420 – 480 = Luas AUC menit 480 – 540 = Luas AUC menit 540 – 600 =

∑ Luas AUC = 37562,81 Luas Kurva Segiempat 100 % = 100 x 600 = 60000

DE600 =


DISOLUSI EFISIENSI Explore Tablet Case Processing Summary Cases Valid Tablet Disolusi_ Efisiensi

N

Missing

Percent

N

Total

Percent

N

Percent

Tablet Floating

3

100.0%

0

.0%

3

100.0%

Tablet A

3

100.0%

0

.0%

3

100.0%

Tablet B

3

100.0%

0

.0%

3

100.0%

Tablet C

3

100.0%

0

.0%

3

100.0%

Tests of Normality a

Kolmogorov-Smirnov Tablet Disolusi_ Efisiensi

Statistic

df

Shapiro-Wilk

Sig.

Statistic

df

Sig.

Tablet Floating

.275

3

.

.943

3

.541

Tablet A

.323

3

.

.878

3

.320

Tablet B

.175

3

.

1.000

3

.995

Tablet C

.354

3

.

.821

3

.166

a. Lilliefors Significance Correction

Oneway Descriptives Disolusi_Efisiensi 95% Confidence Interval for Mean N Tablet Floating Tablet A Tablet B Tablet C Total

Std. Deviation Std. Error

Mean 3 3 3 3 12

66.4333 55.1933 52.7367 54.4967 57.2150

4.59709 1.10961 1.03500 1.50098 6.03705

2.65413 .64063 .59756 .86659 1.74275

Lower Bound 55.0135 52.4369 50.1656 50.7680 53.3792

Upper Bound 77.8531 57.9498 55.3078 58.2253 61.0508

Minimum

Maximum

62.60 53.93 51.70 52.77 51.70

Test of Homogeneity of Variances Disolusi_Efisiensi Levene Statistic 4.178

df1

df2 3

Sig. 8

.047


71.53 56.01 53.77 55.49 71.53

ANOVA Disolusi_Efisiensi Sum of Squares

df

Mean Square

Between Groups Within Groups

349.529 51.377

3 8

Total

400.906

11

116.510 6.422

F

Sig.

18.142

.001

Post Hoc Tests Multiple Comparisons Disolusi_Efisiensi LSD (I) Tablet

(J) Tablet

Mean Difference (I-J)

95% Confidence Interval Std. Error

Sig.

Lower Bound

Upper Bound

Tablet Floating Tablet A

11.24000

*

2.06916

.001

6.4685

16.0115

Tablet B

13.69667

*

2.06916

.000

8.9252

18.4682

11.93667

*

2.06916

.000

7.1652

16.7082

-11.24000

*

2.06916

.001

-16.0115

-6.4685

Tablet B

2.45667

2.06916

.269

-2.3148

7.2282

Tablet C

.69667

2.06916

.745

-4.0748

5.4682

*

2.06916

.000

-18.4682

-8.9252

-2.45667

2.06916

.269

-7.2282

2.3148

-1.76000

2.06916

.420

-6.5315

3.0115

*

2.06916

.000

-16.7082

-7.1652

Tablet A

-.69667

2.06916

.745

-5.4682

4.0748

Tablet B

1.76000

2.06916

.420

-3.0115

6.5315

Tablet C Tablet A

Tablet B

Tablet Floating

Tablet Floating Tablet A Tablet C

Tablet C

Tablet Floating

-13.69667

-11.93667

*. The mean difference is significant at the 0.05 level.


NILAI C Explore Tablet Case Processing Summary Cases Valid Tablet Nilai_C

N

Missing

Percent

N

Total

Percent

N

Percent

Tablet Floating

4

100.0%

0

.0%

4

100.0%

Tablet A

4

100.0%

0

.0%

4

100.0%

Tablet B

4

100.0%

0

.0%

4

100.0%

Tablet C

4

100.0%

0

.0%

4

100.0%

Tests of Normality a

Kolmogorov-Smirnov Tablet Nilai_C

Statistic

df

Shapiro-Wilk

Sig.

Statistic

df

Sig.

Tablet Floating

.242

4

.

.937

4

.634

Tablet A

.225

4

.

.932

4

.604

Tablet B

.236

4

.

.931

4

.600

Tablet C

.229

4

.

.949

4

.707

a. Lilliefors Significance Correction

Oneway Descriptives Nilai_C 95% Confidence Interval for Mean N Tablet Floating Tablet A Tablet B Tablet C Total

Std. Deviation

Mean 4 4 4 4 16

61.5825 52.4988 50.2680 53.1162 54.3664

Std. Error

39.00295 25.29474 25.30952 30.17677 27.60733

19.50148 12.64737 12.65476 15.08839 6.90183

Lower Bound

Upper Bound

-.4799 123.6449 12.2492 92.7483 9.9949 90.5411 5.0983 101.1342 39.6555 69.0773

Minimum Maximum 24.08 25.56 24.24 23.68 23.68

Test of Homogeneity of Variances Nilai_C Levene Statistic .848

df1

df2 3

Sig. 12

.494


109.46 79.88 78.63 90.83 109.46

ANOVA Nilai_C Sum of Squares

df

Mean Square

Between Groups Within Groups

295.680 11136.791

3 12

Total

11432.471

15

98.560 928.066

F

Sig. .106

.955

Post Hoc Tests Multiple Comparisons Nilai_C LSD Mean Difference (I-J)

95% Confidence Interval

(I) Tablet

(J) Tablet

Tablet Floating

Tablet A

9.08375

21.54142

.681

-37.8510

56.0185

Tablet B

11.31450

21.54142

.609

-35.6202

58.2492

Tablet C

8.46625

21.54142

.701

-38.4685

55.4010

-9.08375

21.54142

.681

-56.0185

37.8510

Tablet B

2.23075

21.54142

.919

-44.7040

49.1655

Tablet C

-.61750

21.54142

.978

-47.5522

46.3172

Tablet A

Tablet B

Tablet C

Tablet Floating

Tablet Floating

Std. Error

Sig.

Lower Bound Upper Bound

-11.31450

21.54142

.609

-58.2492

35.6202

Tablet A

-2.23075

21.54142

.919

-49.1655

44.7040

Tablet C

-2.84825

21.54142

.897

-49.7830

44.0865

Tablet Floating

-8.46625

21.54142

.701

-55.4010

38.4685

Tablet A

.61750

21.54142

.978

-46.3172

47.5522

Tablet B

2.84825

21.54142

.897

-44.0865

49.7830


DAFTAR PUSTAKA. Agoes, G. (2012). Sediaan Farmasi Padat : Seri Farmasi Industri 6. Bandung: ITB

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